Published in J Lipid Res on February 01, 2003
Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins. Infect Immun (2005) 3.39
Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells. J Biol Chem (2006) 1.31
Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling. J Cell Biol (2006) 1.14
Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine. J Lipid Res (2012) 0.91
ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease. PLoS One (2009) 0.86
Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport. Dev Cell (2016) 0.83
Reduced sensitivity of Niemann-Pick C1-deficient cells to theta-toxin (perfringolysin O): sequestration of toxin to raft-enriched membrane vesicles. Histochem Cell Biol (2004) 0.83
Real-time analysis of endosomal lipid transport by live cell scintillation proximity assay. J Lipid Res (2004) 0.82
Visualization of cholesterol deposits in lysosomes of Niemann-Pick type C fibroblasts using recombinant perfringolysin O. Orphanet J Rare Dis (2014) 0.81
Apolipoprotein B100 secretion by cultured ARPE-19 cells is modulated by alteration of cholesterol levels. J Neurochem (2010) 0.78
Cholesterol sensing, trafficking, and esterification. Annu Rev Cell Dev Biol (2006) 3.19
A population-based study on the immediate and prolonged effects of the 1999 Taiwan earthquake on mortality. Ann Epidemiol (2003) 2.08
Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. Proc Natl Acad Sci U S A (2004) 1.82
Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. Dev Cell (2009) 1.81
Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in Abca1-deficient macrophages. J Lipid Res (2006) 1.73
Establishment of a high sensitivity plasma assay for human pentraxin3 as a marker for unstable angina pectoris. Arterioscler Thromb Vasc Biol (2006) 1.72
Niemann-Pick type C disease and intracellular cholesterol trafficking. J Biol Chem (2005) 1.56
Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia. Circ J (2015) 1.55
Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice. Exp Dermatol (2014) 1.51
Clot retraction is mediated by factor XIII-dependent fibrin-αIIbβ3-myosin axis in platelet sphingomyelin-rich membrane rafts. Blood (2013) 1.48
Electrophysiological properties of prion-positive cardiac progenitors derived from murine embryonic stem cells. Circ J (2012) 1.40
Mental retardation, spasticity, basal ganglia calcification, cerebral white matter lesions, multiple endocrine defects, telangiectasia and atrophic skin: a new syndrome? Brain Dev (2007) 1.39
Immunoelectron microscopic localization of cholesterol using biotinylated and non-cytolytic perfringolysin O. J Histochem Cytochem (2002) 1.33
The C-terminal domain of perfringolysin O is an essential cholesterol-binding unit targeting to cholesterol-rich microdomains. Eur J Biochem (2002) 1.32
Prognostic significance of prostate cancer susceptibility variants on prostate-specific antigen recurrence after radical prostatectomy. Cancer Epidemiol Biomarkers Prev (2009) 1.31
A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain. J Lipid Res (2004) 1.29
Association of active gamma-secretase complex with lipid rafts. J Lipid Res (2005) 1.24
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proc Natl Acad Sci U S A (2010) 1.23
Characterization of sequential N-cadherin cleavage by ADAM10 and PS1. Neurosci Lett (2006) 1.22
Enhanced autophagy and mitochondrial aberrations in murine G(M1)-gangliosidosis. Biochem Biophys Res Commun (2008) 1.21
The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain. J Biol Chem (2005) 1.21
Noncoding RNAs prevent spreading of a repressive histone mark. Nat Struct Mol Biol (2013) 1.18
Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients. Am J Hypertens (2008) 1.15
Gamma-secretase activity is present in rafts but is not cholesterol-dependent. Biochemistry (2003) 1.15
RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy. Dermatol Res Pract (2011) 1.15
Ubiquitin-proteasome system impairment caused by a missense cardiac myosin-binding protein C mutation and associated with cardiac dysfunction in hypertrophic cardiomyopathy. J Mol Biol (2008) 1.15
Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. Arterioscler Thromb Vasc Biol (2006) 1.14
Individual and cumulative association of prostate cancer susceptibility variants with clinicopathologic characteristics of the disease. Clin Chim Acta (2010) 1.13
Polymorphisms inside microRNAs and microRNA target sites predict clinical outcomes in prostate cancer patients receiving androgen-deprivation therapy. Clin Cancer Res (2010) 1.13
Distinct endosomal compartments in early trafficking of low density lipoprotein-derived cholesterol. J Biol Chem (2003) 1.11
Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Proc Natl Acad Sci U S A (2006) 1.10
A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations. Hum Mol Genet (2011) 1.10
Human acyl-coenzyme A:cholesterol acyltransferase expressed in chinese hamster ovary cells: membrane topology and active site location. Mol Biol Cell (2003) 1.09
Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies. Biochem J (2005) 1.06
N-octyl-beta-valienamine up-regulates activity of F213I mutant beta-glucosidase in cultured cells: a potential chemical chaperone therapy for Gaucher disease. Biochim Biophys Acta (2004) 1.05
The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3. J Cell Sci (2007) 1.05
An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer. EMBO J (2011) 1.03
CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes. FEBS Lett (2003) 1.02
Perfringolysin O, a cholesterol-binding cytolysin, as a probe for lipid rafts. Anaerobe (2004) 1.02
