Hypermethylation-associated transcriptional silencing of E-cadherin in primary sporadic colorectal carcinomas.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMID 12434413)

Published in J Pathol on December 01, 2002

Authors

George A Garinis1, Panayiotis G Menounos, Nick E Spanakis, Kostas Papadopoulos, George Karavitis, Ismailou Parassi, Evangelia Christeli, George P Patrinos, Evangelos N Manolis, George Peros

Author Affiliations

1: Nursing Military Academy, Laboratory of Research, Athens, Greece. garinis@gen.fgg.eur.nl

Articles by these authors

Gene conversion: mechanisms, evolution and human disease. Nat Rev Genet (2007) 4.62

HbVar: A relational database of human hemoglobin variants and thalassemia mutations at the globin gene server. Hum Mutat (2002) 3.65

Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene. Nat Genet (2013) 2.91

Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach. Nat Genet (2011) 2.51

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. Nat Genet (2010) 2.50

Planning the human variome project: the Spain report. Hum Mutat (2009) 2.22

HbVar database of human hemoglobin variants and thalassemia mutations: 2007 update. Hum Mutat (2007) 2.22

Vascular endothelial growth factor polymorphisms in gastric cancer development, prognosis, and survival. J Surg Oncol (2006) 1.80

PhenCode: connecting ENCODE data with mutations and phenotype. Hum Mutat (2007) 1.75

Genomic rearrangements in inherited disease and cancer. Semin Cancer Biol (2010) 1.72

Lymphedema following axillary lymph node dissection for breast cancer. Surg Oncol (2006) 1.68

Asymptomatic cholelithiasis: is cholecystectomy really needed? A critical reappraisal 15 years after the introduction of laparoscopic cholecystectomy. Dig Dis Sci (2007) 1.67

Gene conversion causing human inherited disease: evidence for involvement of non-B-DNA-forming sequences and recombination-promoting motifs in DNA breakage and repair. Hum Mutat (2009) 1.64

Abdominal desmoid tumors. Surg Oncol (2007) 1.62

Idiopathic sclerosing encapsulating peritonitis (or abdominal cocoon). BMC Surg (2006) 1.56

The low prevalence of helicobacter infection in patients with inflammatory bowel disease could be attributed to previous antibiotic treatment. Am J Gastroenterol (2003) 1.45

FINDbase: a relational database recording frequencies of genetic defects leading to inherited disorders worldwide. Nucleic Acids Res (2006) 1.43

Documentation of inherited disorders and mutation frequencies in the different religious communities in Israel in the Israeli National Genetic Database. Hum Mutat (2007) 1.41

Practical guidelines addressing ethical issues pertaining to the curation of human locus-specific variation databases (LSDBs). Hum Mutat (2010) 1.33

RD-Connect: an integrated platform connecting databases, registries, biobanks and clinical bioinformatics for rare disease research. J Gen Intern Med (2014) 1.30

Serum IL-6, TNFalpha and CRP levels in Greek colorectal cancer patients: prognostic implications. World J Gastroenterol (2005) 1.28

Angiographic embolization for gastroduodenal hemorrhage: safety, efficacy, and predictors of outcome. Arch Surg (2008) 1.28

Personalized pharmacogenomics profiling using whole-genome sequencing. Pharmacogenomics (2014) 1.26

Updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucleic Acids Res (2013) 1.23

Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer. Hum Pathol (2011) 1.18

Tumor infiltration by FcγRIII (CD16)+ myeloid cells is associated with improved survival in patients with colorectal carcinoma. Int J Cancer (2010) 1.16

Recent advances and current controversies in the management of DCIS of the breast. Cancer Treat Rev (2008) 1.15

ETHNOS : A versatile electronic tool for the development and curation of national genetic databases. Hum Genomics (2010) 1.15

Capturing all disease-causing mutations for clinical and research use: toward an effortless system for the Human Variome Project. Genet Med (2009) 1.10

Realities and expectations of pharmacogenomics and personalized medicine: impact of translating genetic knowledge into clinical practice. Pharmacogenomics (2010) 1.09

Locus-specific database domain and data content analysis: evolution and content maturation toward clinical use. Hum Mutat (2010) 1.08

The cypriot and Iranian National Mutation Frequency Databases. Hum Mutat (2006) 1.08

DNA hypermethylation: when tumour suppressor genes go silent. Hum Genet (2002) 1.07

