PubRank

Andrew D Hamilton

Author PubWeight™ 145.61‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Label-free immunodetection with CMOS-compatible semiconducting nanowires. Nature 2007 5.25
2 Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res 2004 3.62
3 Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism. J Am Chem Soc 2005 2.95
4 Strategies for targeting protein-protein interactions with synthetic agents. Angew Chem Int Ed Engl 2005 2.65
5 Targeting protein prenylation for cancer therapy. Nat Rev Cancer 2011 2.60
6 Water gelation by small organic molecules. Chem Rev 2004 2.45
7 Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Mol Cancer Ther 2004 2.10
8 Synthetic non-peptide mimetics of alpha-helices. Chem Soc Rev 2007 2.04
9 An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. ACS Chem Biol 2007 1.79
10 Computer-aided design of non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett 2005 1.58
11 Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex. Angew Chem Int Ed Engl 2003 1.55
12 Targeting protein-protein interactions by rational design: mimicry of protein surfaces. J R Soc Interface 2006 1.53
13 Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry. J Am Chem Soc 2002 1.50
14 Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction. Angew Chem Int Ed Engl 2005 1.49
15 Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion. Angew Chem Int Ed Engl 2002 1.47
16 Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics. Curr Opin Chem Biol 2010 1.47
17 Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL. J Am Chem Soc 2005 1.46
18 Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. Antimicrob Agents Chemother 2007 1.43
19 Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells. J Biol Chem 2002 1.43
20 The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. J Biol Chem 2010 1.39
21 Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett 2006 1.38
22 FEP-guided selection of bicyclic heterocycles in lead optimization for non-nucleoside inhibitors of HIV-1 reverse transcriptase. J Am Chem Soc 2006 1.36
23 Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides. Angew Chem Int Ed Engl 2007 1.34
24 Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction. J Am Chem Soc 2005 1.34
25 In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. J Clin Invest 2003 1.33
26 Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Mol Cell Biol 2007 1.32
27 Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. Cancer Res 2003 1.24
28 Protein-protein interaction inhibitors: small molecules from screening techniques. Curr Top Med Chem 2007 1.23
29 Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice. Clin Cancer Res 2011 1.23
30 Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders. Chembiochem 2008 1.21
31 A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. Chem Biol 2009 1.18
32 Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors. Oncogene 2005 1.18
33 Pattern recognition of proteins based on an array of functionalized porphyrins. J Am Chem Soc 2006 1.18
34 Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains. Bioorg Med Chem Lett 2007 1.15
35 Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett 2005 1.15
36 Farnesyltransferase inhibitors as anticancer agents: current status. Curr Opin Investig Drugs 2003 1.13
37 Synthesis of a 2,3';6',3''-terpyridine scaffold as an alpha-helix mimetic. Org Lett 2005 1.12
38 Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation. Angew Chem Int Ed Engl 2010 1.11
39 XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41. AIDS Res Hum Retroviruses 2002 1.10
40 Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. J Med Chem 2009 1.10
41 p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53. Mol Cancer Ther 2005 1.05
42 Benzoylurea oligomers: synthetic foldamers that mimic extended alpha helices. Angew Chem Int Ed Engl 2007 1.05
43 Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor. Cancer Res 2004 1.05
44 Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics. Bioorg Med Chem Lett 2007 1.01
45 Protein surface recognition and proteomimetics: mimics of protein surface structure and function. Curr Opin Chem Biol 2005 1.01
46 Pattern-based detection of different proteins using an array of fluorescent protein surface receptors. J Am Chem Soc 2004 1.01
47 Inhibitors of protein farnesyltransferase as novel anticancer agents. Curr Top Med Chem 2002 0.99
48 In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. Bioorg Med Chem 2004 0.95
49 Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites. J Med Chem 2006 0.95
50 alpha-Helix mimetics as inhibitors of protein-protein interactions. Biochem Soc Trans 2008 0.95
51 Digital analysis of protein properties by an ensemble of DNA quadruplexes. J Am Chem Soc 2009 0.94
