Published in Int J Neuropsychopharmacol on December 01, 2002
Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry (2009) 8.74
Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol (2005) 8.49
Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain Behav Immun (2006) 2.78
The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol Psychiatry (2013) 2.17
A prospective evaluation of the directionality of the depression-inflammation relationship. Brain Behav Immun (2009) 1.88
Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile. BMC Med (2013) 1.78
Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Mol Psychiatry (2010) 1.66
Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions. Brain Behav Immun (2009) 1.61
The inflammasome: pathways linking psychological stress, depression, and systemic illnesses. Brain Behav Immun (2012) 1.42
Depression and immunity: a role for T cells? Brain Behav Immun (2009) 1.40
Socioeconomic and psychosocial predictors of interleukin-6 in the MIDUS national sample. Health Psychol (2010) 1.39
A detailed examination of cytokine abnormalities in Major Depressive Disorder. Eur Neuropsychopharmacol (2007) 1.36
Cytokine-induced depression during IFN-alpha treatment: the role of IL-6 and sleep quality. Brain Behav Immun (2009) 1.31
Cytokines and glucocorticoid receptor signaling. Relevance to major depression. Ann N Y Acad Sci (2009) 1.30
A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol (2009) 1.28
Income, education, and inflammation: differential associations in a national probability sample (The MIDUS study). Psychosom Med (2010) 1.28
Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. J Neural Transm (Vienna) (2010) 1.25
A critical review of human endotoxin administration as an experimental paradigm of depression. Neurosci Biobehav Rev (2009) 1.24
Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later. Isr J Psychiatry Relat Sci (2010) 1.18
Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10. PLoS One (2013) 1.18
Vitamin D intake from foods and supplements and depressive symptoms in a diverse population of older women. Am J Clin Nutr (2011) 1.08
The concept of depression as a dysfunction of the immune system. Curr Immunol Rev (2010) 1.06
Living well with medical comorbidities: a biopsychosocial perspective. J Gerontol B Psychol Sci Soc Sci (2012) 0.98
Sex-specific association of depression and a haplotype in leukotriene A4 hydrolase gene. Psychosom Med (2009) 0.92
Psychobiology of depression/distress in congestive heart failure. Heart Fail Rev (2008) 0.92
Insulin resistance, obesity, inflammation, and depression in polycystic ovary syndrome: biobehavioral mechanisms and interventions. Fertil Steril (2010) 0.92
Sleep quality, social well-being, gender, and inflammation: an integrative analysis in a national sample. Ann N Y Acad Sci (2011) 0.91
The impact of neuroimmune dysregulation on neuroprotection and neurotoxicity in psychiatric disorders--relation to drug treatment. Dialogues Clin Neurosci (2009) 0.90
Interleukin-10: a key cytokine in depression? Cardiovasc Psychiatry Neurol (2009) 0.90
Biological effects of add-on eicosapentaenoic acid supplementation in diabetes mellitus and co-morbid depression: a randomized controlled trial. PLoS One (2012) 0.90
Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target? Expert Rev Neurother (2012) 0.89
Cytokines as mediators of chemotherapy-associated cognitive changes: current evidence, limitations and directions for future research. PLoS One (2013) 0.89
Neuropsychiatric manifestations of depression in multiple sclerosis: neuroinflammatory, neuroendocrine, and neurotrophic mechanisms in the pathogenesis of immune-mediated depression. Dialogues Clin Neurosci (2007) 0.88
Varieties of anger and the inverse link between education and inflammation: toward an integrative framework. Psychosom Med (2013) 0.86
The social patterns of a biological risk factor for disease: race, gender, socioeconomic position, and C-reactive protein. J Gerontol B Psychol Sci Soc Sci (2012) 0.85
Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene × environment interactions. PLoS One (2011) 0.85
Phenotypes, Risk Factors, and Mechanisms of Adult-Onset Asthma. Mediators Inflamm (2015) 0.85
Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls. BMC Psychiatry (2013) 0.84
Increase in IL-6 levels among major depressive disorder patients after a 6-week treatment with duloxetine 60 mg/day: a preliminary observation. Neuropsychiatr Dis Treat (2011) 0.84
Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance. Curr Neuropharmacol (2012) 0.83
Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun (2015) 0.82
Mirtazapine inhibits tumor growth via immune response and serotonergic system. PLoS One (2012) 0.82
Antidepressant therapy in epilepsy: can treating the comorbidities affect the underlying disorder? Br J Pharmacol (2013) 0.81
Association analysis between variants of the interleukin-1beta and the interleukin-1 receptor antagonist gene and antidepressant treatment response in major depression. Neuropsychiatr Dis Treat (2008) 0.81
Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. BMC Med Genet (2008) 0.80
Gastrodiae Rhizoma (tiān má): a review of biological activity and antidepressant mechanisms. J Tradit Complement Med (2011) 0.80
Effects of fluoxetine and escitalopram on C-reactive protein in patients of depression. J Pharmacol Pharmacother (2011) 0.80
Protective effects of fluoxetine on decompression sickness in mice. PLoS One (2012) 0.78
Moclobemide exerts anti-inflammatory effect in lipopolysaccharide-activated primary mixed glial cell culture. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.78
Lithium chloride induces TNFα in mouse macrophages via MEK-ERK-dependent pathway. J Cell Biochem (2014) 0.78
Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia: A Pilot Study. Depress Res Treat (2014) 0.78
Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness. Neural Plast (2016) 0.77
Prevention of unpredictable chronic stress-related phenomena in zebrafish exposed to bromazepam, fluoxetine and nortriptyline. Psychopharmacology (Berl) (2016) 0.77
IL-4/10 prevents stress vulnerability following imipramine discontinuation. J Neuroinflammation (2015) 0.77
Antidepressant compounds can be both pro- and anti-inflammatory in human hippocampal cells. Int J Neuropsychopharmacol (2014) 0.77
Impact of lithium alone and in combination with antidepressants on cytokine production in vitro. J Neural Transm (Vienna) (2014) 0.76
Kynurenine and depressive symptoms in a poststroke population. Neuropsychiatr Dis Treat (2014) 0.76
Paroxetine suppresses recombinant human P2X7 responses. Purinergic Signal (2015) 0.76
Stress-Related Immune Markers in Depression: Implications for Treatment. Int J Neuropsychopharmacol (2016) 0.76
Peripheral Inflammatory Parameters in Late-Life Depression: A Systematic Review. Int J Mol Sci (2016) 0.75
The Historical Development of Immunoendocrine Concepts of Psychiatric Disorders and Their Therapy. Int J Mol Sci (2015) 0.75
Imipramine alters the sterol profile in Leishmania amazonensis and increases its sensitivity to miconazole. Parasit Vectors (2016) 0.75
Mitigation of Inflammation-Induced Mood Dysregulation by Long-Chain Omega-3 Fatty Acids. J Am Coll Nutr (2015) 0.75
Kidney dysfunction, systemic inflammation and mental well-being in elderly post-myocardial infarction patients. BMC Psychol (2017) 0.75
Repeatedly administered antidepressant drugs modulate humoral and cellular immune response in mice through action on macrophages. Exp Biol Med (Maywood) (2016) 0.75
Posttraumatic Stress Disorder: Does the Gut Microbiome Hold the Key? Can J Psychiatry (2016) 0.75
Educational Status, Anger, and Inflammation in the MIDUS National Sample: Does Race Matter? Ann Behav Med (2015) 0.75
Anatomy of the anterolateral ligament of the knee. J Anat (2013) 3.68
Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry (2005) 3.00
So depression is an inflammatory disease, but where does the inflammation come from? BMC Med (2013) 2.02
Relation of levels of serum lipoproteins to depression after acute myocardial infarction. Am J Cardiol (2002) 1.92
Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system. J Clin Psychopharmacol (2002) 1.66
Partial posttraumatic stress disorder revisited. J Affect Disord (2004) 1.60
The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans. Int J Neuropsychopharmacol (2002) 1.60
Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev (2011) 1.58
Activation of the inflammatory response system in autism. Neuropsychobiology (2002) 1.56
Diagnosis of myalgic encephalomyelitis: where are we now? Expert Opin Med Diagn (2013) 1.43
Depression induced by treatment with interferon-alpha in patients affected by hepatitis C virus. J Affect Disord (2002) 1.30
Stability of interleukin 6, soluble interleukin 6 receptor, interleukin 10 and CC16 in human serum. Cytokine (2002) 1.27
The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression. J Psychiatry Neurosci (2004) 1.24
Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway. Mol Neurobiol (2013) 1.23
Inflammatory markers in depressed post-myocardial infarction patients. J Psychiatr Res (2005) 1.13
In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression. Prog Neuropsychopharmacol Biol Psychiatry (2010) 1.06
Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol. J Psychosom Res (2007) 1.04
A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome. Metab Brain Dis (2012) 1.04
Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness. BMC Med (2013) 1.03
Baseline immune activation as a risk factor for the onset of depression during interferon-alpha treatment. Biol Psychiatry (2006) 1.02
Stimulatory effect of antidepressants on the production of IL-6. Int Immunopharmacol (2004) 1.01
Depression, traumatic stress and interleukin-6. J Affect Disord (2010) 1.01
Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6. Psychiatry Res (2005) 1.00
