Published in Blood on October 15, 2002
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med (2005) 3.43
Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest (2010) 2.48
HIF transcription factors, inflammation, and immunity. Immunity (2014) 1.55
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood (2013) 1.48
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest (2011) 1.44
Hypoxia--a key regulator of angiogenesis and inflammation in rheumatoid arthritis. Nat Rev Rheumatol (2012) 1.41
Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation. PLoS One (2011) 1.08
Hypobaric biology: Arabidopsis gene expression at low atmospheric pressure. Plant Physiol (2003) 1.08
Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils. J Immunol (2010) 1.07
Interaction between integrin alpha9beta1 and vascular cell adhesion molecule-1 (VCAM-1) inhibits neutrophil apoptosis. Blood (2005) 0.96
Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function. Arthritis Res Ther (2009) 0.89
Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluid. Rheumatology (Oxford) (2008) 0.88
HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination. J Mol Med (Berl) (2013) 0.83
Bax/Mcl-1 balance affects neutrophil survival in intermittent hypoxia and obstructive sleep apnea: effects of p38MAPK and ERK1/2 signaling. J Transl Med (2012) 0.83
Hypoxia-Inducible Factor (HIF) as a Pharmacological Target for Prevention and Treatment of Infectious Diseases. Infect Dis Ther (2014) 0.82
The Anti-Apoptotic Effect of Respiratory Syncytial Virus on Human Peripheral Blood Neutrophils is Mediated by a Monocyte Derived Soluble Factor. Open Virol J (2011) 0.78
Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression. Blood (2016) 0.77
Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice. Front Aging Neurosci (2015) 0.77
HIF-mediated innate immune responses: cell signaling and therapeutic implications. Hypoxia (Auckl) (2014) 0.77
Hypoxia and its implications in rheumatoid arthritis. J Biomed Sci (2016) 0.76
A review of the proposed role of neutrophils in rodent amebic liver abscess models. Parasite (2016) 0.75
Formation of Neutrophil Extracellular Traps under Low Oxygen Level. Front Immunol (2016) 0.75
Effect of mixed culture supernatants of Pseudomonas aeruginosa and Escherichia coli on apoptosis, necrosis, and oxidative activity of neutrophils. Dokl Biol Sci (2015) 0.75
Hypoxia Modulates the Response of Mast Cells to Staphylococcus aureus Infection. Front Immunol (2017) 0.75
Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD. Nat Rev Gastroenterol Hepatol (2017) 0.75
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med (2005) 3.43
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science (2013) 3.33
Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ Res (2005) 3.16
Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation (2002) 3.08
Treating idiopathic pulmonary fibrosis with the addition of co-trimoxazole: a randomised controlled trial. Thorax (2012) 3.01
Single maintenance and reliever therapy (SMART) of asthma: a critical appraisal. Thorax (2010) 2.86
A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med (2010) 2.72
Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell (2008) 2.54
A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med (2014) 2.51
Neutrophil kinetics in health and disease. Trends Immunol (2010) 2.47
Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation. Thorax (2013) 2.42
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood (2005) 2.35
Use of 111-Indium-labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects. Blood (2012) 2.17
Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake. J Exp Med (2008) 2.13
Non-infectious pulmonary toxicity of rituximab: a systematic review. Rheumatology (Oxford) (2011) 1.95
Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension. Hum Mol Genet (2002) 1.85
Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors. FASEB J (2003) 1.78
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol (2006) 1.76
Mechanism of accumulation of 99mTc-sulesomab in inflammation. J Nucl Med (2003) 1.57
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood (2013) 1.48
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest (2011) 1.44
Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat. Am J Physiol Regul Integr Comp Physiol (2008) 1.41
Sputum proteomics in inflammatory and suppurative respiratory diseases. Am J Respir Crit Care Med (2008) 1.40
ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells. Am J Respir Crit Care Med (2002) 1.39
Acceleration of human neutrophil apoptosis by TRAIL. J Immunol (2003) 1.38
BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia. Am J Hum Genet (2013) 1.29
Dissociation between respiratory burst activity and deoxyglucose uptake in human neutrophil granulocytes: implications for interpretation of (18)F-FDG PET images. J Nucl Med (2002) 1.22
Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema. Am J Respir Cell Mol Biol (2002) 1.21
