PubRank

Wei-Jen Tang

Author PubWeight™ 80.71‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature 2002 3.67
2 Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature 2006 3.21
3 Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2. Nat Cell Biol 2004 2.58
4 Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice. Am J Pathol 2005 2.45
5 Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling. J Exp Med 2005 1.90
6 Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'. Nat Chem Biol 2008 1.74
7 Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells. J Immunol 2005 1.59
8 Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J 2005 1.53
9 Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection. Proc Natl Acad Sci U S A 2004 1.46
10 Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Mol Cell 2005 1.45
11 Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1. J Biol Chem 2007 1.44
12 Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough. J Biol Chem 2003 1.43
13 Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem 2007 1.41
14 Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus. Proc Natl Acad Sci U S A 2008 1.39
15 Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor. Nat Biotechnol 2004 1.37
16 Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage. Microb Pathog 2007 1.36
17 Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PLoS One 2010 1.35
18 Anthrax toxins induce shock in rats by depressed cardiac ventricular function. PLoS One 2007 1.32
19 Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme. Biochemistry 2008 1.31
20 Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins. EMBO J 2002 1.28
21 Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis. J Biol Chem 2009 1.25
22 Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin. EMBO J 2005 1.22
23 Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. J Biol Chem 2009 1.20
24 Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme. J Mol Biol 2009 1.17
25 Calcium dependence of the interaction between calmodulin and anthrax edema factor. J Biol Chem 2003 1.16
26 Noninvasive imaging technologies reveal edema toxin as a key virulence factor in anthrax. Am J Pathol 2011 1.16
27 Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme. EMBO J 2010 1.16
28 The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition. Biochem Biophys Res Commun 2006 1.14
29 Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction. Front Biosci 2007 1.11
30 Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA. Biochemistry 2010 1.09
31 Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor. Proc Natl Acad Sci U S A 2010 1.08
32 Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides. Mol Pharmacol 2008 1.04
33 Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides. Mol Pharmacol 2007 1.03
34 Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate. J Biol Chem 2004 1.02
35 Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin. Infect Immun 2007 1.01
36 Bacillus anthracis edema toxin impairs neutrophil actin-based motility. Infect Immun 2009 1.01
37 Anthrax edema factor potency depends on mode of cell entry. Biochem Biophys Res Commun 2005 0.97
38 Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction. J Biol Chem 2011 0.96
39 Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response. J Biol Chem 2010 0.96
40 Ubiquitin is a novel substrate for human insulin-degrading enzyme. J Mol Biol 2010 0.94
41 Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin. Chem Biol 2004 0.94
42 Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme. Proc Natl Acad Sci U S A 2013 0.94
43 Comparison of three anthrax toxin neutralization assays. Clin Vaccine Immunol 2010 0.92
44 Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor. PLoS One 2013 0.91
45 Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase. Methods Enzymol 2002 0.91
46 Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction. J Biol Chem 2004 0.90
47 Expression of alpha subunit of Gs in Escherichia coli. Methods Enzymol 2002 0.90
48 A 1.3-A structure of zinc-bound N-terminal domain of calmodulin elucidates potential early ion-binding step. J Mol Biol 2007 0.90
49 The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor. J Virol 2007 0.89
50 Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation. J Biol Chem 2009 0.89
51 Insights from atomic-resolution X-ray structures of chemically synthesized HIV-1 protease in complex with inhibitors. J Mol Biol 2007 0.88
52 Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification. Biochemistry 2013 0.86
53 Bis-halogen-anthraniloyl-substituted nucleoside 5'-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin. J Pharmacol Exp Ther 2010 0.85
54 Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues. Int J Mol Med 2008 0.85
55 Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently. J Biol Chem 2008 0.85
56 Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site. Biochem Biophys Res Commun 2004 0.83
57 Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme. FASEB J 2009 0.83
58 Modular total chemical synthesis of a human immunodeficiency virus type 1 protease. J Am Chem Soc 2007 0.83
59 Contributions of edema factor and protective antigen to the induction of protective immunity by Bacillus anthracis edema toxin as an intranasal adjuvant. J Immunol 2010 0.81
60 A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. Biochemistry 2004 0.81
61 Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine. J Pharmacol Exp Ther 2011 0.80
62 Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates. Naunyn Schmiedebergs Arch Pharmacol 2011 0.80
63 Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor. Biochem Pharmacol 2009 0.79
64 A fluorimetric assay for real-time monitoring of adenylyl cyclase activity based on terbium norfloxacin. Anal Biochem 2008 0.79
65 Empirical valence bond simulations of the chemical mechanism of ATP to cAMP conversion by anthrax edema factor. Biochemistry 2013 0.78
66 The case for developing consensus standards for research in microbial pathogenesis: Bacillus anthracis toxins as an example. Infect Immun 2009 0.77
67 Expression and purification of soluble adenylyl cyclase from Escherichia coli. Methods Mol Biol 2004 0.76
68 Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines. Biol Chem 2008 0.76
69 Erratum: ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Nat Commun 2017 0.75