Published in J Infect Dis on October 23, 2002
Searching for Persistence of Infection in Lyme Disease | NCT01143558
Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy. J Clin Invest (2012) 2.44
Persistence of Borrelia burgdorferi following antibiotic treatment in mice. Antimicrob Agents Chemother (2008) 2.02
Development and application of real-time PCR assay for quantification of Mycobacterium ulcerans DNA. J Clin Microbiol (2003) 1.72
Whole-genome sequences of thirteen isolates of Borrelia burgdorferi. J Bacteriol (2010) 1.60
Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. Antimicrob Agents Chemother (2009) 1.60
Antibiotic treatment of animals infected with Borrelia burgdorferi. Clin Microbiol Rev (2009) 1.51
Chronic Lyme disease: a review. Infect Dis Clin North Am (2008) 1.46
Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genes. J Bacteriol (2005) 1.40
Xenodiagnosis to detect Borrelia burgdorferi infection: a first-in-human study. Clin Infect Dis (2014) 1.39
In vitro susceptibility testing of Borrelia burgdorferi sensu lato isolates cultured from patients with erythema migrans before and after antimicrobial chemotherapy. Antimicrob Agents Chemother (2005) 1.23
Resurgence of persisting non-cultivable Borrelia burgdorferi following antibiotic treatment in mice. PLoS One (2014) 1.16
Reviewing molecular adaptations of Lyme borreliosis spirochetes in the context of reproductive fitness in natural transmission cycles. Vet Res (2009) 1.14
Anti-Borrelia burgdorferi antibody profile in post-Lyme disease syndrome. Clin Vaccine Immunol (2011) 1.09
Lyme disease: the next decade. Infect Drug Resist (2011) 0.98
Review of evidence for immune evasion and persistent infection in Lyme disease. Int J Gen Med (2013) 0.94
A systematic review of Borrelia burgdorferi morphologic variants does not support a role in chronic Lyme disease. Clin Infect Dis (2013) 0.93
Evidence of Borrelia autoimmunity-induced component of Lyme carditis and arthritis. J Clin Microbiol (2005) 0.90
Xenodiagnosis for posttreatment Lyme disease syndrome: resolving the conundrum or adding to it? Clin Infect Dis (2014) 0.89
Detection of Borrelia burgdorferi nucleic acids after antibiotic treatment does not confirm viability. J Clin Microbiol (2012) 0.87
Remains of infection. J Clin Invest (2012) 0.87
Persister Development by Borrelia burgdorferi Populations In Vitro. Antimicrob Agents Chemother (2015) 0.85
Dynamic longitudinal antibody responses during Borrelia burgdorferi infection and antibiotic treatment of rhesus macaques. Clin Vaccine Immunol (2012) 0.84
Efficacy of a doxycycline treatment regimen initiated during three different phases of experimental ehrlichiosis. Antimicrob Agents Chemother (2010) 0.84
Borrelia burgdorferi organisms lacking plasmids 25 and 28-1 are internalized by human blood phagocytes at a rate identical to that of the wild-type strain. Infect Immun (2005) 0.80
Evaluation of the preventive capacities of a topically applied azithromycin formulation against Lyme borreliosis in a murine model. J Antimicrob Chemother (2011) 0.79
Decorin binding proteins of Borrelia burgdorferi promote arthritis development and joint specific post-treatment DNA persistence in mice. PLoS One (2015) 0.78
Update on persistent symptoms associated with Lyme disease. Curr Opin Pediatr (2015) 0.78
What ticks do under your skin: two-photon intravital imaging of Ixodes scapularis feeding in the presence of the lyme disease spirochete. Yale J Biol Med (2014) 0.77
Feeding of ticks on animals for transmission and xenodiagnosis in Lyme disease research. J Vis Exp (2013) 0.77
In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii. J Appl Microbiol (2015) 0.76
Lyme Borreliosis: Is there a preexisting (natural) variation in antimicrobial susceptibility among Borrelia burgdorferi strains? Bosn J Basic Med Sci (2015) 0.76
In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. Antimicrob Agents Chemother (2008) 0.75
Diet-Induced Obesity Does Not Alter Tigecycline Treatment Efficacy in Murine Lyme Disease. Front Microbiol (2017) 0.75
Detection of attenuated, noninfectious spirochetes in Borrelia burgdorferi-infected mice, after antibiotic treatment. J Infect Dis (2003) 0.75
The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis (2006) 13.01
Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe. Microbiology (2004) 3.82
Ecology: a prerequisite for malaria elimination and eradication. PLoS Med (2010) 3.19
Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia. Emerg Infect Dis (2011) 3.12
An ecological approach to preventing human infection: vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proc Natl Acad Sci U S A (2004) 2.87
The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature (2005) 2.82
MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi. Proc Natl Acad Sci U S A (2008) 2.67
Fundamental processes in the evolutionary ecology of Lyme borreliosis. Nat Rev Microbiol (2006) 2.65