Viscoelastic properties of differentiating blood cells are fate- and function-dependent. PLoS One (2012) 1.19
Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue. Hum Mol Genet (2008) 1.11
BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways. Am J Physiol Lung Cell Mol Physiol (2004) 1.09
Cellular responses to hypoxia after renal segmental infarction. Kidney Int (2003) 1.09
The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction. Biochem J (2009) 1.07
Use of technetium-99m-labeled eosinophils to detect active eosinophilic inflammation in humans. Am J Respir Crit Care Med (2013) 1.07
HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Am J Pathol (2009) 1.06
BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines. Am J Physiol Lung Cell Mol Physiol (2012) 1.06
Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II. J Biol Chem (2010) 1.05
Role of PI3-kinase-dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival. Blood (2002) 1.04
Sputum trace metals are biomarkers of inflammatory and suppurative lung disease. Chest (2009) 1.03
Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents. J Immunol (2002) 1.03
Pulmonary complications of infliximab therapy in patients with rheumatoid arthritis. J Rheumatol (2006) 1.02
Sarcoid-like granulomatous disease following etanercept treatment for RA. J Rheumatol (2007) 1.02
Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin. J Immunol (2008) 1.01
Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. J Immunol (2002) 1.01
Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease. J Immunol (2010) 1.01
Complement factor H-related hybrid protein deregulates complement in dense deposit disease. J Clin Invest (2013) 1.00
The role of HIF-1alpha in myeloid cell inflammation. Trends Immunol (2005) 0.99
HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. J Mol Cell Cardiol (2006) 0.99
Biomarkers for cystic fibrosis lung disease: application of SELDI-TOF mass spectrometry to BAL fluid. J Cyst Fibros (2008) 0.98
Non-infectious pulmonary complications of newer biological agents for rheumatic diseases--a systematic literature review. Rheumatology (Oxford) (2011) 0.97
Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints. Arthritis Res Ther (2008) 0.97
The survival effect of TNF-alpha in human neutrophils is mediated via NF-kappa B-dependent IL-8 release. Eur J Immunol (2004) 0.97
Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival. PLoS One (2012) 0.97
The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations. Hum Mol Genet (2013) 0.94
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis. J Immunol (2012) 0.94
Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence. Development (2013) 0.94
Islet oxygen consumption and insulin secretion tightly coupled to calcium derived from L-type calcium channels but not from the endoplasmic reticulum. J Biol Chem (2008) 0.93
Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands. J Immunol (2013) 0.93
BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production. PLoS One (2012) 0.93
A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability. Cell Rep (2012) 0.92
Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines. J Leukoc Biol (2012) 0.91
The HIF/VHL pathway: from oxygen sensing to innate immunity. Am J Respir Cell Mol Biol (2007) 0.91
Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils. Am J Respir Cell Mol Biol (2010) 0.90
HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A (2013) 0.90
Angiogenesis regulation by TGFβ signalling: clues from an inherited vascular disease. Biochem Soc Trans (2011) 0.90
Hypoxic induction of cox-2 regulates proliferation of human pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol (2002) 0.90
Interleukin-5 inhibits glucocorticoid-mediated apoptosis in human eosinophils. Thorax (2010) 0.90
A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells. Am J Physiol Endocrinol Metab (2009) 0.89
RhoG regulates the neutrophil NADPH oxidase. J Immunol (2006) 0.89
z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. Blood (2004) 0.89
Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function. Arthritis Res Ther (2009) 0.89
The serpinopathies studying serpin polymerization in vivo. Methods Enzymol (2011) 0.89
Hypoxia interferes with connective tissue growth factor (CTGF) gene expression in human proximal tubular cell lines. Nephrol Dial Transplant (2009) 0.89
Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Mol Cell Biol (2009) 0.88
Use of 18FDG-pet to discriminate between infection and rejection in lung transplant recipients. Transplantation (2004) 0.88
Inconsistent effects of acidosis on HIF-alpha protein and its target genes. Pflugers Arch (2005) 0.87
Eotaxin-1/CC chemokine ligand 11: a novel eosinophil survival factor secreted by human pulmonary artery endothelial cells. J Immunol (2007) 0.87
Hypoxia-inducible transcription factors and their role in renal disease. Semin Nephrol (2007) 0.86