Toxic rise of clozapine plasma concentrations in relation to inflammation. Eur Neuropsychopharmacol (2003) 1.00
Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses. BMC Med (2015) 0.97
Immuno-inflammatory, oxidative and nitrosative stress, and neuroprogressive pathways in the etiology, course and treatment of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry (2012) 0.96
Putative neuroprotective agents in neuropsychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry (2012) 0.96
Schizophrenia: linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neurodevelopment and neuroprogression. Prog Neuropsychopharmacol Biol Psychiatry (2012) 0.94
A review on cognitive behavorial therapy (CBT) and graded exercise therapy (GET) in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS): CBT/GET is not only ineffective and not evidence-based, but also potentially harmful for many patients with ME/CFS. Neuro Endocrinol Lett (2009) 0.94
Selective adsorption and separation of xylene isomers and ethylbenzene with the microporous vanadium(IV) terephthalate MIL-47. Angew Chem Int Ed Engl (2007) 0.92
(Neuro)inflammation and neuroprogression as new pathways and drug targets in depression: from antioxidants to kinase inhibitors. Prog Neuropsychopharmacol Biol Psychiatry (2011) 0.92
Nutrient intakes and the common mental disorders in women. J Affect Disord (2012) 0.92
Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers: evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells. Neuro Endocrinol Lett (2007) 0.91
p-Xylene-selective metal-organic frameworks: a case of topology-directed selectivity. J Am Chem Soc (2011) 0.89
Activation of the inflammatory response system: A new look at the etiopathogenesis of major depression. Neuro Endocrinol Lett (1999) 0.88
Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications. Mol Neurobiol (2013) 0.88
Herpes viruses, cytokines, and altered hemostasis in vital exhaustion. Psychosom Med (2003) 0.87
Serological observations in patients suffering from acute manic episodes. Hum Psychopharmacol (2002) 0.87
The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder. J Affect Disord (2012) 0.87
Serum amino acids, biopterin and neopterin during long-term immunotherapy with interferon-alpha in high-risk melanoma patients. Psychiatry Res (2003) 0.86
Neurodegeneration in Parkinson's disease: interactions of oxidative stress, tryptophan catabolites and depression with mitochondria and sirtuins. Mol Neurobiol (2013) 0.86
Role of immune-inflammatory and oxidative and nitrosative stress pathways in the etiology of depression: therapeutic implications. CNS Drugs (2014) 0.86
Total antioxidant status correlates with cognitive impairment in patients with recurrent depressive disorder. Neurochem Res (2012) 0.85
Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder. J Affect Disord (2011) 0.85
Selective adsorption and separation of ortho-substituted alkylaromatics with the microporous aluminum terephthalate MIL-53. J Am Chem Soc (2008) 0.85
CO2 challenge results in hypothalamic-pituitary-adrenal activation in healthy volunteers. J Psychopharmacol (2005) 0.85
Serotonergic disturbances in autistic disorder: L-5-hydroxytryptophan administration to autistic youngsters increases the blood concentrations of serotonin in patients but not in controls. Life Sci (2005) 0.85
Biological underpinnings of the commonalities in depression, somatization, and Chronic Fatigue Syndrome. Med Hypotheses (2012) 0.85
Single-stage bilateral total hip arthroplasty in patients less than 35 years. Forty arthroplasties with 5-17 years follow-up. Acta Orthop Belg (2009) 0.84
A new animal model of (chronic) depression induced by repeated and intermittent lipopolysaccharide administration for 4 months. Brain Behav Immun (2013) 0.84
Ebola virus: melatonin as a readily available treatment option. J Med Virol (2015) 0.84
Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways. Metab Brain Dis (2013) 0.84
CO2 challenge induced HPA axis activation in panic. Int J Neuropsychopharmacol (2006) 0.84
Lowered omega-3 PUFAs are related to major depression, but not to somatization syndrome. J Affect Disord (2009) 0.84
Inflammation-related disorders in the tryptophan catabolite pathway in depression and somatization. Adv Protein Chem Struct Biol (2012) 0.83
Increased IL-6 trans-signaling in depression: focus on the tryptophan catabolite pathway, melatonin and neuroprogression. Pharmacol Rep (2013) 0.83
Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways. Prog Neuropsychopharmacol Biol Psychiatry (2012) 0.82
Nitric oxide plasma concentration associated with cognitive impairment in patients with recurrent depressive disorder. Neurosci Lett (2012) 0.82
Age-dependent stimulatory effect of desipramine and fluoxetine pretreatment on metastasis formation by B16F10 melanoma in male C57BL/6 mice. Pharmacol Rep (2010) 0.82
Framework breathing in the vapour-phase adsorption and separation of xylene isomers with the metal-organic framework MIL-53. Chemistry (2009) 0.82
