Published in Am J Physiol Gastrointest Liver Physiol on November 01, 2002
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol (2007) 6.54
Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance. Cancer Biol Ther (2011) 1.85
Visualization of glutamine transporter activities in living cells using genetically encoded glutamine sensors. PLoS One (2012) 1.46
Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. Biochem J (2003) 1.12
Bioengineering the liver: scale-up and cool chain delivery of the liver cell biomass for clinical targeting in a bioartificial liver support system. Biores Open Access (2013) 0.97
Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health. Front Chem (2014) 0.96
Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy (2012) 0.94
Altered glutamine metabolism and therapeutic opportunities for lung cancer. Clin Lung Cancer (2013) 0.93
The betaine/GABA transporter and betaine: roles in brain, kidney, and liver. Front Physiol (2014) 0.88
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells. J Biol Chem (2016) 0.88
Glutamine availability up-regulates expression of the amino acid transporter protein ASCT2 in HepG2 cells and stimulates the ASCT2 promoter. Biochem J (2004) 0.85
Evaluation of encapsulated liver cell spheroids in a fluidised-bed bioartificial liver for treatment of ischaemic acute liver failure in pigs in a translational setting. PLoS One (2013) 0.85
Bioactive food components and cancer-specific metabonomic profiles. J Biomed Biotechnol (2010) 0.84
Role of γ-glutamyltranspeptidase in the pathogenesis of Helicobacter suis and Helicobacter pylori infections. Vet Res (2015) 0.79
Differential levels of amino acid transporters System L and ASCT2, and the mTOR protein in placenta of preeclampsia and IUGR. BMC Pregnancy Childbirth (2014) 0.78
Transactivating effect of complete S protein of hepatitis B virus and cloning of genes transactivated by complete S protein using suppression subtractive hybridization technique. World J Gastroenterol (2005) 0.77
Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression. Cell Physiol Biochem (2014) 0.77
GLUT1 and ASCT2 as Predictors for Prognosis of Hepatocellular Carcinoma. PLoS One (2016) 0.75
CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. Oncotarget (2016) 0.75
ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production. Front Immunol (2017) 0.75
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist (2011) 3.05
Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells. Cancer Res (2008) 2.71
Epithelial-to-mesenchymal transition predicts prognosis of pancreatic cancer. Surgery (2013) 2.43
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. Hepatology (2014) 2.40
MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. Gut (2009) 2.39
Building our future: a plea for leadership. World J Surg (2004) 2.12
A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma. Gastroenterology (2011) 2.08
Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. JAMA (2008) 1.94
Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J Biol Chem (2003) 1.92
Biology of desmoplastic melanoma: a case-control comparison with other melanomas. J Clin Oncol (2005) 1.71
Basic science faculty in surgical departments: advantages, disadvantages and opportunities. J Surg Res (2005) 1.71
Mammographic screening: patterns of use and estimated impact on breast carcinoma survival. Cancer (2004) 1.66
The clinical management of hepatocellular carcinoma in the United States, Europe, and Asia: a comprehensive and evidence-based comparison and review. Cancer (2014) 1.65
Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci U S A (2004) 1.63
Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor. BMC Gastroenterol (2010) 1.49
Morbidity and mortality after liver resection: results of the patient safety in surgery study. J Am Coll Surg (2007) 1.45
Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models. J Hepatol (2012) 1.45
Impact of A Smoking Prevention Interactive Experience (ASPIRE), an interactive, multimedia smoking prevention and cessation curriculum for culturally diverse high-school students. Nicotine Tob Res (2008) 1.44
