IL-6 in autoimmune disease and chronic inflammatory proliferative disease.

PubWeight™: 2.99‹?› | Rank: Top 1%

🔗 View Article (PMID 12220549)

Published in Cytokine Growth Factor Rev on September 10, 2002

Authors

Katsuhiko Ishihara1, Toshio Hirano

Author Affiliations

1: Department of Molecular Oncology (C7), Graduate School of Medicine, Osaka University, 2-2 Yamada-oka Suita, Osaka 565-0871, Japan.

Articles citing this

(truncated to the top 100)

A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest (2007) 8.54

Interleukin-6: discovery of a pleiotropic cytokine. Arthritis Res Ther (2006) 2.93

Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators Inflamm (2005) 2.63

Prostate cancer and inflammation: the evidence. Histopathology (2012) 2.60

Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: implications for fatigue. Brain Behav Immun (2007) 2.18

Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8. J Invest Dermatol (2012) 2.02

Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology (2008) 1.90

Destabilization of interleukin-6 mRNA requires a putative RNA stem-loop structure, an AU-rich element, and the RNA-binding protein AUF1. Mol Cell Biol (2006) 1.77

A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner. Arthritis Rheum (2009) 1.70

Psoriasis: what we have learned from mouse models. Nat Rev Rheumatol (2010) 1.61

Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain (2010) 1.58

Inflammatory biomarkers, disease activity and spinal disease measures in patients with ankylosing spondylitis after treatment with infliximab. Ann Rheum Dis (2007) 1.44

Osteoporosis, inflammation and ageing. Immun Ageing (2005) 1.40

Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med (2006) 1.39

Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6. J Virol (2006) 1.38

A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium. Arthritis Rheum (2005) 1.36

c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130. Mol Cell Biol (2008) 1.31

Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus. Immunology (2006) 1.28

Stat3 phosphorylation mediates resistance of primary human T cells to regulatory T cell suppression. J Immunol (2011) 1.26

Poorer self-rated health is associated with elevated inflammatory markers among older adults. Psychoneuroendocrinology (2011) 1.25

Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. Rheumatology (Oxford) (2009) 1.25

Sustained high levels of interleukin-6 contribute to the pathogenesis of enterovirus 71 in a neonate mouse model. J Virol (2011) 1.22

Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir. Proc Jpn Acad Ser B Phys Biol Sci (2010) 1.21

Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment. Clin Exp Immunol (2004) 1.15

IL-6 blocks a discrete early step in lymphopoiesis. Blood (2005) 1.14

Gastrointestinal disease in simian immunodeficiency virus-infected rhesus macaques is characterized by proinflammatory dysregulation of the interleukin-6-Janus kinase/signal transducer and activator of transcription3 pathway. Am J Pathol (2007) 1.13

Inhibition of IL-1, IL-6, and TNF-alpha in immune-mediated inflammatory diseases. Springer Semin Immunopathol (2006) 1.11

Critical role of MARCO in crystalline silica-induced pulmonary inflammation. Toxicol Sci (2009) 1.11

Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis. Exp Cell Res (2014) 1.11

Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3. Immunology (2007) 1.10

STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor. Proc Natl Acad Sci U S A (2013) 1.10

Interleukin-6 (IL-6) and IL-17 synergistically promote viral persistence by inhibiting cellular apoptosis and cytotoxic T cell function. J Virol (2014) 1.08

MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines. Nucleic Acids Res (2009) 1.08

Inflammation-associated interleukin-6/signal transducer and activator of transcription 3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in interleukin-10-deficient mice. Hepatology (2011) 1.07

Src homology 2-containing 5-inositol phosphatase (SHIP) suppresses an early stage of lymphoid cell development through elevated interleukin-6 production by myeloid cells in bone marrow. J Exp Med (2004) 1.06

Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells. BMC Immunol (2010) 1.04

The effects of Th17 cytokines on the inflammatory mediator production and barrier function of ARPE-19 cells. PLoS One (2011) 1.03

Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation. J Biol Chem (2012) 1.03

Subtoxic levels hydrogen peroxide-induced production of interleukin-6 by retinal pigment epithelial cells. Mol Vis (2010) 1.02

Differing effects of clarithromycin and azithromycin on cytokine production by murine dendritic cells. Clin Exp Immunol (2007) 1.02

Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. PLoS Genet (2014) 0.98

Cytokines in Sjögren's syndrome. Oral Dis (2009) 0.98

Role of cytokines as a double-edged sword in sepsis. In Vivo (2013) 0.98

Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages. Am J Physiol Endocrinol Metab (2013) 0.97

