|
1
|
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.
|
Cancer Res
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2004
|
21.36
|
|
2
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Initial genome sequencing and analysis of multiple myeloma.
|
Nature
|
2011
|
17.28
|
|
3
|
The mutational landscape of head and neck squamous cell carcinoma.
|
Science
|
2011
|
16.88
|
|
4
|
A landscape of driver mutations in melanoma.
|
Cell
|
2012
|
12.61
|
|
5
|
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.
|
Cell
|
2012
|
11.69
|
|
6
|
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.
|
Nat Genet
|
2012
|
9.93
|
|
7
|
Melanoma genome sequencing reveals frequent PREX2 mutations.
|
Nature
|
2012
|
7.77
|
|
8
|
Sequence analysis of mutations and translocations across breast cancer subtypes.
|
Nature
|
2012
|
7.76
|
|
9
|
Punctuated evolution of prostate cancer genomes.
|
Cell
|
2013
|
7.23
|
|
10
|
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.
|
Proc Natl Acad Sci U S A
|
2012
|
7.14
|
|
11
|
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
|
Nature
|
2012
|
5.23
|
|
12
|
The genetic landscape of high-risk neuroblastoma.
|
Nat Genet
|
2013
|
4.71
|
|
13
|
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.
|
Nat Genet
|
2013
|
4.48
|
|
14
|
Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.
|
Cancer Discov
|
2014
|
2.64
|
|
15
|
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers.
|
J Clin Invest
|
2012
|
2.42
|
|
16
|
Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis.
|
Blood
|
2003
|
2.23
|
|
17
|
Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.
|
Nat Genet
|
2013
|
2.21
|
|
18
|
Somatic mutation of CDKN1B in small intestine neuroendocrine tumors.
|
Nat Genet
|
2013
|
1.56
|
|
19
|
Identification of genes modulated in multiple myeloma using genetically identical twin samples.
|
Blood
|
2003
|
1.56
|
|
20
|
Elevated serum periostin levels in patients with bone metastases from breast but not lung cancer.
|
Breast Cancer Res Treat
|
2003
|
1.54
|
|
21
|
Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays.
|
Oncogene
|
2002
|
1.45
|
|
22
|
DNA methylation analysis determines the high frequency of genic hypomethylation and low frequency of hypermethylation events in plasma cell tumors.
|
Cancer Res
|
2010
|
1.41
|
|
23
|
Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays.
|
Blood
|
2002
|
1.01
|
|
24
|
Novel chemiluminescence assay for serum periostin levels in women with preeclampsia and in normotensive pregnant women.
|
Am J Obstet Gynecol
|
2002
|
0.78
|