Published in Am J Physiol Endocrinol Metab on February 25, 2003
Bioactive insulin-like growth factor-I in obesity. J Clin Endocrinol Metab (2009) 1.04
The changing face of acromegaly--advances in diagnosis and treatment. Nat Rev Endocrinol (2012) 1.03
Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians' offspring. Aging (Albany NY) (2012) 1.01
Rapid suppression of growth hormone concentration by overeating: potential mediation by hyperinsulinemia. J Clin Endocrinol Metab (2011) 0.90
Igf-I bioactivity in an elderly population: relation to insulin sensitivity, insulin levels, and the metabolic syndrome. Diabetes (2010) 0.90
Addition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases IGF-I bioactivity similarly. Diabetologia (2012) 0.88
Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects. J Clin Endocrinol Metab (2009) 0.86
Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability. EMBO Mol Med (2016) 0.85
Effect of hyperinsulinemia during hemodialysis on the insulin-like growth factor system and inflammatory biomarkers: a randomized open-label crossover study. BMC Nephrol (2013) 0.82
The prevention of diabetic cardiomyopathy by non-mitogenic acidic fibroblast growth factor is probably mediated by the suppression of oxidative stress and damage. PLoS One (2013) 0.81
Bioactive insulin-like growth factors as a possible molecular target for non-islet cell tumor hypoglycemia. Cancer Biol Ther (2014) 0.80
Insulin analogs and cancer: a note of caution. Front Endocrinol (Lausanne) (2014) 0.80
Unbound (bioavailable) IGF1 enhances somatic growth. Dis Model Mech (2011) 0.79
Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency. J Clin Endocrinol Metab (2014) 0.77
In active acromegaly, IGF1 bioactivity is related to soluble Klotho levels and quality of life. Endocr Connect (2014) 0.77
Potency of Full- Length MGF to Induce Maximal Activation of the IGF-I R Is Similar to Recombinant Human IGF-I at High Equimolar Concentrations. PLoS One (2016) 0.76
PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma. Oncotarget (2015) 0.75
Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 Deficiency. J Clin Endocrinol Metab (2016) 0.75
Insulin-like growth factor-I as a candidate metabolic biomarker: military relevance and future directions for measurement. J Diabetes Sci Technol (2009) 0.75
Interferon-β treatment associated with a biochemical profile suggestive of acromegaly. A case report of a patient treated for multiple sclerosis. Scand J Clin Lab Invest (2010) 0.75
Effects of human insulin and insulin aspart preparations on levels of IGF-I, IGFBPs and IGF bioactivity in patients with type 1 diabetes. BMC Endocr Disord (2014) 0.75
Early Pregnancy-Associated Plasma Protein A Concentrations are Associated with Third Trimester Insulin Sensitivity. J Clin Endocrinol Metab (2017) 0.75
One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology. EMBO Mol Med (2017) 0.75
Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest (2002) 3.86
Serum adiponectin predicts all-cause mortality and end stage renal disease in patients with type I diabetes and diabetic nephropathy. Kidney Int (2008) 3.27
Plasma adiponectin, body mass index, and mortality in patients with chronic heart failure. Circulation (2005) 2.81
Structural biology of insulin and IGF1 receptors: implications for drug design. Nat Rev Drug Discov (2002) 2.73
How insulin engages its primary binding site on the insulin receptor. Nature (2013) 2.52
Obesity and cancer risk: the role of the insulin-IGF axis. Trends Endocrinol Metab (2006) 2.52
Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle. Diabetes (2006) 2.24
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol (2006) 2.09
Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab (2003) 1.93
Clinical and epidemiological description of aortic dissection in Turner's syndrome. Cardiol Young (2006) 1.86
Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion. Am J Physiol Endocrinol Metab (2010) 1.82
AMP-activated protein kinase and the regulation of glucose transport. Am J Physiol Endocrinol Metab (2006) 1.80
Weight loss increases circulating levels of ghrelin in human obesity. Clin Endocrinol (Oxf) (2002) 1.76
