Published in Vascul Pharmacol on June 01, 2002
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol (2003) 5.74
Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest (2003) 3.41
Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anat (2005) 3.02
Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology. Cell Mol Neurobiol (2005) 2.58
Tight junctions and the modulation of barrier function in disease. Histochem Cell Biol (2008) 2.13
The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction. Semin Immunopathol (2009) 2.12
The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth. Clin Cancer Res (2010) 1.96
Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage. J Neurosci (2012) 1.89
Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiol Behav (2010) 1.80
Dynamics of CNS barriers: evolution, differentiation, and modulation. Cell Mol Neurobiol (2005) 1.80
The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med (2014) 1.73
Astrocytes in multiple sclerosis: a product of their environment. Cell Mol Life Sci (2008) 1.66
Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice. Stroke (2009) 1.63
Responses of endothelial cell and astrocyte matrix-integrin receptors to ischemia mimic those observed in the neurovascular unit. Stroke (2007) 1.58
Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol (2008) 1.55
Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia. J Neurochem (2009) 1.53
How do immune cells support and shape the brain in health, disease, and aging? J Neurosci (2013) 1.51
Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica). J Comp Neurol (2006) 1.48
Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1. Eur J Neurosci (2004) 1.39
In vitro blood-brain barrier models: current and perspective technologies. J Pharm Sci (2011) 1.36
Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling. J Neurosci (2008) 1.36
Inflammatory cell trafficking across the blood-brain barrier: chemokine regulation and in vitro models. Immunol Rev (2012) 1.30
Blood-brain barrier breakdown and repair by Src after thrombin-induced injury. Ann Neurol (2010) 1.26
Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees. Cell Tissue Res (2008) 1.26
Role of KCNMA1 gene in breast cancer invasion and metastasis to brain. BMC Cancer (2009) 1.26
Manganese neurotoxicity: a focus on the neonate. Pharmacol Ther (2006) 1.26
The role of shear stress in Blood-Brain Barrier endothelial physiology. BMC Neurosci (2011) 1.25
Recent advances in blood-brain barrier disruption as a CNS delivery strategy. AAPS J (2008) 1.24
Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins. PLoS One (2011) 1.24
Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain. Neuroscience (2004) 1.21
Blood-brain barrier breakdown after embolic stroke in rats occurs without ultrastructural evidence for disrupting tight junctions. PLoS One (2013) 1.20
Increasing importance of Balamuthia mandrillaris. Clin Microbiol Rev (2008) 1.20
Neuron-glial interactions in blood-brain barrier formation. Annu Rev Neurosci (2007) 1.20
The blood-brain barrier in neurodegenerative disease: a rhetorical perspective. J Neurochem (2009) 1.20
The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. J Alzheimers Dis (2010) 1.19
The molecular and biophysical characterization of the human blood-nerve barrier: current concepts. J Vasc Res (2013) 1.19
Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke. Dev Neurobiol (2011) 1.18
Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. J Clin Invest (2008) 1.17
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol (2011) 1.16
The impact of microglial activation on blood-brain barrier in brain diseases. Front Cell Neurosci (2014) 1.16
Beta8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain. J Cell Sci (2009) 1.15
Glial influence on the blood brain barrier. Glia (2013) 1.12
Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier. Invest Ophthalmol Vis Sci (2005) 1.09
The blood-brain barrier: an engineering perspective. Front Neuroeng (2013) 1.09
Immunolocalization of tight junction proteins in the adult and developing human brain. Histochem Cell Biol (2004) 1.05
Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS One (2013) 1.04
The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats. Physiol Behav (2012) 1.04
Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin. Mol Biol Cell (2008) 1.03
Fluids and barriers of the CNS: a historical viewpoint. Fluids Barriers CNS (2011) 1.02
Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. J Immunol (2008) 1.02
Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line. Fluids Barriers CNS (2014) 1.02
Monocyte chemoattractant protein-1 and the blood-brain barrier. Cell Mol Life Sci (2013) 1.02
Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. J Alzheimers Dis (2010) 1.01
Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings. Br J Pharmacol (2012) 1.00
Neural circuit mechanisms of post-traumatic epilepsy. Front Cell Neurosci (2013) 0.99
Recombinant human sonic hedgehog protein regulates the expression of ZO-1 and occludin by activating angiopoietin-1 in stroke damage. PLoS One (2013) 0.98
