Published in Bioorg Med Chem Lett on January 06, 2003
1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets. Curr Med Chem (2009) 1.19
Perspectives on chemopreventive and therapeutic potential of curcumin analogs in medicinal chemistry. Mini Rev Med Chem (2010) 1.17
Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo. Clin Cancer Res (2008) 1.03
Mechanisms for the activity of heterocyclic cyclohexanone curcumin derivatives in estrogen receptor negative human breast cancer cell lines. Invest New Drugs (2009) 0.88
Eliminating the heart from the curcumin molecule: monocarbonyl curcumin mimics (MACs). Molecules (2014) 0.85
Syntheses and cytotoxic properties of the curcumin analogs 2,6-bis(benzylidene)-4-phenylcyclohexanones. Arch Pharm (Weinheim) (2008) 0.79
Natural phenolic metabolites with anti-angiogenic properties - a review from the chemical point of view. Beilstein J Org Chem (2015) 0.78
Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-α-induced NF-κB activation. Biomed Res Int (2014) 0.75
A novel curcumin analogue is a potent chemotherapy candidate for human hepatocellular carcinoma. Oncol Lett (2016) 0.75
Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers. Bioorg Med Chem Lett (2013) 0.75
Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med (2011) 3.09
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem (2003) 2.44
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. J Clin Invest (2007) 2.22
Mitogen-actived protein kinase activation is an early event in melanoma progression. Clin Cancer Res (2002) 2.18
Targeted therapy of oral hairy leukoplakia with gentian violet. J Am Acad Dermatol (2008) 2.17
Tuberous sclerosis-associated lesions of the kidney, brain, and skin are angiogenic neoplasms. J Am Acad Dermatol (2002) 2.05
Haemodialysis increases QT(c) interval but not QT(c) dispersion in ESRD patients without manifest cardiac disease. Nephrol Dial Transplant (2002) 1.96
A key role for NOX4 in epithelial cell death during development of lung fibrosis. Antioxid Redox Signal (2011) 1.79
Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice. J Invest Dermatol (2006) 1.72
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. J Clin Invest (2009) 1.68
Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis. Breast Cancer Res (2012) 1.65
Honokiol, a multifunctional antiangiogenic and antitumor agent. Antioxid Redox Signal (2009) 1.53
Keloids demonstrate high-level epidermal expression of vascular endothelial growth factor. J Am Acad Dermatol (2004) 1.52
Investigating FGF-23 concentrations and its relationship with declining renal function in paediatric patients with pre-dialysis CKD Stages 3-5. Nephrol Dial Transplant (2012) 1.45
Have we reached the limits for the treatment of diabetic nephropathy? Expert Opin Investig Drugs (2014) 1.44
Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res (2008) 1.43
Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling. J Biol Chem (2003) 1.39
A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells. Proc Natl Acad Sci U S A (2008) 1.33
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. Mol Cancer Res (2006) 1.32
The reactive oxygen-driven tumor: relevance to melanoma. Pigment Cell Melanoma Res (2008) 1.31
Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase. Mol Med (2002) 1.25
Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors. Clin Cancer Res (2010) 1.25
Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma. Proc Natl Acad Sci U S A (2004) 1.22
Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Cancer (2007) 1.19
CAESAR: a new conformer generation algorithm based on recursive buildup and local rotational symmetry consideration. J Chem Inf Model (2007) 1.18
Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem Pharmacol (2008) 1.17
Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis. J Immunol (2007) 1.16
Gentian violet: a 19th century drug re-emerges in the 21st century. Exp Dermatol (2013) 1.13
AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo. Arch Dermatol (2007) 1.12
Mammalian target of rapamycin (mTOR) is activated in cutaneous vascular malformations in vivo. Lymphat Res Biol (2007) 1.12
Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. Cancer Res (2009) 1.12
Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. Sci Transl Med (2012) 1.12
Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain. J Biol Chem (2004) 1.04
Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex. Neurobiol Dis (2011) 1.03
Vascular calcification in chronic kidney disease. Clin Sci (Lond) (2010) 1.03
Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo. Clin Cancer Res (2008) 1.03
Efficacy of topical application of eosin for ulcerated hemangiomas. J Am Acad Dermatol (2009) 1.03
Effectiveness of gentian violet and similar products commonly used to treat pyodermas. Dermatol Clin (2011) 1.01
Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization. Cancer Res (2009) 1.01
Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma: are angiomyolipomas neoplasms of stem cells? Mol Med (2007) 1.01
Antiangiogenesis drug design: multiple pathways targeting tumor vasculature. Curr Med Chem (2006) 1.00
Molecular design and clinical development of VEGFR kinase inhibitors. Curr Top Med Chem (2007) 0.99
Angiomotin expression promotes hemangioendothelioma invasion. Oncogene (2004) 0.99
Combination therapy of imiquimod and gentian violet for cutaneous melanoma metastases. J Am Acad Dermatol (2012) 0.98
Disruption of the mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes. Free Radic Biol Med (2011) 0.98
