Published in Lipids on December 01, 2002
Functional characterization and localization of Pneumocystis carinii lanosterol synthase. Eukaryot Cell (2009) 0.79
Has the name really been changed? It has for most researchers. Clin Infect Dis (2005) 2.67
CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. J Biol Chem (2005) 1.83
Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. Chem Biol (2007) 1.82
Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J Biol Chem (2009) 1.60
CYP51 from Trypanosoma brucei is obtusifoliol-specific. Biochemistry (2004) 1.45
Pneumocystis and Trypanosoma cruzi: nomenclature and typifications. J Eukaryot Microbiol (2006) 1.34
Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) from Leishmania infantum. J Biol Chem (2011) 1.29
Early acquisition of Pneumocystis carinii in neonatal rats as evidenced by PCR and oral swabs. Eukaryot Cell (2002) 1.27
Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection. PLoS One (2010) 1.26
Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother (2010) 1.26
Phylogenomic analyses support the monophyly of Taphrinomycotina, including Schizosaccharomyces fission yeasts. Mol Biol Evol (2008) 1.20
CYP51: A major drug target in the cytochrome P450 superfamily. Lipids (2008) 1.19
Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. Antimicrob Agents Chemother (2010) 1.12
Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs. Mol Microbiol (2009) 1.11
Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase. J Med Chem (2009) 1.08
Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei. J Lipid Res (2006) 1.08
Pneumocystis: not just pneumonia. Curr Opin Microbiol (2005) 1.05
Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Delta7-24, 25-dihydrolanosterol. J Lipid Res (2011) 1.04
Diversity at the locus associated with transcription of a variable surface antigen of Pneumocystis carinii as an index of population structure and dynamics in infected rats. Infect Immun (2003) 1.04
Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals. Appl Environ Microbiol (2010) 1.04
Gene arrays at Pneumocystis carinii telomeres. Genetics (2005) 1.02
Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei. J Biol Chem (2006) 1.00
Draft assembly and annotation of the Pneumocystis carinii genome. J Eukaryot Microbiol (2006) 0.99
Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds. Antimicrob Agents Chemother (2004) 0.99
Phylogenetic identification of Pneumocystis murina sp. nov., a new species in laboratory mice. Microbiology (2004) 0.99
Biofilm formation by Pneumocystis spp. Eukaryot Cell (2008) 0.96
Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. Bioorg Med Chem Lett (2007) 0.96
Sequence and structure of the linear mitochondrial genome of Pneumocystis carinii. Mol Genet Genomics (2009) 0.96
Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity. Bioorg Med Chem Lett (2009) 0.95
Sterol biosynthesis inhibitors: potential for transition state analogs and mechanism-based inactivators targeted at sterol methyltransferase. Lipids (2007) 0.93
Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia. Bioorg Med Chem Lett (2004) 0.92
Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis. Biochim Biophys Acta (2010) 0.92
Sterol biosynthesis and sterol uptake in the fungal pathogen Pneumocystis carinii. FEMS Microbiol Lett (2010) 0.90
Evolutionarily conserved Delta(25(27))-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii. J Lipid Res (2012) 0.89
The 12th International Workshops on Opportunistic Protists (IWOP-12). J Eukaryot Microbiol (2013) 0.89
Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms. Biochem J (2012) 0.88
Analysis of current antifungal agents and their targets within the Pneumocystis carinii genome. Curr Drug Targets (2012) 0.87
Pneumocystis murina MSG gene family and the structure of the locus associated with its transcription. Fungal Genet Biol (2007) 0.86
Cloning, functional expression and phylogenetic analysis of plant sterol 24C-methyltransferases involved in sitosterol biosynthesis. Phytochemistry (2009) 0.86
Mapping by sequencing the Pneumocystis genome using the ordering DNA sequences V3 tool. Genetics (2003) 0.85
Comparative genomics of pneumocystis species suggests the absence of genes for myo-inositol synthesis and reliance on inositol transport and metabolism. MBio (2014) 0.85