Bipolar disorder: role of immune-inflammatory cytokines, oxidative and nitrosative stress and tryptophan catabolites. Curr Psychiatry Rep (2015) 0.82
Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects. Metab Brain Dis (2012) 0.81
The glutathione system: a new drug target in neuroimmune disorders. Mol Neurobiol (2014) 0.81
Behavioral changes in rats after acute, chronic and repeated administration of interleukin-1beta: relevance for affective disorders. J Affect Disord (2003) 0.81
Biobutanol separation with the metal-organic framework ZIF-8. ChemSusChem (2011) 0.81
Vascular endothelial growth factor receptor 2 gene (KDR) polymorphisms and expression levels in depressive disorder. J Affect Disord (2012) 0.80
Increased nuclear factor-κB and loss of p53 are key mechanisms in Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS). Med Hypotheses (2012) 0.80
The effect of cocaine sensitization on mouse immunoreactivity. Eur J Pharmacol (2004) 0.80
The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs). Mol Neurobiol (2013) 0.80
Metal-organic frameworks as high-potential adsorbents for liquid-phase separations of olefins, alkylnaphthalenes and dichlorobenzenes. Phys Chem Chem Phys (2009) 0.79
Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts. J Affect Disord (2013) 0.79
Malondialdehyde plasma concentration correlates with declarative and working memory in patients with recurrent depressive disorder. Mol Biol Rep (2011) 0.79
Case definitions and diagnostic criteria for Myalgic Encephalomyelitis and Chronic fatigue Syndrome: from clinical-consensus to evidence-based case definitions. Neuro Endocrinol Lett (2013) 0.79
Mitochondrial dysfunction in the pathophysiology of bipolar disorder: effects of pharmacotherapy. Mini Rev Med Chem (2015) 0.79
Psychobiological aspects of somatoform disorders: contributions of monoaminergic transmitter systems. Neuropsychobiology (2004) 0.79
A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior. BMC Med (2013) 0.79
Variants of Base Excision Repair Genes MUTYH , PARP1 and XRCC1 in Alzheimer's Disease Risk. Neuropsychobiology (2015) 0.78
Manganese superoxide dismutase gene expression and cognitive functions in recurrent depressive disorder. Neuropsychobiology (2014) 0.78
An inducible nitric oxide synthase polymorphism is associated with the risk of recurrent depressive disorder. Neurosci Lett (2010) 0.78
Serum testosterone concentration in male autistic youngsters. Neuro Endocrinol Lett (2010) 0.78
Postpartum depression: psychoneuroimmunological underpinnings and treatment. Neuropsychiatr Dis Treat (2013) 0.78
Vascular endothelial growth factor gene (VEGFA) polymorphisms may serve as prognostic factors for recurrent depressive disorder development. Prog Neuropsychopharmacol Biol Psychiatry (2013) 0.78
Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction. Pharmacol Rep (2012) 0.77
Increased mitogen-induced lymphocyte proliferation in treatment resistant depression: a preliminary study. Neuro Endocrinol Lett (2004) 0.77
Inhibitory effects of amantadine on the production of pro-inflammatory cytokines by stimulated in vitro human blood. Pharmacol Rep (2010) 0.77
Fatty acid profile and affective dysregulation in irritable bowel syndrome. Lipids (2004) 0.77
Inhibition of 2,4-dinitrofluorobenzene-induced contact hypersensitivity reaction by antidepressant drugs. Pharmacol Rep (2013) 0.77
Polyunsaturated fatty acids: do they have a role in the pathophysiology of autism? Neuro Endocrinol Lett (2006) 0.77
Inhibitory effect of antidepressants on B16F10 melanoma tumor growth. Pharmacol Rep (2013) 0.77
Total hip arthroplasty in inflammatory arthritis in patients under 35 years. A 7 to 19 year follow-up. Hip Int (2010) 0.77
Gut Permeability and Microbiota in Parkinson's Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatonergic Pathways. Curr Pharm Des (2016) 0.77
How Immune-inflammatory processes link CNS and psychiatric disorders: Classification and Treatment Implications. CNS Neurol Disord Drug Targets (2016) 0.77
The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer's Disease. Curr Pharm Des (2016) 0.76
Psychomotor, neuroendocrine and behavioural effects after oral administration of levodopa in normal volunteers. Psychiatry Res (2004) 0.76
High predictive value of immune-inflammatory biomarkers for schizophrenia diagnosis and association with treatment resistance. World J Biol Psychiatry (2015) 0.76
Crosstalk between contact hypersensitivity reaction and antidepressant drugs. Pharmacol Rep (2013) 0.76
Stimulatory effect of antidepressant drug pretreatment on progression of B16F10 melanoma in high-active male and female C57BL/6J mice. J Neuroimmunol (2011) 0.76
Influence of antidepressants on intracellular levels of cyclic adenosine monophosphate in human peripheral blood mononuclear cells. Eur Neuropsychopharmacol (2003) 0.76
Hypothalamic-pituitary-adrenal axis function following a 35% CO2 inhalation in healthy volunteers. Prog Neuropsychopharmacol Biol Psychiatry (2004) 0.76