Published in J Med Chem on September 26, 2002
Lipid-lowering properties of TAK-475, a squalene synthase inhibitor, in vivo and in vitro. Br J Pharmacol (2003) 1.07
5-Chloro-2-hy-droxy-benzoic acid. Acta Crystallogr Sect E Struct Rep Online (2010) 0.99
Human isoprenoid synthase enzymes as therapeutic targets. Front Chem (2014) 0.86
Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate. J Org Chem (2010) 0.83
Rhodium-catalyzed enantioselective silylation of arene C-H bonds: desymmetrization of diarylmethanols. J Am Chem Soc (2015) 0.82
Lapaquistat acetate, a squalene synthase inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous lesions. Br J Pharmacol (2008) 0.78
Discovery of DF-461, a Potent Squalene Synthase Inhibitor. ACS Med Chem Lett (2013) 0.76
Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like condition. Springerplus (2016) 0.75
Copper-Catalyzed Borylative Aromatization of p-Quinone Methides: Enantioselective Synthesis of Dibenzylic Boronates. ACS Catal (2015) 0.75
High cholesterol level is essential for myelin membrane growth. Nat Neurosci (2005) 2.34
Two novel mutations, L490R and V561X, of the transferrin receptor 2 gene in Japanese patients with hemochromatosis. Haematologica (2005) 2.12
T wave peak-to-end interval and QT dispersion in acquired long QT syndrome: a new index for arrhythmogenicity. Clin Sci (Lond) (2003) 1.86
T-peak to T-end interval may be a better predictor of high-risk patients with hypertrophic cardiomyopathy associated with a cardiac troponin I mutation than QT dispersion. Clin Cardiol (2002) 1.72
Reassessment of the cutoff values of waist circumference and visceral fat area for identifying Japanese subjects at risk for the metabolic syndrome. Diabetes Res Clin Pract (2007) 1.52
Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet (2015) 1.51
Prevalence of metabolic syndrome in the general Japanese population in 2000. J Atheroscler Thromb (2006) 1.50
Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody. Circ Cardiovasc Genet (2015) 1.50
Cholesteryl ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia. Clin Sci (Lond) (2002) 1.48
Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gain-of-Function Mutations. Circ J (2015) 1.41
Changes in cardiac tissue characterization in carriers with gene mutations associated with hypertrophic cardiomyopathy. Int J Cardiol (2005) 1.38
Comparison of waist circumference with body mass index for predicting abdominal adipose tissue. Diabetes Res Clin Pract (2008) 1.28
Impacts of visceral adipose tissue and subcutaneous adipose tissue on metabolic risk factors in middle-aged Japanese. Obesity (Silver Spring) (2009) 1.23
Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels. Am J Gastroenterol (2005) 1.18
Report of the Japan Atherosclerosis Society (JAS) Guideline for Diagnosis and Treatment of Hyperlipidemia in Japanese adults. J Atheroscler Thromb (2002) 1.17
Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide. J Biol Chem (2004) 1.15
Acute urinary retention as an unusual manifestation of aseptic meningitis. Intern Med (2002) 1.09
Comparison of contrast agents for atherosclerosis imaging using cultured macrophages: FDG versus ultrasmall superparamagnetic iron oxide. J Nucl Med (2013) 1.08
Lipid-lowering properties of TAK-475, a squalene synthase inhibitor, in vivo and in vitro. Br J Pharmacol (2003) 1.07
Synthesis and structural analysis of five novel oligosaccharides prepared by glucosyltransfer from beta-D-glucose 1-phosphate to isokestose and nystose using Thermoanaerobacter brockii kojibiose phosphorylase. Carbohydr Res (2003) 1.06
Association of estrogen receptor-alpha gene polymorphisms with coronary artery disease in patients with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol (2002) 1.05
Differentiation between patients with takotsubo cardiomyopathy and those with anterior acute myocardial infarction. Circ J (2005) 1.05
Serum lipid survey and its recent trend in the general Japanese population in 2000. J Atheroscler Thromb (2005) 1.03
Reduction of hemolysis without reoperation following mitral valve repair. Circ J (2003) 1.03
Calcineurin inhibition attenuates mineralocorticoid-induced cardiac hypertrophy. Circulation (2002) 1.02
Long-term course of lipoprotein lipase (LPL) deficiency due to homozygous LPL(Arita) in a patient with recurrent pancreatitis, retained glucose tolerance, and atherosclerosis. J Clin Endocrinol Metab (2005) 1.02
High incidence of sudden cardiac death with conduction disturbances and atrial cardiomyopathy caused by a nonsense mutation in the STA gene. Circulation (2005) 0.98
Tissue gene expression of renin-angiotensin system in human type 2 diabetic nephropathy. Diabetes Care (2006) 0.98
Effects of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrahydrofolate reductase gene in Japanese. Atherosclerosis (2002) 0.95
