Published in Brain Res on January 17, 2003
Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster. Nat Struct Biol (2003) 1.71
Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC). J Biol Chem (2013) 1.22
Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1. Anesthesiology (2010) 0.93
Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol action. Br J Pharmacol (2007) 0.91
Differential actions of ethanol and trichloroethanol at sites in the M3 and M4 domains of the NMDA receptor GluN2A (NR2A) subunit. Br J Pharmacol (2009) 0.84
Different sites of alcohol action in the NMDA receptor GluN2A and GluN2B subunits. Neuropharmacology (2015) 0.83
Modulation of TRPC5 cation channels by halothane, chloroform and propofol. Br J Pharmacol (2008) 0.81
A novel alcohol-sensitive position in the N-methyl-D-aspartate receptor GluN2A subunit M3 domain regulates agonist affinity and ion channel gating. Mol Pharmacol (2013) 0.81
The molecular pharmacology of volatile anesthetics. Int Anesthesiol Clin (2015) 0.75
Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci U S A (2004) 7.51
Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nat Biotechnol (2003) 3.43
The current cost of heart failure to the National Health Service in the UK. Eur J Heart Fail (2002) 3.17
Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci (2005) 2.91
Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature (2003) 2.89
Extrasynaptic GABAA receptors: form, pharmacology, and function. J Neurosci (2009) 2.39
An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons. J Neurophysiol (2005) 2.22
Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors. Sci Transl Med (2012) 1.68
Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus. J Neurosci (2008) 1.45
Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice. Alcohol Clin Exp Res (2007) 1.39
Additive effects of sevoflurane and propofol on gamma-aminobutyric acid receptor function. Anesthesiology (2006) 1.31
Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus. J Pharmacol Exp Ther (2008) 1.22
A fusidic acid-resistant clone of Staphylococcus aureus associated with impetigo bullosa is spreading in Norway. J Antimicrob Chemother (2002) 1.20
Alcohol regulates gene expression in neurons via activation of heat shock factor 1. J Neurosci (2007) 1.19
Charged residues in the beta2 subunit involved in GABAA receptor activation. J Biol Chem (2003) 1.18
General anesthetic actions on GABA(A) receptors. Curr Neuropharmacol (2010) 1.16
A highly conserved aspartic acid residue in the signature disulfide loop of the alpha 1 subunit is a determinant of gating in the glycine receptor. J Biol Chem (2003) 1.14
Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol. J Pharmacol Exp Ther (2006) 1.14
Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABA(A) receptor alpha1 subunit. J Neurophysiol (2002) 1.14
Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus. J Pharmacol Exp Ther (2007) 1.13
4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor. J Med Chem (2002) 1.11
How life history influences population dynamics in fluctuating environments. Am Nat (2013) 1.10
A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists. J Biol Chem (2004) 1.09
The actions of sevoflurane and desflurane on the gamma-aminobutyric acid receptor type A: effects of TM2 mutations in the alpha and beta subunits. Anesthesiology (2003) 1.08
Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure. Neuropharmacology (2002) 1.08
Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats. Anesth Analg (2008) 1.08
A conserved tyrosine in the beta2 subunit M4 segment is a determinant of gamma-aminobutyric acid type A receptor sensitivity to propofol. Anesthesiology (2007) 1.07
Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane. Anesthesiology (2007) 1.07
Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons. Eur J Neurosci (2006) 1.06
Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. J Pharmacol Exp Ther (2005) 1.03
Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels. J Neurosci (2012) 1.02
Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor. J Biol Chem (2004) 0.99
