Published in Glycobiology on November 01, 2002
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. J Exp Med (2007) 3.27
Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions. EMBO Rep (2006) 2.82
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology. EMBO J (2013) 2.58
A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation. Proc Natl Acad Sci U S A (2003) 2.56
Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family. Glycobiology (2011) 2.56
miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis. Cancer Cell (2011) 2.30
A systematic approach to protein glycosylation analysis: a path through the maze. Nat Chem Biol (2010) 2.30
Probing mucin-type O-linked glycosylation in living animals. Proc Natl Acad Sci U S A (2006) 1.85
COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity. PLoS Genet (2007) 1.79
Regulation of O-glycosylation through Golgi-to-ER relocation of initiation enzymes. J Cell Biol (2010) 1.63
Recent insights into the biological roles of mucin-type O-glycosylation. Glycoconj J (2008) 1.53
Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers. Proc Natl Acad Sci U S A (2009) 1.51
Familial tumoral calcinosis: from characterization of a rare phenotype to the pathogenesis of ectopic calcification. J Invest Dermatol (2009) 1.51
The diversity of O-linked glycans expressed during Drosophila melanogaster development reflects stage- and tissue-specific requirements for cell signaling. J Biol Chem (2008) 1.47
Site mapping and characterization of O-glycan structures on alpha-dystroglycan isolated from rabbit skeletal muscle. J Biol Chem (2010) 1.43
A novel homozygous missense mutation in FGF23 causes Familial Tumoral Calcinosis associated with disseminated visceral calcification. Hum Genet (2005) 1.43
Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Mol Cell Biol (2007) 1.38
Glycosyltransferase function in core 2-type protein O glycosylation. Mol Cell Biol (2009) 1.30
The beginnings of mucin biosynthesis: the crystal structure of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1. Proc Natl Acad Sci U S A (2004) 1.28
Association of single nucleotide polymorphisms in glycosylation genes with risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev (2008) 1.26
Emerging methods for the production of homogeneous human glycoproteins. Nat Chem Biol (2009) 1.26
Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness. Proc Natl Acad Sci U S A (2013) 1.26
Structure and function of beta -1,4-galactosyltransferase. Curr Drug Targets (2008) 1.20
The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection. J Biol Chem (2008) 1.20
UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. Glycobiology (2011) 1.17
CFTR, mucins, and mucus obstruction in cystic fibrosis. Cold Spring Harb Perspect Med (2012) 1.15
Familial tumoral calcinosis and the role of O-glycosylation in the maintenance of phosphate homeostasis. Biochim Biophys Acta (2008) 1.10
Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man. Cell Metab (2011) 1.09
Conservation of peptide acceptor preferences between Drosophila and mammalian polypeptide-GalNAc transferase ortholog pairs. Glycobiology (2008) 1.07
Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin. Neoplasia (2011) 1.07
Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas. Br J Cancer (2013) 1.06
Molecular pathology of the fibroblast growth factor family. Hum Mutat (2009) 1.06
Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. J Biol Chem (2008) 1.05
The role of mucin-type O-glycans in eukaryotic development. Semin Cell Dev Biol (2010) 1.04
A mucin-type O-glycosyltransferase modulates cell adhesion during Drosophila development. J Biol Chem (2008) 1.04
Organization of Golgi glycosyltransferases in membranes: complexity via complexes. J Membr Biol (2004) 1.01
An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand. J Biol Chem (2010) 1.00
Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma. J Histochem Cytochem (2008) 0.99
Lectin domains of polypeptide GalNAc transferases exhibit glycopeptide binding specificity. J Biol Chem (2011) 0.98
Role of the polypeptide N-acetylgalactosaminyltransferase 3 in ovarian cancer progression: possible implications in abnormal mucin O-glycosylation. Oncotarget (2014) 0.98
Enzymatic glycosylation of peptide arrays on gold surfaces. Chembiochem (2008) 0.97
Polypeptide N-acetylgalactosaminyltransferase 6 expression in pancreatic cancer is an independent prognostic factor indicating better overall survival. Br J Cancer (2011) 0.96
Engineering of mucin-type human glycoproteins in yeast cells. Proc Natl Acad Sci U S A (2008) 0.95
Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal. J Biol Chem (2011) 0.95
Biosynthesis of a new UDP-sugar, UDP-2-acetamido-2-deoxyxylose, in the human pathogen Bacillus cereus subspecies cytotoxis NVH 391-98. J Biol Chem (2010) 0.92
Skp1 prolyl 4-hydroxylase of dictyostelium mediates glycosylation-independent and -dependent responses to O2 without affecting Skp1 stability. J Biol Chem (2011) 0.92
GALNT3, a gene associated with hyperphosphatemic familial tumoral calcinosis, is transcriptionally regulated by extracellular phosphate and modulates matrix metalloproteinase activity. Biochim Biophys Acta (2008) 0.92