Neuroimmunology of central nervous system viral infections: the cells, molecules and mechanisms involved. Curr Opin Pharmacol (2008) 0.96

IL-6 and high glucose synergistically upregulate MMP-1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun. J Cell Biochem (2010) 0.95

TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40. Proc Natl Acad Sci U S A (2009) 0.94

High interleukin-6 and tumor necrosis factor-alpha serum levels in hepatitis C infection associated or not with mixed cryoglobulinemia. Clin Rheumatol (2009) 0.94

MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. Biochim Biophys Acta (2013) 0.94

Podocytes regulate neutrophil recruitment by glomerular endothelial cells via IL-6-mediated crosstalk. J Immunol (2014) 0.94

Interleukin-6 production in CD40-engaged fibrocytes in thyroid-associated ophthalmopathy: involvement of Akt and NF-κB. Invest Ophthalmol Vis Sci (2012) 0.94

Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer. Prostate Cancer (2013) 0.94

PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity: implications to thyroid-associated ophthalmopathy. PLoS One (2010) 0.93

Thyrotropin regulates IL-6 expression in CD34+ fibrocytes: clear delineation of its cAMP-independent actions. PLoS One (2013) 0.92

Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27. Arthritis Res Ther (2004) 0.91

Control of early Theiler's murine encephalomyelitis virus replication in macrophages by interleukin-6 occurs in conjunction with STAT1 activation and nitric oxide production. J Virol (2012) 0.91

The -174 G/C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype. Br J Cancer (2004) 0.91

Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review). Oncol Lett (2015) 0.90

The anti-inflammatory role of vitamin e in prevention of osteoporosis. Adv Pharmacol Sci (2011) 0.89

Proinflammatory cytokine gene induction by human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 Tax in primary human glial cells. J Virol (2006) 0.89

Mechanisms for suppression of interleukin-6 expression in peritoneal macrophages from docosahexaenoic acid-fed mice. J Nutr Biochem (2008) 0.88

Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity. Neuropsychopharmacology (2016) 0.88

Anti-inflammatory treatment of uveitis with biologicals: new treatment options that reflect pathogenetic knowledge of the disease. Graefes Arch Clin Exp Ophthalmol (2010) 0.88

Cytokines in common variable immunodeficiency as signs of immune dysregulation and potential therapeutic targets - a review of the current knowledge. J Clin Immunol (2014) 0.86

CCAAT/enhancer binding protein beta is a major mediator of inflammation and viral replication in the gastrointestinal tract of simian immunodeficiency virus-infected rhesus macaques. Am J Pathol (2008) 0.86

Electrospun SF/PLCL nanofibrous membrane: a potential scaffold for retinal progenitor cell proliferation and differentiation. Sci Rep (2015) 0.86

Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis. J Inflamm (Lond) (2009) 0.86

Preexisting mild sleep disturbance as a vulnerability factor for inflammation-induced depressed mood: a human experimental study. Transl Psychiatry (2016) 0.85

Coactivation of TLR4 and TLR2/6 coordinates an additive augmentation on IL-6 gene transcription via p38MAPK pathway in U937 mononuclear cells. Mol Immunol (2011) 0.85

A stimulatory thyrotropin receptor antibody (M22) and thyrotropin increase interleukin-6 expression and secretion in Graves' orbital preadipocyte fibroblasts. Thyroid (2010) 0.85

Antihypertriglyceridemia and anti-inflammatory activities of monascus-fermented dioscorea in streptozotocin-induced diabetic rats. Exp Diabetes Res (2011) 0.84

A role for syntaxin 3 in the secretion of IL-6 from dendritic cells following activation of toll-like receptors. Front Immunol (2015) 0.84

Immune responses to non-tumor antigens in the central nervous system. Front Oncol (2014) 0.83

Elevated levels of serum IL-12 and IL-18 are associated with lower frequencies of CD4(+)CD25 (high)FOXP3 (+) regulatory t cells in young patients with type 1 diabetes. Inflammation (2014) 0.83

The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis. Adv Pharmacol Sci (2012) 0.83

Th1/Th2 cytokines and their genotypes as predictors of hepatitis B virus related hepatocellular carcinoma. World J Hepatol (2015) 0.82

Nigella sativa: A Potential Antiosteoporotic Agent. Evid Based Complement Alternat Med (2012) 0.82

