Published in J Diabetes Complications on March 04, 2003
Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus (2009) 1.84
Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine. Psychopharmacology (Berl) (2009) 1.27
Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala. Mol Psychiatry (2011) 1.11
Mood, food, and obesity. Front Psychol (2014) 1.07
Neurobehavioral deficits in db/db diabetic mice. Physiol Behav (2010) 1.04
The role of leptin in the control of insulin-glucose axis. Front Neurosci (2013) 1.00
Metabolic disturbances connecting obesity and depression. Front Neurosci (2013) 0.95
Leptin-deficient mice retain normal appetitive spatial learning yet exhibit marked increases in anxiety-related behaviours. Psychopharmacology (Berl) (2010) 0.90
Diabetes as a chronic metabolic stressor: causes, consequences and clinical complications. Exp Neurol (2011) 0.90
Responses to drugs of abuse and non-drug rewards in leptin deficient ob/ob mice. Psychopharmacology (Berl) (2016) 0.83
Controversies about a common etiology for eating and mood disorders. Front Psychol (2014) 0.81
Leptin/LepRb in the Ventral Tegmental Area Mediates Anxiety-Related Behaviors. Int J Neuropsychopharmacol (2015) 0.78
The impact of leptin on perinatal development and psychopathology. J Chem Neuroanat (2014) 0.76
Relationship between affective symptoms and malnutrition severity in severe Anorexia Nervosa. PLoS One (2012) 0.75
The frequency of hippocampal theta rhythm is modulated on a circadian period and is entrained by food availability. Front Behav Neurosci (2015) 0.75
Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer's Disease. Front Aging Neurosci (2017) 0.75
Insulin resistance in Alzheimer's disease. Transl Res (2016) 0.75
The Molecular Mechanism of Glucagon-Like Peptide-1 Therapy in Alzheimer's Disease, Based on a Mechanistic Target of Rapamycin Pathway. CNS Drugs (2017) 0.75
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest (2006) 12.32
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet (2008) 9.39
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab (2006) 3.34
Neuroepithelial cells supply an initial transient wave of MSC differentiation. Cell (2007) 3.26
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest (2008) 3.25
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet (2010) 2.81
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat Med (2004) 2.51
Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem (2005) 2.45
Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc (2011) 2.34
Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes. Diabetes (2002) 2.28
PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest (2003) 2.23
Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med (2005) 2.18
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem (2004) 2.15
Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology (2003) 2.14
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab (2009) 2.13
Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass. Nat Genet (2006) 2.05
Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology (2011) 1.92
Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J Clin Endocrinol Metab (2008) 1.91
Status of c-erbB-2 in gastric adenocarcinoma: a comparative study of immunohistochemistry, fluorescence in situ hybridization and enzyme-linked immuno-sorbent assay. Int J Cancer (2002) 1.80
Alpha-lipoic acid and insulin autoimmune syndrome. Diabetes Care (2007) 1.74
Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver. J Clin Invest (2002) 1.65
Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy. Int J Cancer (2005) 1.65
Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol (2003) 1.62
The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells. Nat Immunol (2009) 1.55
Anorexia in hemodialysis patients: the possible role of des-acyl ghrelin. Am J Nephrol (2007) 1.53
Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Lett (2008) 1.51
Impact of Helicobacter pylori eradication on circulating adiponectin in humans. Helicobacter (2012) 1.50
Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. J Clin Invest (2011) 1.50
Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization. J Clin Invest (2005) 1.49
Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. Cell Metab (2011) 1.49
Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice. Mol Cell Biol (2008) 1.46
Standardized endoscopic reporting. J Gastroenterol Hepatol (2014) 1.46
Skp2 controls adipocyte proliferation during the development of obesity. J Biol Chem (2006) 1.41
High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases. Clin Cancer Res (2004) 1.41
Therapy insight: Cancer anorexia-cachexia syndrome--when all you can eat is yourself. Nat Clin Pract Oncol (2005) 1.41
Isolation of novel mouse genes that were differentially expressed in W/W(V) mouse fundus. J Gastroenterol (2004) 1.39
Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. J Hum Genet (2009) 1.38
Ghrelin gene products and the regulation of food intake and gut motility. Pharmacol Rev (2009) 1.38
Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology (2005) 1.32
Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects. Clin Pharmacol Ther (2002) 1.30
Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1. J Biol Chem (2002) 1.30
Primary levofloxacin resistance and gyrA/B mutations among Helicobacter pylori in Japan. Helicobacter (2006) 1.28
Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation. Nat Med (2008) 1.27
Is obesity an inflammatory disease? Surgery (2003) 1.26
Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia. Endocrinology (2007) 1.25
A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum Mol Genet (2004) 1.24
Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile. Endocrinology (2007) 1.23
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Hum Mol Genet (2012) 1.23
Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects. Biol Pharm Bull (2002) 1.23
Requirement of fibroblast growth factor 10 in development of white adipose tissue. Genes Dev (2002) 1.21
Cancer cachexia--pathophysiology and management. J Gastroenterol (2013) 1.20
Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. J Hum Genet (2007) 1.19
Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats. Am J Physiol Regul Integr Comp Physiol (2007) 1.18
Neural control of the anorexia-cachexia syndrome. Am J Physiol Endocrinol Metab (2008) 1.18
Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice. Peptides (2009) 1.15
Cancer anorexia-cachexia syndrome: cytokines and neuropeptides. Curr Opin Clin Nutr Metab Care (2004) 1.15
Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabetic mice: a possible role of oxidative stress. Bone (2006) 1.14
Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action. Diabetes (2010) 1.14
A feature-segmentation model of short-term visual memory. Perception (2002) 1.14
An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice. Endocrinology (2010) 1.13
Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J Clin Invest (2009) 1.13
PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. J Clin Invest (2005) 1.12
Anorexia in space and possible etiologies: an overview. Nutrition (2002) 1.11
Effects of pioglitazone and metformin on intracellular lipid content in liver and skeletal muscle of individuals with type 2 diabetes mellitus. Metabolism (2007) 1.11
Favorable genetic polymorphisms predictive of clinical outcome of chemoradiotherapy for stage II/III esophageal squamous cell carcinoma in Japanese. Am J Clin Oncol (2007) 1.10
Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation. Diabetes (2011) 1.10
Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects. Diabetes (2006) 1.09
Identification and characterization of an alternative promoter of the human PGC-1alpha gene. Biochem Biophys Res Commun (2009) 1.09
RBP4, an unexpected adipokine. Nat Med (2006) 1.09
Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin. Biol Psychiatry (2008) 1.09
Novel pathogenic mutations and copy number variations in the VPS13A gene in patients with chorea-acanthocytosis. Am J Med Genet B Neuropsychiatr Genet (2011) 1.08
Evidence-based clinical practice guidelines for functional dyspepsia. J Gastroenterol (2015) 1.08
Role of S6K1 in regulation of SREBP1c expression in the liver. Biochem Biophys Res Commun (2011) 1.07
Experimental studies on the role of fructose in the development of diabetic complications. Kobe J Med Sci (2002) 1.07
CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis. Nat Med (2012) 1.06
PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am J Physiol Endocrinol Metab (2010) 1.06
Spatiochromatic receptive field properties derived from information-theoretic analyses of cone mosaic responses to natural scenes. Neural Comput (2003) 1.05
Role of Krüppel-like factor 15 in PEPCK gene expression in the liver. Biochem Biophys Res Commun (2005) 1.05
L-Serine, D- and L-proline and alanine as respiratory substrates of Helicobacter pylori: correlation between in vitro and in vivo amino acid levels. Microbiology (2003) 1.04
BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms. Int J Cancer (2005) 1.04
Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice. Peptides (2006) 1.03
Synergistic effects of Y2 and Y4 receptors on adiposity and bone mass revealed in double knockout mice. Mol Cell Biol (2003) 1.03
Neurobiologic changes in the hypothalamus associated with weight loss after gastric bypass. J Am Coll Surg (2004) 1.02
Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. Am J Hum Genet (2010) 1.01
Association of VEGF genotype with mRNA level in colorectal adenocarcinomas. Biochem Biophys Res Commun (2004) 1.01
Role of Akt in growth and survival of PANC-1 pancreatic cancer cells. Pancreas (2002) 1.01
Plasma obestatin concentrations are negatively correlated with body mass index, insulin resistance index, and plasma leptin concentrations in obesity and anorexia nervosa. Biol Psychiatry (2007) 1.01
MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer. Drug Metab Pharmacokinet (2006) 1.00
Analysis of factors affecting increase in bone mineral density at lumbar spine by bisphosphonate treatment in postmenopausal osteoporosis. J Bone Miner Metab (2008) 1.00
The role of leptin in the control of insulin-glucose axis. Front Neurosci (2013) 1.00
Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy. Endocrinology (2004) 0.99
Different contribution of CYP2C19 in the in vitro metabolism of three proton pump inhibitors. Biol Pharm Bull (2003) 0.99
A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance. Biochem Biophys Res Commun (2004) 0.99
Cortical involvement for action imitation of hand/arm postures versus finger configurations: an fMRI study. Neuroreport (2002) 0.99