Published in Am J Hum Genet on November 01, 2002
The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health (2007) 3.67
Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. Biol Psychiatry (2011) 2.45
Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. Hum Mol Genet (2008) 2.26
ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. Mol Psychiatry (2011) 2.05
Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. Am J Hum Genet (2016) 1.53
Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. Alcohol Clin Exp Res (2008) 1.41
Predicting Carriers of Ongoing Selective Sweeps without Knowledge of the Favored Allele. PLoS Genet (2015) 1.40
Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. Subst Use Misuse (2010) 1.39
Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia. Am J Hum Genet (2007) 1.37
Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. Alcohol Clin Exp Res (2011) 1.30
Do initial responses to drugs predict future use or abuse? Neurosci Biobehav Rev (2012) 1.26
The genetics of substance dependence. Annu Rev Genomics Hum Genet (2012) 1.25
ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. Hum Mol Genet (2009) 1.18
Less drinking, yet more problems: understanding African American drinking and related problems. Psychol Bull (2013) 1.13
Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. Alcohol Clin Exp Res (2010) 1.11
Genes encoding enzymes involved in ethanol metabolism. Alcohol Res (2012) 1.09
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. Hum Genet (2013) 1.04
Genetics and alcoholism. Nat Rev Gastroenterol Hepatol (2013) 1.03
Polygenic scores predict alcohol problems in an independent sample and show moderation by the environment. Genes (Basel) (2014) 1.01
ALDH2, ADH1B and alcohol expectancies: integrating genetic and learning perspectives. Psychol Addict Behav (2009) 0.93
ADH1B*3 and response to alcohol in African-Americans. Alcohol Clin Exp Res (2010) 0.87
ALDH2 and ADH1B interactions in retrospective reports of low-dose reactions and initial sensitivity to alcohol in Asian American college students. Alcohol Clin Exp Res (2011) 0.86
Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India. Hum Genomics (2009) 0.85
Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism. Alcohol Res (2016) 0.84
Alcoholism and liver disease in Mexico: genetic and environmental factors. World J Gastroenterol (2013) 0.82
Variation in the ADH1B proximal promoter affects expression. Chem Biol Interact (2010) 0.82
Advances in genetic studies of substance abuse in China. Shanghai Arch Psychiatry (2013) 0.81
Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico. World J Gastroenterol (2015) 0.80
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. Hum Mol Genet (2010) 0.80
Candidate genes for alcohol dependence: A genetic association study from India. Indian J Med Res (2016) 0.80
Under-Researched Demographics: Heavy Episodic Drinking and Alcohol-Related Problems Among Asian Americans. Alcohol Res (2016) 0.79
Focus on alcoholic liver disease: from nosography to treatment. World J Gastroenterol (2014) 0.78
ADH1B polymorphism, alcohol consumption, and binge drinking in Slavic Caucasians: results from the Czech HAPIEE study. Alcohol Clin Exp Res (2011) 0.76
Genetics of addictions. Psychiatr Clin North Am (2010) 0.75
Systems genetics of alcoholism. Alcohol Res Health (2008) 0.75
Genetics of addictions. Clin Lab Med (2010) 0.75
Peter Riederer "70th birthday" neurobiological foundations of modern addiction treatment. J Neural Transm (Vienna) (2012) 0.75
Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Am J Hum Genet (1999) 3.03
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet (2002) 2.60
Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology (1986) 2.20
Aldehyde dehydrogenase genotypes in Japanese alcoholics. Lancet (1994) 1.91
Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism. Alcohol Clin Exp Res (1997) 1.79
Alcohol-metabolising genes and alcoholism among Taiwanese Han men: independent effect of ADH2, ADH3 and ALDH2. Br J Psychiatry (1996) 1.49
Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatology (2000) 1.41
Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders. Alcohol Clin Exp Res (1994) 1.38
ADH genotypes and alcohol use and dependence in Europeans. Alcohol Clin Exp Res (1998) 1.31
Polymorphisms of ethanol metabolizing enzyme genes and alcoholism. Alcohol Alcohol Suppl (1994) 1.23
Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease. Alcohol Alcohol (1997) 1.13
Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis. J Gastroenterol Hepatol (2002) 1.09
Characteristics of Japanese alcoholics with the atypical aldehyde dehydrogenase 2*2. I. A comparison of the genotypes of ALDH2, ADH2, ADH3, and cytochrome P-4502E1 between alcoholics and nonalcoholics. Alcohol Clin Exp Res (1996) 1.05
Alcohol and aldehyde dehydrogenase genotypes and drinking behavior of Chinese living in Shanghai. Hum Genet (1995) 1.02
High incidence of ADH2*1/ALDH2*1 genes among Japanese alcohol dependents and patients with alcoholic liver disease. Hepatology (1996) 1.01
Alcohol dehydrogenase ADH2-1 and ADH2-2 allelic isoforms in the Russian population correlate with type of alcoholic disease. Addict Biol (2001) 1.00
Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population. J Korean Med Sci (2001) 0.99
Alcohol-metabolizing enzyme polymorphisms and alcoholism in Japan. Alcohol Clin Exp Res (1995) 0.98
ADH and ALDH genotype profiles in Caucasians with alcohol-related problems and controls. Addiction (1993) 0.94
Polymorphism of alcohol dehydrogenase genes in alcoholic and nonalcoholic individuals from Valencia (Spain). Hereditas (1997) 0.84
Human hepatic alcohol and aldehyde dehydrogenases: genetic polymorphism and activities. Proc Natl Sci Counc Repub China B (1997) 0.82
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. Biol Psychiatry (2011) 2.87
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychol Med (2005) 2.45
Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nat Genet (2009) 2.29
Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. Hum Mol Genet (2008) 2.26
Genetic effects on alcohol dependence risk: re-evaluating the importance of psychiatric and other heritable risk factors. Psychol Med (2004) 2.23
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. Am J Hum Genet (2008) 2.01
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A (2011) 2.01
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol (2009) 1.81
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med (2013) 1.70
H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. Addict Biol (2010) 1.64
Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: I. Analyte definition and proposal of a candidate reference method. Clin Chem Lab Med (2007) 1.63
Traditional markers of excessive alcohol use. Addiction (2003) 1.62
Alcohol consumption indices of genetic risk for alcohol dependence. Biol Psychiatry (2009) 1.54
Heritabilities of apolipoprotein and lipid levels in three countries. Twin Res (2002) 1.50
The Brisbane Systems Genetics Study: genetical genomics meets complex trait genetics. PLoS One (2012) 1.49
CDT, GGT, and AST as markers of alcohol use: the WHO/ISBRA collaborative project. Alcohol Clin Exp Res (2002) 1.41
The genetics of coronary heart disease: the contribution of twin studies. Twin Res (2003) 1.33
A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. Twin Res Hum Genet (2010) 1.30
Long-term stability and heritability of telephone interview measures of alcohol consumption and dependence. Twin Res Hum Genet (2008) 1.28
Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twins. Twin Res Hum Genet (2005) 1.26
Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene. Proc Natl Acad Sci U S A (2012) 1.24
ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. Hum Mol Genet (2009) 1.18
Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study. PLoS Med (2013) 1.18
The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample. Alcohol Clin Exp Res (2008) 1.14
Genetic epidemiology of alcohol-induced blackouts. Arch Gen Psychiatry (2004) 1.12
Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure. Circulation (2008) 1.12
Heritability and stability of resting blood pressure in Australian twins. Twin Res Hum Genet (2006) 1.11
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. BMC Med Genet (2011) 1.06
Butyrylcholinesterase: association with the metabolic syndrome and identification of 2 gene loci affecting activity. Clin Chem (2006) 1.03
Association of the gastric alcohol dehydrogenase gene ADH7 with variation in alcohol metabolism. Hum Mol Genet (2007) 1.01
Common genetic contributions to alcohol and cannabis use and dependence symptomatology. Alcohol Clin Exp Res (2009) 0.98
Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations. Hum Mol Genet (2011) 0.98
Effects of variation at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans. Alcohol Clin Exp Res (2006) 0.98
Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions. Eur J Hum Genet (2005) 0.98
