Published in Carcinogenesis on October 01, 2002
Epigenetic inactivation of CHFR in human tumors. Proc Natl Acad Sci U S A (2003) 1.57
Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma. World J Gastroenterol (2003) 1.37
Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Mol Cell Biol (2004) 1.10
Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint. Neoplasia (2008) 1.04
Safeguarding entry into mitosis: the antephase checkpoint. Mol Cell Biol (2010) 1.03
The significance of aberrant CHFR methylation for clinical response to microtubule inhibitors in gastric cancer. J Gastroenterol (2006) 1.00
Yeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-dependent ubiquitination. Cell Cycle (2007) 0.97
CHFR: A Novel Mitotic Checkpoint Protein and Regulator of Tumorigenesis. Transl Oncol (2008) 0.95
Promoter hypermethylation of the Chfr gene in neoplastic and non-neoplastic gastric epithelia. Br J Cancer (2004) 0.94
CHFR is important for the first wave of ubiquitination at DNA damage sites. Nucleic Acids Res (2012) 0.93
Review of the alterations in DNA methylation in esophageal squamous cell carcinoma. Surg Today (2013) 0.92
Emerging evidence for CHFR as a cancer biomarker: from tumor biology to precision medicine. Cancer Metastasis Rev (2014) 0.89
Epigenetic and genetic silencing of CHFR in esophageal adenocarcinomas. Cancer (2010) 0.88
Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasias. Virchows Arch (2004) 0.88
Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. J Clin Invest (2009) 0.85
Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma. Chin J Cancer (2012) 0.85
RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis. Acta Biochim Biophys Sin (Shanghai) (2011) 0.82
Methylation in esophageal carcinogenesis. World J Gastroenterol (2006) 0.80
Overexpression of Cdc25C predicts response to radiotherapy and survival in esophageal squamous cell carcinoma patients treated with radiotherapy followed by surgery. Chin J Cancer (2013) 0.80
Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer. World J Gastroenterol (2009) 0.79
Towards understanding the epigenetics of transcription by chromatin structure and the nuclear matrix. Gene Ther Mol Biol (2005) 0.79
Regulation of the DNA damage response by ubiquitin conjugation. Front Genet (2015) 0.78
Methylation of CHFR sensitizes esophageal squamous cell cancer to docetaxel and paclitaxel. Genes Cancer (2015) 0.76
Epigenetic silencing of checkpoint with fork-head associated and ring finger gene expression in esophageal cancer. Oncol Lett (2013) 0.76
Association between CHFR gene hypermethylation and gastric cancer risk: a meta-analysis. Onco Targets Ther (2016) 0.75
Sustained expression of miR-26a promotes chromosomal instability and tumorigenesis through regulation of CHFR. Nucleic Acids Res (2017) 0.75
Epigenetics modulates the effect of chemotherapy on gastric cancer. J Gastroenterol (2006) 0.75
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science (2004) 61.56
Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48
Randomized phase III study of gemcitabine plus S-1, S-1 alone, or gemcitabine alone in patients with locally advanced and metastatic pancreatic cancer in Japan and Taiwan: GEST study. J Clin Oncol (2013) 3.26
miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer. Cancer Res (2008) 2.80
Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res (2007) 2.54
Interpretation of and preference for probability expressions among Japanese patients and physicians. Fam Pract (2002) 2.43
Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks. Cell (2003) 2.38
RNASEN regulates cell proliferation and affects survival in esophageal cancer patients. Clin Cancer Res (2006) 2.21
PIK3CA mutation status in Japanese lung cancer patients. Lung Cancer (2006) 2.15
microRNA expression profile in undifferentiated gastric cancer. Int J Oncol (2009) 1.95
Association of neural and physiological responses during voluntary emotion suppression. Neuroimage (2005) 1.91
Epidermal growth factor receptor gene mutation defines distinct subsets among small adenocarcinomas of the lung. Lung Cancer (2006) 1.78
HDAC6 expression is correlated with better survival in breast cancer. Clin Cancer Res (2004) 1.74
Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*. Breast Cancer Res Treat (2005) 1.71
Nras and Kras mutation in Japanese lung cancer patients: Genotyping analysis using LightCycler. Oncol Rep (2007) 1.62
Guidelines for management of idiopathic normal pressure hydrocephalus. Neurol Med Chir (Tokyo) (2008) 1.55
Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice. J Hepatol (2010) 1.54
Japanese lung cancer registry study of 11,663 surgical cases in 2004: demographic and prognosis changes over decade. J Thorac Oncol (2011) 1.53
Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells. Stem Cells (2010) 1.52
EGFR Mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler. Clin Cancer Res (2005) 1.47
Interstitial deletion of 13q14.13-q32.3 presenting with Arima syndrome and bilateral retinoblastoma. Brain Dev (2010) 1.45
Proposal of a risk-stratification system for the Japanese population based on blood pressure levels: the Ohasama study. Hypertens Res (2008) 1.43
Immunohistochemical evaluation of hormone receptor status for predicting response to endocrine therapy in metastatic breast cancer. Breast Cancer (2006) 1.42
Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. Oncol Rep (2007) 1.42