52 Protein recognition and denaturation by self-assembling fragments on a DNA quadruplex scaffold. Angew Chem Int Ed Engl 2007 0.94
53 Controlling curvature in a family of oligoamide alpha-helix mimetics. Angew Chem Int Ed Engl 2008 0.93
54 Rigid macrocyclic triamides as anion receptors: anion-dependent binding stoichiometries and 1H chemical shift changes. J Am Chem Soc 2003 0.93
55 Recent advances in the development of aryl-based foldamers. Chem Soc Rev 2009 0.92
56 Amphiphilic α-helix mimetics based on a benzoylurea scaffold. Org Biomol Chem 2012 0.92
57 Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. Angew Chem Int Ed Engl 2005 0.92
58 Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). Biochem Pharmacol 2005 0.92
59 Protein recognition by an ensemble of fluorescent DNA G-quadruplexes. Angew Chem Int Ed Engl 2009 0.90
60 Farnesylated RhoB prevents cell cycle arrest and actin cytoskeleton disruption caused by the geranylgeranyltransferase I inhibitor GGTI-298. Cell Cycle 2003 0.90
61 Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells. Blood 2005 0.89
62 Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix. Org Lett 2006 0.89
63 An organic hydrogel as a matrix for the growth of calcite crystals. Org Biomol Chem 2003 0.89
64 Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic. Org Lett 2009 0.88
65 Synthetic mimetics of protein secondary structure domains. Philos Trans A Math Phys Eng Sci 2010 0.88
66 Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Org Biomol Chem 2006 0.88
67 Design of a synthetic foldamer that modifies the growth of calcite crystals. J Am Chem Soc 2004 0.88
68 Use of proximity ligation to screen for inhibitors of interactions between vascular endothelial growth factor A and its receptors. Clin Chem 2008 0.88
69 Protein recognition using synthetic surface-targeted agents. Mol Divers 2004 0.88
70 Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem Biol 2009 0.88
71 Recognition of solvent exposed protein surfaces using anthracene derived receptors. Org Biomol Chem 2006 0.88
72 Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. J Med Chem 2004 0.87
73 Alkyne-linked 2,2-disubstituted-indolin-3-one oligomers as extended beta-strand mimetics. J Am Chem Soc 2009 0.87
74 Synthetic inhibitors of extended helix-protein interactions based on a biphenyl 4,4'-dicarboxamide scaffold. Chembiochem 2009 0.87
75 Design and evaluation of nonfluorous CO2-soluble oligomers and polymers. J Phys Chem B 2009 0.86
76 Combinatorial protein recognition as an alternative approach to antibody-mimetics. Curr Opin Chem Biol 2010 0.86
77 Novel 7-(dimethylamino)fluorene-based fluorescent probes and their binding to human serum albumin. Org Biomol Chem 2009 0.86
78 Directed denaturation: room temperature and stoichiometric unfolding of cytochrome C by a metalloporphyrin dimer. J Am Chem Soc 2003 0.86
79 Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics. Chem Commun (Camb) 2012 0.86
80 Allosteric control of self-assembly: modulating the formation of guanine quadruplexes through orthogonal aromatic interactions. Angew Chem Int Ed Engl 2007 0.85
81 Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein. Bioorg Med Chem Lett 2004 0.85
82 A tetraguanidinium ligand binds to the surface of the tetramerization domain of protein P53. Angew Chem Int Ed Engl 2004 0.85
83 Peracetylated sugar derivatives show high solubility in liquid and supercritical carbon dioxide. Org Lett 2002 0.85
84 A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro. Antimicrob Agents Chemother 2009 0.84
85 Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding. Bioorg Med Chem Lett 2003 0.84
86 Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface. ChemMedChem 2009 0.84
87 Modulation of protein-protein interactions by synthetic receptors: design of molecules that disrupt serine protease-proteinaceous inhibitor interaction. Proc Natl Acad Sci U S A 2002 0.83
88 Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf. Oncogene 2003 0.83
89 Catalytic unfolding and proteolysis of cytochrome C induced by synthetic binding agents. J Am Chem Soc 2004 0.83
90 Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold. Bioorg Med Chem Lett 2010 0.83
91 Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA. Life Sci 2006 0.83
92 Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I. Org Biomol Chem 2006 0.83
93 Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold. J Med Chem 2002 0.83
94 Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation. J Med Chem 2008 0.82
95 Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments. Bioorg Med Chem Lett 2005 0.82
96 Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. Curr Top Microbiol Immunol 2011 0.82
97 Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold. J Am Chem Soc 2009 0.82
98 Altered binding of a multimeric protein by changing the self-assembling properties of its substrate. J Am Chem Soc 2010 0.82
