Molecular interactions mediating T cell antigen recognition.

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med (2009) 4.68

Checkpoint blockade in cancer immunotherapy. Adv Immunol (2006) 4.09

A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PLoS Comput Biol (2008) 3.71

Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. J Exp Med (2005) 3.63

The design and implementation of the immune epitope database and analysis resource. Immunogenetics (2005) 3.00

Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions. J Immunol (2008) 2.54

Structural and kinetic basis for heightened immunogenicity of T cell vaccines. J Exp Med (2005) 2.22

A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. Immunity (2011) 2.11

An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells. Blood (2011) 2.10

T cell cross-reactivity and conformational changes during TCR engagement. J Exp Med (2004) 1.99

Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. EMBO J (2005) 1.98

Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells. Immunity (2013) 1.95

Display technologies: application for the discovery of drug and gene delivery agents. Adv Drug Deliv Rev (2006) 1.92

Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. J Biol Chem (2005) 1.92

Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat Immunol (2014) 1.91

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol (2005) 1.85

T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes. J Exp Med (2005) 1.69

HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor. J Exp Med (2004) 1.60

Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity. PLoS Biol (2008) 1.57

Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. Proc Natl Acad Sci U S A (2009) 1.57

VLR-based adaptive immunity. Annu Rev Immunol (2012) 1.56

Functional classification of immune regulatory proteins. Structure (2013) 1.49

Class II major histocompatibility complex tetramer staining: progress, problems, and prospects. Immunology (2008) 1.47

CD8 kinetically promotes ligand binding to the T-cell antigen receptor. Biophys J (2005) 1.38

Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3. Proc Natl Acad Sci U S A (2004) 1.38

Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs). Proc Natl Acad Sci U S A (2006) 1.35

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor. Nature (2010) 1.35

Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors. J Exp Med (2006) 1.32

TCR recognition of peptide/MHC class II complexes and superantigens. Semin Immunol (2007) 1.30

Structural and biophysical determinants of αβ T-cell antigen recognition. Immunology (2012) 1.30

The receptor deformation model of TCR triggering. FASEB J (2007) 1.27

Interferon γ limits the effectiveness of melanoma peptide vaccines. Blood (2010) 1.26

Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma. J Clin Invest (2005) 1.24

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region. Eur J Immunol (2007) 1.24

γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response. Immunity (2012) 1.22

The impact of TCR-binding properties and antigen presentation format on T cell responsiveness. J Immunol (2009) 1.20

The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. J Cell Biol (2009) 1.20

A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey. Proc Natl Acad Sci U S A (2010) 1.20

Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathog (2010) 1.18

New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation. J Immunol (2009) 1.18

Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection. EMBO J (2011) 1.17

Selective ligand recognition by a diversity-generating retroelement variable protein. PLoS Biol (2008) 1.17

Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions. Proc Natl Acad Sci U S A (2006) 1.16

Different cell surface oligomeric states of B7-1 and B7-2: implications for signaling. Proc Natl Acad Sci U S A (2005) 1.15

Attenuated T cell responses to a high-potency ligand in vivo. PLoS Biol (2010) 1.15

Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction. Proc Natl Acad Sci U S A (2006) 1.12

T cell receptor-ligand interactions: a conformational preequilibrium or an induced fit. Proc Natl Acad Sci U S A (2004) 1.10

Recognition of self-peptide-MHC complexes by autoimmune T-cell receptors. Trends Biochem Sci (2007) 1.07

T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J Exp Med (2007) 1.06

Potent T cell agonism mediated by a very rapid TCR/pMHC interaction. Eur J Immunol (2007) 1.06

High throughput T epitope mapping and vaccine development. J Biomed Biotechnol (2010) 1.04

Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin. Genes Immun (2010) 1.04

Engineering higher affinity T cell receptors using a T cell display system. J Immunol Methods (2008) 1.00

Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases. Alzheimers Res Ther (2009) 1.00

Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells. Proc Natl Acad Sci U S A (2008) 0.99

Kinetic evidence for a ligand-binding-induced conformational transition in the T cell receptor. Proc Natl Acad Sci U S A (2007) 0.98

Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors. Protein Eng Des Sel (2010) 0.98

A coupled diffusion-kinetics model for analysis of contact-area FRAP experiment. Biophys J (2008) 0.97

A conserved hydrophobic patch on Vβ domains revealed by TCRβ chain crystal structures: Implications for pre-TCR dimerization. Front Immunol (2011) 0.97

Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease. J Exp Med (2013) 0.95

Distinct sets of alphabeta TCRs confer similar recognition of tumor antigen NY-ESO-1157-165 by interacting with its central Met/Trp residues. Proc Natl Acad Sci U S A (2008) 0.94

The molecular determinants of CD8 co-receptor function. Immunology (2012) 0.94

T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions. J Biol Chem (2013) 0.93

Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation. J Biol Chem (2009) 0.93

Mitochondria are gate-keepers of T cell function by producing the ATP that drives purinergic signaling. J Biol Chem (2014) 0.93

Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters. Biophys J (2008) 0.93

New assay to detect low-affinity interactions and characterization of leukocyte receptors for collagen including leukocyte-associated Ig-like receptor-1 (LAIR-1). Eur J Immunol (2009) 0.92

T cell sensitivity and the outcome of viral infection. Clin Exp Immunol (2009) 0.92

Sculpting the immunological response to dengue fever by polytopic vaccination. Vaccine (2005) 0.92

Force measurements of TCR/pMHC recognition at T cell surface. PLoS One (2011) 0.91

Cannabinoid CB2 receptors contribute to upregulation of β-endorphin in inflamed skin tissues by electroacupuncture. Mol Pain (2011) 0.91

CD28 Costimulation: From Mechanism to Therapy. Immunity (2016) 0.90

Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition. Proc Natl Acad Sci U S A (2009) 0.89

Isolation and partial purification of macrophage- and dendritic cell-activating components from Mycoplasma arthritidis: association with organism virulence and involvement with Toll-like receptor 2. Infect Immun (2005) 0.89

T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity. Int Rev Immunol (2006) 0.88

Novel p65 binding glucocorticoid-induced leucine zipper peptide suppresses experimental autoimmune encephalomyelitis. J Biol Chem (2011) 0.88

Low 2-dimensional CD4 T cell receptor affinity for myelin sets in motion delayed response kinetics. PLoS One (2012) 0.88

Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors. Cancer Immunol Immunother (2012) 0.88

Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens. Clin Exp Immunol (2005) 0.88

Weak self-association in a carbohydrate system. Biophys J (2007) 0.87

High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics. Mol Immunol (2010) 0.87

The HLA system: genetics, immunology, clinical testing, and clinical implications. Yonsei Med J (2007) 0.86

Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering. J Biol Chem (2010) 0.86

L-selectin-mediated leukocyte tethering in shear flow is controlled by multiple contacts and cytoskeletal anchorage facilitating fast rebinding events. Proc Natl Acad Sci U S A (2004) 0.86

Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex. Proc Natl Acad Sci U S A (2011) 0.86

Mechanical modulation of receptor-ligand interactions at cell-cell interfaces. Biophys J (2012) 0.86

Engineering improved T cell receptors using an alanine-scan guided T cell display selection system. J Immunol Methods (2013) 0.85

TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential. J Immunol (2014) 0.84

Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough. Front Immunol (2013) 0.84

TCR Signaling in T Cell Memory. Front Immunol (2015) 0.84

Conformationally constrained peptides from CD2 to modulate protein-protein interactions between CD2 and CD58. J Med Chem (2011) 0.83

Structural basis for the restoration of TCR recognition of an MHC allelic variant by peptide secondary anchor substitution. J Exp Med (2004) 0.83

Bi-specific MHC heterodimers for characterization of cross-reactive T cells. J Biol Chem (2010) 0.83

Mechanical force in T cell receptor signal initiation. Front Immunol (2012) 0.83

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC. J Exp Med (2013) 0.83

Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation. J Immunol (2010) 0.82

Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells. Proc Natl Acad Sci U S A (2014) 0.82

γδ T cell surveillance via CD1 molecules. Trends Immunol (2014) 0.82

A peptide from the beta-strand region of CD2 protein that inhibits cell adhesion and suppresses arthritis in a mouse model. Chem Biol Drug Des (2010) 0.81

Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβ TCR Recognition during T Lineage Subset Commitment. Front Immunol (2013) 0.80

A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer. Nat Methods (2006) 4.54

SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood (2007) 2.95

Crystal structure of a soluble CD28-Fab complex. Nat Immunol (2005) 2.46

The interaction properties of costimulatory molecules revisited. Immunity (2002) 2.43

Glycoprotein structural genomics: solving the glycosylation problem. Structure (2007) 2.40

Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists. J Exp Med (2003) 1.70

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D. Nat Struct Biol (2003) 1.68

Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism. Science (2007) 1.64

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. J Exp Med (2013) 1.48

Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells. Proc Natl Acad Sci U S A (2007) 1.44

DySCo: quantitating associations of membrane proteins using two-color single-molecule tracking. Biophys J (2009) 1.30

Structure and interactions of the human programmed cell death 1 receptor. J Biol Chem (2013) 1.27

Deep analysis of cellular transcriptomes - LongSAGE versus classic MPSS. BMC Genomics (2007) 1.21

Inhibition of hybrid- and complex-type glycosylation reveals the presence of the GlcNAc transferase I-independent fucosylation pathway. Glycobiology (2006) 1.18

Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans. Nat Immunol (2007) 1.14

An early HIV mutation within an HLA-B*57-restricted T cell epitope abrogates binding to the killer inhibitory receptor 3DL1. J Virol (2011) 1.13

The T cell surface--how well do we know it? Immunity (2003) 1.01

The platelet receptor CLEC-2 is active as a dimer. Biochemistry (2009) 1.00

O-glycan sialylation and the structure of the stalk-like region of the T cell co-receptor CD8. J Biol Chem (2003) 1.00

Immunology. The immunological synapse--a multitasking system. Science (2002) 0.98

What controls T cell receptor phosphorylation? Cell (2010) 0.98

The T cell receptor triggering apparatus is composed of monovalent or monomeric proteins. J Biol Chem (2011) 0.97

A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus. J Biol Chem (2009) 0.96

Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48. J Biol Chem (2006) 0.93

CD6 attenuates early and late signaling events, setting thresholds for T-cell activation. Eur J Immunol (2011) 0.93

Unraveling receptor stoichiometry using bret. Front Endocrinol (Lausanne) (2012) 0.92

Taking T cells beyond the diffraction limit. Nat Immunol (2010) 0.91

A theoretical framework for quantitative analysis of the molecular basis of costimulation. J Immunol (2005) 0.89

Comparison of the N-linked glycans from soluble and GPI-anchored CD59 expressed in CHO cells. Glycobiology (2002) 0.87

T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements. J Biol Chem (2012) 0.87

Ferroportin: lack of evidence for multimers. Blood Cells Mol Dis (2007) 0.87

Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering. J Biol Chem (2010) 0.86

Domain metastability: a molecular basis for immunoglobulin deposition? J Mol Biol (2010) 0.85

A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase. J Biol Chem (2011) 0.84

Late arrival: recruiting coreceptors to the T cell receptor complex. Immunity (2011) 0.84

Imaging and characterisation of the surface of live cells. Curr Opin Chem Biol (2011) 0.84

Disruption of alpha-mannosidase processing induces non-canonical hybrid-type glycosylation. FEBS Lett (2007) 0.83

A quantitative comparison of single-dye tracking analysis tools using Monte Carlo simulations. PLoS One (2013) 0.83

TCR triggering: co-receptor-dependent or -independent? Trends Immunol (2003) 0.82

Super-Resolved Traction Force Microscopy (STFM). Nano Lett (2016) 0.81

Molecular cloning and analysis of SSc5D, a new member of the scavenger receptor cysteine-rich superfamily. Mol Immunol (2009) 0.81

IL-2 and IL-15 signaling complexes: different but the same. Nat Immunol (2012) 0.80

Analysis of variable N-glycosylation site occupancy in glycoproteins by liquid chromatography electrospray ionization mass spectrometry. Anal Biochem (2006) 0.79

Differential remodeling of a T-cell transcriptome following CD8- versus CD3-induced signaling. Cell Res (2008) 0.77

The contribution of conformational adjustments and long-range electrostatic forces to the CD2/CD58 interaction. J Biol Chem (2007) 0.77

Quantitative analysis predicts the relative therapeutic efficacy of different forms of CTLA4Ig. Mol Immunol (2011) 0.77

Imaging the cell surface and its organization down to the level of single molecules. Philos Trans R Soc Lond B Biol Sci (2012) 0.77

A streamlined implementation of the glutamine synthetase-based protein expression system. BMC Biotechnol (2013) 0.76

Use of the α-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.76

On the Control of TCR Phosphorylation. Front Immunol (2012) 0.75

Transcriptome-based identification of candidate membrane proteins. Methods Mol Biol (2009) 0.75

Glycan Remodeling with Processing Inhibitors and Lectin-Resistant Eukaryotic Cells. Methods Mol Biol (2015) 0.75