Published in Development on October 01, 2002
Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels. BMC Biochem (2006) 1.62
The emerging role of the COP9 signalosome in cancer. Mol Cancer Res (2005) 1.57
Protein competition switches the function of COP9 from self-renewal to differentiation. Nature (2014) 1.52
Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol (2003) 1.46
Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases. Plant Cell (2007) 1.40
JAB1/CSN5: a new player in cell cycle control and cancer. Cell Div (2010) 1.29
COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Mol Cell Biol (2003) 1.26
Revisiting the COP9 signalosome as a transcriptional regulator. EMBO Rep (2009) 1.24
Jab1 is a specificity factor for E2F1-induced apoptosis. Genes Dev (2006) 1.17
Geminiviruses subvert ubiquitination by altering CSN-mediated derubylation of SCF E3 ligase complexes and inhibit jasmonate signaling in Arabidopsis thaliana. Plant Cell (2011) 1.16
Loss of the CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome subunit 5 is sufficient to cause the cop/det/fus mutant phenotype in Arabidopsis. Plant Cell (2005) 1.14
The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development. Plant Cell (2004) 1.10
Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1. Proc Natl Acad Sci U S A (2013) 1.08
COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. EMBO Rep (2002) 1.07
Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression. Mol Syst Biol (2007) 1.04
Mechanisms of macrophage migration inhibitory factor (MIF)-dependent tumor microenvironmental adaptation. Exp Mol Pathol (2009) 1.04
CSN-5, a component of the COP9 signalosome complex, regulates the levels of UNC-96 and UNC-98, two components of M-lines in Caenorhabditis elegans muscle. Mol Biol Cell (2009) 1.03
Retinoblastoma protein regulation by the COP9 signalosome. Mol Biol Cell (2007) 1.02
An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation. Proc Natl Acad Sci U S A (2007) 1.02
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. Cancer Res (2008) 1.01
Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability. BMC Biochem (2007) 0.99
The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription. Int J Biochem Cell Biol (2008) 0.97
COPing with hypoxia. Semin Cell Dev Biol (2005) 0.96
The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting. J Neurosci (2009) 0.93
Neddylation and deneddylation in cardiac biology. Am J Cardiovasc Dis (2014) 0.90
Role of individual subunits of the Neurospora crassa CSN complex in regulation of deneddylation and stability of cullin proteins. PLoS Genet (2010) 0.89
Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development. Nucleic Acids Res (2014) 0.89
Auxin responses in mutants of the Arabidopsis CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome. Plant Physiol (2008) 0.88
CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner. Sci Rep (2013) 0.88
A cDNA microarray, UniShrimpChip, for identification of genes relevant to testicular development in the black tiger shrimp (Penaeus monodon). BMC Mol Biol (2011) 0.85
The organization of a CSN5-containing subcomplex of the COP9 signalosome. J Biol Chem (2012) 0.85
The csnD/csnE signalosome genes are involved in the Aspergillus nidulans DNA damage response. Genetics (2005) 0.85
CSN-mediated deneddylation differentially modulates Ci(155) proteolysis to promote Hedgehog signalling responses. Nat Commun (2011) 0.80
The CSN/COP9 signalosome regulates synaptonemal complex assembly during meiotic prophase I of Caenorhabditis elegans. PLoS Genet (2014) 0.78
The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair. Biomolecules (2015) 0.78
The eta7/csn3-3 auxin response mutant of Arabidopsis defines a novel function for the CSN3 subunit of the COP9 signalosome. PLoS One (2013) 0.77
The coregulator Alien. Nucl Recept Signal (2007) 0.77
The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence. PLoS Genet (2014) 0.77
The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila. PLoS One (2008) 0.77
COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase. J Biol Chem (2013) 0.77
Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation. PLoS One (2011) 0.76
The DenA/DEN1 Interacting Phosphatase DipA Controls Septa Positioning and Phosphorylation-Dependent Stability of Cytoplasmatic DenA/DEN1 during Fungal Development. PLoS Genet (2016) 0.75
The Evolution of COP9 Signalosome in Unicellular and Multicellular Organisms. Genome Biol Evol (2016) 0.75