Molecular Network Associated with MITF in Skin Melanoma Development and Progression. J Skin Cancer (2011) 1.01
A role for sphingomyelin-rich lipid domains in the accumulation of phosphatidylinositol-4,5-bisphosphate to the cleavage furrow during cytokinesis. Mol Cell Biol (2012) 1.00
Site-specific regulation of the GEF Cdc24p by the scaffold protein Far1p during yeast mating. EMBO J (2004) 1.00
Clinical significance of runt-related transcription factor 1 polymorphism in prostate cancer. BJU Int (2010) 1.00
Genetic variants in microRNAs and microRNA target sites predict biochemical recurrence after radical prostatectomy in localized prostate cancer. Int J Cancer (2014) 0.99
Trafficking defects in endogenously synthesized cholesterol in fibroblasts, macrophages, hepatocytes, and glial cells from Niemann-Pick type C1 mice. J Lipid Res (2003) 0.99
Age-associated up-regulation of a negative co-stimulatory receptor PD-1 in mouse CD4+ T cells. Exp Gerontol (2009) 0.99
Before the loss: neuronal dysfunction in Niemann-Pick Type C disease. Biochim Biophys Acta (2004) 0.99
Human acyl-coenzyme A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminus. J Biol Chem (2004) 0.98
Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: in vivo and in vitro studies. Lab Invest (2003) 0.97
A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system. Glia (2013) 0.97
The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein. Am J Pathol (2005) 0.95
The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice. J Clin Invest (2009) 0.94
Lack of Niemann-Pick type C1 induces age-related degeneration in the mouse retina. Mol Cell Neurosci (2009) 0.94
Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin. Chembiochem (2009) 0.94
Single-cell analysis reveals cell-specific patterns of expression of a family of putative voltage-gated sodium channel genes in the leech. J Neurobiol (2003) 0.93
Ultrastructural localization of flotillin-1 to cholesterol-rich membrane microdomains, rafts, in rat brain tissue. Brain Res (2003) 0.93
Role of the N-terminal hydrophilic domain of acyl-coenzyme A:cholesterol acyltransferase 1 on the enzyme's quaternary structure and catalytic efficiency. Biochemistry (2002) 0.93
TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation. J Lipid Res (2009) 0.93
Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma. Biochem J (2006) 0.93
Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. Circ Res (2010) 0.92
Axonal dystrophy of dorsal root ganglion sensory neurons in a mouse model of Niemann-Pick disease type C. Exp Neurol (2004) 0.92
Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin. Biochem Biophys Res Commun (2006) 0.92
Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease. Mol Ther (2013) 0.92
Vascular endothelial cells that express dystroglycan are involved in angiogenesis. J Cell Sci (2002) 0.92
Cholesterol-binding toxins and anti-cholesterol antibodies as structural probes for cholesterol localization. Subcell Biochem (2010) 0.91
Significant associations of prostate cancer susceptibility variants with survival in patients treated with androgen-deprivation therapy. Int J Cancer (2011) 0.91
Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis. Acta Biochim Biophys Sin (Shanghai) (2006) 0.91
Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1. J Biol Chem (2003) 0.91
Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor. J Biol Chem (2003) 0.90
Brainstem neuropathology in a mouse model of Niemann-Pick disease type C. J Neurol Sci (2008) 0.90
Association analysis of Wnt pathway genes on prostate-specific antigen recurrence after radical prostatectomy. Ann Surg Oncol (2009) 0.90
Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). J Neurosci Res (2007) 0.90
A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth. J Mol Cell Biol (2013) 0.90
Intracellular cholesterol mobilization involved in the ABCA1/apolipoprotein-mediated assembly of high density lipoprotein in fibroblasts. J Lipid Res (2004) 0.89
Enzyme enhancement activity of N-octyl-beta-valienamine on beta-glucosidase mutants associated with Gaucher disease. Biochim Biophys Acta (2007) 0.89
Structure and function of lipid rafts in human activated T cells. Int Immunol (2005) 0.89
The disulfide linkage and the free sulfhydryl accessibility of acyl-coenzyme A:cholesterol acyltransferase 1 as studied by using mPEG5000-maleimide. Biochemistry (2005) 0.88
A novel hairless mouse model for malignant melanoma. J Dermatol Sci (2011) 0.88
Production of ACAT1 56-kDa isoform in human cells via trans-splicing involving the ampicillin resistance gene. Cell Res (2013) 0.88
Fluorescence image screening for chemical compounds modifying cholesterol metabolism and distribution. J Lipid Res (2011) 0.88
Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity. J Lipid Res (2010) 0.88
A stable upstream stem-loop structure enhances selection of the first 5'-ORF-AUG as a main start codon for translation initiation of human ACAT1 mRNA. Acta Biochim Biophys Sin (Shanghai) (2004) 0.88
Workers' exposures and potential health risks to air toxics in a petrochemical complex assessed by improved methodology. Int Arch Occup Environ Health (2005) 0.88
Impairment of ubiquitin-proteasome system by E334K cMyBPC modifies channel proteins, leading to electrophysiological dysfunction. J Mol Biol (2011) 0.87
Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein. FASEB J (2003) 0.87
Smad expression of hepatic stellate cells in liver cirrhosis in vivo and hepatic stellate cell line in vitro. Pathol Int (2003) 0.87
Mutant acyl-coenzyme A:cholesterol acyltransferase 1 devoid of cysteine residues remains catalytically active. J Biol Chem (2001) 0.86