Published in Genome Res on November 01, 2002
Uniform sampling of steady-state flux spaces: means to design experiments and to interpret enzymopathies. Biophys J (2004) 2.12
Formulating genome-scale kinetic models in the post-genome era. Mol Syst Biol (2008) 1.64
k-Cone analysis: determining all candidate values for kinetic parameters on a network scale. Biophys J (2004) 1.58
Systems-biology approaches for predicting genomic evolution. Nat Rev Genet (2011) 1.23
A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis. BMC Syst Biol (2009) 0.93
Using in silico models to simulate dual perturbation experiments: procedure development and interpretation of outcomes. BMC Syst Biol (2009) 0.87
Parallel competition analysis of Saccharomyces cerevisiae strains differing by a single base using polymerase colonies. Nucleic Acids Res (2003) 0.86
Path to facilitate the prediction of functional amino acid substitutions in red blood cell disorders--a computational approach. PLoS One (2011) 0.85
Analysis of genetic variation and potential applications in genome-scale metabolic modeling. Front Bioeng Biotechnol (2015) 0.83
Revitalizing personalized medicine: respecting biomolecular complexities beyond gene expression. CPT Pharmacometrics Syst Pharmacol (2014) 0.78
Evaluation of rate law approximations in bottom-up kinetic models of metabolism. BMC Syst Biol (2016) 0.77
Evaluation of liver and kidney function in favism patients. Med J Islam Repub Iran (2013) 0.75
A Multi-scale Computational Platform to Mechanistically Assess the Effect of Genetic Variation on Drug Responses in Human Erythrocyte Metabolism. PLoS Comput Biol (2016) 0.75
Accessing genetic variation: genotyping single nucleotide polymorphisms. Nat Rev Genet (2001) 5.00
The challenges of in silico biology. Nat Biotechnol (2000) 2.54
Diverse point mutations in the human glucose-6-phosphate dehydrogenase gene cause enzyme deficiency and mild or severe hemolytic anemia. Proc Natl Acad Sci U S A (1988) 2.33
Metabolic regulation and mathematical models. Prog Biophys Mol Biol (1977) 2.06
Toward metabolic phenomics: analysis of genomic data using flux balances. Biotechnol Prog (1999) 1.93
Dynamic simulation of the human red blood cell metabolic network. Bioinformatics (2001) 1.92
Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. Proc Natl Acad Sci U S A (2001) 1.91
Metabolic dynamics in the human red cell. Part I--A comprehensive kinetic model. J Theor Biol (1989) 1.58
Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency. Structure (2000) 1.57
DIFFERENT ENZYMIC EXPRESSIONS OF MUTANTS OF HUMAN GLUCOSE-6-PHOSPHATE DEHYDROGENASE. Proc Natl Acad Sci U S A (1960) 1.51
Glucose 6-phosphate dehydrogenase from human erythrocytes. I. Further purification and characterization. J Biol Chem (1962) 1.48
Use of mathematical models for predicting the metabolic effect of large-scale enzyme activity alterations. Application to enzyme deficiencies of red blood cells. Eur J Biochem (1995) 1.48
Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: computer simulation and metabolic control analysis. Biochem J (1999) 1.31
The genetics of glucose-6-phosphate dehydrogenase deficiency. Semin Hematol (1990) 1.25
Mathematical modelling of metabolic pathways affected by an enzyme deficiency. A mathematical model of glycolysis in normal and pyruvate-kinase-deficient red blood cells. Eur J Biochem (1985) 1.24
Metabolic dynamics in the human red cell. Part IV--Data prediction and some model computations. J Theor Biol (1990) 1.12
Regulation of the human-erythrocyte hexose-monophosphate shunt under conditions of oxidative stress. A study using NMR spectroscopy, a kinetic isotope effect, a reconstituted system and computer simulation. Eur J Biochem (1985) 1.07
A comprehensive model of human erythrocyte metabolism: extensions to include pH effects. Biomed Biochim Acta (1990) 1.06
Red cell enzymopathies of the glycolytic pathway. Semin Hematol (1990) 1.03
Chronic non-spherocytic haemolytic disorders associated with glucose-6-phosphate dehydrogenase variants. Baillieres Best Pract Res Clin Haematol (2000) 1.03
Genetic variation of glucose-6-phosphate dehydrogenase: a catalog and future prospects. Medicine (Baltimore) (1988) 1.00
Identification of the binding domain for NADP+ of human glucose-6-phosphate dehydrogenase by sequence analysis of mutants. Proc Natl Acad Sci U S A (1989) 0.98
Hemolytic anemias due to erythrocyte enzyme deficiencies. Mol Aspects Med (1996) 0.94
A mathematical model for the influence of fructose 6-phosphate, ATP, potassium, ammonium and magnesium on the phosphofructokinase from rat erythrocytes;. Eur J Biochem (1974) 0.93
[Mathematical modelling of glycolysis and adenine nucleotide metabolism of human erythrocytes. I. Reaction-kinetic statements, analysis of in vivo state and determination of starting conditions for in vitro experiments]. Acta Biol Med Ger (1981) 0.92
Red cell pyruvate kinase deficiency: from genetics to clinical manifestations. Baillieres Best Pract Res Clin Haematol (2000) 0.92
Red cell NADP+ and NADPH in glucose-6-phosphate dehydrogenase deficiency. J Clin Invest (1975) 0.91
Mathematical analysis of multienzyme systems. I. Modelling of the glycolysis of human erythrocytes. Biosystems (1975) 0.90
Regulation of glucose-6-phosphate dehydrogenase in human erythrocytes. J Biol Chem (1986) 0.89
Recommended methods for the characterization of red cell pyruvate kinase variants. International Committee for Standardization in Haematology. Br J Haematol (1979) 0.88
Deficiencies of glycolytic enzymes as a possible cause of hemolytic anemia. Biochim Biophys Acta (2000) 0.87
Regulation of glucose-6-phosphate dehydrogenase activity in red blood cells from hemolytic and nonhemolytic variant subjects. Blood (1973) 0.82
Kinetic and thermodynamic properties of two electrophoretically similar genetic variants of human erythrocyte glucose-6-phosphate dehydrogenase. Biochimie (1996) 0.77
Metabolic pathways in the post-genome era. Trends Biochem Sci (2003) 2.57
The genome-scale metabolic extreme pathway structure in Haemophilus influenzae shows significant network redundancy. J Theor Biol (2002) 1.69
Network-based analysis of metabolic regulation in the human red blood cell. J Theor Biol (2003) 1.23