GrowthHormone Research Society workshop summary: consensus guidelines for recombinant human growth hormone therapy in Prader-Willi syndrome. J Clin Endocrinol Metab (2013) 1.74
Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Horm IGF Res (2008) 1.72
Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes (2005) 1.71
Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome. Diabetes (2002) 1.69
Low IGF-I and elevated testosterone during puberty in subjects with type 1 diabetes developing microalbuminuria in comparison to normoalbuminuric control subjects: the Oxford Regional Prospective Study. Diabetes Care (2003) 1.68
Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects. Eur Heart J (2007) 1.63
Leptin, not adiponectin, predicts hypertension in the Copenhagen City Heart Study. Am J Hypertens (2009) 1.61
Adiponectin and lipoprotein particle size. Diabetes Care (2009) 1.60
Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling. Diabetes (2008) 1.59
The metabolic syndrome is frequent in Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism. Diabetes Care (2006) 1.52
Hypoglycemia due to paraneoplastic secretion of insulin-like growth factor-I in a patient with metastasizing large-cell carcinoma of the lung. J Clin Endocrinol Metab (2007) 1.49
Human growth hormone responses to repeated bouts of sprint exercise with different recovery periods between bouts. J Appl Physiol (1985) (2005) 1.45
Continuous glucose monitoring in interstitial subcutaneous adipose tissue and skeletal muscle reflects excursions in cerebral cortex. Diabetes (2005) 1.44
Osteoprotegerin predicts long-term outcome in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. Cardiology (2012) 1.44
OPPORTUNITY™: a large-scale randomized clinical trial of growth hormone in hemodialysis patients. Nephrol Dial Transplant (2011) 1.44
Optimizing insulin secretagogue therapy in patients with type 2 diabetes: a randomized double-blind study with repaglinide. Diabetes Care (2002) 1.38
Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists. Proc Natl Acad Sci U S A (2010) 1.36
Serum adiponectin is increased in type 1 diabetic patients with nephropathy. Diabetes Care (2005) 1.35
Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation. Mol Syst Biol (2009) 1.33
Effects of exercise training on subcutaneous and visceral adipose tissue in normal- and high-fat diet-fed rats. Am J Physiol Endocrinol Metab (2009) 1.31
Cardiovascular disease and insulin-like growth factor I. Circulation (2002) 1.30
Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5. Mol Endocrinol (2006) 1.29
Impact of exercise training on insulin sensitivity, physical fitness, and muscle oxidative capacity in first-degree relatives of type 2 diabetic patients. Am J Physiol Endocrinol Metab (2005) 1.29
Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice. Diabetes (2008) 1.25
Insulin-like growth factor I (IGF-I) replacement therapy increases albumin concentration in liver cirrhosis: results of a pilot randomized controlled clinical trial. J Hepatol (2005) 1.23
Overexpression of hyaluronan in the tunica media promotes the development of atherosclerosis. Circ Res (2005) 1.23
Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J (2008) 1.23
Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue. J Clin Endocrinol Metab (2011) 1.23
Elevated levels of mannan-binding lectin in patients with type 1 diabetes. J Clin Endocrinol Metab (2003) 1.18
Plasma adiponectin in patients with active, early, and chronic rheumatoid arthritis who are steroid- and disease-modifying antirheumatic drug-naive compared with patients with osteoarthritis and controls. J Rheumatol (2009) 1.18
Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. J Clin Endocrinol Metab (2004) 1.17
Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles. J Appl Physiol (1985) (2002) 1.16
Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains. J Biol Chem (2009) 1.16
How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor. J Mol Biol (2004) 1.15
Ghrelin and its relationship to growth hormones during normal pregnancy. Clin Endocrinol (Oxf) (2005) 1.15
AICAR stimulates adiponectin and inhibits cytokines in adipose tissue. Biochem Biophys Res Commun (2004) 1.14
Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women. J Appl Physiol (1985) (2008) 1.13
