Published in J Cell Sci on November 01, 2002
Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci U S A (2003) 4.09
The GSK3 hypothesis of Alzheimer's disease. J Neurochem (2007) 3.16
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J (2004) 2.24
Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. J Cell Biol (2003) 2.07
Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A (2004) 1.99
Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway. Cell Death Differ (2007) 1.80
The desmosome. Cold Spring Harb Perspect Biol (2009) 1.77
A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol (2006) 1.66
Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation. J Cell Biochem (2011) 1.59
β-catenin causes renal dysplasia via upregulation of Tgfβ2 and Dkk1. J Am Soc Nephrol (2011) 1.52
Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder. Pharmacol Rev (2013) 1.52
Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Oncogene (2004) 1.47
Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol Biol Cell (2005) 1.47
Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders. Pharmacol Ther (2010) 1.39
Glucocorticoid-induced bone loss in mice can be reversed by the actions of parathyroid hormone and risedronate on different pathways for bone formation and mineralization. Arthritis Rheum (2008) 1.33
When Wnts antagonize Wnts. J Cell Biol (2003) 1.29
Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools. PLoS One (2009) 1.24
The catenin family at a glance. J Cell Sci (2010) 1.24
Wnt modulators in the biotech pipeline. Dev Dyn (2010) 1.23
Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells. J Biol Chem (2004) 1.22
Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival. Blood (2008) 1.16
Evolution of the Wnt pathways. Methods Mol Biol (2008) 1.13
Sca-1-expressing nonmyogenic cells contribute to fibrosis in aged skeletal muscle. J Gerontol A Biol Sci Med Sci (2008) 1.12
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. Oncogene (2004) 1.10
Noncanonical Wnt signaling promotes apoptosis in thymocyte development. J Exp Med (2007) 1.10
Canonical Wnt signaling is required for ophthalmic trigeminal placode cell fate determination and maintenance. Dev Biol (2007) 1.08
Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Dev Biol (2007) 1.05
Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. Am J Pathol (2007) 1.04
Molecular signaling networks that choreograph epimorphic fin regeneration in zebrafish - a mini-review. Gerontology (2009) 1.03
Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex. Genes Dev (2013) 1.01
Segregation of myoblast fusion and muscle-specific gene expression by distinct ligand-dependent inactivation of GSK-3β. Cell Mol Life Sci (2010) 0.99
Mesodermal fate decisions of a stem cell: the Wnt switch. Cell Mol Life Sci (2008) 0.99
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis (2016) 0.97
miR-93 suppresses proliferation and colony formation of human colon cancer stem cells. World J Gastroenterol (2011) 0.96
Wnt7b is an important intrinsic regulator of hair follicle stem cell homeostasis and hair follicle cycling. Stem Cells (2014) 0.96
Osterix controls cementoblast differentiation through downregulation of Wnt-signaling via enhancing DKK1 expression. Int J Biol Sci (2015) 0.94
Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer. Prostate Cancer (2013) 0.94
Mechanism of β-catenin-mediated transcriptional regulation of epidermal growth factor receptor expression in glycogen synthase kinase 3 β-inactivated prostate cancer cells. J Biol Chem (2012) 0.94
β-catenin at the centrosome: discrete pools of β-catenin communicate during mitosis and may co-ordinate centrosome functions and cell cycle progression. Bioessays (2013) 0.92
Activation of intracellular calcium by multiple Wnt ligands and translocation of β-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/β-catenin pathways. J Biol Chem (2013) 0.92
The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Mol Cell Biol (2006) 0.91
Downregulation of ROCK-I and ROCK-II gene expression in the cadmium-induced ventral body wall defect chick model. Pediatr Surg Int (2008) 0.91
Nek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1. Mol Biol Cell (2014) 0.89
Analysis of dishevelled localization and function in the early sea urchin embryo. Dev Biol (2007) 0.89
Expression patterns of WNT/β-CATENIN signaling molecules during human tooth development. J Mol Histol (2014) 0.88
Stem cells in the adult pancreas and liver. Biochem J (2007) 0.88
Dynamic association with donor cell filopodia and lipid-modification are essential features of Wnt8a during patterning of the zebrafish neuroectoderm. PLoS One (2014) 0.87
The implications of cancer stem cells for cancer therapy. Int J Mol Sci (2012) 0.87
Aberrant stalk development and breakdown of tip dominance in Dictyostelium cell lines with RNAi-silenced expression of calcineurin B. BMC Dev Biol (2006) 0.87
Neuroprotective action of lithium in disorders of the central nervous system. Zhong Nan Da Xue Xue Bao Yi Xue Ban (2011) 0.87
Modulation of β-catenin signaling by glucagon receptor activation. PLoS One (2012) 0.86