Noninvasive method for monitoring Pneumocystis carinii pneumonia. Emerg Infect Dis (2003) 0.84
Susceptibility of Pneumocystis to echinocandins in suspension and biofilm cultures. Antimicrob Agents Chemother (2011) 0.84
Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities. J Med Chem (2004) 0.83
Molecular characterization and functional analysis of Glycine max sterol methyl transferase 2 genes involved in plant membrane sterol biosynthesis. Plant Mol Biol (2010) 0.83
Therapeutic potential of caspofungin combined with trimethoprim-sulfamethoxazole for pneumocystis pneumonia: a pilot study in mice. PLoS One (2013) 0.82
Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumonia. Infect Immun (2013) 0.82
Fine analysis of the Pneumocystis carinii f. sp. carinii genome by two-dimensional pulsed-field gel electrophoresis. Gene (2002) 0.82
Pneumocystis workshop: 10th anniversary summary. Eukaryot Cell (2009) 0.81
Competitive coexistence of two Pneumocystis species. Infect Genet Evol (2005) 0.81
Sterol C24-methyltransferase: mechanistic studies of the C-methylation reaction with 24-fluorocycloartenol. Bioorg Med Chem Lett (2007) 0.80
Analogs of pentamidine as potential anti-Pneumocystis chemotherapeutics. Eur J Med Chem (2011) 0.80
Effect of substrate features and mutagenesis of active site tyrosine residues on the reaction course catalysed by Trypanosoma brucei sterol C-24-methyltransferase. Biochem J (2011) 0.80
Microaerophilic conditions increase viability and affect responses of Pneumocystis carinii to drugs in vitro. J Eukaryot Microbiol (2006) 0.80
Imidazoquines as antimalarial and antipneumocystis agents. J Med Chem (2009) 0.80
Novel bisbenzimidazoles with antileishmanial effectiveness. Bioorg Med Chem Lett (2008) 0.80
Mechanism-based active site modification of the soybean sterol methyltransferase by 26,27-dehydrocycloartenol. Bioorg Med Chem Lett (2004) 0.80
Generation of sequencing libraries for the Pneumocystis Genome project. J Eukaryot Microbiol (2003) 0.79
Sterol methyltransferase2: purification, properties, and inhibition. Arch Biochem Biophys (2003) 0.79
Functional characterization and localization of Pneumocystis carinii lanosterol synthase. Eukaryot Cell (2009) 0.79
Purification, characterization and inhibition of sterol C24-methyltransferase from Candida albicans. Arch Biochem Biophys (2010) 0.79
Molecular probing of the Saccharomyces cerevisiae sterol 24-C methyltransferase reveals multiple amino acid residues involved with C2-transfer activity. Biochim Biophys Acta (2008) 0.79
C-24-methylation of 26-fluorocycloartenols by recombinant sterol C-24-methyltransferase from soybean: evidence for channel switching and its phylogenetic implications. Biochem J (2013) 0.78
Sterol C24-methyltransferase: Physio- and stereo-chemical features of the sterol C3 group required for catalytic competence. Arch Biochem Biophys (2012) 0.77
Cyclobranol: a substrate for C25-methyl sterol side chains and potent mechanism-based inactivator of plant sterol methyltransferase. Bioorg Med Chem Lett (2008) 0.77
Inactivation of soybean sterol 24-C-methyltransferase by elongated sterol side chains at C26. Bioorg Med Chem Lett (2007) 0.77
Large-scale characterization of introns in the Pneumocystis carinii genome. J Eukaryot Microbiol (2006) 0.76
The state of research for AIDS-associated opportunistic infections and the importance of sustaining smaller research communities. Eukaryot Cell (2011) 0.75
Highlights and summaries of the 11th International Workshops on Opportunistic Protists. J Eukaryot Microbiol (2010) 0.75
Sequence of the mitochondrial genome of Pneumocystis carinii: implications for biological function and identification of potential drug targets. J Eukaryot Microbiol (2006) 0.75
Expression profiling of the responses of Pneumocystis carinii to drug treatment using DNA macroarrays. J Eukaryot Microbiol (2003) 0.75
Mechanism-based enzyme inactivators of phytosterol biosynthesis. Molecules (2004) 0.75
Photoaffinity labeling and mutational analysis of 24-C-sterol methyltransferase defines the AdoMet binding site. Lipids (2008) 0.75
The International Workshops on Opportunistic Protists. J Eukaryot Microbiol (2006) 0.75