GABAA receptors in the thalamus: alpha4 subunit expression and alcohol sensitivity. Alcohol (2007) 0.98
The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor. J Physiol (2006) 0.98
The modulation of synaptic GABA(A) receptors in the thalamus by eszopiclone and zolpidem. J Pharmacol Exp Ther (2008) 0.97
Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation. Biochemistry (2004) 0.93
Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors. Neurosci Lett (2004) 0.93
Agonist-dependent single channel current and gating in alpha4beta2delta and alpha1beta2gamma2S GABAA receptors. J Gen Physiol (2008) 0.92
Menthol shares general anesthetic activity and sites of action on the GABA(A) receptor with the intravenous agent, propofol. Eur J Pharmacol (2008) 0.91
Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit. J Chem Inf Model (2008) 0.91
The regulation of neuronal gene expression by alcohol. Pharmacol Ther (2009) 0.90
Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit. Brain Res (2005) 0.90
The activation mechanism of alpha1beta2gamma2S and alpha3beta3gamma2S GABAA receptors. J Gen Physiol (2010) 0.89
Human embryonic stem cell model of ethanol-mediated early developmental toxicity. Exp Neurol (2011) 0.89
Uncomplicated urinary tract infections. Bacterial findings and efficacy of empirical antibacterial treatment. Scand J Prim Health Care (2005) 0.89
Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms. Neuropharmacology (2008) 0.86
The effects of isoflurane on desensitized wild-type and alpha 1(S270H) gamma-aminobutyric acid type A receptors. Anesth Analg (2004) 0.86
Multilocus sequence typing and ftsI sequencing: a powerful tool for surveillance of penicillin-binding protein 3-mediated beta-lactam resistance in nontypeable Haemophilus influenzae. BMC Microbiol (2014) 0.84
Anesthetics interfere with axon guidance in developing mouse neocortical neurons in vitro via a γ-aminobutyric acid type A receptor mechanism. Anesthesiology (2013) 0.84
Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists. Anesthesiology (2003) 0.83
Discrete M3-M4 intracellular loop subdomains control specific aspects of γ-aminobutyric acid type A receptor function. J Biol Chem (2011) 0.83
Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway. Brain Behav (2013) 0.82
A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor. J Biol Chem (2009) 0.82
Inverse effects on gating and modulation caused by a mutation in the M2-M3 Linker of the GABA(A) receptor gamma subunit. Mol Pharmacol (2009) 0.82
The apparent voltage dependence of GABAA receptor activation and modulation is inversely related to channel open probability. Mol Pharmacol (2011) 0.81
Regulation of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor function by protein kinase C at serine-818 and threonine-840. Mol Pharmacol (2014) 0.81
Effects of γ-Aminobutyric Acid Type A Receptor Modulation by Flumazenil on Emergence from General Anesthesia. Anesthesiology (2016) 0.81
GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice. Brain Res (2006) 0.80
Alcohol-induced tolerance and physical dependence in mice with ethanol insensitive alpha1 GABA A receptors. Alcohol Clin Exp Res (2008) 0.79
Hemoglobin metabolites mimic benzodiazepines and are possible mediators of hepatic encephalopathy. Blood (2003) 0.77
Emergence of fluoroquinolone-resistant clonal group A: clonal analysis of Norwegian and Russian E. coli isolates. APMIS (2010) 0.77
Knockin' on the door of general anesthetic mechanisms: but will U.S. researchers be shut out? Anesth Analg (2003) 0.76
In Reply. Anesthesiology (2017) 0.75
Acetaldehyde, not ethanol, impairs myelin formation and viability in primary mouse oligodendrocytes. Alcohol Clin Exp Res (2015) 0.75
Anesthetic-Receptor Relationship Status: It's Complicated. Anesthesiology (2016) 0.75
High levels of multiresistance in quinolone resistant urinary tract isolates of Escherichia coli from Norway; a non clonal phenomen? BMC Res Notes (2014) 0.75
General anesthesia research: aroused from a deep sleep? Nat Neurosci (2002) 0.75
Subunit-dependent block by isoflurane of wild-type and mutant alpha(1)S270H GABA(A) receptor currents in Xenopus oocytes. Neurosci Lett (2005) 0.75