COP9 signalosome subunits protect Capicua from MAP kinase-dependent and independent mechanisms of degradation. Development (2017) 0.75
Characterisation of the COP9 signalosome in Schistosoma mansoni parasites. Parasitol Res (2013) 0.75
A cis-regulatory map of the Drosophila genome. Nature (2011) 4.80
Commensal bacteria play a role in mating preference of Drosophila melanogaster. Proc Natl Acad Sci U S A (2010) 3.30
Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h. Plant Cell (2004) 1.58
QPath: a method for querying pathways in a protein-protein interaction network. BMC Bioinformatics (2006) 1.46
Extrachromosomal circular DNA of tandemly repeated genomic sequences in Drosophila. Genome Res (2003) 1.38
Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development. Proc Natl Acad Sci U S A (2002) 1.28
Concise review: Kidney stem/progenitor cells: differentiate, sort out, or reprogram? Stem Cells (2010) 1.23
Drosophila Ada2b is required for viability and normal histone H3 acetylation. Mol Cell Biol (2004) 1.21
Expression of stem cell markers in the human fetal kidney. PLoS One (2009) 1.21
Drosophila brakeless interacts with atrophin and is required for tailless-mediated transcriptional repression in early embryos. PLoS Biol (2007) 1.15
Large-scale analysis of Arabidopsis transcription reveals a basal co-regulation network. BMC Syst Biol (2009) 1.15
The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets. EMBO Mol Med (2012) 1.15
The Arabidopsis COP9 signalosome subunit 7 is a model PCI domain protein with subdomains involved in COP9 signalosome assembly. Plant Cell (2008) 1.13
Drosophila JAB1/CSN5 acts in photoreceptor cells to induce glial cells. Neuron (2002) 1.12
Extrachromosomal circular DNA derived from tandemly repeated genomic sequences in plants. Plant J (2007) 1.11
Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling. J Am Soc Nephrol (2013) 1.09
Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. PLoS One (2010) 1.06
Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression. Mol Syst Biol (2007) 1.04
Kidney spheroids recapitulate tubular organoids leading to enhanced tubulogenic potency of human kidney-derived cells. Tissue Eng Part A (2011) 1.02
Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation. EMBO J (2008) 1.02
Extrachromosomal circles of satellite repeats and 5S ribosomal DNA in human cells. Mob DNA (2010) 1.01
Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models. PLoS One (2011) 1.01
The COP9 signalosome: mediating between kinase signaling and protein degradation. Curr Protein Pept Sci (2004) 0.98
COP9 signalosome subunit 5 (CSN5/Jab1) regulates the development of the Drosophila immune system: effects on Cactus, Dorsal and hematopoiesis. Genes Cells (2007) 0.97
Genomic occupancy of the transcriptional co-activators p300 and CBP. Transcription (2012) 0.97
Reactivation of NCAM1 defines a subpopulation of human adult kidney epithelial cells with clonogenic and stem/progenitor properties. Am J Pathol (2013) 0.96
Drosophila Reptin and other TIP60 complex components promote generation of silent chromatin. Genetics (2006) 0.95
Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development. Genes Cells (2008) 0.94
The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting. J Neurosci (2009) 0.93
Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies. PLoS One (2010) 0.93
The CBP coactivator functions both upstream and downstream of Dpp/Screw signaling in the early Drosophila embryo. Dev Biol (2003) 0.93
EHD2 mediates trafficking from the plasma membrane by modulating Rac1 activity. Biochem J (2011) 0.92
Gene regulation by the lysine demethylase KDM4A in Drosophila. Dev Biol (2012) 0.92
Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryos. PLoS Genet (2012) 0.91
Evidence for rolling circle replication of tandem genes in Drosophila. Nucleic Acids Res (2005) 0.91
Stanniocalcin-1 secretion and receptor regulation in kidney cells. Am J Physiol Renal Physiol (2008) 0.90
Drosophila Past1 is involved in endocytosis and is required for germline development and survival of the adult fly. J Cell Sci (2009) 0.89
Arabidopsis eIF3e is regulated by the COP9 signalosome and has an impact on development and protein translation. Plant J (2007) 0.89
The acetyltransferase activity of Drosophila CBP is dispensable for regulation of the Dpp pathway in the early embryo. Dev Biol (2007) 0.89
Protein homeostasis: a degrading role for Int6/eIF3e. Curr Biol (2003) 0.88