IL-6 Plays a Crucial Role in HBV Infection. J Clin Transl Hepatol (2015) 0.82

Association between interleukin-6 receptor gene variations and atherosclerotic lipid profiles among young adolescents in Taiwan. Lipids Health Dis (2011) 0.81

Interleukin-6: a new therapeutic target in systemic sclerosis? Clin Transl Immunology (2013) 0.81

Eurycoma longifolia: Medicinal Plant in the Prevention and Treatment of Male Osteoporosis due to Androgen Deficiency. Evid Based Complement Alternat Med (2012) 0.81

The effects of tualang honey on bone metabolism of postmenopausal women. Evid Based Complement Alternat Med (2012) 0.81

Different signaling mechanisms regulating IL-6 expression by LPS between gingival fibroblasts and mononuclear cells: seeking the common target. Clin Immunol (2012) 0.81

T-helper1/T-helper2 cytokine imbalance in the iris of patients with glaucoma. PLoS One (2015) 0.80

Cross talk between peritoneal macrophages and B-1 cells in vitro. PLoS One (2013) 0.80

Alterations in cytokines and effects of dexamethasone immunosuppression during subclinical infections of invasive Klebsiella pneumoniae with hypermucoviscosity phenotype in rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques. Comp Med (2010) 0.80

T-cell vaccination leads to suppression of intrapancreatic Th17 cells through Stat3-mediated RORγt inhibition in autoimmune diabetes. Cell Res (2011) 0.80

Targeting TNF-alpha with a tetravalent mini-antibody TNF-TeAb. Biochem J (2007) 0.80

The profile of prostate epithelial cytokines and its impact on sera prostate specific antigen levels. Inflammation (2009) 0.80

Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism. Cytotechnology (2013) 0.80

Strontium-doped calcium phosphate and hydroxyapatite granules promote different inflammatory and bone remodelling responses in normal and ovariectomised rats. PLoS One (2013) 0.79

IL-6 as a druggable target in psoriasis: focus on pustular variants. J Immunol Res (2014) 0.79

Transgenic models for cytokine-induced neurological disease. Biochim Biophys Acta (2009) 0.79

Regulation of osteoclastogenesis by Simon extracts composed of caffeic acid and related compounds: successful suppression of bone destruction accompanied with adjuvant-induced arthritis in rats. Histochem Cell Biol (2005) 0.79

Memory B cells from older people express normal levels of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation. Cell Immunol (2010) 0.79

Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion. BMC Biotechnol (2012) 0.79

Splenic stromal cells from aged mice produce higher levels of IL-6 compared to young mice. Mediators Inflamm (2014) 0.78

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response. Sci Rep (2016) 0.78

rAAV Gene Therapy in a Canavan's Disease Mouse Model Reveals Immune Impairments and an Extended Pathology Beyond the Central Nervous System. Mol Ther (2016) 0.78

Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia. Proc Natl Acad Sci U S A (2009) 0.78

Articles by these authors

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol (2003) 4.25

Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity (2008) 2.81

NetPath: a public resource of curated signal transduction pathways. Genome Biol (2010) 2.62

Zinc is a novel intracellular second messenger. J Cell Biol (2007) 2.46

Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses. Nat Immunol (2007) 2.38

The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors. Cancer Sci (2003) 2.36

Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer. Nature (2004) 2.36

Hepatic interleukin-7 expression regulates T cell responses. Immunity (2009) 2.25

IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J Immunol (2004) 2.12

Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nat Immunol (2006) 1.98

Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes. Circ Res (2003) 1.96

Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J Cell Biol (2005) 1.91

Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier. Cell (2012) 1.90

Zinc homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem (2011) 1.89

Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells. J Exp Med (2011) 1.78

The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. PLoS One (2008) 1.76

IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state. Int Immunol (2007) 1.69

Stat3 Controls Cell Movements during Zebrafish Gastrulation. Dev Cell (2002) 1.57

A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J Exp Med (2002) 1.57

Intracellular zinc homeostasis and zinc signaling. Cancer Sci (2008) 1.52

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling. Blood (2002) 1.41

Zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons. Dev Dyn (2004) 1.40

Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med (2006) 1.39

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest (2013) 1.39

Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells. Cancer Sci (2007) 1.35

IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells. Immunity (2005) 1.32

Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J Clin Invest (2007) 1.32

Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Development (2003) 1.32

c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130. Mol Cell Biol (2008) 1.31

Inflammation amplifier, a new paradigm in cancer biology. Cancer Res (2013) 1.31

The zinc transporter SLC39A14/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth. PLoS One (2011) 1.18

IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb. J Immunol (2006) 1.17

Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2. Oncogene (2003) 1.15

An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J Exp Med (2006) 1.15

Zinc is required for Fc epsilon RI-mediated mast cell activation. J Immunol (2006) 1.14

Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation. J Cell Biol (2002) 1.11

Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. J Mol Biol (2002) 1.08

Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation. Int Immunol (2008) 1.05

Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling. J Clin Invest (2007) 1.04

Biochemical characterization of human ZIP13 protein: a homo-dimerized zinc transporter involved in the spondylocheiro dysplastic Ehlers-Danlos syndrome. J Biol Chem (2011) 1.03

TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation. EMBO J (2006) 1.03

The pathological and physiological roles of IL-6 amplifier activation. Int J Biol Sci (2012) 1.03

Molecular basis of the cell specificity of cytokine action. Biochim Biophys Acta (2002) 1.01

Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling. Circ Res (2011) 0.98

Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction. J Exp Med (2009) 0.97

Zinc suppresses Th17 development via inhibition of STAT3 activation. Int Immunol (2010) 0.97

STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension. J Cell Biol (2004) 0.95

STAT3 down-regulates the expression of cyclin D during liver development. J Biol Chem (2002) 0.95

New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27. Growth Factors (2004) 0.95

Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina. Mol Cell Neurosci (2004) 0.95

Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathway. J Biol Chem (2008) 0.94

IL-6 positively regulates Foxp3+CD8+ T cells in vivo. Int Immunol (2009) 0.94

Genetic evidence for involvement of maternally derived Wnt canonical signaling in dorsal determination in zebrafish. Mech Dev (2004) 0.94

Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor. J Biol Chem (2004) 0.94

A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish. Mech Dev (2002) 0.93

SHP2-mediated signaling cascade through gp130 is essential for LIF-dependent I CaL, [Ca2+]i transient, and APD increase in cardiomyocytes. J Mol Cell Cardiol (2007) 0.92

CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4. Int Immunol (2006) 0.92

Disease-association analysis of an inflammation-related feedback loop. Cell Rep (2013) 0.91

Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells. Mol Cell Biol (2003) 0.90

IL-6 amplifier, NF-κB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses. J Immunol (2012) 0.89

A four-step model for the IL-6 amplifier, a regulator of chronic inflammations in tissue-specific MHC class II-associated autoimmune diseases. Front Immunol (2011) 0.89

Revival of the autoantibody model in rheumatoid arthritis. Nat Immunol (2002) 0.89

Adapter molecule Grb2-associated binder 1 is specifically expressed in marginal zone B cells and negatively regulates thymus-independent antigen-2 responses. J Immunol (2002) 0.88

Tyrosine dephosphorylation of STAT3 in SARS coronavirus-infected Vero E6 cells. FEBS Lett (2004) 0.86

Gab2, via PI-3K, regulates ARF1 in FcεRI-mediated granule translocation and mast cell degranulation. J Immunol (2011) 0.86

The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis. Int Immunol (2004) 0.84

SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene. J Mol Cell Cardiol (2010) 0.84

Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments. Blood (2004) 0.84

IFN-gamma expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death. Int Immunol (2008) 0.83

Evidence of a novel IL-2/15R beta-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells. J Immunol (2004) 0.83

Organizer formation and function. Results Probl Cell Differ (2002) 0.82

Epidermal growth factor signaling mediated by grb2 associated binder1 is required for the spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord. Stem Cells (2007) 0.81

A novel role of the L-type calcium channel α1D subunit as a gatekeeper for intracellular zinc signaling: zinc wave. PLoS One (2012) 0.80

Cytokines in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev (2002) 0.80

The molecular mechanisms of chronic inflammation development. Front Immunol (2012) 0.79

Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Gene Expr Patterns (2004) 0.79

A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish. Development (2003) 0.78

IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation. Int Immunol (2013) 0.78

Development of CD4+ macrophages from intrathymic T cell progenitors is induced by thymic epithelial cells. J Immunol (2004) 0.77

[Role of zinc/zinc transporter in allergic response]. Seikagaku (2010) 0.75

[IL-6 signal transduction and its physiological roles]. Nihon Rinsho (2012) 0.75

[Role of zinc for mast cell degranulation]. Tanpakushitsu Kakusan Koso (2008) 0.75

[gp130F759 mouse]. Nihon Rinsho (2005) 0.75