| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation.
|
FASEB J
|
2006
|
3.37
|
|
2
|
Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs.
|
Gastroenterology
|
2005
|
2.58
|
|
3
|
Concern
A beta-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction.
|
Proc Natl Acad Sci U S A
|
2004
|
2.13
|
|
4
|
The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver.
|
Gastroenterology
|
2006
|
2.08
|
|
5
|
The bile acid receptor FXR is a modulator of intestinal innate immunity.
|
J Immunol
|
2009
|
1.69
|
|
6
|
PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation.
|
Hepatology
|
2004
|
1.42
|
|
7
|
The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis.
|
Hepatology
|
2005
|
1.38
|
|
8
|
NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice.
|
Proc Natl Acad Sci U S A
|
2002
|
1.36
|
|
9
|
Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage.
|
Gastroenterology
|
2002
|
1.33
|
|
10
|
Antiatherosclerotic effect of farnesoid X receptor.
|
Am J Physiol Heart Circ Physiol
|
2008
|
1.26
|
|
11
|
Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis.
|
Immunity
|
2002
|
1.25
|
|
12
|
Targeting farnesoid X receptor for liver and metabolic disorders.
|
Trends Mol Med
|
2007
|
1.23
|
|
13
|
NCX-1000, a nitric oxide-releasing derivative of ursodeoxycholic acid, ameliorates portal hypertension and lowers norepinephrine-induced intrahepatic resistance in the isolated and perfused rat liver.
|
J Hepatol
|
2003
|
1.19
|
|
14
|
The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis.
|
PLoS One
|
2011
|
1.11
|
|
15
|
Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin.
|
FASEB J
|
2003
|
1.09
|
|
16
|
Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation.
|
PLoS One
|
2011
|
1.08
|
|
17
|
Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells.
|
Biochem Pharmacol
|
2010
|
1.07
|
|
18
|
VSL#3 resets insulin signaling and protects against NASH and atherosclerosis in a model of genetic dyslipidemia and intestinal inflammation.
|
PLoS One
|
2012
|
1.02
|
|
19
|
Inhibition of NF-κB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells.
|
Eur J Pharmacol
|
2011
|
1.01
|
|
20
|
Inhibition of intestinal bacterial translocation with rifaximin modulates lamina propria monocytic cells reactivity and protects against inflammation in a rodent model of colitis.
|
Digestion
|
2002
|
0.98
|
|
21
|
The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis.
|
J Immunol
|
2009
|
0.98
|
|
22
|
Dissociation of intestinal and hepatic activities of FXR and LXRα supports metabolic effects of terminal ileum interposition in rodents.
|
Diabetes
|
2013
|
0.97
|
|
23
|
Nitric oxide and inflammation.
|
Inflamm Allergy Drug Targets
|
2006
|
0.93
|
|
24
|
Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(Acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherence.
|
J Pharmacol Exp Ther
|
2004
|
0.93
|
|
25
|
Development of FXR, PXR and CAR agonists and antagonists for treatment of liver disorders.
|
Curr Top Med Chem
|
2012
|
0.93
|
|
26
|
Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter.
|
Biochim Biophys Acta
|
2011
|
0.91
|
|
27
|
Marine sponge steroids as nuclear receptor ligands.
|
Trends Pharmacol Sci
|
2012
|
0.90
|
|
28
|
Retracted
Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice.
|
Br J Pharmacol
|
2004
|
0.90
|
|
29
|
The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation.
|
PLoS One
|
2013
|
0.90
|
|
30
|
Role of PAR2 in pain and inflammation.
|
Trends Pharmacol Sci
|
2002
|
0.90
|
|
31
|
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.
|
Br J Pharmacol
|
2003
|
0.88
|
|
32
|
Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition.
|
FASEB J
|
2012
|
0.88
|
|
33
|
Development of non-antibiotic macrolide that corrects inflammation-driven immune dysfunction in models of inflammatory bowel diseases and arthritis.
|
Eur J Pharmacol
|
2011
|
0.87
|
|
34
|
SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts.
|
Inflamm Res
|
2011
|
0.87
|
|
35
|
Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation.
|
World J Gastroenterol
|
2009
|
0.87
|
|
36
|
Targeting FXR in cholestasis: hype or hope.
|
Expert Opin Ther Targets
|
2014
|
0.85
|
|
37
|
NCX-4016, a nitric oxide-releasing aspirin, protects endothelial cells against apoptosis by modulating mitochondrial function.
|
FASEB J
|
2002
|
0.83
|
|
38
|
The plant sterol guggulsterone attenuates inflammation and immune dysfunction in murine models of inflammatory bowel disease.
|
Biochem Pharmacol
|
2009
|
0.83
|
|
39
|
Cyclo-oxygenase (COX) inhibiting nitric oxide donating (CINODs) drugs: a review of their current status.
|
Curr Top Med Chem
|
2007
|
0.82
|
|
40
|
Nitric oxide regulates immune cell bioenergetic: a mechanism to understand immunomodulatory functions of nitric oxide-releasing anti-inflammatory drugs.
|
J Immunol
|
2004
|
0.80
|
|
41
|
Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs in mice.
|
Br J Pharmacol
|
2011
|
0.79
|
|
42
|
Role of nuclear receptors in lipid dysfunction and obesity-related diseases.
|
Drug Metab Dispos
|
2012
|
0.79
|
|
43
|
Anti-inflammatory activity of a new class of nitric oxide synthase inhibitors that release nitric oxide.
|
ChemMedChem
|
2008
|
0.78
|
|
44
|
Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis.
|
Mar Drugs
|
2013
|
0.78
|
|
45
|
PAR-2 modulates pepsinogen secretion from gastric-isolated chief cells.
|
Am J Physiol Gastrointest Liver Physiol
|
2003
|
0.78
|
|
46
|
The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate.
|
Biochim Biophys Acta
|
2011
|
0.77
|
|
47
|
Farnesoid X receptor modulators (2011 - 2014): a patent review.
|
Expert Opin Ther Pat
|
2015
|
0.77
|
|
48
|
Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs and aspirin in mice.
|
Br J Pharmacol
|
2013
|
0.77
|
|
49
|
The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice.
|
PLoS One
|
2010
|
0.77
|
|
50
|
Cardiac safety and antitumoral activity of a new nitric oxide derivative of pegylated epirubicin in mice.
|
Anticancer Drugs
|
2007
|
0.75
|
|
51
|
Molecular determinants of gastrointestinal and liver cancers: role of bile acid activated nuclear receptors.
|
Curr Top Med Chem
|
2012
|
0.75
|
|
52
|
FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents.
|
Pharmacol Res
|
2013
|
0.75
|