Published in Blood on September 12, 2002
Homeostatic regulation of blood neutrophil counts. J Immunol (2008) 1.81
Neutrophil apoptosis: selective regulation by different ligands of integrin alphaMbeta2. J Immunol (2008) 1.56
Wound-healing defect of CD18(-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation. EMBO J (2005) 1.22
In vivo interleukin-6 protects neutrophils from apoptosis in osteomyelitis. Infect Immun (2004) 1.22
Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Blood (2005) 1.16
Unique and redundant roles of alpha4 and beta2 integrins in kinetics of recruitment of lymphoid vs myeloid cell subsets to the inflamed peritoneum revealed by studies of genetically deficient mice. Exp Hematol (2007) 0.96
Genetic heterogeneity in severe congenital neutropenia: how many aberrant pathways can kill a neutrophil? Curr Opin Allergy Clin Immunol (2007) 0.94
Resolution of LPS-induced airway inflammation and goblet cell hyperplasia is independent of IL-18. Respir Res (2007) 0.91
Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections. J Immunol (2013) 0.89
Modulation of CXC chemokine receptor expression and function in human neutrophils during aging in vitro suggests a role in their clearance from circulation. Mediators Inflamm (2009) 0.86
Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathway. PLoS One (2012) 0.85
Beta(2) integrin deficiency yields unconventional double-negative T cells distinct from mature classical natural killer T cells in mice. Immunology (2009) 0.79
The role of CD18 in the production and release of neutrophils from the bone marrow. Lab Invest (2010) 0.78
Adaptive immune response to model antigens is impaired in murine leukocyte-adhesion deficiency-1 revealing elevated activation thresholds in vivo. Clin Dev Immunol (2012) 0.76
Improved apoptosis detection in ovine neutrophils by annexin V and carboxyfluorescein diacetate staining. Cytotechnology (2007) 0.75
Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med (2002) 4.02
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest (2011) 3.69
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature (2013) 2.62
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell (2012) 2.60
Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs. Nat Immunol (2012) 2.45
p16INK4A is a robust in vivo biomarker of cellular aging in human skin. Aging Cell (2006) 2.34
Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells. J Exp Med (2004) 2.04
Dasatinib inhibits proinflammatory functions of mature human neutrophils. Blood (2012) 1.75
P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules. J Exp Med (2003) 1.73
Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation (2004) 1.70
Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils. Blood (2009) 1.66
Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation. J Clin Invest (2006) 1.65
Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation. J Clin Invest (2006) 1.58
Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events. Ann N Y Acad Sci (2002) 1.56
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J Pharmacol Exp Ther (2009) 1.51
Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein. Genesis (2004) 1.48
Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction. Cardiovasc Res (2008) 1.43
Recommendation: daily sun protection in the prevention of chronic UV-induced skin damage. J Dtsch Dermatol Ges (2007) 1.41
Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response. Blood (2013) 1.41
Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation. Hepatology (2012) 1.40
Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages. J Clin Invest (2008) 1.25
Beta2 integrins separate graft-versus-host disease and graft-versus-leukemia effects. Blood (2007) 1.23
Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation. Blood (2006) 1.23
Wound-healing defect of CD18(-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation. EMBO J (2005) 1.22
Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells. J Clin Invest (2002) 1.18
The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration. Blood (2006) 1.18
Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications. Thromb Haemost (2007) 1.17
RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo. Blood (2010) 1.14
Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free Radic Biol Med (2005) 1.14
Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. Gut (2012) 1.09
Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue. Aging Cell (2010) 1.09
Oxidative stress in chronic venous leg ulcers. Wound Repair Regen (2005) 1.08
Human neutrophils promote angiogenesis by a paracrine feedforward mechanism involving endothelial interleukin-8. Am J Physiol Heart Circ Physiol (2004) 1.06
RhoH is important for positive thymocyte selection and T-cell receptor signaling. Blood (2006) 1.06
