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1
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Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.
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Cell
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2007
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8.84
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2
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HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.
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Cell
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2012
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2.94
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3
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Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.
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Science
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2013
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2.79
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4
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17AAG: low target binding affinity and potent cell activity--finding an explanation.
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Mol Cancer Ther
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2003
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2.74
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5
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Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
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Proc Natl Acad Sci U S A
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2009
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2.35
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6
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Altered Hsp90 function in cancer: a unique therapeutic opportunity.
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Mol Cancer Ther
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2004
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2.16
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7
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High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.
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Proc Natl Acad Sci U S A
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2011
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2.03
|
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8
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Fitness trade-offs restrict the evolution of resistance to amphotericin B.
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PLoS Biol
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2013
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1.88
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9
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Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study.
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Clin Cancer Res
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2007
|
1.80
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10
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Hsp90: an emerging target for breast cancer therapy.
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Anticancer Drugs
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2004
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1.64
|
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11
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A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study.
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Clin Cancer Res
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2007
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1.61
|
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12
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Actin microfilament aggregation induced by withaferin A is mediated by annexin II.
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Nat Chem Biol
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2005
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1.55
|
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13
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Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.
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Nat Biotechnol
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2013
|
1.33
|
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14
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Using the heat-shock response to discover anticancer compounds that target protein homeostasis.
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ACS Chem Biol
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2011
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1.31
|
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15
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Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.
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J Clin Invest
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2012
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1.25
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16
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Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
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J Nat Prod
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2006
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1.20
|
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17
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Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors.
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Clin Cancer Res
|
2003
|
1.12
|
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18
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2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera.
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Bioorg Med Chem
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2008
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1.12
|
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19
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A rhizosphere fungus enhances Arabidopsis thermotolerance through production of an HSP90 inhibitor.
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Plant Physiol
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2007
|
1.11
|
|
20
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Heat shock protein 90: a unique chemotherapeutic target.
|
Semin Oncol
|
2006
|
1.06
|
|
21
|
Hsp90 is essential in the filarial nematode Brugia pahangi.
|
Int J Parasitol
|
2005
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1.05
|
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22
|
Cytotoxic constituents of Aspergillus terreus from the rhizosphere of Opuntia versicolor of the Sonoran Desert.
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J Nat Prod
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2003
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1.01
|
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23
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Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin.
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Int J Cancer
|
2005
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1.00
|
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24
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Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.
|
J Nat Prod
|
2004
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0.99
|
|
25
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Two cases of pediatric neuroblastoma with tumor thrombus in the inferior vena cava.
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J Pediatr Hematol Oncol
|
2002
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0.98
|
|
26
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Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity.
|
ACS Chem Biol
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2012
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0.98
|
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27
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Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues.
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J Nat Prod
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2012
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0.96
|
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28
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Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans.
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Cell Stress Chaperones
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2003
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0.92
|
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29
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HSP90: a rising star on the horizon of anticancer targets.
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Future Oncol
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2005
|
0.92
|
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30
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The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways.
|
Mol Cancer Ther
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2005
|
0.91
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31
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Isolation, optimization of production and structure-activity relationship studies of monocillin I, the cytotoxic constituent of Paraphaeosphaeria quadriseptata.
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J Antibiot (Tokyo)
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2004
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0.90
|
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32
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Structure-activity relationships for withanolides as inducers of the cellular heat-shock response.
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J Med Chem
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2014
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0.88
|
|
33
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Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.
|
Bioorg Med Chem Lett
|
2011
|
0.87
|
|
34
|
A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity.
|
Bioorg Med Chem
|
2006
|
0.87
|
|
35
|
Autoantibodies to villin occur frequently in IPEX, a severe immune dysregulation, syndrome caused by mutation of FOXP3.
|
Clin Immunol
|
2011
|
0.87
|
|
36
|
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.
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Bioorg Med Chem Lett
|
2012
|
0.85
|
|
37
|
Evidence for a Novel, Caspase-8-Independent, Fas Death Domain-Mediated Apoptotic Pathway.
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J Biomed Biotechnol
|
2004
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0.81
|
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38
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Biomimetic kinetic resolution: highly enantio- and diastereoselective transfer hydrogenation of aglain ketones to access flavagline natural products.
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J Am Chem Soc
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2014
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0.81
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39
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ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans.
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Beilstein J Org Chem
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2013
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0.81
|
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40
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Design of quinolinedione-based geldanamycin analogues.
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Bioorg Med Chem Lett
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2003
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0.76
|
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41
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Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors.
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Bioorg Med Chem
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2013
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0.76
|
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42
|
Preface.
|
Adv Cancer Res
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2016
|
0.75
|