Published in J Am Chem Soc on January 15, 2003
Oxidant types in copper-dioxygen chemistry: the ligand coordination defines the Cu(n)-O2 structure and subsequent reactivity. J Biol Inorg Chem (2004) 2.36
Copper active sites in biology. Chem Rev (2014) 1.90
Mononuclear Cu-O2 complexes: geometries, spectroscopic properties, electronic structures, and reactivity. Acc Chem Res (2007) 1.64
A [Cu2O]2+ core in Cu-ZSM-5, the active site in the oxidation of methane to methanol. Proc Natl Acad Sci U S A (2009) 1.62
O2 activation by binuclear Cu sites: noncoupled versus exchange coupled reaction mechanisms. Proc Natl Acad Sci U S A (2004) 1.46
X-ray absorption edge spectroscopy and computational studies on LCuO2 species: Superoxide-Cu(II) versus peroxide-Cu(III) bonding. J Am Chem Soc (2006) 1.45
Intermediates in the oxygenation of a nonheme diiron(II) complex, including the first evidence for a bound superoxo species. Proc Natl Acad Sci U S A (2005) 1.43
O2 and N2O activation by Bi-, Tri-, and tetranuclear Cu clusters in biology. Acc Chem Res (2007) 1.25
Copper dioxygen (bio)inorganic chemistry. Faraday Discuss (2011) 1.20
Spectroscopic and computational insight into the activation of O2 by the mononuclear Cu center in polysaccharide monooxygenases. Proc Natl Acad Sci U S A (2014) 1.08
Spectroscopic and computational studies of an end-on bound superoxo-Cu(II) complex: geometric and electronic factors that determine the ground state. Inorg Chem (2010) 1.04
Reduction of dioxygen by enzymes containing copper. J Biol Inorg Chem (2006) 1.04
Transition-metal ions in zeolites: coordination and activation of oxygen. Inorg Chem (2010) 1.00
An anionic, tetragonal copper(II) superoxide complex. J Am Chem Soc (2010) 1.00
Effects of thioether substituents on the O2 reactivity of beta-diketiminate-Cu(I) complexes: probing the role of the methionine ligand in copper monooxygenases. J Am Chem Soc (2006) 0.96
Cu-ZSM-5: A biomimetic inorganic model for methane oxidation. J Catal (2011) 0.94
Mechanistic insights into the oxidation of substituted phenols via hydrogen atom abstraction by a cupric-superoxo complex. J Am Chem Soc (2014) 0.93
Models for dioxygen activation by the CuB site of dopamine beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase. J Biol Inorg Chem (2005) 0.90
Correlation of the electronic and geometric structures in mononuclear copper(II) superoxide complexes. Inorg Chem (2013) 0.89
Defining the electronic and geometric structure of one-electron oxidized copper-bis-phenoxide complexes. J Am Chem Soc (2008) 0.88
Stepwise protonation and electron-transfer reduction of a primary copper-dioxygen adduct. J Am Chem Soc (2013) 0.87
Imino-oxy acetic acid dealkylation as evidence for an inner-sphere alcohol intermediate in the reaction catalyzed by peptidylglycine alpha-hydroxylating monooxygenase. J Am Chem Soc (2009) 0.86
How useful are vibrational frequencies of isotopomeric O2 fragments for assessing local symmetry? Some simple systems and the vexing case of a galactose oxidase model. J Biol Inorg Chem (2005) 0.84
Using synthetic chemistry to understand copper protein active sites: a personal perspective. J Biol Inorg Chem (2006) 0.83
L-edge X-ray absorption spectroscopy and DFT calculations on Cu2O2 species: direct electrophilic aromatic attack by side-on peroxo bridged dicopper(II) complexes. J Am Chem Soc (2013) 0.82
Theoretical modelling of tripodal CuN3 and CuN4 cuprous complexes interacting with O2, CO or CH3CN. J Biol Inorg Chem (2006) 0.81
Spectroscopic and computational characterization of CuII-OOR (R = H or cumyl) complexes bearing a Me6-tren ligand. Dalton Trans (2011) 0.81
Kinetics and DFT studies on the reaction of copper(II) complexes and H2O2. J Biol Inorg Chem (2005) 0.79
Comments on the nature of the bonding in oxygenated dinuclear copper enzyme models. J Mol Struct (2006) 0.78