Sustained reduction of serum cholesterol in low-dose 6-year simvastatin treatment with minimum side effects in 51,321 Japanese hypercholesterolemic patients. Circ J (2003) 0.95
Postprandial lipoprotein metabolism: VLDL vs chylomicrons. Clin Chim Acta (2011) 0.93
Increased circulating matrix metalloproteinase-2 in patients with hypertrophic cardiomyopathy with systolic dysfunction. Circ J (2004) 0.93
Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency. J Lipid Res (2003) 0.92
Difference in the risk factors for coronary, renal and other peripheral arteriosclerosis in heterozygous familial hypercholesterolemia. Circ J (2004) 0.91
A novel mutation Lys273Glu in the cardiac troponin T gene shows high degree of penetrance and transition from hypertrophic to dilated cardiomyopathy. Am J Cardiol (2002) 0.91
Clinical efficacy of pitavastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in patients with hyperlipidemia. Dose-finding study using the double-blind, three-group parallel comparison. Arzneimittelforschung (2002) 0.91
A randomized, double-blind trial comparing the efficacy and safety of pitavastatin versus pravastatin in patients with primary hypercholesterolemia. Atherosclerosis (2002) 0.91
Effect of walking with a pedometer on serum lipid and adiponectin levels in Japanese middle-aged men. J Atheroscler Thromb (2006) 0.90
Gene mutations in adult Japanese patients with dilated cardiomyopathy. Circ J (2005) 0.89
The relationship of percent body fat by bioelectrical impedance analysis with blood pressure, and glucose and lipid parameters. J Atheroscler Thromb (2006) 0.89
Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG. Clin Sci (Lond) (2004) 0.89
Long-term treatment with pitavastatin (NK-104), a new HMG-CoA reductase inhibitor, of patients with heterozygous familial hypercholesterolemia. Atherosclerosis (2002) 0.89
Treatment of congenital nephrogenic diabetes insipidus with hydrochlorothiazide and amiloride in an adult patient. Horm Res (2003) 0.89
Generation and gender differences in the components contributing to the diagnosis of the metabolic syndrome according to the Japanese criteria. Circ J (2007) 0.89
Formation of prebeta1-HDL during lipolysis of triglyceride-rich lipoprotein. Biochem Biophys Res Commun (2008) 0.88
Decreased post-prandial triglyceride response and diminished remnant lipoprotein formation in cholesteryl ester transfer protein (CETP) deficiency. Atherosclerosis (2007) 0.88
Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus. Hum Mutat (2002) 0.88
Sixteen-slice computed tomography, transthoracic real-time 3-dimensional echocardiography and magnetic resonance imaging assessment of a long-term survivor of rupture of sinus of valsalva aneurysm. Intern Med (2005) 0.88
Telmisartan treatment decreases visceral fat accumulation and improves serum levels of adiponectin and vascular inflammation markers in Japanese hypertensive patients. Hypertens Res (2007) 0.88
The E32K variant of PCSK9 exacerbates the phenotype of familial hypercholesterolaemia by increasing PCSK9 function and concentration in the circulation. Atherosclerosis (2009) 0.88
ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects. Clin Sci (Lond) (2005) 0.88
Identification of two novel missense mutations (p.R1221C and p.R1357W) in the ABCC6 (MRP6) gene in a Japanese patient with pseudoxanthoma elasticum (PXE). Intern Med (2004) 0.87
Clinical effects of rosuvastatin, a new HMG-CoA reductase inhibitor, in Japanese patients with primary hypercholesterolemia: an early phase II study. J Atheroscler Thromb (2002) 0.87
Diagnostic value of abnormal Q waves for identification of preclinical carriers of hypertrophic cardiomyopathy based on a molecular genetic diagnosis. Eur Heart J (2004) 0.87
TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans. Antimicrob Agents Chemother (2005) 0.87
Comparison of the effects of pioglitazone and rosiglitazone on macrophage foam cell formation. Biochem Biophys Res Commun (2004) 0.86
Molecular genetic analysis of familial hypercholesterolemia: spectrum and regional difference of LDL receptor gene mutations in Japanese population. Atherosclerosis (2002) 0.86
Difference between fasting and nonfasting triglyceridemia; the influence of waist circumference. J Atheroscler Thromb (2009) 0.86
6-Alpha-glucosyltransferase and 3-alpha-isomaltosyltransferase from Bacillus globisporus N75. J Biosci Bioeng (2003) 0.86
Structural analysis of actinidin and a comparison of cadmium and sulfur anomalous signals from actinidin crystals measured using in-house copper- and chromium-anode X-ray sources. Acta Crystallogr D Biol Crystallogr (2010) 0.86
Spontaneous development of left ventricular aneurysm in a patient with untreated cardiac sarcoidosis. Circ J (2002) 0.86
