PubRank

George D Yancopoulos

Author PubWeight™ 273.94‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006 8.48
2 Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology 2012 8.29
3 Effect of a monoclonal antibody to PCSK9 on LDL cholesterol. N Engl J Med 2012 8.24
4 VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci U S A 2002 8.10
5 The knockout mouse project. Nat Genet 2004 7.80
6 The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell 2004 7.60
7 High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol 2003 7.47
8 Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 2006 7.01
9 SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 2006 6.79
10 Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell 2002 6.41
11 CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest 2008 5.96
12 Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 2007 5.73
13 Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med 2013 5.29
14 Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 2008 4.67
15 Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 2004 4.47
16 Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis 2012 4.42
17 Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A 2004 4.06
18 Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum 2008 3.36
19 Cytokine traps: multi-component, high-affinity blockers of cytokine action. Nat Med 2002 3.36
20 Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus. Neuron 2005 3.21
21 Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nat Med 2005 3.18
22 RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology 2008 3.13
23 F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses. Nat Biotechnol 2006 3.13
24 Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 2007 3.01
25 The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat Rev Cancer 2007 2.96
26 Agouti-related protein-deficient mice display an age-related lean phenotype. Cell Metab 2005 2.75
27 Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat Med 2010 2.75
28 Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. J Immunol 2006 2.74
29 VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med 2006 2.67
30 Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Elife 2013 2.66
31 Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy. Mol Cell Biol 2004 2.58
32 Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung. J Exp Med 2009 2.51
33 Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nat Immunol 2007 2.50
34 Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc Natl Acad Sci U S A 2002 2.45
35 IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 2012 2.36
36 Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1). Genes Dev 2004 2.32
37 Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. J Biol Chem 2004 2.32
38 Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells. J Clin Invest 2002 2.26
39 Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci U S A 2004 2.23
40 Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol 2002 2.20
41 VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. Proc Natl Acad Sci U S A 2007 2.19
42 Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci U S A 2010 2.06
43 Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res 2003 2.06
44 Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci U S A 2006 2.03
45 Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood 2003 2.03
46 Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. J Clin Invest 2002 1.95
47 Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci U S A 2003 1.82
48 Dupilumab treatment in adults with moderate-to-severe atopic dermatitis. N Engl J Med 2014 1.82
49 Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. J Allergy Clin Immunol 2006 1.79
50 Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2012 1.78
51 Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice. J Invest Dermatol 2006 1.72
52 Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury. Kidney Int 2008 1.70
53 Suppression of diabetic retinopathy with angiopoietin-1. Am J Pathol 2002 1.68
54 Loss-of-function analysis of EphA receptors in retinotectal mapping. J Neurosci 2004 1.67
55 Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering. Nat Struct Biol 2003 1.63
56 Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model. Clin Cancer Res 2007 1.60
57 EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells. FASEB J 2002 1.58
58 VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma. Int J Radiat Oncol Biol Phys 2007 1.55
59 Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study. Arthritis Care Res (Hoboken) 2012 1.53
60 Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proc Natl Acad Sci U S A 2011 1.51
61 Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody. Circ Cardiovasc Genet 2015 1.50
62 Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. Cancer Res 2012 1.50
63 Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke. Eur Heart J 2013 1.47
64 TLR8 deficiency leads to autoimmunity in mice. J Clin Invest 2010 1.46
65 Mice completely lacking immunoproteasomes show major changes in antigen presentation. Nat Immunol 2011 1.45
66 Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis. Proc Natl Acad Sci U S A 2007 1.45
67 Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proc Natl Acad Sci U S A 2011 1.44
68 p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J 2003 1.44
69 Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1. Mol Cell Biol 2006 1.42
70 Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation. J Immunol 2008 1.41
