Published in Trends Cell Biol on September 01, 2002
Puzzles, promises and a cure for ageing. Nature (2008) 3.23
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol (2008) 3.15
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol (2003) 2.79
Posttranslational modification of p53: cooperative integrators of function. Cold Spring Harb Perspect Biol (2009) 2.34
Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell (2007) 2.13
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats. PLoS One (2011) 1.81
SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. Oncogene (2012) 1.70
Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor. Mol Endocrinol (2007) 1.43
Chromatin remodeling in cardiovascular development and physiology. Circ Res (2011) 1.34
Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration. J Alzheimers Dis (2010) 1.34
DNA damage and the balance between survival and death in cancer biology. Nat Rev Cancer (2015) 1.25
Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair. Stroke (2008) 1.18
SIRT1 stabilizes PML promoting its sumoylation. Cell Death Differ (2010) 1.10
Emerging beneficial roles of sirtuins in heart failure. Basic Res Cardiol (2012) 1.08
Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells. Carcinogenesis (2008) 1.08
Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer. Oncotarget (2013) 1.03
New tricks of an old molecule: lifespan regulation by p53. Aging Cell (2006) 1.03
Aging and Autophagy in the Heart. Circ Res (2016) 1.00
Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula. J Org Chem (2009) 0.95
The role of epithelial plasticity in prostate cancer dissemination and treatment resistance. Cancer Metastasis Rev (2014) 0.94
Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapy. Curr Cancer Drug Targets (2010) 0.91
Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures. PLoS One (2013) 0.90
Dual role of SIRT1 in UVB-induced skin tumorigenesis. Oncogene (2014) 0.89
Differential expression of sirtuins in the aging rat brain. Front Cell Neurosci (2015) 0.87
Serum withdrawal up-regulates human SIRT1 gene expression in a p53-dependent manner. J Cell Mol Med (2009) 0.87
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis. Mol Cancer (2014) 0.87
c-MYC and SIRT1 locked in a vicious cycle. Oncotarget (2012) 0.85
Malyngolide dimer, a bioactive symmetric cyclodepside from the panamanian marine cyanobacterium Lyngbya majuscula. J Nat Prod (2010) 0.85
The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes. Aging (Albany NY) (2012) 0.83
Nutrition, sirtuins and aging. Genes Nutr (2006) 0.83
Regulating aging in adult stem cells with microRNA. Z Gerontol Geriatr (2013) 0.82
Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions. Aging (Albany NY) (2009) 0.81
Molecular dynamic simulation insights into the normal state and restoration of p53 function. Int J Mol Sci (2012) 0.78
Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro. Aging (Albany NY) (2015) 0.78
SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway. Sci Rep (2016) 0.77
Aging genetics and aging. Aging Dis (2011) 0.76
Can Sir(2) regulate cancer? Cellscience (2008) 0.76
Potentiation of the anticancer effects of everolimus using a dual mTORC1/2 inhibitor in hepatocellular carcinoma cells. Oncotarget (2016) 0.75
Mechanisms of transcription factor acetylation and consequences in hearts. Biochim Biophys Acta (2016) 0.75
Ototoxic Model of Oxaliplatin and Protection from Nicotinamide Adenine Dinucleotide. J Otol (2013) 0.75
Bridge-Induced Translocation between NUP145 and TOP2 Yeast Genes Models the Genetic Fusion between the Human Orthologs Associated With Acute Myeloid Leukemia. Front Oncol (2017) 0.75