Exploration of the APC/beta-catenin (WNT) pathway and a histologic classification system for pulmonary artery intimal sarcoma. A study of 18 cases. Virchows Arch (2008) 0.86
Dysregulated MicroRNA Expression and Chronic Lung Allograft Rejection in Recipients With Antibodies to Donor HLA. Am J Transplant (2015) 0.86
Wnt signaling in limb organogenesis. Organogenesis (2008) 0.85
Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2). Mol Endocrinol (2009) 0.85
Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction. J Biol Chem (2010) 0.84
Proteomic snapshot of breast cancer cell cycle: G1/S transition point. Proteomics (2013) 0.84
Abnormal β-catenin immunohistochemical expression as a prognostic factor in gastric cancer: a meta-analysis. World J Gastroenterol (2014) 0.84
Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules. Int J Mol Sci (2016) 0.83
Induction of a mesenchymal expression program in lung epithelial cells by wingless protein (Wnt)/β-catenin requires the presence of c-Jun N-terminal kinase-1 (JNK1). Am J Respir Cell Mol Biol (2012) 0.83
Regulator of G-protein signaling 3 isoform 1 (PDZ-RGS3) enhances canonical Wnt signaling and promotes epithelial mesenchymal transition. J Biol Chem (2012) 0.83
Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis. Theor Biol Med Model (2013) 0.83
The Wnt signaling pathway is involved in the regulation of phagocytosis of virus in Drosophila. Sci Rep (2013) 0.82
Unlocking mechanisms in interleukin-1β-induced changes in hippocampal neurogenesis--a role for GSK-3β and TLX. Transl Psychiatry (2012) 0.82
β-Catenin independent cross-control between the estradiol and Wnt pathways in osteoblasts. Gene (2011) 0.81
Amyloid beta: multiple mechanisms of toxicity and only some protective effects? Oxid Med Cell Longev (2014) 0.81
Using whole mount in situ hybridization to link molecular and organismal biology. J Vis Exp (2011) 0.81
BDNF is associated with SFRP1 expression in luminal and basal-like breast cancer cell lines and primary breast cancer tissues: a novel role in tumor suppression? PLoS One (2014) 0.80
Key transcription factors in the differentiation of mesenchymal stem cells. Differentiation (2016) 0.80
The GDNF target Vsnl1 marks the ureteric tip. J Am Soc Nephrol (2011) 0.80
Activation of Wnt/β-catenin pathway in monocytes derived from chronic kidney disease patients. PLoS One (2013) 0.79
Wnt10b promotes differentiation of mouse hair follicle melanocytes. Int J Med Sci (2013) 0.79
Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han population. Oncotarget (2016) 0.78
Brief review of the role of glycogen synthase kinase-3β in amyotrophic lateral sclerosis. Neurol Res Int (2011) 0.78
Canonical Wnt signaling activity in early stages of chick lung development. PLoS One (2014) 0.77
Overexpression of cyclin D1 induces the reprogramming of differentiated epidermal cells into stem cell-like cells. Cell Cycle (2016) 0.77
Intestinal stem cells and stem cell-based therapy for intestinal diseases. Cytotechnology (2014) 0.77
Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis. J Biochem Mol Biol (2003) 0.77
Next-generation sequencing analysis of gene regulation in the rat model of retinopathy of prematurity. Doc Ophthalmol (2013) 0.76
The role of Wnt regulation in heart development, cardiac repair and disease: A tissue engineering perspective. Biochem Biophys Res Commun (2015) 0.76
GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. PLoS One (2013) 0.75
The defect of SFRP2 modulates an influx of extracellular calcium in B lymphocytes. BMC Res Notes (2014) 0.75
Role of the Wnt signaling molecules in the tooth. Jpn Dent Sci Rev (2016) 0.75
The relationship between amniotic fluid miRNAs and congenital obstructive nephropathy. Am J Transl Res (2017) 0.75
Loss of secreted frizzled-related protein-1 leads to deterioration of cardiac function in mice and plays a role in human cardiomyopathy. Circ Heart Fail (2015) 0.75
LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974. Sci Rep (2017) 0.75
beta-Catenin expression during vascular development and degeneration of avian mesonephros. J Anat (2005) 0.75
Induction of CXC chemokines in human mesenchymal stem cells by stimulation with secreted frizzled-related proteins through non-canonical Wnt signaling. World J Stem Cells (2015) 0.75
ceRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins. Sci Rep (2017) 0.75
Modulating the wnt signaling pathway with small molecules. Protein Sci (2017) 0.75
Measured Effects of Wnt3a on Proliferation of HEK293T Cells Depend on the Applied Assay. Int J Cell Biol (2015) 0.75
CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3β signaling pathway. Oncotarget (2016) 0.75
Social Isolation Modulates CLOCK Protein and Beta-Catenin Expression Pattern in Gonadotropin-Inhibitory Hormone Neurons in Male Rats. Front Endocrinol (Lausanne) (2017) 0.75
GSK-3b participates in the regulation of hepatic lipid deposition in large yellow croaker (Larmichthys crocea). Fish Physiol Biochem (2016) 0.75
β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein. J Biol Chem (2013) 0.78
Hypoxia regulates the sperm associated antigen 4 (SPAG4) via HIF, which is expressed in renal clear cell carcinoma and promotes migration and invasion in vitro. Mol Carcinog (2013) 0.76