Published in Physiol Rev on October 01, 2002
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Major cellular and physiological impacts of ocean acidification on a reef building coral. PLoS One (2012) 1.70
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A 3D Monte Carlo analysis of the role of dyadic space geometry in spark generation. Biophys J (2005) 1.34
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Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle. Proc Natl Acad Sci U S A (2009) 1.33
Insect ryanodine receptors: molecular targets for novel pest control chemicals. Invert Neurosci (2008) 1.29
Pannexin 3 functions as an ER Ca(2+) channel, hemichannel, and gap junction to promote osteoblast differentiation. J Cell Biol (2011) 1.29
Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease. BMC Neurosci (2009) 1.26
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Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries. J Physiol (2004) 1.25
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Immuno-proteomic approach to excitation--contraction coupling in skeletal and cardiac muscle: molecular insights revealed by the mitsugumins. Cell Calcium (2007) 1.24
Two rings of negative charges in the cytosolic vestibule of type-1 ryanodine receptor modulate ion fluxes. Biophys J (2005) 1.23
Distinct effects on Ca2+ handling caused by malignant hyperthermia and central core disease mutations in RyR1. Biophys J (2004) 1.23
The ryanodine receptor mediates early zymogen activation in pancreatitis. Proc Natl Acad Sci U S A (2005) 1.23
Spontaneous and voltage-activated Ca2+ release in adult mouse skeletal muscle fibres expressing the type 3 ryanodine receptor. J Physiol (2007) 1.23
S100A1 and calmodulin compete for the same binding site on ryanodine receptor. J Biol Chem (2008) 1.23
T-tubule biogenesis and triad formation in skeletal muscle and implication in human diseases. Skelet Muscle (2011) 1.22
Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains. Mol Biol Cell (2004) 1.20
Probing the role of negatively charged amino acid residues in ion permeation of skeletal muscle ryanodine receptor. Biophys J (2005) 1.20
Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels. Circ Res (2011) 1.19
Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release. J Neurosci (2009) 1.19
Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin. J Mol Cell Cardiol (2011) 1.19
Protein protein interactions between triadin and calsequestrin are involved in modulation of sarcoplasmic reticulum calcium release in cardiac myocytes. J Physiol (2007) 1.18
Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. J Biol Chem (2011) 1.17
Regulation of the cardiac muscle ryanodine receptor by O(2) tension and S-nitrosoglutathione. Biochemistry (2008) 1.17
Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation. J Biol Chem (2010) 1.16
Synthetic localized calcium transients directly probe signalling mechanisms in skeletal muscle. J Physiol (2012) 1.15
Spatiotemporal patterning of IP3-mediated Ca2+ signals in Xenopus oocytes by Ca2+-binding proteins. J Physiol (2004) 1.14
Pathophysiology of neuropathic lysosomal storage disorders. J Inherit Metab Dis (2010) 1.13
Mechanisms underlying variations in excitation-contraction coupling across the mouse left ventricular free wall. J Physiol (2006) 1.12
Modulation of sarcoplasmic reticulum Ca2+ release by glycolysis in cat atrial myocytes. J Physiol (2005) 1.11
Single ryanodine receptor channel basis of caffeine's action on Ca2+ sparks. Biophys J (2011) 1.11
Mechanism of calmodulin inhibition of cardiac sarcoplasmic reticulum Ca2+ release channel (ryanodine receptor). Biophys J (2004) 1.10
The ryanodine receptor in cardiac physiology and disease. Adv Pharmacol (2010) 1.09
Dysregulated sarcoplasmic reticulum calcium release: potential pharmacological target in cardiac disease. Pharmacol Ther (2008) 1.09
Ryanodine receptor-mediated arrhythmias and sudden cardiac death. Pharmacol Ther (2009) 1.08
Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells. J Vasc Res (2008) 1.08
GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes. Proc Natl Acad Sci U S A (2009) 1.08
Calcium regulation of single ryanodine receptor channel gating analyzed using HMM/MCMC statistical methods. J Gen Physiol (2004) 1.06
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Dantrolene prevents arrhythmogenic Ca2+ release in heart failure. Am J Physiol Heart Circ Physiol (2011) 1.06
Ryanodine receptor current amplitude controls Ca2+ sparks in cardiac muscle. Circ Res (2012) 1.05