Deciphering structural elements of mucin glycoprotein recognition. ACS Chem Biol (2012) 0.92
Loss of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 and reduced O-glycosylation in colon carcinoma cells selected for hepatic metastasis. Glycoconj J (2010) 0.92
Decreased expression of hepatocyte nuclear factor 4α (Hnf4α)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity. J Biol Chem (2014) 0.92
Probing polypeptide GalNAc-transferase isoform substrate specificities by in vitro analysis. Glycobiology (2014) 0.91
Identification of Novel Peptidyl Serine α-Galactosyltransferase Gene Family in Plants. J Biol Chem (2014) 0.91
Polypeptide N-acetylgalactosaminyltransferase 2 regulates cellular metastasis-associated behavior in gastric cancer. Int J Mol Med (2012) 0.90
Engineering of N. benthamiana L. plants for production of N-acetylgalactosamine-glycosylated proteins--towards development of a plant-based platform for production of protein therapeutics with mucin type O-glycosylation. BMC Biotechnol (2010) 0.90
Substrate-induced conformational changes and dynamics of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-2. J Mol Biol (2007) 0.88
Multiple members of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family are essential for viability in Drosophila. J Biol Chem (2011) 0.87
Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses. J Biol Chem (2010) 0.86
A heterozygous mutation of GALNTL5 affects male infertility with impairment of sperm motility. Proc Natl Acad Sci U S A (2014) 0.85
Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations. Epigenetics (2014) 0.84
Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus. Biochem J (2004) 0.84
Dissecting the biological role of mucin-type O-glycosylation using RNA interference in Drosophila cell culture. J Biol Chem (2010) 0.84
GALNT2 expression is reduced in patients with Type 2 diabetes: possible role of hyperglycemia. PLoS One (2013) 0.84
Requirement for a core 1 galactosyltransferase in the Drosophila nervous system. Dev Dyn (2008) 0.84
Addition of α-O-GlcNAc to threonine residues define the post-translational modification of mucin-like molecules in Trypanosoma cruzi. Glycoconj J (2013) 0.84
Mutant glycosyltransferases assist in the development of a targeted drug delivery system and contrast agents for MRI. AAPS J (2006) 0.83
Role of resistant starch in improving gut health, adiposity, and insulin resistance. Adv Nutr (2015) 0.83
Strong expression of polypeptide N-acetylgalactosaminyltransferase 3 independently predicts shortened disease-free survival in patients with early stage oral squamous cell carcinoma. Tumour Biol (2015) 0.83
Clinical significance of polypeptide N-acetylgalactosaminyl transferase-5 (GalNAc-T5) expression in patients with gastric cancer. Br J Cancer (2014) 0.83
Multiple site-specific in vitro labeling of single-chain antibody. Bioconjug Chem (2009) 0.83
Molecular analysis of a UDP-GlcNAc:polypeptide alpha-N-acetylglucosaminyltransferase implicated in the initiation of mucin-type O-glycosylation in Trypanosoma cruzi. Glycobiology (2009) 0.83
Expression of the functional recombinant human glycosyltransferase GalNAcT2 in Escherichia coli. Microb Cell Fact (2015) 0.82
Identification of distinct glycoforms of IgA1 in plasma from patients with immunoglobulin A (IgA) nephropathy and healthy individuals. Mol Cell Proteomics (2014) 0.82
Glycan specificity of the Vibrio vulnificus hemolysin lectin outlines evolutionary history of membrane targeting by a toxin family. J Mol Biol (2014) 0.82
Evolutional and clinical implications of the epigenetic regulation of protein glycosylation. Clin Epigenetics (2011) 0.82
Transmembrane mucins as novel therapeutic targets. Expert Rev Endocrinol Metab (2011) 0.82
A sensor of protein O-glycosylation based on sequential processing in the Golgi apparatus. Traffic (2012) 0.81
Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma. Tumour Biol (2015) 0.81
Characterization of an immunodominant cancer-specific O-glycopeptide epitope in murine podoplanin (OTS8). Glycoconj J (2010) 0.81
GALNT2 suppresses malignant phenotypes through IGF-1 receptor and predicts favorable prognosis in neuroblastoma. Oncotarget (2014) 0.81
Glycan analysis of therapeutic glycoproteins. MAbs (2015) 0.81
Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability. EBioMedicine (2016) 0.81
C1GALT1 overexpression promotes the invasive behavior of colon cancer cells through modifying O-glycosylation of FGFR2. Oncotarget (2014) 0.81
A glycogene mutation map for discovery of diseases of glycosylation. Glycobiology (2014) 0.80
Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma. J Hematol Oncol (2016) 0.80
Structure-based evolutionary relationship of glycosyltransferases: a case study of vertebrate β1,4-galactosyltransferase, invertebrate β1,4-N-acetylgalactosaminyltransferase and α-polypeptidyl-N-acetylgalactosaminyltransferase. Curr Opin Struct Biol (2010) 0.80
Syntheses of mucin-type O-glycopeptides and oligosaccharides using transglycosylation and reverse-hydrolysis activities of Bifidobacterium endo-alpha-N-acetylgalactosaminidase. Glycoconj J (2009) 0.80