Structure of the Reduced Copper Active Site in Preprocessed Galactose Oxidase: Ligand Tuning for One-Electron O2 Activation in Cofactor Biogenesis. J Am Chem Soc (2016) 0.75
Copper is a Cofactor of the Formylglycine-Generating Enzyme. Chembiochem (2016) 0.75
Stopped-Flow Studies of the Reduction of the Copper Centers Suggest a Bifurcated Electron Transfer Pathway in Peptidylglycine Monooxygenase. Biochemistry (2016) 0.75
Copper(I)-Dioxygen Adducts and Copper Enzyme Mechanisms. Isr J Chem (2016) 0.75
Substrate-Induced Carbon Monoxide Reactivity Suggests Multiple Enzyme Conformations at the Catalytic Copper M-Center of Peptidylglycine Monooxygenase. Biochemistry (2016) 0.75
A personal perspective on the discovery of dioxygen adducts of copper and iron by Nobumasa Kitajima. J Biol Inorg Chem (2017) 0.75
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell (2006) 18.81
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature (2010) 14.62
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature (2009) 11.46
lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature (2011) 11.31
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature (2008) 8.38
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature (2011) 8.03
Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell (2007) 7.60
Highly parallel identification of essential genes in cancer cells. Proc Natl Acad Sci U S A (2008) 7.45
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell (2009) 6.55
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature (2008) 6.24
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet (2010) 6.10
Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science (2009) 6.07
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proc Natl Acad Sci U S A (2009) 5.15
A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. Cell (2009) 4.98
A public genome-scale lentiviral expression library of human ORFs. Nat Methods (2011) 4.98
(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science (2013) 4.88
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell (2009) 4.71
Conserved pathways within bacteria and yeast as revealed by global protein network alignment. Proc Natl Acad Sci U S A (2003) 4.68
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. J Clin Invest (2011) 4.41
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc Natl Acad Sci U S A (2011) 4.15
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition. Nature (2013) 3.38
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell (2012) 3.33
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell (2010) 2.92
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Cancer Discov (2013) 2.49
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature (2013) 2.46
Proteomic and genetic approaches identify Syk as an AML target. Cancer Cell (2009) 2.39
Tyrosinase reactivity in a model complex: an alternative hydroxylation mechanism. Science (2005) 2.23
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell (2009) 2.15
Oxygen activation by the noncoupled binuclear copper site in peptidylglycine alpha-hydroxylating monooxygenase. Reaction mechanism and role of the noncoupled nature of the active site. J Am Chem Soc (2004) 2.01
Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models. J Clin Invest (2010) 1.98
Cancer vulnerabilities unveiled by genomic loss. Cell (2012) 1.95
ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens. Genome Res (2012) 1.86
Systematic discovery of TLR signaling components delineates viral-sensing circuits. Cell (2011) 1.83
Spectroscopic and quantum chemical studies on low-spin FeIV=O complexes: Fe-O bonding and its contributions to reactivity. J Am Chem Soc (2007) 1.74
Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymes. Proc Natl Acad Sci U S A (2006) 1.63
Towards patient-based cancer therapeutics. Nat Biotechnol (2010) 1.63
Solvent tuning of electrochemical potentials in the active sites of HiPIP versus ferredoxin. Science (2007) 1.63