71 VEGF-mediated inflammation precedes angiogenesis in adult brain. Exp Neurol 2004 1.39
72 Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period. Development 2005 1.38
73 Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen. J Biol Chem 2002 1.38
74 Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis. Diabetes 2007 1.34
75 Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association. Sci Signal 2011 1.32
76 Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice. Proc Natl Acad Sci U S A 2014 1.32
77 Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model. Clin Cancer Res 2005 1.32
78 Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc Natl Acad Sci U S A 2011 1.26
79 Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation. Mol Cancer Res 2008 1.25
80 Impact of vessel maturation on antiangiogenic therapy in ovarian cancer. Am J Obstet Gynecol 2008 1.25
81 Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endocrinol 2009 1.24
82 Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood 2011 1.19
83 VEGF-dependent conjunctivalization of the corneal surface. Invest Ophthalmol Vis Sci 2003 1.17
84 The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis. Proc Natl Acad Sci U S A 2004 1.15
85 Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. Int J Oncol 2009 1.15
86 Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes. Proc Natl Acad Sci U S A 2014 1.15
87 Interleukin-19 protects mice from innate-mediated colonic inflammation. Inflamm Bowel Dis 2010 1.15
88 The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow. Blood 2011 1.13
89 Angiopoietin-1 activates both anti- and proapoptotic mitogen-activated protein kinases. FASEB J 2003 1.12
90 Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells. Microvasc Res 2002 1.11
91 Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina. J Neurosci 2006 1.09
92 Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination. Proc Natl Acad Sci U S A 2010 1.08
93 A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap. Invest Ophthalmol Vis Sci 2010 1.06
94 Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice. J Biol Chem 2011 1.05
95 Abnormal recruitment of periendothelial cells to lymphatic capillaries in digestive organs of angiopoietin-2-deficient mice. Cell Tissue Res 2007 1.03
96 Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo. J Biol Chem 2005 1.00
97 Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis. Proc Natl Acad Sci U S A 2009 1.00
98 Peptide YY regulates bone turnover in rodents. Gastroenterology 2007 0.98
99 Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4. Circulation 2011 0.98
100 Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis. Circ Res 2009 0.98
101 Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. Arthritis Rheum 2010 0.97
102 The anti-inflammatory actions of angiopoietin-1. EXS 2005 0.95
103 Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice. J Exp Med 2012 0.95
104 Conditionals by inversion provide a universal method for the generation of conditional alleles. Proc Natl Acad Sci U S A 2013 0.95
105 TNP-470 promotes initial vascular sprouting in xenograft tumors. Mol Cancer Ther 2004 0.94
106 Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections. J Immunol 2008 0.93
107 Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. Int J Oncol 2004 0.92
108 The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. Development 2008 0.92
109 Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation. J Immunol 2005 0.91
110 The loss-of-allele assay for ES cell screening and mouse genotyping. Methods Enzymol 2010 0.91
111 IL-22 promotes fibroblast-mediated wound repair in the skin. J Invest Dermatol 2012 0.91
112 Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection. J Pharmacol Sci 2010 0.90
113 Dexamethasone treatment and ICAM-1 deficiency impair VEGF-induced angiogenesis in adult brain. J Vasc Res 2007 0.90
114 Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1. Psychoneuroendocrinology 2010 0.90
115 Mistargeting hippocampal axons by expression of a truncated Eph receptor. Proc Natl Acad Sci U S A 2002 0.89
116 Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice. Am J Pathol 2004 0.89
117 VelociMouse: fully ES cell-derived F0-generation mice obtained from the injection of ES cells into eight-cell-stage embryos. Methods Mol Biol 2009 0.88
118 Rapid decrease in tumor perfusion following VEGF blockade predicts long-term tumor growth inhibition in preclinical tumor models. Angiogenesis 2012 0.87
119 Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5. Proc Natl Acad Sci U S A 2005 0.85
120 Producing fully ES cell-derived mice from eight-cell stage embryo injections. Methods Enzymol 2010 0.85
121 Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses. Pain 2007 0.84
122 Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents. Cancer Metastasis Rev 2006 0.84
123 Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus. Eur J Immunol 2011 0.83
124 Effects of gene delivery on collateral development in chronic hypoperfusion: diverse effects of angiopoietin-1 versus vascular endothelial growth factor. J Am Coll Cardiol 2004 0.82
125 Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Novartis Found Symp 2007 0.81
126 Rilonacept for gout flare prevention during initiation of uric acid-lowering therapy: results from the PRESURGE-2 international, phase 3, randomized, placebo-controlled trial. Rheumatology (Oxford) 2013 0.78
127 Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985. 40: 271-281. J Immunol 2012 0.75
128 Generation of fertile and fecund F0 XY female mice from XY ES cells. Transgenic Res 2014 0.75