Melanoma, version 2.2013: featured updates to the NCCN guidelines. J Natl Compr Canc Netw (2013) 1.44
Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. J Biol Chem (2004) 1.42
The future-oriented department chair. Acad Med (2004) 1.41
Scientific data from clinical trials: investigators' responsibilities and rights. Surg Endosc (2002) 1.39
The effect of tumor size and lymph node status on breast carcinoma lethality. Cancer (2003) 1.39
Melanoma. J Natl Compr Canc Netw (2009) 1.37
Anti-oxidant activities of curcumin and related enones. Bioorg Med Chem (2005) 1.37
Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha. J Biol Chem (2002) 1.35
Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma. Clin Cancer Res (2014) 1.33
The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism. J Biol Chem (2005) 1.30
A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome. Clin Cancer Res (2008) 1.27
Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage. Am J Physiol Gastrointest Liver Physiol (2007) 1.26
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer (2014) 1.23
Prevention of hepatocellular carcinoma: potential targets, experimental models, and clinical challenges. Curr Cancer Drug Targets (2012) 1.23
Aberrant accumulation of fibulin-3 in the endoplasmic reticulum leads to activation of the unfolded protein response and VEGF expression. Invest Ophthalmol Vis Sci (2005) 1.23
Viral oncolysis. Oncologist (2002) 1.22
Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin release. Endocrinology (2004) 1.20
Reinventing the academic health center. Acad Med (2005) 1.19
Melanoma in the young: differences and similarities with adult melanoma: a case-matched controlled analysis. Cancer (2007) 1.18
Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: role of nuclear factor-kappaB and activating protein-1. Cancer Res (2004) 1.18
Capsaicin-sensitive vagal afferents modulate posttranscriptional regulation of the rat Na+/glucose cotransporter SGLT1. Am J Physiol Gastrointest Liver Physiol (2008) 1.15
Rapid upregulation of sodium-glucose transporter SGLT1 in response to intestinal sweet taste stimulation. Ann Surg (2010) 1.13
Inducible antisense RNA targeting amino acid transporter ATB0/ASCT2 elicits apoptosis in human hepatoma cells. Am J Physiol Gastrointest Liver Physiol (2003) 1.11
Diurnal rhythmicity in glucose uptake is mediated by temporal periodicity in the expression of the sodium-glucose cotransporter (SGLT1). Surgery (2008) 1.11
Intraoperative US in patients undergoing surgery for liver neoplasms: comparison with MR imaging. Radiology (2004) 1.09
Molecular MRI of collagen to diagnose and stage liver fibrosis. J Hepatol (2013) 1.08
Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell. Cancer Lett (2007) 1.08
Melanoma, version 4.2014. J Natl Compr Canc Netw (2014) 1.07
Liver-directed surgery for metastatic squamous cell carcinoma to the liver: results of a multi-center analysis. Ann Surg Oncol (2007) 1.07
Gallbladder lesions identified on ultrasound. Lessons from the last 10 years. J Gastrointest Surg (2011) 1.06
Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience. Arch Surg (2009) 1.06
Activation of NFkappaB is inhibited by curcumin and related enones. Bioorg Med Chem (2005) 1.05
Phase I/II study of oncolytic herpes simplex virus NV1020 in patients with extensively pretreated refractory colorectal cancer metastatic to the liver. Hum Gene Ther (2010) 1.05
Role of antilipopolysaccharide antibodies in serum bactericidal activity against Salmonella enterica serovar Typhimurium in healthy adults and children in the United States. Clin Vaccine Immunol (2013) 1.03
Regulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5. J Clin Invest (2002) 1.03
Melanoma, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw (2016) 1.02
Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils. Infect Immun (2008) 1.02
Challenges confronting female surgical leaders: overcoming the barriers. J Surg Res (2006) 1.02
Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases. Ann Surg Oncol (2006) 1.02
Epithelial to mesenchymal transition is associated with shorter disease-free survival in hepatocellular carcinoma. Ann Surg Oncol (2014) 1.02
Effect of GLP-2 on mucosal morphology and SGLT1 expression in tissue-engineered neointestine. Am J Physiol Gastrointest Liver Physiol (2003) 1.01
Branched-chain amino acid-enriched nutritional support in surgical and cancer patients. J Nutr (2006) 1.01
Mouse models of subcutaneous spleen reservoir for multiple portal venous injections to treat liver malignancies. Cancer Res (2005) 1.01
Using multidetector CT for preoperative vascular evaluation of liver neoplasms: technique and results. AJR Am J Roentgenol (2002) 0.99
Expression of the pro-angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 by human breast carcinomas is responsive to nutrient deprivation and endoplasmic reticulum stress. Mol Cancer (2004) 0.99
Molecular magnetic resonance imaging of pulmonary fibrosis in mice. Am J Respir Cell Mol Biol (2013) 0.99
Project ASPIRE: an Interactive, Multimedia Smoking Prevention and Cessation curriculum for culturally diverse high school students. Subst Use Misuse (2010) 0.97
Long-term risk of false-positive screening results and subsequent biopsy as a function of mammography use. Radiology (2006) 0.97
Advances in the treatment of liver tumors. Curr Probl Surg (2002) 0.96
Diurnal rhythmicity in the transcription of jejunal drug transporters. J Pharmacol Sci (2008) 0.95
Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. J Immunol (2012) 0.94
Differential role of vagus nerve in maintaining diurnal gene expression rhythms in the proximal small intestine. J Surg Res (2005) 0.94
Concurrent induction of necrosis, apoptosis, and autophagy in ischemic preconditioned human livers formerly treated by chemotherapy. J Hepatol (2009) 0.94
Positron emission tomography of herpes simplex virus 1 oncolysis. Cancer Res (2007) 0.94
Regulation of herpes simplex virus 1 replication using tumor-associated promoters. Ann Surg (2002) 0.93
Cost-effectiveness of hepatic metastasectomy in patients with metastatic colorectal carcinoma: a state-transition Monte Carlo decision analysis. Ann Surg (2003) 0.93
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene. Cancer (2002) 0.93
Viral oncolysis by herpes simplex virus and other viruses. Cancer Biol Ther (2005) 0.92
Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene. Hum Mol Genet (2007) 0.92
Is completion lymphadenectomy after a positive sentinel lymph node biopsy for cutaneous melanoma always necessary? Arch Surg (2004) 0.91
MicroRNA mir-16 is anti-proliferative in enterocytes and exhibits diurnal rhythmicity in intestinal crypts. Exp Cell Res (2010) 0.91
Melanoma. J Natl Compr Canc Netw (2012) 0.90
Nonmetabolizable glucose compounds impart cryotolerance to primary rat hepatocytes. Tissue Eng (2006) 0.90
Scientific data from clinical trials: investigators' responsibilities and rights. World J Surg (2002) 0.89
Diurnal expression of the rat intestinal sodium-glucose cotransporter 1 (SGLT1) is independent of local luminal factors. Surgery (2009) 0.88
Viral oncolysis. Surg Oncol Clin N Am (2002) 0.88
In vitro coculture assay to assess pathogen induced neutrophil trans-epithelial migration. J Vis Exp (2014) 0.87
Oncolysis by viral replication and inhibition of angiogenesis by a replication-conditional herpes simplex virus that expresses mouse endostatin. Cancer (2004) 0.87
HSV-1 viral oncolysis and molecular imaging with PET. Curr Cancer Drug Targets (2007) 0.87
Selectivity of an oncolytic herpes simplex virus for cells expressing the DF3/MUC1 antigen. Cancer Res (2004) 0.86
Novel P2 promoter-derived HNF4alpha isoforms with different N-terminus generated by alternate exon insertion. Exp Cell Res (2009) 0.85
The age at which women begin mammographic screening. Cancer (2004) 0.84
Expression of HNF4alpha variants in pancreatic islets and Ins-1 beta cells. Diabetes Metab Res Rev (2008) 0.84
The new leader: new demands in a changing, turbulent environment. J Am Coll Surg (2003) 0.84