Published in Annu Rev Physiol on November 19, 2002
Structure and rearrangements in the carboxy-terminal region of SpIH channels. Structure (2007) 3.09
Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons. Neuron (2004) 2.74
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci U S A (2003) 2.53
TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain. Neuron (2009) 2.30
HCN1 channels constrain synaptically evoked Ca2+ spikes in distal dendrites of CA1 pyramidal neurons. Neuron (2007) 2.20
Long-term potentiation in rat hippocampal neurons is accompanied by spatially widespread changes in intrinsic oscillatory dynamics and excitability. Neuron (2007) 2.16
HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. EMBO J (2007) 2.13
Structure and function of TRPV1. Pflugers Arch (2005) 1.91
Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2. J Gen Physiol (2006) 1.84
Increased size and stability of CA1 and CA3 place fields in HCN1 knockout mice. Neuron (2011) 1.77
HCN hyperpolarization-activated cation channels inhibit EPSPs by interactions with M-type K(+) channels. Nat Neurosci (2009) 1.76
Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4. Proc Natl Acad Sci U S A (2011) 1.71
Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain. Neuron (2014) 1.70
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels. J Gen Physiol (2004) 1.68
Fever, febrile seizures and epilepsy. Trends Neurosci (2007) 1.67
The multiple personalities of h-channels. Trends Neurosci (2003) 1.64
Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus. J Physiol (2006) 1.61
A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews. J Cardiovasc Electrophysiol (2010) 1.60
Ventral tegmental area glutamate neurons: electrophysiological properties and projections. J Neurosci (2012) 1.57
Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis (2005) 1.49
Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment. Cell (2014) 1.48
Corticospinal-specific HCN expression in mouse motor cortex: I(h)-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control. J Neurophysiol (2011) 1.48
The h channel mediates location dependence and plasticity of intrinsic phase response in rat hippocampal neurons. J Neurosci (2008) 1.46
Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment. Proc Natl Acad Sci U S A (2004) 1.44
Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy. Structure (2007) 1.44
A cyclic nucleotide modulated prokaryotic K+ channel. J Gen Physiol (2004) 1.42
Role of HCN channels in neuronal hyperexcitability after subarachnoid hemorrhage in rats. J Neurosci (2012) 1.42
Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels. J Gen Physiol (2003) 1.37
S4 movement in a mammalian HCN channel. J Gen Physiol (2003) 1.36
Dendritic ion channel trafficking and plasticity. Trends Neurosci (2010) 1.36
Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs. Exp Neurol (2009) 1.35
Amygdalocortical circuitry in schizophrenia: from circuits to molecules. Neuropsychopharmacology (2010) 1.34
Interneuron diversity in layers 2-3 of monkey prefrontal cortex. Cereb Cortex (2008) 1.33
HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease. Nat Neurosci (2010) 1.32
Inhibition-induced theta resonance in cortical circuits. Neuron (2013) 1.31
Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis. J Neurosci (2009) 1.31
Computation by oscillations: implications of experimental data for theoretical models of grid cells. Hippocampus (2008) 1.30
Exploring HCN channels as novel drug targets. Nat Rev Drug Discov (2011) 1.28
A biophysical signature of network affiliation and sensory processing in mitral cells. Nature (2012) 1.28
Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels. J Physiol (2006) 1.28
The road to biological pacing. Nat Rev Cardiol (2011) 1.27
Dendritic HCN channels shape excitatory postsynaptic potentials at the inner hair cell afferent synapse in the mammalian cochlea. J Neurophysiol (2010) 1.27
Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem (2011) 1.26
Ectopic expression of multiple microbial rhodopsins restores ON and OFF light responses in retinas with photoreceptor degeneration. J Neurosci (2009) 1.25
Sodium leak channels in neuronal excitability and rhythmic behaviors. Neuron (2011) 1.25
The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4. J Neurosci (2015) 1.24
Characterization and functional role of voltage gated cation conductances in the glucagon-like peptide-1 secreting GLUTag cell line. J Physiol (2004) 1.23
Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Neurobiol Dis (2007) 1.23
Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C. Pflugers Arch (2007) 1.21
