Protection against experimental Helicobacter pylori infection after immunization with inactivated H. pylori whole-cell vaccines.

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Published in Infect Immun on November 01, 2002

Authors

S Raghavan1, M Hjulström, J Holmgren, A-M Svennerholm

Author Affiliations

1: Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute (GUVAX), Göteborg University, S 41346 Göteborg, Sweden.

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Local and systemic antibody responses to dextran-cholera toxin B subunit conjugates. Infect Immun (1995) 1.32

Protein reagent modification of cholera toxin: characterization of effects on antigenic, receptor-binding and toxic properties. J Gen Microbiol (1975) 1.32

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Intestinal and systemic immune responses in humans after oral immunization with a bivalent B subunit-O1/O139 whole cell cholera vaccine. Vaccine (1996) 1.27

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