Symbiotic bacteria are responsible for diet-induced mating preference in Drosophila melanogaster, providing support for the hologenome concept of evolution. Gut Microbes (2011) 0.87
A rapid in vivo assay system for analyzing the organogenetic capacity of human kidney cells. Organogenesis (2011) 0.87
The organization of a CSN5-containing subcomplex of the COP9 signalosome. J Biol Chem (2012) 0.85
Unfolded protein response in Gaucher disease: from human to Drosophila. Orphanet J Rare Dis (2013) 0.85
Expression, purification and crystallization of a PCI domain from the COP9 signalosome subunit 7 (CSN7). Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.83
Transcriptional regulation by CHIP/LDB complexes. PLoS Genet (2010) 0.83
Arabidopsis eIF3e interacts with subunits of the ribosome, Cop9 signalosome and proteasome. Plant Signal Behav (2008) 0.83
Differential inhibition of α-synuclein oligomeric and fibrillar assembly in parkinson's disease model by cinnamon extract. Biochim Biophys Acta (2012) 0.82
Evaluating Drosophila p53 as a model system for studying cancer mutations. J Biol Chem (2012) 0.82
Drosomycin, an innate immunity peptide of Drosophila melanogaster, interacts with the fly voltage-gated sodium channel. J Biol Chem (2009) 0.81
A mutation in the tomato DDB1 gene affects cell and chloroplast compartment size and CDT1 transcript. Plant Signal Behav (2008) 0.80
Wollknauel is required for embryo patterning and encodes the Drosophila ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase. Development (2008) 0.80
Neuropeptide Y: identification of a novel rat mRNA splice-variant that is downregulated in the hippocampus and the prefrontal cortex of a depression-like model. Peptides (2012) 0.80
Human cytomegalovirus immediate-early-gene expression disrupts embryogenesis in transgenic Drosophila. Transgenic Res (2007) 0.80
COP9 signalosome subunit 7 from Arabidopsis interacts with and regulates the small subunit of ribonucleotide reductase (RNR2). Plant Mol Biol (2011) 0.80
Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. Oncogene (2005) 0.79
Drosophila LIM-only is a positive regulator of transcription during thoracic bristle development. Genetics (2008) 0.79
A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD). J Biol Chem (2013) 0.79
Development of allogeneic NK cell adoptive transfer therapy in metastatic melanoma patients: in vitro preclinical optimization studies. PLoS One (2013) 0.79
Modularity of CHIP/LDB transcription complexes regulates cell differentiation. Fly (Austin) (2011) 0.78
Bacteria-induced sexual isolation in Drosophila. Fly (Austin) (2011) 0.78
Structural basis for inhibiting β-amyloid oligomerization by a non-coded β-breaker-substituted endomorphin analogue. ACS Chem Biol (2011) 0.77
Monitoring and targeting the initial dimerization stage of amyloid self-assembly. Angew Chem Int Ed Engl (2014) 0.77
Generic inhibition of amyloidogenic proteins by two naphthoquinone-tryptophan hybrid molecules. Proteins (2012) 0.77
The angular interval between the direction of progression and body orientation in normal, alcohol- and cocaine treated fruit flies. PLoS One (2013) 0.77
The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila. PLoS One (2008) 0.77
Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity. J Alzheimers Dis (2016) 0.76
Methylations of tryptophan-modified naphthoquinone affect its inhibitory potential toward Aβ aggregation. J Phys Chem B (2013) 0.76
Structural insights into the folding defects of oncogenic pVHL lead to correction of its function in vitro. PLoS One (2013) 0.76
Chromatin-modifying agents reactivate embryonic renal stem/progenitor genes in human adult kidney epithelial cells but abrogate dedifferentiation and stemness. Cell Reprogram (2013) 0.76
A novel, sensitive assay for behavioral defects in Parkinson's disease model Drosophila. Parkinsons Dis (2012) 0.75
Correction: Past1 Modulates Drosophila Eye Development. PLoS One (2017) 0.75
Identification of a light-regulated protein kinase activity from seedlings of Arabidopsis thaliana. Photochem Photobiol (2002) 0.75
Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity. Neurodegener Dis (2016) 0.75
A systems approach to the COP9 signalosome. Plant Physiol (2003) 0.75
Life in science. Lab family feud. Science (2010) 0.75
Structure-function analysis of the Drosophila melanogaster Caudal transcription factor provides insights into core promoter-preferential activation. J Biol Chem (2015) 0.75