Published in Pharmacogenomics J on January 01, 2002
Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nat Rev Drug Discov (2007) 2.32
The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure. J Pharmacol Exp Ther (2013) 1.05
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Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym(®), a Mechanistic Model of Drug-Induced Liver Injury. CPT Pharmacometrics Syst Pharmacol (2016) 0.77
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Association of UDP-glucuronosyltransferase 1A9 polymorphisms with adverse reactions to catechol-O-methyltransferase inhibitors in Parkinson's disease patients. Eur J Clin Pharmacol (2012) 0.76
Evolutionary Diagnosis of non-synonymous variants involved in differential drug response. BMC Med Genomics (2015) 0.75
Emerging strategies and applications of pharmacogenomics. Hum Genomics (2004) 0.75
A systematic review and integrative approach to decode the common molecular link between levodopa response and Parkinson's disease. BMC Med Genomics (2017) 0.75
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Replicating genotype-phenotype associations. Nature (2007) 16.11
Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA (2009) 12.35
Covariation in frequencies of substitution, deletion, transposition, and recombination during eutherian evolution. Genome Res (2003) 11.12
HTRA1 promoter polymorphism in wet age-related macular degeneration. Science (2006) 7.12
The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants. Proc Natl Acad Sci U S A (2007) 5.76
A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science (2006) 5.67
Distinguishing regulatory DNA from neutral sites. Genome Res (2003) 5.63
Effect of iodine intake on thyroid diseases in China. N Engl J Med (2006) 5.46
Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol (2007) 5.31
Sequential transphosphorylation of the BRI1/BAK1 receptor kinase complex impacts early events in brassinosteroid signaling. Dev Cell (2008) 3.58
Regulatory potential scores from genome-wide three-way alignments of human, mouse, and rat. Genome Res (2004) 3.53
Identification and functional analysis of in vivo phosphorylation sites of the Arabidopsis BRASSINOSTEROID-INSENSITIVE1 receptor kinase. Plant Cell (2005) 3.48
Genetic signatures of exceptional longevity in humans. PLoS One (2012) 3.20
Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. Am J Hum Genet (2005) 3.19
BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell-death pathways. Curr Biol (2007) 2.97
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Nat Genet (2010) 2.75
Power and sample size calculations for case-control genetic association tests when errors are present: application to single nucleotide polymorphisms. Hum Hered (2002) 2.74
OrthoDB: a hierarchical catalog of animal, fungal and bacterial orthologs. Nucleic Acids Res (2012) 2.68
MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol (2010) 2.63
A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. J Clin Invest (2002) 2.47
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47
Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans. J Am Coll Cardiol (2006) 2.30
In silico genetics: identification of a functional element regulating H2-Ealpha gene expression. Science (2004) 2.17
Systematic review and meta-analysis of the association between complement factor H Y402H polymorphisms and age-related macular degeneration. Hum Mol Genet (2006) 2.07
Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24,968 initially healthy women. Clin Chem (2007) 2.05
OrthoDB: the hierarchical catalog of eukaryotic orthologs in 2011. Nucleic Acids Res (2010) 2.02
Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study. Eur Heart J (2004) 1.99
An anti-infective peptide that selectively modulates the innate immune response. Nat Biotechnol (2007) 1.97
Update on hybrid conjugate-view SPECT tumor dosimetry and response in 131I-tositumomab therapy of previously untreated lymphoma patients. J Nucl Med (2003) 1.95
Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Proc Natl Acad Sci U S A (2004) 1.95
In vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genes. PLoS One (2012) 1.74
Occupational and genetic risk factors associated with intervertebral disc disease. Spine (Phila Pa 1976) (2007) 1.74
Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. Circulation (2004) 1.73
Health-related hot topic detection in online communities using text clustering. PLoS One (2013) 1.69
Trace amine-associated receptor 1 modulates dopaminergic activity. J Pharmacol Exp Ther (2007) 1.69
Sum statistics for the joint detection of multiple disease loci in case-control association studies with SNP markers. Genet Epidemiol (2003) 1.69
Assessment of genotype imputation methods. BMC Proc (2009) 1.68
Localization of a susceptibility gene for common forms of stroke to 5q12. Am J Hum Genet (2002) 1.67
Toward a roadmap in global biobanking for health. Eur J Hum Genet (2012) 1.65
Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems. Toxicol Sci (2003) 1.64
BRL1, a leucine-rich repeat receptor-like protein kinase, is functionally redundant with BRI1 in regulating Arabidopsis brassinosteroid signaling. Plant J (2004) 1.64
Separation and identification of major plant sphingolipid classes from leaves. J Biol Chem (2006) 1.63
Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25-30 months. Clin Endocrinol (Oxf) (2010) 1.63
The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genomics (2004) 1.63