Impaired hippocampal rhythmogenesis in a mouse model of mesial temporal lobe epilepsy. Proc Natl Acad Sci U S A (2007) 1.21
Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease. FASEB J (2011) 1.19
Mechanisms of intrinsic beating variability in cardiac cell cultures and model pacemaker networks. Biophys J (2007) 1.19
Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels. J Gen Physiol (2007) 1.19
Population diversity and function of hyperpolarization-activated current in olfactory bulb mitral cells. Sci Rep (2011) 1.19
Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels. J Physiol (2006) 1.17
Subunits act independently in a cyclic nucleotide-activated K(+) channel. EMBO Rep (2007) 1.17
Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy. Front Neurosci (2009) 1.17
Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. J Biol Chem (2010) 1.16
Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon. Prog Neurobiol (2011) 1.16
Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus. Eur J Neurosci (2006) 1.15
Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy. J Physiol (2006) 1.15
Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A (2012) 1.15
Ion channels and signaling in the pituitary gland. Endocr Rev (2010) 1.14
Rhythms of the hippocampal network. Nat Rev Neurosci (2016) 1.14
Cooperative gating between single HCN pacemaker channels. J Gen Physiol (2006) 1.14
Temporal synchrony and gamma-to-theta power conversion in the dendrites of CA1 pyramidal neurons. Nat Neurosci (2013) 1.14
Differentiation and functional incorporation of embryonic stem cell-derived GABAergic interneurons in the dentate gyrus of mice with temporal lobe epilepsy. J Neurosci (2012) 1.13
Pathophysiology of HCN channels. Pflugers Arch (2007) 1.13
Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci (2007) 1.13
HCN channels in behavior and neurological disease: too hyper or not active enough? Mol Cell Neurosci (2010) 1.13
How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels. Nat Chem Biol (2011) 1.12
Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited. Ther Adv Neurol Disord (2008) 1.12
HCN-related channelopathies. Pflugers Arch (2010) 1.11
Structural insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1 channel. Proc Natl Acad Sci U S A (2011) 1.11
C-terminal movement during gating in cyclic nucleotide-modulated channels. J Biol Chem (2008) 1.11
Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus. J Neurophysiol (2013) 1.11
The magnitudes of hyperpolarization-activated and low-voltage-activated potassium currents co-vary in neurons of the ventral cochlear nucleus. J Neurophysiol (2011) 1.10
State-dependent cAMP binding to functioning HCN channels studied by patch-clamp fluorometry. Biophys J (2011) 1.09
alpha2-Noradrenergic receptors activation enhances excitability and synaptic integration in rat prefrontal cortex pyramidal neurons via inhibition of HCN currents. J Physiol (2007) 1.08
D1 receptor modulation of action potential firing in a subpopulation of layer 5 pyramidal neurons in the prefrontal cortex. J Neurosci (2012) 1.08
Towards an integrated view of HCN channel role in epilepsy. Curr Opin Neurobiol (2011) 1.08
Novel mechanism for suppression of hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by receptor-like tyrosine phosphatase-alpha. J Biol Chem (2008) 1.08
Morphological, neurochemical and electrophysiological features of parvalbumin-expressing cells: a likely source of axo-axonic inputs in the mouse spinal dorsal horn. J Physiol (2012) 1.08
Double electron-electron resonance reveals cAMP-induced conformational change in HCN channels. Proc Natl Acad Sci U S A (2014) 1.07
Mechanisms of efferent-mediated responses in the turtle posterior crista. J Neurosci (2006) 1.06
Different levels of Ih determine distinct temporal integration in bursting and regular-spiking neurons in rat subiculum. J Physiol (2006) 1.06
Converting cold into pain. Exp Brain Res (2009) 1.06
The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path. Proc Natl Acad Sci U S A (2005) 1.06
The presence of pacemaker HCN channels identifies theta rhythmic GABAergic neurons in the medial septum. J Physiol (2008) 1.05
Parvalbumin-positive basket interneurons in monkey and rat prefrontal cortex. J Neurophysiol (2008) 1.05
Increased seizure severity and seizure-related death in mice lacking HCN1 channels. Epilepsia (2010) 1.05
Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs. Int Rev Neurobiol (2010) 1.05
An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision. J Neurosci (2012) 1.03