99 Anion-dependent switching: dynamically controlling the conformation of hydrogen-bonded diphenylacetylenes. Angew Chem Int Ed Engl 2011 0.81
100 Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. Cancer Lett 2005 0.81
101 Noncovalent template-assisted mimicry of multiloop protein surfaces: assembling discontinuous and functional domains. J Am Chem Soc 2012 0.81
102 Contrasting effects of prenyltransferase inhibitors on estrogen-dependent cell cycle progression and estrogen receptor-mediated transcriptional activity in MCF-7 cells. Endocrinology 2003 0.81
103 Self-assembling DNA quadruplex conjugated to MRI contrast agents. Bioconjug Chem 2009 0.81
104 Examination of the effect of the annealing cation on higher order structures containing guanine or isoguanine repeats. Chemistry 2009 0.81
105 Diphenylacetylene-linked peptide strands induce bidirectional β-sheet formation. Angew Chem Int Ed Engl 2014 0.80
106 Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents. Bioorg Med Chem 2008 0.80
107 De novo protein surface design: use of cation-pi interactions to enhance binding between an alpha-helical peptide and a cationic molecule in 50 % aqueous solution. Angew Chem Int Ed Engl 2002 0.80
108 Fiber formation by highly CO2-soluble bisureas containing peracetylated carbohydrate groups. Angew Chem Int Ed Engl 2007 0.79
109 A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic. Chem Commun (Camb) 2012 0.79
110 Surface binding inhibitors of the SCF-KIT protein-protein interaction. Chembiochem 2009 0.78
111 The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents. Prog Cell Cycle Res 2003 0.78
112 Enaminone-based mimics of extended and hydrophilic α-helices. Chemistry 2012 0.78
113 Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I. Bioorg Med Chem 2005 0.78
114 Recent developments in the identification of chemotherapeutics for Chagas disease. Curr Med Chem 2005 0.78
115 Small molecules in biology. Chem Soc Rev 2011 0.78
116 Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase. Org Biomol Chem 2006 0.77
117 β-Strand mimetic foldamers rigidified through dipolar repulsion. Angew Chem Int Ed Engl 2015 0.77
118 Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. J Med Chem 2010 0.77
119 Oligophenylenaminones as scaffolds for α-helix mimicry. J Org Chem 2011 0.77
120 Self-assembly of a four-helix bundle on a DNA quadruplex. Angew Chem Int Ed Engl 2009 0.77
121 Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver cancer cell lines. Mol Pharmacol 2003 0.77
122 Designed molecular switches: controlling the conformation of benzamido-diphenylacetylenes. Org Lett 2010 0.77
123 Blocking HIV-1 entry by a gp120 surface binding inhibitor. Bioorg Med Chem Lett 2012 0.76
124 Protein farnesyltransferase: flexible docking studies on inhibitors using computational modeling. J Comput Aided Mol Des 2006 0.76
125 Remote conformational control of a molecular switch via methylation and deprotonation. Org Biomol Chem 2014 0.76
126 Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions. Chem Commun (Camb) 2010 0.76
127 Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen. Bioorg Med Chem 2012 0.76
128 A Lewis acid-mediated conformational switch. Org Biomol Chem 2014 0.76
129 Ultrafast energy transfer within pyropheophorbide-a tethered to self-assembling DNA quadruplex. Chem Commun (Camb) 2009 0.76
130 Inhibition of chymotrypsin by a self-assembled DNA quadruplex functionalized with cyclic peptide binding fragments. Chemistry 2009 0.76
131 Quantifying intrinsic ion-driven conformational changes in diphenylacetylene supramolecular switches with cryogenic ion vibrational spectroscopy. J Phys Chem A 2013 0.76
132 pH-dependent conformational switching in 2,6-benzamidodiphenylacetylenes. Angew Chem Int Ed Engl 2011 0.76
133 Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates. Tetrahedron Lett 2009 0.75
134 Much binding in the lab. Nature 2002 0.75
135 Low molecular weight organogelators for water. Chem Commun (Camb) 2003 0.75
136 Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein-protein interaction in C. hominis TS-DHFR. Medchemcomm 2013 0.75
137 Profile. Andrew D. Hamilton. Org Biomol Chem 2003 0.75
138 Synthesis and self-assembling properties of polymerizable organogelators. Chemistry 2002 0.75
139 Fiber formation in water by a mono-urea dicarboxylic acid. Chem Commun (Camb) 2003 0.75
140 Supramolecular dendrimers: convenient synthesis by programmed self-assembly and tunable thermoresponsivity. Chemistry 2012 0.75
141 Oxygenated hydrocarbon ionic surfactants exhibit CO2 solubility. J Am Chem Soc 2005 0.75
142 Solvent and pH effects on the fluorescence of 7-(dimethylamino)-2-fluorenesulfonate. J Fluoresc 2007 0.75
143 Foldamer-mediated Structural Rearrangement Attenuates Aβ Oligomerization and Cytotoxicity. J Am Chem Soc 2017 0.75