Published in Br J Cancer on September 23, 2002
Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov (2011) 5.79
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol (2003) 3.84
Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms. Biochim Biophys Acta (2009) 1.67
Role of glucose and ketone bodies in the metabolic control of experimental brain cancer. Br J Cancer (2003) 1.61
The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol (2012) 1.61
New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy. J Biomed Biotechnol (2012) 1.57
Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy. Cancer Res (2009) 1.42
SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Mol Cancer Res (2008) 1.30
Global metabolic profiling of infection by an oncogenic virus: KSHV induces and requires lipogenesis for survival of latent infection. PLoS Pathog (2012) 1.26
Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models. Ann Neurol (2009) 1.22
Anticancer agents that counteract tumor glycolysis. ChemMedChem (2012) 1.17
Non-thermal plasma with 2-deoxy-D-glucose synergistically induces cell death by targeting glycolysis in blood cancer cells. Sci Rep (2015) 1.13
Enhanced radiosensitivity and chemosensitivity of breast cancer cells by 2-deoxy-d-glucose in combination therapy. J Breast Cancer (2012) 1.11
Antiangiogenic activity of 2-deoxy-D-glucose. PLoS One (2010) 1.08
Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet. Nutr Metab (Lond) (2008) 1.07
Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment. Br J Cancer (2004) 1.07
Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction. Mol Cancer Ther (2013) 1.05
Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer. Front Oncol (2014) 1.00
Assay of the multiple energy-producing pathways of mammalian cells. PLoS One (2011) 0.98
Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress. Free Radic Biol Med (2010) 0.96
p53 Protects lung cancer cells against metabolic stress. Int J Oncol (2010) 0.96
2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer. Br J Cancer (2008) 0.96
Differential expression of lipid metabolism-related proteins in different breast cancer subtypes. PLoS One (2015) 0.94
The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis. J Biol Chem (2012) 0.93
Identification of links between small molecules and miRNAs in human cancers based on transcriptional responses. Sci Rep (2012) 0.92
Caloric restriction mimetic 2-deoxyglucose antagonizes doxorubicin-induced cardiomyocyte death by multiple mechanisms. J Biol Chem (2011) 0.92
FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice. Cell Death Dis (2012) 0.92
A new view of carcinogenesis and an alternative approach to cancer therapy. Mol Med (2009) 0.90
Golgi apparatus dis- and reorganizations studied with the aid of 2-deoxy-D-glucose and visualized by 3D-electron tomography. Histochem Cell Biol (2016) 0.89
Antitumor activity of efrapeptins, alone or in combination with 2-deoxyglucose, in breast cancer in vitro and in vivo. Cell Stress Chaperones (2010) 0.89
Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer. Redox Biol (2014) 0.88
p53 is an important factor for the radiosensitization effect of 2-deoxy-D-glucose. Int J Oncol (2009) 0.86
2-Deoxy-D-glucose treatment changes the Golgi apparatus architecture without blocking synthesis of complex lipids. Histochem Cell Biol (2014) 0.85
Emerging glycolysis targeting and drug discovery from chinese medicine in cancer therapy. Evid Based Complement Alternat Med (2012) 0.84
Glucose is a pH-dependent motor for sperm beat frequency during early activation. PLoS One (2012) 0.83
Cell number, cell growth, antheridiogenesis, and callose amount is reduced and atrophy induced by deoxyglucose in Anemia phyllitidis gametophytes. Plant Cell Rep (2008) 0.83
High glucose-induced resistance to 5-fluorouracil in pancreatic cancer cells alleviated by 2-deoxy-D-glucose. Biomed Rep (2013) 0.78
Ouabain targets the unfolded protein response for selective killing of HepG2 cells during glucose deprivation. Cancer Biother Radiopharm (2012) 0.78
The combination of tephrosin with 2-deoxy-D-glucose enhances the cytotoxicity via accelerating ATP depletion and blunting autophagy in human cancer cells. Cancer Biol Ther (2011) 0.78
Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects. World J Gastroenterol (2016) 0.77
Designing polymers with sugar-based advantages for bioactive delivery applications. J Control Release (2015) 0.77
Site-specific metabolic phenotypes in metastatic breast cancer. J Transl Med (2014) 0.77
Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells. Oncotarget (2016) 0.77
The effects of nutrient depleted microenvironments and delta-like 1 homologue (DLK1) on apoptosis in neuroblastoma. Nutr Res Pract (2010) 0.77
Metabolic phenotypes in primary unknown metastatic carcinoma. J Transl Med (2014) 0.76
Reduction of neointimal hyperplasia in porcine coronary arteries by 2-deoxy-D-glucose. Clin Res Cardiol (2009) 0.75
A validated bioanalytical HPLC method for pharmacokinetic evaluation of 2-deoxyglucose in human plasma. Biomed Chromatogr (2011) 0.75
On the origin of cancer cells. Science (1956) 49.55
BCL-2 family members and the mitochondria in apoptosis. Genes Dev (1999) 13.52
Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell (1993) 10.83
Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res (1987) 10.80
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev (2001) 5.12
Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol (2001) 5.10
Localization of the primary metabolic block produced by 2-deoxyglucose. J Biol Chem (1957) 4.79
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol Cell (2000) 4.10
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem (2000) 3.74
Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science (1987) 3.44
An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci U S A (2000) 3.13
An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res (2000) 2.47
bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci U S A (1993) 2.39
A unique glucose-dependent apoptotic pathway induced by c-Myc. Proc Natl Acad Sci U S A (1998) 2.34
Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study. Cancer (1993) 2.26
Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism? Ann N Y Acad Sci (2000) 2.25
Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas. Int J Radiat Oncol Biol Phys (1996) 2.15
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Lett (2001) 2.11
Metabolic trapping as a principle of oradiopharmaceutical design: some factors resposible for the biodistribution of [18F] 2-deoxy-2-fluoro-D-glucose. J Nucl Med (1978) 2.07
Over-expression of facilitative glucose transporter genes in human cancer. Biochem Biophys Res Commun (1990) 2.06
Enzymology of cancer cells (second of two parts). N Engl J Med (1977) 2.00
Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP. J Biol Chem (1988) 1.97
Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production. J Biol Chem (1994) 1.90
Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers. Cancer Res (1996) 1.84
Primary and metastatic breast carcinoma: initial clinical evaluation with PET with the radiolabeled glucose analogue 2-[F-18]-fluoro-2-deoxy-D-glucose. Radiology (1991) 1.80
Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science (1987) 1.70
Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells. J Biol Chem (1998) 1.61
GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst. Proc Natl Acad Sci U S A (2000) 1.60
Effects of 2-deoxyglucose on drug-sensitive and drug-resistant human breast cancer cells: toxicity and magnetic resonance spectroscopy studies of metabolism. Cancer Res (1990) 1.59
Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line. J Exp Med (1994) 1.53
GLUT1 expression in human breast carcinoma: correlation with known prognostic markers. Anticancer Res (1996) 1.42
Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells. Free Radic Biol Med (1999) 1.35
Germline manipulation of glucose homeostasis via alteration of glucose transporter levels in skeletal muscle. J Biol Chem (1993) 1.32
Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway. J Biol Chem (1999) 1.31
Glut-1 and hexokinase expression: relationship with 2-fluoro-2-deoxy-D-glucose uptake in A431 and T47D cells in culture. Cancer Res (1999) 1.31
Induction of the mitochondrial permeability transition mediates the killing of HeLa cells by staurosporine. Cancer Res (2001) 1.30
Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase. Cancer Res (1996) 1.29
Certain metabolic and pharmacologic effects in cancer patients given infusions of 2-deoxy-D-glucose. J Natl Cancer Inst (1958) 1.24
Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location. J Biol Chem (1983) 1.20
Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines. Int J Radiat Oncol Biol Phys (2001) 1.19
Influence of glucose antimetabolites on the Walker tumor. Cancer Res (1957) 1.13
Enzymic and cerebral metabolic effects of 2-deoxy-D-glucose. J Neurochem (1973) 1.10
Effects of glucose analogues (2-deoxy-D-glucose, 2-deoxy-D-galactose) on experimental tumors. J Natl Cancer Inst (1960) 1.08
Glucose deprivation-induced cytotoxicity in drug resistant human breast carcinoma MCF-7/ADR cells: role of c-myc and bcl-2 in apoptotic cell death. J Cell Sci (1997) 1.06
Functional organization of mammalian hexokinase II. Retention of catalytic and regulatory functions in both the NH2- and COOH-terminal halves. J Biol Chem (1996) 1.03
The multidrug resistance phenotype: 31P nuclear magnetic resonance characterization and 2-deoxyglucose toxicity. Cancer Res (1991) 1.01
An introduction to the isoenzymes of mammalian hexokinase types I-III. Biochem Soc Trans (1997) 0.99
Nutrient control of GLUT1 processing and turnover in 3T3-L1 adipocytes. J Biol Chem (1995) 0.97
The interaction among glucose transport, hexokinase, and glucose-6-phosphatase with respect to 3H-2-deoxyglucose retention in murine tumor models. Nucl Med Biol (1996) 0.97
Evidence against apoptosis as a major mechanism for reproductive cell death following treatment of cell lines with anti-cancer drugs. Br J Cancer (2001) 0.96
Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells. Int J Radiat Oncol Biol Phys (1985) 0.96
The effect of glucose analogues on the metabolism of human leukemic cells. J Natl Cancer Inst (1958) 0.95
Glucose transporters and transport kinetics in retinoic acid-differentiated T47D human breast cancer cells. Am J Physiol Endocrinol Metab (2000) 0.94