Successful delivery derived from vitrified-warmed spermatozoa from a patient with nonobstructive azoospermia. Fertil Steril (2012) 1.41
EGFR and erbB2 mutation status in Japanese lung cancer patients. Int J Cancer (2006) 1.40
Increased serum concentration of eosinophil-derived neurotoxin in patients with Graves' disease. Thyroid (2003) 1.39
Preservation of phrenic nerve involved by stage III thymoma. Ann Thorac Surg (2010) 1.38
Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors. Circ Res (2007) 1.36
Thoracic and cardiovascular surgery in Japan during 2009: annual report by the Japanese Association for Thoracic Surgery. Gen Thorac Cardiovasc Surg (2011) 1.35
Induction of GVHD-like skin disease by passively transferred CD8(+) T-cell receptor transgenic T cells into keratin 14-ovalbumin transgenic mice. J Invest Dermatol (2004) 1.33
EGFR exon 20 insertion mutation in Japanese lung cancer. Lung Cancer (2007) 1.32
Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer. Cancer Sci (2008) 1.31
PIK3CA gene amplification in Japanese non-small cell lung cancer. Lung Cancer (2007) 1.30
Expression profiling of micro-RNAs in human esophageal squamous cell carcinoma using RT-PCR. Med Mol Morphol (2009) 1.30
Expression of PTTG (pituitary tumor transforming gene) in esophageal cancer. Jpn J Clin Oncol (2002) 1.29
Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers. Oncogene (2002) 1.29
Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay. Lung Cancer (2005) 1.28
Dual roles of zygotic and maternal Scribble1 in neural migration and convergent extension movements in zebrafish embryos. Development (2005) 1.26
Low phosphorylation of estrogen receptor alpha (ERalpha) serine 118 and high phosphorylation of ERalpha serine 167 improve survival in ER-positive breast cancer. Endocr Relat Cancer (2008) 1.25
Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells. BMC Cancer (2009) 1.25
Thoracic and cardiovascular surgery in Japan during 2008: annual report by The Japanese Association for Thoracic Surgery. Gen Thorac Cardiovasc Surg (2010) 1.24
Thymic carcinoma: 30 cases at a single institution. J Thorac Oncol (2008) 1.22
Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer. Breast Cancer Res (2003) 1.21
Cerebral glucose metabolism associated with a fear network in panic disorder. Neuroreport (2005) 1.20
Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization. Cancer Res (2010) 1.19
Diagnostic value of adenosine deaminase in tuberculous pleural effusion: a meta-analysis. Ann Clin Biochem (2003) 1.19
Thoracic and cardiovascular surgery in Japan during 2006: annual report by the Japanese Association for Thoracic Surgery. Gen Thorac Cardiovasc Surg (2008) 1.18
Cten mRNA expression was correlated with tumor progression in lung cancers. Lung Cancer (2003) 1.18
Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages. Gastroenterology (2008) 1.18
Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Biochim Biophys Acta (2011) 1.17
Kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii Korth. inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway. Oncol Lett (2012) 1.17
Multimodality therapeutic outcomes in anaplastic thyroid carcinoma: improved survival in subgroups of patients with localized primary tumors. Head Neck (2011) 1.17
Uncommon V599E BRAF mutations in Japanese patients with lung cancer. J Surg Res (2005) 1.16
Phase I/II study of capecitabine plus oxaliplatin (XELOX) plus bevacizumab as first-line therapy in Japanese patients with metastatic colorectal cancer. Jpn J Clin Oncol (2010) 1.16
Encapsulation of concentrated hemoglobin solution in phospholipid vesicles retards the reaction with NO, but not CO, by intracellular diffusion barrier. J Biol Chem (2007) 1.15
Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells. Neuro Oncol (2010) 1.15
Histone deacetylase 1 mRNA expression in lung cancer. Lung Cancer (2004) 1.14
Reproductive history and breast cancer risk. Breast Cancer (2012) 1.14
Japanese Lung Cancer Registry Study: first prospective enrollment of a large number of surgical and nonsurgical cases in 2002. J Thorac Oncol (2010) 1.13
Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells. Oncogene (2003) 1.13
Reduced expression of the breast cancer metastasis suppressor 1 mRNA is correlated with poor progress in breast cancer. Clin Cancer Res (2006) 1.13
Phosphorylation of estrogen receptor alpha serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer. Breast Cancer Res (2005) 1.12
Optimal cutoff level of breath carbon monoxide for assessing smoking status in patients with asthma and COPD. Chest (2003) 1.11
Perceived health as related to income, socio-economic status, lifestyle, and social support factors in a middle-aged Japanese. J Epidemiol (2005) 1.11
Patient's perceived need and psychological distress and/or quality of life in ambulatory breast cancer patients in Japan. Psychooncology (2011) 1.10
Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers. BMC Cancer (2008) 1.09
Epidermal growth factor receptor gene mutation and computed tomographic findings in peripheral pulmonary adenocarcinoma. J Thorac Oncol (2006) 1.09
FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity. Stem Cells (2011) 1.09
Expression of estrogen receptor beta wild-type and its variant ERbetacx/beta2 is correlated with better prognosis in breast cancer. Jpn J Clin Oncol (2007) 1.09