Detection of differentially expressed wound-healing-related glycogenes in galectin-3-deficient mice. Invest Ophthalmol Vis Sci (2009) 0.80
Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Proc Natl Acad Sci U S A (2016) 0.79
Two protein N-acetylgalactosaminyl transferases regulate synaptic plasticity by activity-dependent regulation of integrin signaling. J Neurosci (2014) 0.79
Sialic Acids on Varicella-Zoster Virus Glycoprotein B Are Required for Cell-Cell Fusion. J Biol Chem (2015) 0.79
Identification of a family of four UDP-polypeptide N-acetylgalactosaminyl transferases in Cryptosporidium species. Mol Biochem Parasitol (2013) 0.79
GalNAc-T14 promotes metastasis through Wnt dependent HOXB9 expression in lung adenocarcinoma. Oncotarget (2015) 0.79
A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis. PLoS One (2012) 0.78
Rescue of Drosophila Melanogaster l(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11. Glycoconj J (2010) 0.78
A computational and experimental study of O-glycosylation. Catalysis by human UDP-GalNAc polypeptide:GalNAc transferase-T2. Org Biomol Chem (2014) 0.78
Polypeptide N-acetylgalactosaminyltransferase-6 expression independently predicts poor overall survival in patients with lung adenocarcinoma after curative resection. Oncotarget (2016) 0.78
Glycophenotypic alterations induced by Pteridium aquilinum in mice gastric mucosa: synergistic effect with Helicobacter pylori infection. PLoS One (2012) 0.78
The cellular microenvironment and cell adhesion: a role for O-glycosylation. Biochem Soc Trans (2011) 0.78
A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts. PLoS Comput Biol (2016) 0.77
O-linked glycosylation of the mucin domain of the herpes simplex virus type 1-specific glycoprotein gC-1 is temporally regulated in a seed-and-spread manner. J Biol Chem (2014) 0.77
Policy: NIH plans to enhance reproducibility. Nature (2014) 15.71
Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family. Glycobiology (2011) 2.56
Deconvoluting the functions of polypeptide N-alpha-acetylgalactosaminyltransferase family members by glycopeptide substrate profiling. Chem Biol (2004) 1.78
Dentistry on the road(map). J Am Dent Assoc (2004) 1.60
Research funding. A framework for decisions about research with HPAI H5N1 viruses. Science (2013) 1.52
Oral health research at the crossroads: translate we must! J Endod (2004) 1.44
Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Mol Cell Biol (2007) 1.38
Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression. Endocrinology (2009) 1.37
Dynamic association between the catalytic and lectin domains of human UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-2. J Biol Chem (2006) 1.36
The beginnings of mucin biosynthesis: the crystal structure of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1. Proc Natl Acad Sci U S A (2004) 1.28
Identification of common and unique peptide substrate preferences for the UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases T1 and T2 derived from oriented random peptide substrates. J Biol Chem (2006) 1.22
The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection. J Biol Chem (2008) 1.20
Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases. J Biol Chem (2011) 1.19
UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. Glycobiology (2011) 1.17
Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family. Glycobiology (2003) 1.12
Biomedical research: strength from diversity. Science (2013) 1.10
Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man. Cell Metab (2011) 1.09
Small molecule inhibitors of mucin-type O-linked glycosylation from a uridine-based library. Chem Biol (2004) 1.07
NIH Roadmap interdisciplinary research initiatives. PLoS Comput Biol (2005) 1.05
Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2. J Biol Chem (2009) 1.00
Isoform-specific O-glycosylation of osteopontin and bone sialoprotein by polypeptide N-acetylgalactosaminyltransferase-1. J Biol Chem (2009) 0.90
Beyond the "omics": translating science into improved health. J Am Dent Assoc (2008) 0.89
Retracted An inhibitor of O-glycosylation induces apoptosis in NIH3T3 cells and developing mouse embryonic mandibular tissues. J Biol Chem (2004) 0.81
Genetics and its implications for clinical dental practice and education: report of panel 3 of the Macy study. J Dent Educ (2008) 0.81
Dental, oral, and craniofacial research: the view from the NIDCR. J Dent Res (2004) 0.80
A view of the future: dentistry and oral health in America. J Am Dent Assoc (2009) 0.79
A computational and experimental study of O-glycosylation. Catalysis by human UDP-GalNAc polypeptide:GalNAc transferase-T2. Org Biomol Chem (2014) 0.78
Analysis of isoproterenol-induced changes in parotid gland gene expression. Physiol Genomics (2002) 0.78
Response to: "Rescuing the NIH before it is too late". J Clin Invest (2006) 0.75
Facing the future: the NIDCR celebrates its 60th Anniversary. J Dent Res (2008) 0.75
An inhibitor of O-glycosylation induces apoptosis in NIH3T3 cells and developing mouse embryonic mandibular tissues. J Biol Chem (2008) 0.75
Erratum: UDP-N-acetyl-α-D-galactosamine: polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. Glycobiology (2015) 0.75