Expression of Wilms tumor 1 gene distinguishes vascular malformations from proliferative endothelial lesions. Arch Dermatol (2005) 0.97
Synthesis and biological evaluation of aromatic enones related to curcumin. Bioorg Med Chem (2005) 0.97
Tuberculosis complicating tertiary hyperparathyroidism in a patient with end-stage renal disease: a case report. J Nephrol (2008) 0.97
Infectious angiogenesis: Bartonella bacilliformis infection results in endothelial production of angiopoetin-2 and epidermal production of vascular endothelial growth factor. Am J Pathol (2003) 0.96
Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest. Int J Oncol (2007) 0.96
Targeting NADPH oxidases for the treatment of cancer and inflammation. Cell Mol Life Sci (2012) 0.96
Rapamycin (sirolimus) as a steroid-sparing agent in dermatomyositis. J Am Acad Dermatol (2005) 0.96
Curcumin as an inhibitor of angiogenesis. Adv Exp Med Biol (2007) 0.95
Weight loss-induced calciphylaxis: potential role of matrix metalloproteinases. J Dermatol (2003) 0.94
The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis. Mol Cancer Ther (2008) 0.94
The role of angiogenesis in the pathogenesis of psoriasis. Autoimmunity (2009) 0.93
Association between the malnutrition-inflammation score and post-transplant anaemia. Nephrol Dial Transplant (2010) 0.93
Molecular pathogenesis of vascular anomalies: classification into three categories based upon clinical and biochemical characteristics. Lymphat Res Biol (2003) 0.92
Angiogenesis in cutaneous lesions of leprosy: implications for treatment. Arch Dermatol (2007) 0.91
Tuberous sclerosis-associated neoplasms express activated p42/44 mitogen-activated protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth. Clin Cancer Res (2003) 0.91
Immunosuppression may be present within condyloma acuminata. J Am Acad Dermatol (2008) 0.90
Facile purification of honokiol and its antiviral and cytotoxic properties. J Med Chem (2006) 0.90
gli-1 Oncogene is highly expressed in granulomatous skin disorders, including sarcoidosis, granuloma annulare, and necrobiosis lipoidica diabeticorum. Arch Dermatol (2005) 0.90
Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB. J Biol Chem (2005) 0.90
Cinacalcet for cardiovascular disease in patients undergoing dialysis. N Engl J Med (2013) 0.89
Reductions in funding for medical research. JAMA (2013) 0.89
The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathways. Cancer Lett (2013) 0.88
Inactivation of NADPH oxidases NOX4 and NOX5 protects human primary fibroblasts from ionizing radiation-induced DNA damage. Radiat Res (2015) 0.88
Enhanced MCP-1 release by keloid CD14+ cells augments fibroblast proliferation: role of MCP-1 and Akt pathway in keloids. Exp Dermatol (2010) 0.88
Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors. Expert Rev Anti Infect Ther (2007) 0.88
Prevalence and management of anaemia in renal transplant recipients: data from ten European centres. Nephron Clin Pract (2010) 0.87
Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol. Bioorg Med Chem Lett (2007) 0.86
Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa. J Infect Dis (2008) 0.86
PSK and Trx80 inhibit B-cell growth in EBV-infected cord blood mononuclear cells through T cells activated by the monocyte products IL-15 and IL-12. Blood (2004) 0.86
The antidepressant sertraline downregulates Akt and has activity against melanoma cells. Pigment Cell Melanoma Res (2008) 0.85
Maspin expression, angiogenesis, prognostic parameters, and outcome in malignant melanoma. J Am Acad Dermatol (2009) 0.85
Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells. Am J Physiol Gastrointest Liver Physiol (2012) 0.85
Efficacy of rapamycin in scleroderma: a case study. Lymphat Res Biol (2008) 0.84
Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis. Am J Pathol (2002) 0.84
Tumor necrosis factor-related apoptosis-inducing ligand can induce apoptosis in subsets of premalignant cells. Am J Pathol (2004) 0.84
Total parathyroidectomy without autotransplantation after renal transplantation for tertiary hyperparathyroidism: long-term follow-up. Int Urol Nephrol (2011) 0.84
Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells. J Biol Chem (2002) 0.82
Cutaneous lesions of secondary syphilis are highly angiogenic. J Am Acad Dermatol (2003) 0.82
Shb gene knockdown increases the susceptibility of SVR endothelial tumor cells to apoptotic stimuli in vitro and in vivo. J Invest Dermatol (2007) 0.81
Recent advances in small molecule inhibitors of VEGFR and EGFR signaling pathways. Curr Top Med Chem (2011) 0.81
Combination therapy of doxycycline and topical tacrolimus for venous ulcers. Arch Dermatol (2005) 0.81
Honokiol stimulates osteoblastogenesis by suppressing NF-κB activation. Int J Mol Med (2011) 0.81
The duality of angiogenesis: implications for therapy of human disease. J Invest Dermatol (2006) 0.81
A nonsteroidal alternative to impetiginized eczema in the emergency room. J Am Acad Dermatol (2010) 0.81
Rapid improvement of nephrogenic systemic fibrosis with rapamycin therapy: possible role of phospho-70-ribosomal-S6 kinase. J Am Acad Dermatol (2010) 0.81
Regulation of endothelial cell differentiation and transformation by H-Ras. Exp Cell Res (2003) 0.80
Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia. Biochim Biophys Acta (2012) 0.80
Honokiol inhibits androgen receptor activity in prostate cancer cells. Prostate (2013) 0.80
Wilms tumor 1 expression present in most melanomas but nearly absent in nevi. Arch Dermatol (2006) 0.80