Resonance (approximately 10 Hz) of excitatory networks in motor cortex: effects of voltage-dependent ion channel blockers. J Physiol (2006) 1.03
Hyperpolarization-activated graded persistent activity in the prefrontal cortex. Proc Natl Acad Sci U S A (2008) 1.03
A homology model of the pore region of HCN channels. Biophys J (2005) 1.02
In the ventral cochlear nucleus Kv1.1 and subunits of HCN1 are colocalized at surfaces of neurons that have low-voltage-activated and hyperpolarization-activated conductances. Neuroscience (2008) 1.02
A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP. J Biol Chem (2014) 1.01
Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes. Biochim Biophys Acta (2009) 1.01
Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses. Neuron (2003) 2.42
TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain. Neuron (2009) 2.30
The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells. Cell (2003) 2.24
HCN1 channels constrain synaptically evoked Ca2+ spikes in distal dendrites of CA1 pyramidal neurons. Neuron (2007) 2.20
Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction. J Neurosci (2004) 2.08
Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation. Proc Natl Acad Sci U S A (2004) 2.01
Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nat Neurosci (2005) 1.91
Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2. J Gen Physiol (2006) 1.84
Recruitment of N-Type Ca(2+) channels during LTP enhances low release efficacy of hippocampal CA1 perforant path synapses. Neuron (2009) 1.82
Increased size and stability of CA1 and CA3 place fields in HCN1 knockout mice. Neuron (2011) 1.77
HCN hyperpolarization-activated cation channels inhibit EPSPs by interactions with M-type K(+) channels. Nat Neurosci (2009) 1.76
Recurrent circuitry dynamically shapes the activation of piriform cortex. Neuron (2011) 1.71
Regulation of hyperpolarization-activated HCN channels by cAMP through a gating switch in binding domain symmetry. Neuron (2003) 1.59
Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling. Neuron (2002) 1.58
A role for synaptic inputs at distal dendrites: instructive signals for hippocampal long-term plasticity. Neuron (2007) 1.53
Strong CA2 pyramidal neuron synapses define a powerful disynaptic cortico-hippocampal loop. Neuron (2010) 1.49
Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy. Structure (2007) 1.44
Synapses and memory storage. Cold Spring Harb Perspect Biol (2012) 1.39
Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels. J Gen Physiol (2003) 1.37
Altered presynaptic vesicle release and cycling during mGluR-dependent LTD. Neuron (2002) 1.29
Homologue structure of the SLAC1 anion channel for closing stomata in leaves. Nature (2010) 1.22
Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C. Pflugers Arch (2007) 1.21
12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses. J Neurosci (2003) 1.20
Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels. J Gen Physiol (2007) 1.19
A conserved tripeptide in CNG and HCN channels regulates ligand gating by controlling C-terminal oligomerization. Neuron (2004) 1.18
TRIP8b regulates HCN1 channel trafficking and gating through two distinct C-terminal interaction sites. J Neurosci (2011) 1.17
TRIP8b splice forms act in concert to regulate the localization and expression of HCN1 channels in CA1 pyramidal neurons. Neuron (2011) 1.15
Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. Proc Natl Acad Sci U S A (2005) 1.10
Increased seizure severity and seizure-related death in mice lacking HCN1 channels. Epilepsia (2010) 1.05
A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow. Neuron (2013) 1.03
Calcium release from presynaptic ryanodine-sensitive stores is required for long-term depression at hippocampal CA3-CA3 pyramidal neuron synapses. J Neurosci (2004) 1.00
Prefrontal cortex HCN1 channels enable intrinsic persistent neural firing and executive memory function. J Neurosci (2013) 0.93
Effects of surface water on protein dynamics studied by a novel coarse-grained normal mode approach. Biophys J (2008) 0.90
Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination. Pflugers Arch (2008) 0.82
12-Lipoxygenase regulates hippocampal long-term potentiation by modulating L-type Ca2+ channels. J Neurosci (2010) 0.82
Pathway and endpoint free energy calculations for cyclic nucleotide binding to HCN channels. Biophys J (2008) 0.82
Antagonistic modulation of a hyperpolarization-activated Cl(-) current in Aplysia sensory neurons by SCP(B) and FMRFamide. J Neurophysiol (2003) 0.81
Making the grade with models of persistent activity. Neuron (2006) 0.75