A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. PLoS Genet (2011) 0.97
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. Twin Res Hum Genet (2012) 0.95
Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study. Twin Res Hum Genet (2008) 0.94
Mining the human phenome using allelic scores that index biological intermediates. PLoS Genet (2013) 0.94
Longitudinal genetic analysis of plasma lipids. Twin Res Hum Genet (2006) 0.93
Genome-wide association study identifies loci affecting blood copper, selenium and zinc. Hum Mol Genet (2013) 0.93
GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors. Hum Mol Genet (2011) 0.91
Genetic architecture of circulating lipid levels. Eur J Hum Genet (2011) 0.88
Genome-wide scan for blood pressure in Australian and Dutch subjects suggests linkage at 5P, 14Q, and 17P. Hypertension (2007) 0.88
Major depression and the metabolic syndrome. Twin Res Hum Genet (2010) 0.87
Hazardous alcohol consumption and other barriers to antiviral treatment among hepatitis C positive people receiving opioid maintenance treatment. Drug Alcohol Rev (2007) 0.87
Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: II. Performance of a laboratory network running the HPLC candidate reference measurement procedure and evaluation of a candidate reference material. Clin Chem Lab Med (2010) 0.87
Genome-wide association study identifies two loci strongly affecting transferrin glycosylation. Hum Mol Genet (2011) 0.87
A longitudinal genetic study of uric acid and liver enzymes in adolescent twins. Twin Res Hum Genet (2007) 0.86
Erythrocyte aldehyde dehydrogenase activity: lack of association with alcohol use and dependence or alcohol reactions in Australian twins. Alcohol Alcohol (2005) 0.86
Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? Alcohol Clin Exp Res (2009) 0.85
Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population. Eur J Hum Genet (2003) 0.85
Genetics of serum dehydroepiandrosterone sulfate and its relationship to insulin in a population-based cohort of twin subjects. J Clin Endocrinol Metab (2002) 0.84
Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels. Twin Res (2003) 0.83
A longitudinal genetic study of plasma lipids in adolescent twins. Twin Res Hum Genet (2007) 0.83
Evidence of differential allelic effects between adolescents and adults for plasma high-density lipoprotein. PLoS One (2012) 0.81
Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses. J Am Coll Cardiol (2012) 0.81
Genome-wide linkage scan for loci influencing plasma triglycerides. Clin Chim Acta (2006) 0.80
Combining carbohydrate-deficient transferrin and gamma-glutamyltransferase to increase diagnostic accuracy for problem drinking. Alcohol Alcohol (2003) 0.80
Linkage analysis of alcohol dependence symptoms in the community. Alcohol Clin Exp Res (2009) 0.79
Linkage and association analyses of longitudinally measured lipid phenotypes in adolescence. Twin Res Hum Genet (2008) 0.78
Evidence of age-dependent genetic influences on plasma total cholesterol. Eur J Cardiovasc Prev Rehabil (2005) 0.78
Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins. Am J Hypertens (2011) 0.78
Serum gamma-glutamyltransferase and risk of disease. Clin Chem (2007) 0.78
International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents. Circ Cardiovasc Genet (2016) 0.77
Association between in vivo alcohol metabolism and genetic variation in pathways that metabolize the carbon skeleton of ethanol and NADH reoxidation in the alcohol challenge twin study. Alcohol Clin Exp Res (2012) 0.76
Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: III. Performance of native serum and serum spiked with disialotransferrin proves that harmonization of CDT assays is possible. Clin Chem Lab Med (2013) 0.76
Transferrin saturation and mortality. Clin Chem (2011) 0.76
Assessment of alcohol consumption among hepatitis C-positive people receiving opioid maintenance treatment using direct ethanol metabolites and self-report: a pilot study. Addict Biol (2007) 0.75
Transferrin isoform analysis for the diagnosis and management of hazardous or dependent drinking. Clin Chem (2002) 0.75
Clinical Chemistry and Laboratory Medicine: progress and new challenges for our 50-year-old journal. Clin Chem Lab Med (2013) 0.75
Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet (2017) 0.75
Molecular biology and genetics in clinical chemistry and laboratory medicine. Clin Chem Lab Med (2010) 0.75
Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nat Commun (2015) 0.75