Niche partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the same tick vector and mammalian reservoir species. Am J Trop Med Hyg (2009) 2.45
A climate-based model predicts the spatial distribution of the Lyme disease vector Ixodes scapularis in the United States. Environ Health Perspect (2003) 2.36
Human risk of infection with Borrelia burgdorferi, the Lyme disease agent, in eastern United States. Am J Trop Med Hyg (2012) 2.22
Human Borrelia miyamotoi infection in the United States. N Engl J Med (2013) 2.11
Persistence of Borrelia burgdorferi following antibiotic treatment in mice. Antimicrob Agents Chemother (2008) 2.02
Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection. PLoS One (2012) 2.01
Typing of Borrelia relapsing fever group strains. Emerg Infect Dis (2004) 2.01
Spatial analysis of West Nile virus: rapid risk assessment of an introduced vector-borne zoonosis. Vector Borne Zoonotic Dis (2002) 1.97
'One medicine---one pathology': are veterinary and human pathology prepared? Lab Invest (2007) 1.87
Effect of Climate Change on Lyme Disease Risk in North America. Ecohealth (2005) 1.82
Borrelia burgdorferi population dynamics and prototype gene expression during infection of immunocompetent and immunodeficient mice. Infect Immun (2003) 1.82
Borrelia burgdorferi population kinetics and selected gene expression at the host-vector interface. Infect Immun (2002) 1.76
Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected mice. Infect Immun (2004) 1.72
Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events. Proc Natl Acad Sci U S A (2009) 1.71
Epidemic spread of Lyme borreliosis, northeastern United States. Emerg Infect Dis (2006) 1.69
Climate and tick seasonality are predictors of Borrelia burgdorferi genotype distribution. Appl Environ Microbiol (2009) 1.64
Modeling the spatial distribution of mosquito vectors for West Nile virus in Connecticut, USA. Vector Borne Zoonotic Dis (2006) 1.60
Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. Antimicrob Agents Chemother (2009) 1.60
Forest fragmentation predicts local scale heterogeneity of Lyme disease risk. Oecologia (2005) 1.55
Population genetics, taxonomy, phylogeny and evolution of Borrelia burgdorferi sensu lato. Infect Genet Evol (2011) 1.54
Use of quantitative real-time PCR for the detection of Salmonella spp. in fecal samples from horses at a veterinary teaching hospital. Vet J (2009) 1.48
Ecological factors associated with West Nile virus transmission, northeastern United States. Emerg Infect Dis (2008) 1.47
Borrelia burgdorferi infection in a natural population of Peromyscus Leucopus mice: a longitudinal study in an area where Lyme Borreliosis is highly endemic. J Infect Dis (2004) 1.46
Examination of the Borrelia burgdorferi transcriptome in Ixodes scapularis during feeding. J Bacteriol (2002) 1.43
Genetic variability within Borrelia burgdorferi sensu lato genospecies established by PCR-single-strand conformation polymorphism analysis of the rrfA-rrlB intergenic spacer in ixodes ricinus ticks from the Czech Republic. Appl Environ Microbiol (2003) 1.40
Interaction and transmission of two Borrelia burgdorferi sensu stricto strains in a tick-rodent maintenance system. Appl Environ Microbiol (2004) 1.38
Fitness variation of Borrelia burgdorferi sensu stricto strains in mice. Appl Environ Microbiol (2007) 1.36
Comparison of the reservoir competence of medium-sized mammals and Peromyscus leucopus for Anaplasma phagocytophilum in Connecticut. Vector Borne Zoonotic Dis (2002) 1.34
Geographic variation in the relationship between human Lyme disease incidence and density of infected host-seeking Ixodes scapularis nymphs in the Eastern United States. Am J Trop Med Hyg (2012) 1.34
From whence will they come? - A perspective on the acute shortage of pathologists in biomedical research. J Vet Diagn Invest (2007) 1.32
Simultaneous serodetection of 10 highly prevalent mouse infectious pathogens in a single reaction by multiplex analysis. Clin Diagn Lab Immunol (2005) 1.29
Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks. PLoS Pathog (2007) 1.24
Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold. J Clin Invest (2010) 1.21
Differential detection of five mouse-infecting helicobacter species by multiplex PCR. Clin Diagn Lab Immunol (2005) 1.20
Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: a summary of the literature and recent observations. Ticks Tick Borne Dis (2012) 1.18
Antibody-mediated disease remission in the mouse model of lyme borreliosis. Infect Immun (2006) 1.17
An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands. J Exp Med (2006) 1.17
Enhancing West Nile virus surveillance, United States. Emerg Infect Dis (2004) 1.16
Multilocus sequence analysis of Borrelia bissettii strains from North America reveals a new Borrelia species, Borrelia kurtenbachii. Ticks Tick Borne Dis (2010) 1.13