alpha-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: melanocortin peptides as a novel treatment strategy for scleroderma? Arthritis Rheum (2009) 1.06
Linking neuron and skin: matrix metalloproteinases in amyotrophic lateral sclerosis (ALS). J Neurol Sci (2009) 1.05
A 9-centimorgan interval of chromosome 10 controls the T cell-dependent psoriasiform skin disease and arthritis in a murine psoriasis model. J Immunol (2008) 1.05
Expression of stromal cell markers in distinct compartments of human skin cancers. J Cutan Pathol (2006) 1.04
Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration. Mol Cell Endocrinol (2009) 1.03
Direct comparison of [18F]FDG PET/CT with PET alone and with side-by-side PET and CT in patients with malignant melanoma. Eur J Nucl Med Mol Imaging (2007) 1.03
CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis. J Immunol (2003) 1.03
Critical role of platelet P-selectin in the response to arterial injury in apolipoprotein-E-deficient mice. Arterioscler Thromb Vasc Biol (2004) 1.03
CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B. Eur J Immunol (2010) 1.02
[AWMF Guideline no. 013/066. Diagnosis and therapy of circumscribed scleroderma]. J Dtsch Dermatol Ges (2009) 1.02
Heterozygous deficiency of manganese superoxide dismutase in mice (Mn-SOD+/-): a novel approach to assess the role of oxidative stress for the development of nitrate tolerance. Mol Pharmacol (2005) 1.02
Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae. J Immunol (2011) 0.98
Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen species-studies in white blood cells and in animal models. Antioxid Redox Signal (2013) 0.98
Senescent BALB/c mice are able to develop resistance to Leishmania major infection. Infect Immun (2004) 0.96
Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo. J Vasc Res (2007) 0.95
Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo. BMC Immunol (2007) 0.95
Cutting edge: egress of newly generated plasma cells from peripheral lymph nodes depends on beta 2 integrin. J Immunol (2005) 0.95
Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J Immunol (2008) 0.95
Combined anticoagulant and antiselectin treatments prevent lethal intravascular coagulation. Blood (2002) 0.95
Midkine in inflammation. ScientificWorldJournal (2011) 0.94
The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via β2 integrins (CD11/CD18). Blood (2014) 0.92
Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis. J Immunol (2009) 0.92
TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis. J Clin Invest (2008) 0.91
A fundamental role of mAbp1 in neutrophils: impact on beta(2) integrin-mediated phagocytosis and adhesion in vivo. Blood (2009) 0.90
Truncated Cockayne syndrome B protein represses elongation by RNA polymerase I. J Mol Biol (2008) 0.90
Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology. J Cell Physiol (2011) 0.89
Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis. Am J Physiol Heart Circ Physiol (2012) 0.89
Syk-mediated translocation of PI3Kdelta to the leading edge controls lamellipodium formation and migration of leukocytes. PLoS One (2007) 0.88
Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice. J Immunol (2010) 0.88
Creation of multiple nanodots by single ions. Nat Nanotechnol (2007) 0.88
Key role of macrophages in the pathogenesis of CD18 hypomorphic murine model of psoriasis. J Invest Dermatol (2009) 0.88
Acral erythrodysesthesia syndrome caused by intravenous infusion of docetaxel in breast cancer. Am J Clin Oncol (2002) 0.87
Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in beta2 integrin-deficient mice. J Leukoc Biol (2006) 0.87
Photoaging as a consequence of natural and therapeutic ultraviolet irradiation--studies on PUVA-induced senescence-like growth arrest of human dermal fibroblasts. Exp Gerontol (2003) 0.87
Small molecular antioxidants effectively protect from PUVA-induced oxidative stress responses underlying fibroblast senescence and photoaging. Free Radic Biol Med (2008) 0.87
Phototherapy and photochemotherapy. Clin Dermatol (2008) 0.87
Mitochondrial oxidative stress and nitrate tolerance--comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD+/- mice. BMC Cardiovasc Disord (2006) 0.87
Reduced CD18 levels drive regulatory T cell conversion into Th17 cells in the CD18hypo PL/J mouse model of psoriasis. J Immunol (2013) 0.86
LFA-1 contributes to signal I of T-cell activation and to the production of T(h)1 cytokines. J Invest Dermatol (2010) 0.86
The effect of adipose tissue derived MSCs delivered by a chemically defined carrier on full-thickness cutaneous wound healing. Biomaterials (2013) 0.86
Activated neutrophils exert antitumor activity against human melanoma cells: reactive oxygen species-induced mechanisms and their modulation by granulocyte-macrophage-colony-stimulating factor. J Invest Dermatol (2003) 0.86
Site of blood vessel damage and relevance of CD18 in a murine model of immune complex-mediated vasculitis. J Invest Dermatol (2006) 0.85