Peritoneal tuberculosis in pregnancy mimicking advanced ovarian cancer: a plea to avoid hasty, radical and irreversible surgical decisions. Int J Infect Dis (2009) 1.06

Developments in FINDbase worldwide database for clinically relevant genomic variation allele frequencies. Nucleic Acids Res (2013) 1.02

A T-to-G transversion at nucleotide -567 upstream of HBG2 in a GATA-1 binding motif is associated with elevated hemoglobin F. Mol Cell Biol (2008) 1.01

Myoid hamartoma of the breast: a case report and review of the literature. Breast J (2007) 1.01

FINDbase: a worldwide database for genetic variation allele frequencies updated. Nucleic Acids Res (2010) 1.00

Isolation and characterization of hematopoietic transcription factor complexes by in vivo biotinylation tagging and mass spectrometry. Ann N Y Acad Sci (2005) 1.00

Key challenges for next-generation pharmacogenomics: Science & Society series on Science and Drugs. EMBO Rep (2014) 0.99

Erythroid phenotypes associated with KLF1 mutations. Haematologica (2011) 0.99

Celiac artery stenosis: an underappreciated and unpleasant surprise in patients undergoing pancreaticoduodenectomy. J Am Coll Surg (2007) 0.98

Cross-transmission of multidrug-resistant Acinetobacter baumannii clonal strains causing episodes of sepsis in a trauma intensive care unit. Infect Control Hosp Epidemiol (2008) 0.98

A1ATVar: a relational database of human SERPINA1 gene variants leading to alpha1-antitrypsin deficiency and application of the VariVis software. Hum Mutat (2009) 0.97

Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder. Pharmacogenomics (2011) 0.96

Direct-access genetic testing: the view from Europe. Nat Rev Genet (2011) 0.96

Intratumoral budding as a potential parameter of tumor progression in mismatch repair-proficient and mismatch repair-deficient colorectal cancer patients. Hum Pathol (2011) 0.95

Large-scale population genetic analysis for hemoglobinopathies reveals different mutation spectra in central Greece compared to the rest of the country. Am J Hematol (2007) 0.95

VarioML framework for comprehensive variation data representation and exchange. BMC Bioinformatics (2012) 0.95

Mutations in the paralogous human alpha-globin genes yielding identical hemoglobin variants. Ann Hematol (2008) 0.93

Population-specific documentation of pharmacogenomic markers and their allelic frequencies in FINDbase. Pharmacogenomics (2011) 0.92

Cytokine serum levels in patients with chronic HCV infection. J Clin Lab Anal (2002) 0.92

Mechanisms and natural history of pain in chronic pancreatitis: a surgical perspective. J Clin Gastroenterol (2007) 0.92

Multiple endocrine neoplasia type 2A in two families with the familial medullary thyroid carcinoma associated G533C mutation of the RET proto-oncogene. Eur J Endocrinol (2008) 0.90

Systematic assessment of protein phenotypes characterizing high-grade tumour budding in mismatch repair-proficient colorectal cancer. Histopathology (2010) 0.90

Relevance of pharmacogenomics for developing countries in Europe. Drug Metabol Drug Interact (2011) 0.89

Thyroid nodules: does the suspicion for malignancy really justify the increased thyroidectomy rates? Surg Oncol (2006) 0.89

The Israeli National Genetic Database. Isr Med Assoc J (2009) 0.88

Genetic recombination as a major cause of mutagenesis in the human globin gene clusters. Clin Biochem (2009) 0.88

Telecytology: a tool for quality assessment and improvement in the evaluation of thyroid fine-needle aspiration specimens. Telemed J E Health (2009) 0.88

The expression of matrix metalloproteinases-2 and -9 and their tissue inhibitor 2 in pancreatic ductal and ampullary carcinoma and their relation to angiogenesis and clinicopathological parameters. Anticancer Res (2008) 0.87

Stakeholder analysis in pharmacogenomics and genomic medicine in Greece. Public Health Genomics (2014) 0.87

Applied vascular anatomy of the colon and rectum: clinical implications for the surgical oncologist. Surg Oncol (2006) 0.86

An overview of current microarray-based human globin gene mutation detection methods. Hemoglobin (2007) 0.86

Genetic databases and their potential in pharmacogenomics. Curr Pharm Des (2010) 0.86