Exposure to lipopolysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cells. PLoS One (2012) 0.98
Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats. BMC Neurol (2010) 0.97
Guanine nucleotide-binding protein Gαi2: a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cells. J Cereb Blood Flow Metab (2012) 0.97
Protection after stroke: cellular effectors of neurovascular unit integrity. Front Cell Neurosci (2014) 0.97
Progranulin deficiency promotes post-ischemic blood-brain barrier disruption. J Neurosci (2013) 0.96
Blood-brain barrier breakdown involves four distinct stages of vascular damage in various models of experimental focal cerebral ischemia. J Cereb Blood Flow Metab (2014) 0.96
Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles. Int J Nanomedicine (2011) 0.96
Evidence for differential changes of junctional complex proteins in murine neurocysticercosis dependent upon CNS vasculature. Brain Res (2007) 0.96
Superoxide dismutase-loaded PLGA nanoparticles protect cultured human neurons under oxidative stress. Appl Biochem Biotechnol (2008) 0.95
Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis. Epilepsia (2012) 0.95
Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity. Nat Commun (2014) 0.94
Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes. PLoS One (2014) 0.94
Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro. PLoS One (2013) 0.93
A detailed method for preparation of a functional and flexible blood-brain barrier model using porcine brain endothelial cells. Brain Res (2013) 0.93
Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5. Cell Mol Neurobiol (2006) 0.93
Pcbs and tight junction expression. Environ Toxicol Pharmacol (2008) 0.92
Holey barrier: claudins and the regulation of brain endothelial permeability. J Cell Biol (2003) 0.92
Monocytes form a vascular barrier and participate in vessel repair after brain injury. Blood (2005) 0.91
Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance. Brain Res (2012) 0.90
Increased expression of the beta4 and alpha5 integrin subunits in cerebral blood vessels of transgenic mice chronically producing the pro-inflammatory cytokines IL-6 or IFN-alpha in the central nervous system. Mol Cell Neurosci (2006) 0.90
Pathogenesis of meningococcemia. Cold Spring Harb Perspect Med (2013) 0.90
Monocytes mediate HIV neuropathogenesis: mechanisms that contribute to HIV associated neurocognitive disorders. Curr HIV Res (2014) 0.89
Models and mechanisms for hippocampal dysfunction in obesity and diabetes. Neuroscience (2015) 0.89
Altered expression of zonula occludens-2 precedes increased blood-brain barrier permeability in a murine model of fulminant hepatic failure. J Invest Surg (2008) 0.88
Breaching the blood-brain barrier as a gate to psychiatric disorder. Cardiovasc Psychiatry Neurol (2009) 0.88
Steps to translate preconditioning from basic research to the clinic. Transl Stroke Res (2012) 0.88
Protein kinase Cβ as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2013) 0.88
Pathogenesis of hepatic encephalopathy. Gastroenterol Res Pract (2012) 0.88
Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function. Physiol Genomics (2009) 0.88
Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro. J Neuroinflammation (2011) 0.86
Defense at the border: the blood-brain barrier versus bacterial foreigners. Future Microbiol (2012) 0.86
Transcriptome analysis of the Octopus vulgaris central nervous system. PLoS One (2012) 0.86
Microbial induction of vascular pathology in the CNS. J Neuroimmune Pharmacol (2010) 0.86
Pathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriers. Ther Deliv (2014) 0.86
Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood-brain barrier divide. Expert Opin Drug Deliv (2013) 0.85
Late stage infection in sleeping sickness. PLoS One (2012) 0.85
Cell-culture models of the blood-brain barrier. Stroke (2014) 0.85
In vitro cerebrovascular modeling in the 21st century: current and prospective technologies. Pharm Res (2014) 0.84
Immunolocalization of tight junction proteins in blood vessels in human germinal matrix and cortex. Histochem Cell Biol (2006) 0.84
Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life. J Transl Med (2009) 0.84
Association of plasminogen activators and matrix metalloproteinase-9 proteolytic cascade with blood-CNS barrier damage of angiostrongyliasis. Int J Exp Pathol (2006) 0.84
Biological and medical applications of a brain-on-a-chip. Exp Biol Med (Maywood) (2014) 0.84
Excess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia. Sci Rep (2015) 0.84
alpha-Tropomyosin mutations Asp(175)Asn and Glu(180)Gly affect cardiac function in transgenic rats in different ways. Am J Physiol Regul Integr Comp Physiol (2004) 0.86
Over-expression of angiotensin converting enzyme-1 augments cardiac hypertrophy in transgenic rats. Hum Mol Genet (2004) 0.85
Two genetic rat models of arterial hypertension show different mechanisms by which adult hippocampal neurogenesis is increased. Dev Neurosci (2007) 0.85
Cell type-specific expression of the Mas proto-oncogene in testis. J Histochem Cytochem (2002) 0.80
Freeze-fracture studies of cerebral endothelial tight junctions. Methods Mol Med (2003) 0.78