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Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. J Biol Chem (2011) 1.05
Ryanodine receptor luminal Ca2+ regulation: swapping calsequestrin and channel isoforms. Biophys J (2009) 1.05
Fixing ryanodine receptor Ca leak - a novel therapeutic strategy for contractile failure in heart and skeletal muscle. Drug Discov Today Dis Mech (2010) 1.04
Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. FEBS Lett (2010) 1.04
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Regulation of sarcoplasmic reticulum Ca²⁺ leak by cytosolic Ca²⁺ in rabbit ventricular myocytes. J Physiol (2011) 1.03
Temperature dependence and thermodynamic properties of Ca2+ sparks in rat cardiomyocytes. Biophys J (2005) 1.03
Three-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptor. Biophys J (2005) 1.03
Pernicious attrition and inter-RyR2 CICR current control in cardiac muscle. J Mol Cell Cardiol (2013) 1.03
The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis. Front Cell Neurosci (2014) 1.02
Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts. J Biol Chem (2011) 1.01
Flux regulation of cardiac ryanodine receptor channels. J Gen Physiol (2009) 1.01
Single channel properties of heterotetrameric mutant RyR1 ion channels linked to core myopathies. J Biol Chem (2008) 1.01
Modulation of hair cell efferents. Hear Res (2010) 1.01
Modulation of NAADP (nicotinic acid-adenine dinucleotide phosphate) receptors by K+ ions: evidence for multiple NAADP receptor conformations. Biochem J (2003) 1.00
Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca2+ release. J Physiol (2014) 0.99
Bcl-X(L) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum. J Cell Biol (2005) 0.99
The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca(2+) signaling of airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2009) 0.99
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Ca2+-dependent excitation-contraction coupling triggered by the heterologous cardiac/brain DHPR beta2a-subunit in skeletal myotubes. Biophys J (2003) 0.98
Luminal Ca(2+) content regulates intracellular Ca(2+) release in subepicardial myocytes of intact beating mouse hearts: effect of exogenous buffers. Am J Physiol Heart Circ Physiol (2010) 0.98
Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics. Front Cell Neurosci (2013) 0.98
The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels. Cell Calcium (2011) 0.97
TNFalpha: a trigger of autonomic dysfunction. Neuroscientist (2007) 0.97
Cardiac alternans and intracellular calcium cycling. Clin Exp Pharmacol Physiol (2014) 0.97
Frequency and release flux of calcium sparks in rat cardiac myocytes: a relation to RYR gating. J Gen Physiol (2010) 0.96
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature (2002) 2.59
Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. J Biol Chem (2007) 1.17
Effects of cytosolic NADH/NAD(+) levels on sarcoplasmic reticulum Ca(2+) release in permeabilized rat ventricular myocytes. J Physiol (2004) 1.14
Single ryanodine receptor channel basis of caffeine's action on Ca2+ sparks. Biophys J (2011) 1.11
Halothane modulation of skeletal muscle ryanodine receptors: dependence on Ca2+, Mg2+, and ATP. Am J Physiol Cell Physiol (2008) 0.91
CGP-37157 inhibits the sarcoplasmic reticulum Ca²+ ATPase and activates ryanodine receptor channels in striated muscle. Mol Pharmacol (2010) 0.88
Differential modulation of cardiac and skeletal muscle ryanodine receptors by NADH. FEBS Lett (2003) 0.87
Ryanodine receptor function in newborn rat heart. Am J Physiol Heart Circ Physiol (2004) 0.86
Ryanodol action on calcium sparks in ventricular myocytes. Pflugers Arch (2010) 0.83
Ryanoids and imperatoxin affect the modulation of cardiac ryanodine receptors by dihydropyridine receptor Peptide A. Biochim Biophys Acta (2008) 0.82
Modulation of cardiac ryanodine receptor channels by alkaline earth cations. PLoS One (2011) 0.81
Coupled gating of skeletal muscle ryanodine receptors is modulated by Ca2+, Mg2+, and ATP. Am J Physiol Cell Physiol (2012) 0.80
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Voltage-dependent modulation of cardiac ryanodine receptors (RyR2) by protamine. PLoS One (2009) 0.79
A biochemical characterization of the major peptides from the Venom of the giant Neotropical hunting ant Dinoponera australis. Toxicon (2009) 0.77
Cross-reactivity of ryanodine receptors with plasma membrane ion channel modulators. Mol Pharmacol (2011) 0.77
Eudistomin D and penaresin derivatives as modulators of ryanodine receptor channels and sarcoplasmic reticulum Ca2+ ATPase in striated muscle. Mol Pharmacol (2014) 0.75