Identification of a novel missense mutation in the sterol 27-hydroxylase gene in two Japanese patients with cerebrotendinous xanthomatosis. Intern Med (2010) 0.85
Inhibition of Rac activation as a mechanism for negative regulation of actin cytoskeletal reorganization and cell motility by cAMP. Biochem J (2005) 0.85
Serum lipoprotein lipase mass: clinical significance of its measurement. Clin Chim Acta (2006) 0.85
Mutational and haplotype analysis of AGL in patients with glycogen storage disease type III. J Hum Genet (2002) 0.85
Haplotype analyses of cholesteryl ester transfer protein gene promoter: a clue to an unsolved mystery of TaqIB polymorphism. J Mol Med (Berl) (2003) 0.85
Compound heterozygosity for mutations Asp611-->Tyr in KCNQ1 and Asp609-->Gly in KCNH2 associated with severe long QT syndrome. Clin Sci (Lond) (2005) 0.84
Comparing myotoxic effects of squalene synthase inhibitor, T-91485, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in human myocytes. Biochem Pharmacol (2003) 0.84
High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia. Arterioscler Thromb Vasc Biol (2007) 0.84
Differences in diagnostic value of four electrocardiographic voltage criteria for hypertrophic cardiomyopathy in a genotyped population. Am J Cardiol (2005) 0.84
Cytochrome aa(3) in Haloferax volcanii. J Bacteriol (2002) 0.84
Lipid-lowering effects of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia. Eur J Pharmacol (2003) 0.84
Production of cyclic tetrasaccharide from starch using a novel enzyme system from Bacillus globisporus C11. J Biosci Bioeng (2002) 0.84
Association of genetic variation of the adiponectin gene with body fat distribution and carotid atherosclerosis in Japanese obese subjects. J Atheroscler Thromb (2007) 0.84
Clinical and electrophysiological characteristics of Brugada syndrome caused by a missense mutation in the S5-pore site of SCN5A. J Cardiovasc Electrophysiol (2005) 0.84
Post-prandial remnant lipoprotein metabolism in autosomal recessive hypercholesterolaemia. Eur J Clin Invest (2012) 0.84
Simultaneous, clonally identical T cell expansion in tonsil and synovium in a patient with rheumatoid arthritis and chronic tonsillitis. Arthritis Rheum (2003) 0.83
Characterization of a novel missense mutation E637K in the pore-S6 loop of HERG in a patient with long QT syndrome. Cardiovasc Res (2002) 0.83
Efficacy of a novel, orally active GSK-3 inhibitor 6-Methyl-N-[3-[[3-(1-methylethoxy)propyl]carbamoyl]-1H-pyrazol-4-yl]pyridine-3-carboxamide in tau transgenic mice. Brain Res (2009) 0.83
Altered metabolism of low-density lipoprotein and very-low-density lipoprotein remnant in autosomal recessive hypercholesterolemia: results from stable isotope kinetic study in vivo. Circ Cardiovasc Genet (2011) 0.82
Primary cardiovascular events and serum lipid levels in elderly Japanese with hypercholesterolemia undergoing 6-year simvastatin treatment: a subanalysis of the Japan lipid intervention trial. J Am Geriatr Soc (2004) 0.82
Polymorphisms in four genes related to triglyceride and HDL-cholesterol levels in the general Japanese population in 2000. J Atheroscler Thromb (2005) 0.82
A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients. J Am Coll Cardiol (2003) 0.82
Heterogeneity of cardiac sympathetic nerve activity and systolic dysfunction in patients with hypertrophic cardiomyopathy. J Nucl Med (2002) 0.82
Images in cardiovascular medicine. Free-floating thrombus in right heart and massive pulmonary embolism migrating into pulmonary artery. Circulation (2005) 0.82
Effects of gender on the number of diseased vessels and clinical outcome in Japanese patients with acute coronary syndrome. Circ J (2002) 0.82
An LMNA variant is associated with dyslipidemia and insulin resistance in the Japanese. Metabolism (2002) 0.82
Infantile Cases of Sitosterolaemia with Novel Mutations in the ABCG5 Gene: Extreme Hypercholesterolaemia is Exacerbated by Breastfeeding. JIMD Rep (2015) 0.82
Raloxifene promotes adipocyte differentiation of 3T3-L1 cells. Eur J Pharmacol (2006) 0.82
Difference in coronary blood flow dynamics between patients with hypertension and those with hypertrophic cardiomyopathy. Hypertens Res (2002) 0.81
Sex Differences in Associations Among Obesity, Metabolic Abnormalities, and Chronic Kidney Disease in Japanese Men and Women. J Epidemiol (2016) 0.81
Hemodynamic changes and prognosis in patients with hypertrophic cardiomyopathy and abnormal blood pressure responses during exercise. Clin Cardiol (2003) 0.81
A novel missense mutation in the SCN5A gene associated with Brugada syndrome bidirectionally affecting blocking actions of antiarrhythmic drugs. J Cardiovasc Electrophysiol (2005) 0.81
The first reported case of spotted fever in Fukui Prefecture, the northern part of central Japan. Jpn J Infect Dis (2005) 0.81