The importance of glucose transport activity as the rate-limiting step of 2-deoxyglucose uptake in tumor cells in vitro. Nucl Med Biol (1998) 0.93
Hypoglycemia-induced c-Jun phosphorylation is mediated by c-Jun N-terminal kinase 1 and Lyn kinase in drug-resistant human breast carcinoma MCF-7/ADR cells. J Biol Chem (1997) 0.93
Effect of glucose deprivation of GLUT 1 expression in 3T3-L1 adipocytes. J Biol Chem (1993) 0.92
Translocation of GLUT1 does not account for elevated glucose transport in glucose-deprived 3T3-L1 adipocytes. J Biol Chem (1996) 0.91
Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model. Br J Haematol (2001) 0.91
Metabolic oxidative stress-induced HSP70 gene expression is mediated through SAPK pathway. Role of Bcl-2 and c-Jun NH2-terminal kinase. J Biol Chem (1998) 0.90
Inhibition of established rat fibrosarcoma growth by the glucose antagonist 2-deoxy-D-glucose. Surgery (1987) 0.89
Activation of Glut1 glucose transporter in response to inhibition of oxidative phosphorylation. Arch Biochem Biophys (1999) 0.89
Hexokinase receptors: preferential enzyme binding in normal cells to nonmitochondrial sites and in transformed cells to mitochondrial sites. J Bioenerg Biomembr (1992) 0.88
Information from combined 1H and 31P NMR studies of cell extracts: differences in metabolism between drug-sensitive and drug-resistant MCF-7 human breast cancer cells. Biochem Biophys Res Commun (1990) 0.88
Detection of poly(ADP-ribose) polymerase and its apoptosis-specific fragment by a nonisotopic activity-western blot technique. Anal Biochem (1995) 0.87
3T3-L1 adipocyte glucose transporter (HepG2 class): sequence and regulation of protein and mRNA expression by insulin, differentiation, and glucose starvation. Arch Biochem Biophys (1990) 0.86
Functional interaction between the N- and C-terminal halves of human hexokinase II. J Biol Chem (1999) 0.86
Glucose deprivation induces Akt-dependent synthesis and incorporation of GLUT1, but not of GLUT4, into the plasma membrane of 3T3-L1 adipocytes. Eur J Cell Biol (2000) 0.85
Hypoglycemia-induced AP-1 transcription factor and basic fibroblast growth factor gene expression in multidrug resistant human breast carcinoma MCF-7/ADR cells. Mol Cell Biochem (1996) 0.81
Differential effect of glucose deprivation on MAPK activation in drug sensitive human breast carcinoma MCF-7 and multidrug resistant MCF-7/ADR cells. Mol Cell Biochem (1997) 0.81
Glucose deprivation induces the selective accumulation of hexose transporter protein GLUT-1 in the plasma membrane of normal rat kidney cells. Mol Endocrinol (1991) 0.80
Reassessment of FDG uptake in tumor cells: high FDG uptake as a reflection of oxygen-independent glycolysis dominant energy production. Nucl Med Biol (1997) 0.80
Glucose deprivation does not affect GLUT1 targeting in 3T3-L1 adipocytes. Biochem Biophys Res Commun (2000) 0.77
Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation. Cancer Res (2000) 1.48
Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells. Oncogene (2011) 1.02
Heat shock inhibits radiation-induced activation of NF-kappaB via inhibition of I-kappaB kinase. J Biol Chem (1999) 0.99
The new field of epigenomics: implications for cancer and other common disease research. Cold Spring Harb Symp Quant Biol (2004) 0.98
Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase. Cancer Res (2001) 0.98
Cell cycle-coupled variation in topoisomerase IIalpha mRNA is regulated by the 3'-untranslated region. Possible role of redox-sensitive protein binding in mRNA accumulation. J Biol Chem (2000) 0.95
Redox factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat shock. J Biol Chem (1999) 0.93
Radiation signaling mediated by Jun activation following dissociation from a cell type-specific repressor. J Biol Chem (1993) 0.93
Evidence that activation of the Egr-1 promoter by v-Raf involves serum response elements. Oncogene (1992) 0.88
Heat shock and the activation of AP-1 and inhibition of NF-kappa B DNA-binding activity: possible role of intracellular redox status. Int J Hyperthermia (2004) 0.86
Isolation and imprinting analysis of the porcine DLX5 gene and its association with carcass traits. Anim Genet (2008) 0.79
Increased activator protein 1 activity as well as resistance to heat-induced radiosensitization, hydrogen peroxide, and cisplatin are inhibited by indomethacin in oxidative stress-resistant cells. Cancer Res (2001) 0.78
Inhibition of cyclooxygenase-2 with NS-398 and the prevention of radiation-induced transformation, micronuclei formation and clonogenic cell death in C3H 10T1/2 cells. Int J Radiat Biol (2003) 0.77
Association and activation of fructose 1,6-bisphosphase during unfolding and refolding: spectroscopic and enzymatic studies. J Protein Chem (2001) 0.77
Indomethacin lowers the threshold thermal exposure for hyperthermic radiosensitization and heat-shock inhibition of ionizing radiation-induced activation of NF-kappaB. Int J Radiat Biol (2002) 0.75
[Feasibility of device closure for multiple atrial septal defects using 3D printing and ultrasound-guided intervention technique]. Zhonghua Yi Xue Za Zhi (2017) 0.75
Changes in sub-nuclear structures and functional perturbations: implications for radiotherapy. J Cell Biochem Suppl (2000) 0.75