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. J Exp Med (2014) 1.62
A [Cu2O]2+ core in Cu-ZSM-5, the active site in the oxidation of methane to methanol. Proc Natl Acad Sci U S A (2009) 1.62
Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers. Cancer Discov (2011) 1.57
A 1:1 copper-dioxygen adduct is an end-on bound superoxo copper(II) complex which undergoes oxygenation reactions with phenols. J Am Chem Soc (2007) 1.54
Description of the ground state wave functions of Ni dithiolenes using sulfur K-edge X-ray absorption spectroscopy. J Am Chem Soc (2003) 1.52
VTVH-MCD and DFT studies of thiolate bonding to [FeNO]7/[FeO2]8 complexes of isopenicillin N synthase: substrate determination of oxidase versus oxygenase activity in nonheme Fe enzymes. J Am Chem Soc (2007) 1.50
Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer. Gastrointest Endosc (2011) 1.49
Mechanism of N2O reduction by the mu4-S tetranuclear CuZ cluster of nitrous oxide reductase. J Am Chem Soc (2006) 1.46
O2 activation by binuclear Cu sites: noncoupled versus exchange coupled reaction mechanisms. Proc Natl Acad Sci U S A (2004) 1.46
Dioxygen activation by copper, heme and non-heme iron enzymes: comparison of electronic structures and reactivities. Curr Opin Chem Biol (2005) 1.46
Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism. Chem Biol (2004) 1.45
X-ray absorption edge spectroscopy and computational studies on LCuO2 species: Superoxide-Cu(II) versus peroxide-Cu(III) bonding. J Am Chem Soc (2006) 1.45
Nature of the peroxo intermediate of the W48F/D84E ribonucleotide reductase variant: implications for O2 activation by binuclear non-heme iron enzymes. J Am Chem Soc (2004) 1.43
Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Sci Transl Med (2012) 1.42
In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Cancer Cell (2013) 1.42
CD and MCD of CytC3 and taurine dioxygenase: role of the facial triad in alpha-KG-dependent oxygenases. J Am Chem Soc (2007) 1.41
Structure and reactivity of a mononuclear non-haem iron(III)-peroxo complex. Nature (2011) 1.40
L-edge X-ray absorption spectroscopy of non-heme iron sites: experimental determination of differential orbital covalency. J Am Chem Soc (2003) 1.39
Oxygen activation by the noncoupled binuclear copper site in peptidylglycine alpha-hydroxylating monooxygenase. Spectroscopic definition of the resting sites and the putative CuIIM-OOH intermediate. Biochemistry (2004) 1.36
Spectroscopic and quantum chemical characterization of the electronic structure and bonding in a non-heme FeIV[double bond]O complex. J Am Chem Soc (2004) 1.35
Density-functional investigation on the mechanism of H-atom abstraction by lipoxygenase. J Biol Inorg Chem (2002) 1.34
Physical fitness and 4-year mortality in an 80-year-old population. J Gerontol A Biol Sci Med Sci (2007) 1.31
Description of the ground-state covalencies of the bis(dithiolato) transition-metal complexes from X-ray absorption spectroscopy and time-dependent density-functional calculations. Chemistry (2007) 1.30
Nature of the intermediate formed in the reduction of O(2) to H(2)O at the trinuclear copper cluster active site in native laccase. J Am Chem Soc (2002) 1.30
Direct hydrogen-atom abstraction by activated bleomycin: an experimental and computational study. J Am Chem Soc (2006) 1.29
Sulfur K-edge X-ray absorption spectroscopy as a probe of ligand-metal bond covalency: metal vs ligand oxidation in copper and nickel dithiolene complexes. J Am Chem Soc (2007) 1.29
Structure-function correlations in oxygen activating non-heme iron enzymes. Chem Commun (Camb) (2005) 1.28
Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov (2013) 1.27
Mitochondrial and nuclear genomic responses to loss of LRPPRC expression. J Biol Chem (2010) 1.27
Rapid C-H bond activation by a monocopper(III)-hydroxide complex. J Am Chem Soc (2011) 1.27