Role of histone and transcription factor acetylation in diabetes pathogenesis. Diabetes Metab Res Rev (2005) 1.13
Nocturnal hypertension and impaired sympathovagal tone in Turner syndrome. J Hypertens (2006) 1.13
Gender differences of oligomers and total adiponectin during puberty: a cross-sectional study of 859 Danish school children. J Clin Endocrinol Metab (2007) 1.12
Elevated levels of high-molecular-weight adiponectin in type 1 diabetes. J Clin Endocrinol Metab (2008) 1.12
Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin. Crit Care (2009) 1.10
Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle. Biochem J (2010) 1.10
Reference intervals for insulin-like growth factor-1 (igf-i) from birth to senescence: results from a multicenter study using a new automated chemiluminescence IGF-I immunoassay conforming to recent international recommendations. J Clin Endocrinol Metab (2014) 1.09
Constant intravenous ghrelin infusion in healthy young men: clinical pharmacokinetics and metabolic effects. Am J Physiol Endocrinol Metab (2007) 1.08
Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. PLoS One (2011) 1.07
Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor. Biochemistry (2004) 1.07
Insulin fibrillation and protein design: topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir. J Diabetes Sci Technol (2012) 1.07
High-affinity insulin binding: insulin interacts with two receptor ligand binding sites. Biochemistry (2008) 1.07
Gene expression in skeletal muscle biopsies from people with type 2 diabetes and relatives: differential regulation of insulin signaling pathways. PLoS One (2009) 1.07
CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle. Am J Physiol Endocrinol Metab (2010) 1.05
Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes. Diabetes Care (2008) 1.04
Plasma adiponectin levels in relation to carotid intima media thickness and markers of insulin resistance. Arterioscler Thromb Vasc Biol (2006) 1.03
Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins. J Biol Chem (2009) 1.02
Resveratrol in metabolic health: an overview of the current evidence and perspectives. Ann N Y Acad Sci (2013) 1.01
Sex-discordant associations with adiponectin levels and lipid profiles in children. Diabetes (2006) 1.00
Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24 hours after administration. Basic Clin Pharmacol Toxicol (2008) 0.99
GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus. Am J Physiol Endocrinol Metab (2006) 0.99
Serum adiponectin in elderly men does not correlate with fracture risk. J Clin Endocrinol Metab (2008) 0.99
The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Project: rationale and planned nationwide studies of genetic predictors, physical exercise, and individualized pharmacological treatment. Clin Epidemiol (2012) 0.99
SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress. PLoS One (2009) 0.99
The role of insulin-like growth factor (IGF) binding protein-2 in the insulin-mediated decrease in IGF-I bioactivity. J Clin Endocrinol Metab (2009) 0.98
Effects of cortisol on carbohydrate, lipid, and protein metabolism: studies of acute cortisol withdrawal in adrenocortical failure. J Clin Endocrinol Metab (2007) 0.98
Normal values of circulating insulin-like growth factor-I bioactivity in the healthy population: comparison with five widely used IGF-I immunoassays. J Clin Endocrinol Metab (2008) 0.98
Early elective insulin therapy can reduce hyperglycemia and increase insulin-like growth factor-I levels in very low birth weight infants. J Pediatr (2007) 0.98
Elevated circulating adiponectin in type 1 diabetes is associated with long diabetes duration. Clin Endocrinol (Oxf) (2006) 0.98
LKB1 regulates lipid oxidation during exercise independently of AMPK. Diabetes (2013) 0.98
Growth hormone replacement therapy for adults: into the new millennium. Growth Horm IGF Res (2002) 0.97
Growth hormone signaling in vivo in human muscle and adipose tissue: impact of insulin, substrate background, and growth hormone receptor blockade. J Clin Endocrinol Metab (2008) 0.97
Adiponectin and risk of congestive heart failure. JAMA (2006) 0.96
Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes. J Clin Endocrinol Metab (2012) 0.96