Remotely-sensed vegetation indices identify mosquito clusters of West Nile virus vectors in an urban landscape in the northeastern United States. Vector Borne Zoonotic Dis (2008) 1.13
Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States. Emerg Infect Dis (2014) 1.13
Advancing translational research. Science (2011) 1.11
Effects of tick control by acaricide self-treatment of white-tailed deer on host-seeking tick infection prevalence and entomologic risk for Ixodes scapularis-borne pathogens. Vector Borne Zoonotic Dis (2009) 1.09
Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks. J Exp Med (2010) 1.08
A dispersal model for the range expansion of blacklegged tick (Acari: Ixodidae). J Med Entomol (2004) 1.03
Role of outer surface protein D in the Borrelia burgdorferi life cycle. Infect Immun (2007) 1.03
Real-time PCR for simultaneous detection and quantification of Borrelia burgdorferi in field-collected Ixodes scapularis ticks from the Northeastern United States. Appl Environ Microbiol (2003) 1.02
Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection. J Immunol (2012) 0.99
Infection and inflammation in skeletal muscle from nonhuman primates infected with different genospecies of the Lyme disease spirochete Borrelia burgdorferi. Infect Immun (2003) 0.99
One Health approach to identify research needs in bovine and human babesioses: workshop report. Parasit Vectors (2010) 0.99
Lymphoadenopathy during lyme borreliosis is caused by spirochete migration-induced specific B cell activation. PLoS Pathog (2011) 0.98
Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. J Immunol (2002) 0.97
The mouse as a model for investigation of human granulocytic ehrlichiosis: current knowledge and future directions. Comp Med (2002) 0.97
Immunogenicity of Borrelia burgdorferi arthritis-related protein. Infect Immun (2003) 0.97
Monitoring human babesiosis emergence through vector surveillance New England, USA. Emerg Infect Dis (2014) 0.97
Spinal cord involvement in the nonhuman primate model of Lyme disease. Lab Invest (2004) 0.96
Analysis of the intergenic sequences provided by Feria-Arroyo et al. does not support the claim of high Borrelia burgdorferi tick infection rates in Texas and northeastern Mexico. Parasit Vectors (2014) 0.95
Langerhans cell deficiency impairs Ixodes scapularis suppression of Th1 responses in mice. Infect Immun (2009) 0.95
Coinfection with Anaplasma phagocytophilum alters Borrelia burgdorferi population distribution in C3H/HeN mice. Infect Immun (2005) 0.95
Roles of neutrophil beta 2 integrins in kinetics of bacteremia, extravasation, and tick acquisition of Anaplasma phagocytophila in mice. Blood (2002) 0.94
Infection of mice with lyme disease spirochetes constitutively producing outer surface proteins a and B. Infect Immun (2007) 0.94
The United States Department of Agriculture's Northeast Area-wide Tick Control Project: summary and conclusions. Vector Borne Zoonotic Dis (2009) 0.93
Cardiac involvement in non-human primates infected with the Lyme disease spirochete Borrelia burgdorferi. Lab Invest (2004) 0.92
Quantitative PCR for detection of Babesia microti in Ixodes scapularis ticks and in human blood. Vector Borne Zoonotic Dis (2013) 0.91
Detection of Borrelia burgdorferi DNA in tissues from dogs with presumptive Lyme borreliosis. J Am Vet Med Assoc (2006) 0.90
Evaluation of the United States Department Of Agriculture Northeast Area-wide Tick Control Project by meta-analysis. Vector Borne Zoonotic Dis (2009) 0.90
The United States Department Of Agriculture Northeast Area-wide Tick Control Project: history and protocol. Vector Borne Zoonotic Dis (2009) 0.90
Kinetics of CD11b/CD18 up-regulation during infection with the agent of human granulocytic ehrlichiosis in mice. Lab Invest (2002) 0.89
The early dissemination defect attributed to disruption of decorin-binding proteins is abolished in chronic murine Lyme borreliosis. Infect Immun (2013) 0.89
MyD88 deficiency enhances acquisition and transmission of Borrelia burgdorferi by Ixodes scapularis ticks. Infect Immun (2006) 0.86
Immunoglobulin-regulated expression of Borrelia burgdorferi outer surface protein A in vivo. Infect Immun (2005) 0.86
Effectiveness of mosquito traps in measuring species abundance and composition. J Med Entomol (2008) 0.86
Recombinant Helicobacter bilis protein P167 for mouse serodiagnosis in a multiplex microbead assay. Clin Diagn Lab Immunol (2004) 0.86
Cloning and expression of a Helicobacter bilis immunoreactive protein. Clin Diagn Lab Immunol (2002) 0.85
Over 60% of NIH extramural funding involves animal-related research. Vet Pathol (2007) 0.85
Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis. FEMS Immunol Med Microbiol (2007) 0.84
Blood transfusion transmission of the tick-borne relapsing fever spirochete Borrelia miyamotoi in mice. Transfusion (2014) 0.84
Experimental infection of domestic cats with passaged genotype I Bartonella henselae. Vet Microbiol (2007) 0.83