Published in J Appl Physiol (1985) on December 27, 2002
Effects of spaceflight on murine skeletal muscle gene expression. J Appl Physiol (1985) (2008) 1.49
Effects of spaceflight on innate immune function and antioxidant gene expression. J Appl Physiol (1985) (2009) 1.20
Spaceflight effects on T lymphocyte distribution, function and gene expression. J Appl Physiol (1985) (2008) 1.16
Effects of long-term space flight on erythrocytes and oxidative stress of rodents. PLoS One (2012) 0.88
Changes in mouse thymus and spleen after return from the STS-135 mission in space. PLoS One (2013) 0.85
Three weeks of murine hindlimb unloading induces shifts from B to T and from th to tc splenic lymphocytes in absence of stress and differentially reduces cell-specific mitogenic responses. PLoS One (2014) 0.85
Impact of space flight on bacterial virulence and antibiotic susceptibility. Infect Drug Resist (2015) 0.81
Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest. PLoS One (2013) 0.80
Acute and fractionated exposure to high-LET (56)Fe HZE-particle radiation both result in similar long-term deficits in adult hippocampal neurogenesis. Radiat Res (2013) 0.80
Post-Spaceflight (STS-135) Mouse Splenocytes Demonstrate Altered Activation Properties and Surface Molecule Expression. PLoS One (2015) 0.79
Hypergravity exposure during gestation modifies the TCRβ repertoire of newborn mice. Sci Rep (2015) 0.78
Changes in the distribution and function of leukocytes after whole-body iron ion irradiation. J Radiat Res (2016) 0.76
Hormetic Effect of Chronic Hypergravity in a Mouse Model of Allergic Asthma and Rhinitis. Sci Rep (2016) 0.75
Osteoclast differentiation and activation. Nature (2003) 18.59
Regulation of cancer cell migration and bone metastasis by RANKL. Nature (2006) 5.27
Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell (2010) 5.23
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res (2008) 4.82
Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res (2009) 4.40
Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell (2009) 3.16
Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest (2003) 3.09
Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99
Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev (2007) 2.82
Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl Physiol (1985) (2007) 2.70
Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone (2006) 2.59
Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength. J Bone Miner Res (2010) 2.52
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL. J Bone Miner Res (2009) 2.51
Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice. Circulation (2008) 2.44
A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane. Blood (2003) 2.24
Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab. Nat Rev Drug Discov (2012) 2.07
Bone development and age-related bone loss in male C57BL/6J mice. Bone (2003) 2.02
Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton. Blood (2010) 1.99
Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J Bone Miner Res (2002) 1.94
Mouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene. Hum Mol Genet (2003) 1.83
The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral hypercalcemia of malignancy. Endocrinology (2005) 1.78
Novel method for high-throughput phenotyping of sleep in mice. Physiol Genomics (2006) 1.77
Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones. J Bone Miner Res (2011) 1.70
Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing. J Bone Miner Res (2009) 1.68
Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats. J Bone Miner Res (2010) 1.65
Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Blood (2002) 1.58
Microarray analysis of spaceflown murine thymus tissue reveals changes in gene expression regulating stress and glucocorticoid receptors. J Cell Biochem (2010) 1.57
Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arterioscler Thromb Vasc Biol (2003) 1.56
Absence of erythroblast macrophage protein (Emp) leads to failure of erythroblast nuclear extrusion. J Biol Chem (2006) 1.53
Effects of spaceflight on murine skeletal muscle gene expression. J Appl Physiol (1985) (2008) 1.49
Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis. Clin Exp Metastasis (2007) 1.42
Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet (2003) 1.40
Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor. Proc Natl Acad Sci U S A (2010) 1.34
Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice. Blood (2008) 1.32
Implementing large-scale ENU mutagenesis screens in North America. Genetica (2004) 1.31
Prevention of glucocorticoid-induced bone loss in mice by inhibition of RANKL. Arthritis Rheum (2009) 1.27
Early increase in osteoclast number in mice after whole-body irradiation with 2 Gy X rays. Radiat Res (2008) 1.26
Invited review: Identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains. J Appl Physiol (1985) (2003) 1.24
Melanosome morphologies in murine models of hermansky-pudlak syndrome reflect blocks in organelle development. J Invest Dermatol (2002) 1.24
Inhibition of receptor activator of NF-kappaB ligand by denosumab attenuates vascular calcium deposition in mice. Am J Pathol (2009) 1.23
Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice. Blood (2008) 1.23
Ribosomal protein S19 expression during erythroid differentiation. Blood (2002) 1.20
Effects of spaceflight on innate immune function and antioxidant gene expression. J Appl Physiol (1985) (2009) 1.20
Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations. Bone (2009) 1.20
Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47. Blood (2002) 1.20
Mice as a mammalian model for research on the genetics of aging. ILAR J (2011) 1.20
Combined deletion of mouse dematin-headpiece and beta-adducin exerts a novel effect on the spectrin-actin junctions leading to erythrocyte fragility and hemolytic anemia. J Biol Chem (2006) 1.19
High-LET radiation induces inflammation and persistent changes in markers of hippocampal neurogenesis. Radiat Res (2005) 1.19
Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1). Blood (2003) 1.18
Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1). J Am Soc Nephrol (2007) 1.18
Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex. Blood (2004) 1.17
Spaceflight effects on T lymphocyte distribution, function and gene expression. J Appl Physiol (1985) (2008) 1.16
Variable hematopoietic responses to acute photons, protons and simulated solar particle event protons. In Vivo (2008) 1.15
N-myristoyltransferase 1 is essential in early mouse development. J Biol Chem (2005) 1.14
Dose and dose rate effects of whole-body proton irradiation on leukocyte populations and lymphoid organs: part I. Immunol Lett (2002) 1.14
Impaired synaptic plasticity and learning in mice lacking beta-adducin, an actin-regulating protein. J Neurosci (2005) 1.13
Hippocampal neurogenesis and neuroinflammation after cranial irradiation with (56)Fe particles. Radiat Res (2008) 1.11
Role of hepatocyte nuclear factor 4alpha in control of blood coagulation factor gene expression. J Mol Med (Berl) (2005) 1.11
RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis. J Bone Miner Res (2005) 1.11
Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL. J Biol Chem (2010) 1.10
Indicators of hippocampal neurogenesis are altered by 56Fe-particle irradiation in a dose-dependent manner. Radiat Res (2004) 1.08
RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis. J Periodontol (2007) 1.08
Long-term dose response of trabecular bone in mice to proton radiation. Radiat Res (2008) 1.08
Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes. Proc Natl Acad Sci U S A (2010) 1.08
Role of RANK ligand and denosumab, a targeted RANK ligand inhibitor, in bone health and osteoporosis: a review of preclinical and clinical data. Clin Ther (2012) 1.06
RANKL inhibition with osteoprotegerin increases bone strength by improving cortical and trabecular bone architecture in ovariectomized rats. J Bone Miner Res (2008) 1.06
Infrequent delivery of a long-acting PTH-Fc fusion protein has potent anabolic effects on cortical and cancellous bone. J Bone Miner Res (2007) 1.05
Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury. J Bone Miner Res (2011) 1.05
Soluble RANKL induces high bone turnover and decreases bone volume, density, and strength in mice. Calcif Tissue Int (2008) 1.03
Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. I. Immune population distributions. J Appl Physiol (1985) (2003) 1.02
Increased bone formation and bone mass induced by sclerostin antibody is not affected by pretreatment or cotreatment with alendronate in osteopenic, ovariectomized rats. Endocrinology (2011) 1.00
Effect of proton irradiation followed by hindlimb unloading on bone in mature mice: a model of long-duration spaceflight. Bone (2012) 1.00