Vasculoprotective effect of insulin in the ischemic/reperfused canine heart: role of Akt-stimulated NO production. Cardiovasc Res (2005) 1.62
Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosis. Diabetes (2007) 1.56
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes (2011) 1.55
A susceptibility locus for migraine with aura, on chromosome 4q24. Am J Hum Genet (2002) 1.55
An R package suite for microarray meta-analysis in quality control, differentially expressed gene analysis and pathway enrichment detection. Bioinformatics (2012) 1.54
Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK. Biochim Biophys Acta (2006) 1.54
Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. J Biol Chem (2006) 1.54
Cancer and non-cancer mortality among Inhabitants in the high background radiation area of Yangjiang, China (1979-1998). Health Phys (2012) 1.50
Intravenous sildenafil is a potent pulmonary vasodilator in children with congenital heart disease. Circulation (2003) 1.50
Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem (2006) 1.50
The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin in HK-2 cells. Food Chem Toxicol (2011) 1.49
Molecular genetics of pseudoxanthoma elasticum: type and frequency of mutations in ABCC6. Hum Mutat (2005) 1.47
MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus. Arthritis Rheum (2010) 1.45
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J Biol Chem (2002) 1.44
Saxagliptin added to a thiazolidinedione improves glycemic control in patients with type 2 diabetes and inadequate control on thiazolidinedione alone. J Clin Endocrinol Metab (2009) 1.44
Development of thyroid dysfunction and autoantibodies in Graves' multiplex families: an eight-year follow-up study in Chinese Han pedigrees. Thyroid (2011) 1.42
Insulin alleviates posttrauma cardiac dysfunction by inhibiting tumor necrosis factor-α-mediated reactive oxygen species production. Crit Care Med (2013) 1.42
Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells. J Biol Chem (2008) 1.41
Isoquinoline-1,3,4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species. J Biol Chem (2008) 1.41
A comparison of association methods correcting for population stratification in case-control studies. Ann Hum Genet (2011) 1.40
A novel unsupervised method to identify genes important in the anti-viral response: application to interferon/ribavirin in hepatitis C patients. PLoS One (2007) 1.39
Pretreatment sequence diversity differences in the full-length hepatitis C virus open reading frame correlate with early response to therapy. J Virol (2007) 1.38
TCP1 modulates brassinosteroid biosynthesis by regulating the expression of the key biosynthetic gene DWARF4 in Arabidopsis thaliana. Plant Cell (2010) 1.38
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease. Nat Genet (2008) 1.38
Genetic evidence for an indispensable role of somatic embryogenesis receptor kinases in brassinosteroid signaling. PLoS Genet (2012) 1.37
Recent advances in understanding the biochemical and molecular mechanism of diabetic nephropathy. Biochem Biophys Res Commun (2013) 1.36
Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis. Hum Mol Genet (2003) 1.33
Electrical impedance myography for monitoring motor neuron loss in the SOD1 G93A amyotrophic lateral sclerosis rat. Clin Neurophysiol (2011) 1.32
Actinomycetes for marine drug discovery isolated from mangrove soils and plants in China. Mar Drugs (2009) 1.31
MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther (2013) 1.31
The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China. BMC Med Genet (2010) 1.31
Genomic insights into salt adaptation in a desert poplar. Nat Commun (2013) 1.30
Common variants on chromosome 2 and risk of primary open-angle glaucoma in the Afro-Caribbean population of Barbados. Proc Natl Acad Sci U S A (2009) 1.30
Species variation in the fecal metabolome gives insight into differential gastrointestinal function. J Proteome Res (2007) 1.30
HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH. Invest Ophthalmol Vis Sci (2008) 1.28
The immunogenicity and safety of vaccination with purified Vero cell rabies vaccine (PVRV) in China under a 2-1-1 regimen. Hum Vaccin (2011) 1.28
Modeling the impact of random screening and contact tracing in reducing the spread of HIV. Math Biosci (2003) 1.28
Efficiency of single-nucleotide polymorphism haplotype estimation from pooled DNA. Proc Natl Acad Sci U S A (2003) 1.27
A case-control association study of the 12 single-nucleotide polymorphisms implicated in Parkinson disease by a recent genome scan. Am J Hum Genet (2006) 1.26
Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice. Neurobiol Aging (2006) 1.26
Biomarker detection in the integration of multiple multi-class genomic studies. Bioinformatics (2009) 1.25
A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth. Nat Neurosci (2002) 1.25
The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3-dependent Wnt activation. Hepatology (2010) 1.25
Growth rate, catalase and superoxide dismutase activities in rock carp (Procypris rabaudi Tchang) exposed to supersaturated total dissolved gas. J Zhejiang Univ Sci B (2011) 1.24
The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration. Spine (Phila Pa 1976) (2005) 1.24
Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake. Biochim Biophys Acta (2006) 1.23
Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice. Arthritis Rheum (2013) 1.23