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Cell (2012) 1.26
Normal mode analysis of Pyrococcus furiosus rubredoxin via nuclear resonance vibrational spectroscopy (NRVS) and resonance raman spectroscopy. J Am Chem Soc (2005) 1.26
Cupric superoxo-mediated intermolecular C-H activation chemistry. J Am Chem Soc (2011) 1.26
Spectroscopic and electronic structure studies of intermediate X in ribonucleotide reductase R2 and two variants: a description of the FeIV-oxo bond in the FeIII-O-FeIV dimer. J Am Chem Soc (2007) 1.26
Synthesis, characterization, and reactivities of manganese(V)-oxo porphyrin complexes. J Am Chem Soc (2007) 1.25
Fe L-edge XAS studies of K4[Fe(CN)6] and K3[Fe(CN)6]: a direct probe of back-bonding. J Am Chem Soc (2006) 1.25
Oxygen activation by nonheme iron(II) complexes: alpha-keto carboxylate versus carboxylate. J Am Chem Soc (2003) 1.25
Dioxygen activation at a single copper site: structure, bonding, and mechanism of formation of 1:1 Cu-O2 adducts. J Am Chem Soc (2004) 1.24
Spectroscopic and DFT investigation of [M{HB(3,5-iPr2pz)3}(SC6F5)] (M = Mn, Fe, Co, Ni, Cu, and Zn) model complexes: periodic trends in metal-thiolate bonding. Inorg Chem (2005) 1.24
Spectroscopic definition of the ferroxidase site in M ferritin: comparison of binuclear substrate vs cofactor active sites. J Am Chem Soc (2008) 1.24
Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells. Cell Stem Cell (2012) 1.24
CK1epsilon is required for breast cancers dependent on beta-catenin activity. PLoS One (2010) 1.22
Elucidation of the Fe(IV)=O intermediate in the catalytic cycle of the halogenase SyrB2. Nature (2013) 1.22
Spectroscopic and density functional studies of the red copper site in nitrosocyanin: role of the protein in determining active site geometric and electronic structure. J Am Chem Soc (2005) 1.21
A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration. Genes Dev (2010) 1.21
Electronic structure and reactivity of low-spin Fe(III)-hydroperoxo complexes: comparison to activated bleomycin. J Am Chem Soc (2002) 1.21
Preface: biomimetic inorganic chemistry. Chem Rev (2004) 1.20
Geometric and electronic structure and reactivity of a mononuclear "side-on" nickel(III)-peroxo complex. Nat Chem (2009) 1.19
Peroxo-type intermediates in class I ribonucleotide reductase and related binuclear non-heme iron enzymes. J Am Chem Soc (2009) 1.19
Substrate activation for O2 reactions by oxidized metal centers in biology. Proc Natl Acad Sci U S A (2007) 1.19
Comparison between the geometric and electronic structures and reactivities of [FeNO]7 and [FeO2]8 complexes: a density functional theory study. J Am Chem Soc (2004) 1.18
Contrasting copper-dioxygen chemistry arising from alike tridentate alkyltriamine copper(I) complexes. J Am Chem Soc (2002) 1.16
Toluene and ethylbenzene aliphatic C-H bond oxidations initiated by a dicopper(II)-mu-1,2-peroxo complex. J Am Chem Soc (2009) 1.16
Spectroscopic and electronic structure studies of the trinuclear Cu cluster active site of the multicopper oxidase laccase: nature of its coordination unsaturation. J Am Chem Soc (2005) 1.16
Resonance raman investigation of equatorial ligand donor effects on the Cu(2)O(2)(2+) core in end-on and side-on mu-peroxo-dicopper(II) and bis-mu-oxo-dicopper(III) complexes. J Am Chem Soc (2003) 1.16
A flexible data analysis tool for chemical genetic screens. Chem Biol (2004) 1.15
Variable-temperature, variable-field magnetic circular dichroism studies of tris-hydroxy- and mu3-oxo-bridged trinuclear Cu(II) complexes: evaluation of proposed structures of the native intermediate of the multicopper oxidases. J Am Chem Soc (2005) 1.15
A functional nitric oxide reductase model. Proc Natl Acad Sci U S A (2008) 1.14
Shall we dance? How a multicopper oxidase chooses its electron transfer partner. Acc Chem Res (2007) 1.14
MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma. Sci Signal (2012) 1.13