Morphometric microvascular characteristics in the prognosis of pancreatic and ampullary carcinoma. Pancreas (2007) 0.85

Region-specific genetic heterogeneity of HBB mutation distribution in South-Western Greece. Hemoglobin (2010) 0.85

Economic evaluation of pharmacogenomics: a value-based approach to pragmatic decision making in the face of complexity. Public Health Genomics (2014) 0.85

Spread of an unusual penicillin- and imipenem-resistant but ampicillin-susceptible phenotype among Enterococcus faecalis clinical isolates. J Antimicrob Chemother (2005) 0.85

Pharmacogenomics and public health: implementing 'populationalized' medicine. Pharmacogenomics (2012) 0.85

Desmoid tumor of the supraclavicular region: a case report. Cases J (2009) 0.85

An electronic infrastructure for research and treatment of the thalassemias and other hemoglobinopathies: the Euro-mediterranean ITHANET project. Hemoglobin (2009) 0.85

A comparative study of Greek nondeletional hereditary persistence of fetal hemoglobin and beta-thalassemia compound heterozygotes. J Mol Med (Berl) (2001) 0.84

Lymph node harvesting in colorectal carcinoma specimens. Tumori (2011) 0.84

DruGeVar: an online resource triangulating drugs with genes and genomic biomarkers for clinical pharmacogenomics. Public Health Genomics (2014) 0.84

Functional analysis of the role of the TPMT gene promoter VNTR polymorphism in TPMT gene transcription. Pharmacogenomics (2010) 0.84

A pharmacokinetic binding model for bevacizumab and VEGF165 in colorectal cancer patients. Cancer Chemother Pharmacol (2015) 0.84

Collaborative Crowdsourcing for the Diagnosis of Rare Genetic Syndromes: The DYSCERNE Experience. Public Health Genomics (2015) 0.84

Allelic imbalance of expression and epigenetic regulation within the alpha-synuclein wild-type and p.Ala53Thr alleles in Parkinson disease. Hum Mutat (2010) 0.83

Study on the reproducibility of thyroid lesions telecytology diagnoses based upon digitized images. Diagn Cytopathol (2010) 0.83

Increased gamma-globin gene expression in beta-thalassemia intermedia patients correlates with a mutation in 3'HS1. Am J Hematol (2007) 0.83

Human epidermal growth factor receptor-2 gene amplification in gastric cancer using tissue microarray technology. World J Gastroenterol (2012) 0.83

Assessment of the pharmacogenomics educational environment in Southeast Europe. Public Health Genomics (2014) 0.83

Alkaline reflux gastritis: early and late results of surgery. World J Surg (2006) 0.83

Sequelae following axillary lymph node dissection for breast cancer. Expert Rev Anticancer Ther (2006) 0.82

Association of estrogen receptor alpha (ERα) gene polymorphisms with endometrial thickness and lipid profile in women with breast cancer treated with aromatase inhibitors. Gynecol Endocrinol (2012) 0.82

Principles of war surgery: current concepts and future perspectives. Am J Emerg Med (2008) 0.82

Granulomatous cheilitis associated with exacerbations of Crohn's disease: a case report. J Med Case Rep (2008) 0.82

Institutional Profile: Golden Helix Institute of Biomedical Research: interdisciplinary research and educational activities in pharmacogenomics and personalized medicine. Pharmacogenomics (2012) 0.82

Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups: a retrospective analysis of biomarkers in matched primary tumor and lymph node metastases. Cancer (2010) 0.82

Relation between Helicobacter pylori infection, thyroid hormone levels and cardiovascular risk factors on blood donors. Hepatogastroenterology (2003) 0.82

The genetic basis of hereditary medullary thyroid cancer: clinical implications for the surgeon, with a particular emphasis on the role of prophylactic thyroidectomy. Endocr Relat Cancer (2008) 0.82

Role of tumor size in the pre-operative management of rectal cancer patients. BMC Gastroenterol (2010) 0.81

Clinical applicability of sequence variations in genes related to drug metabolism. Curr Drug Metab (2011) 0.81

Serum gastrin levels in patients with inflammatory bowel disease. Hepatogastroenterology (2003) 0.81

Comparative study and meta-analysis of meta-analysis studies for the correlation of genomic markers with early cancer detection. Hum Genomics (2013) 0.81

KLF10 gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in β-hemoglobinopathy patients. Pharmacogenomics (2012) 0.81