Published in Am J Physiol Lung Cell Mol Physiol on April 04, 2003
Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis (2010) 4.24
Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem (2009) 2.69
Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy. J Immunol (2006) 1.94
Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis. Am J Pathol (2005) 1.82
MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis. J Leukoc Biol (2013) 1.78
Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis. Am J Respir Cell Mol Biol (2006) 1.75
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response. Proc Natl Acad Sci U S A (2005) 1.46
Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production. Gastroenterology (2010) 1.26
Arginase: marker, effector, or candidate gene for asthma? J Clin Invest (2003) 1.24
Cationic amino acid transporter-2 regulates immunity by modulating arginase activity. PLoS Pathog (2008) 1.19
Genetic polymorphisms in arginase I and II and childhood asthma and atopy. J Allergy Clin Immunol (2005) 1.19
Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy. PLoS One (2010) 1.16
Arginase and pulmonary diseases. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.16
Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives. Br J Pharmacol (2009) 1.16
Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders. Curr Mol Med (2008) 1.07
Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol (2008) 0.99
Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice. J Immunol (2008) 0.96
L-citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats. Pediatr Res (2010) 0.95
Arginase and arginine dysregulation in asthma. J Allergy (Cairo) (2011) 0.92
SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis. Am J Pathol (2011) 0.86
Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation. J Toxicol Environ Health A (2007) 0.82
Immunohistochemical detection of arginase-I expression in formalin-fixed lung and other tissues. J Histotechnol (2013) 0.82
Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats. J Appl Toxicol (2012) 0.78
The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis. Respir Res (2010) 0.78
The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis. J Allergy Clin Immunol (2016) 0.77
Species differences in expression pattern of arginase isoenzymes and differential effects of arginase inhibition on collagen synthesis in human and rat pulmonary fibroblasts. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.77
Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties. Protoplasma (2015) 0.77
Label-free quantitative urinary proteomics identifies the arginase pathway as a new player in congenital obstructive nephropathy. Mol Cell Proteomics (2014) 0.76
Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis. PLoS One (2016) 0.76
Bosutinib Therapy Ameliorates Lung Inflammation and Fibrosis in Experimental Silicosis. Front Physiol (2017) 0.75
Expression of galectin-3 as a testis inflammatory marker in vasectomised mice. Cell J (2013) 0.75
Expression of arginase I and inducible nitric oxide synthase in the peripheral blood and lymph nodes of HIV‑positive patients. Mol Med Rep (2015) 0.75
Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis. Sci Rep (2017) 0.75
Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo. Metabolites (2017) 0.75
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev (2004) 9.24
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature (2013) 7.51
ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest (2002) 6.48
Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2005) 5.83
DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J Exp Med (2005) 4.02
Interstitial lung disease in Japanese patients with lung cancer: a cohort and nested case-control study. Am J Respir Crit Care Med (2008) 3.00
Hypertensive myocardial fibrosis and diastolic dysfunction: another model of inflammation? Hypertension (2004) 2.89
Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ Res (2007) 2.87
Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy. Hum Mol Genet (2008) 2.27
A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice. J Am Coll Cardiol (2012) 2.23
Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis. J Clin Microbiol (2002) 2.21
Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J Cell Biol (2003) 2.15
Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am J Pathol (2004) 1.97
Systemic lupus erythematosus complicated by cytomegalovirus-induced hemophagocytic syndrome and colitis. Intern Med (2002) 1.89
Computed tomography findings in pathological usual interstitial pneumonia: relationship to survival. Am J Respir Crit Care Med (2007) 1.85
Acute interstitial pneumonia: comparison of high-resolution computed tomography findings between survivors and nonsurvivors. Am J Respir Crit Care Med (2002) 1.85
The ER stress pathway involving CHOP is activated in the lungs of LPS-treated mice. J Biochem (2005) 1.84
Targeted deletion of CC chemokine receptor 2 attenuates left ventricular remodeling after experimental myocardial infarction. Am J Pathol (2004) 1.79
CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J Am Soc Nephrol (2003) 1.73
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress. Mol Biol Cell (2010) 1.70
Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors. Pathol Int (2009) 1.68
Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J Biol Chem (2002) 1.68
Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med (2005) 1.61
Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. Arterioscler Thromb Vasc Biol (2007) 1.60
C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation. J Immunol (2006) 1.59
The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques. Arterioscler Thromb Vasc Biol (2010) 1.56
Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer. Clin Cancer Res (2004) 1.54
MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. J Immunol (2005) 1.53
A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. J Immunol (2007) 1.52
Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3. EMBO J (2008) 1.51
Successful treatment of primary pulmonary angiosarcoma. Chest (2003) 1.51
Clinical significance of macrophage heterogeneity in human malignant tumors. Cancer Sci (2013) 1.50
Two cases of Sjögren's syndrome with multiple bullae. Intern Med (2002) 1.48
Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. J Biol Chem (2008) 1.48
Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models. Oncogene (2004) 1.47
Immunoglobulin G4-related lung disease: clinicoradiological and pathological features. Respirology (2013) 1.47
Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma. Cancer Sci (2011) 1.46
Endoplasmic reticulum stress and diabetes mellitus. Intern Med (2003) 1.45
mRNA study on Cu/Zn superoxide dismutase induction by hemodialysis treatment. Nephron Clin Pract (2005) 1.43
Impact of endoplasmic reticulum stress pathway on pancreatic beta-cells and diabetes mellitus. Exp Biol Med (Maywood) (2003) 1.41
Effects of induction therapy on wound healing at bronchial anastomosis sites in rats. Jpn J Thorac Cardiovasc Surg (2003) 1.38
Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology (2005) 1.38
Prognostic value of circulating KL-6 in idiopathic pulmonary fibrosis. Respirology (2006) 1.37
Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach. Pathol Int (2007) 1.34
Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis. Arthritis Res Ther (2010) 1.33
Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis. Am J Pathol (2009) 1.32
Molecular mechanisms of the LPS-induced non-apoptotic ER stress-CHOP pathway. J Biochem (2009) 1.31
Nitric oxide and endoplasmic reticulum stress. Arterioscler Thromb Vasc Biol (2006) 1.30
AM-3K, an anti-macrophage antibody, recognizes CD163, a molecule associated with an anti-inflammatory macrophage phenotype. J Histochem Cytochem (2006) 1.29
Delta F508 CFTR pool in the endoplasmic reticulum is increased by calnexin overexpression. Mol Biol Cell (2003) 1.29
LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice. Biol Reprod (2006) 1.27
Differentiation of mouse and human embryonic stem cells into hepatic lineages. Genes Cells (2008) 1.27
C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation. Arterioscler Thromb Vasc Biol (2011) 1.26
Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma. Cancer Sci (2010) 1.24
Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages. Circulation (2008) 1.24
Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals. Med Electron Microsc (2002) 1.24
Arginine metabolic enzymes, nitric oxide and infection. J Nutr (2004) 1.24
Differentiation, maturation, and survival of dendritic cells by osteopontin regulation. Clin Diagn Lab Immunol (2005) 1.23
Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. J Biol Chem (2002) 1.23
CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation. Mol Cell Biol (2006) 1.20
Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Cancer Res (2007) 1.18
Expression of constitutively activated EGFRvIII in non-small cell lung cancer. Cancer Sci (2003) 1.17
Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy. PLoS One (2010) 1.16
Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice. J Biol Chem (2010) 1.16
Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. Proc Natl Acad Sci U S A (2003) 1.15
Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth. Cancer Res (2007) 1.15
CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation. FEBS Lett (2006) 1.15
Ratio of M2 macrophage expression is closely associated with poor prognosis for Angioimmunoblastic T-cell lymphoma (AITL). Pathol Int (2010) 1.15
Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation. Diabetes (2007) 1.13
Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells. Blood (2002) 1.12
Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo. J Biol Chem (2002) 1.11
Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation. Cancer Sci (2010) 1.11
Prediction of prognosis for acute respiratory distress syndrome with thin-section CT: validation in 44 cases. Radiology (2005) 1.08
Molecular mechanism and role of endothelial monocyte chemoattractant protein-1 induction by vascular endothelial growth factor. Arterioscler Thromb Vasc Biol (2003) 1.07
Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis. Biochem Biophys Res Commun (2008) 1.07
Importance of direct macrophage-tumor cell interaction on progression of human glioma. Cancer Sci (2012) 1.07
Weekly chemotherapy with cisplatin, vincristine, doxorubicin, and etoposide is an effective treatment for advanced thymic carcinoma. Cancer (2003) 1.07
Role of MAPK phosphatase-1 in the induction of monocyte chemoattractant protein-1 during the course of adipocyte hypertrophy. J Biol Chem (2007) 1.07
Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells. Leuk Lymphoma (2006) 1.06
A novel murine gene, Sickle tail, linked to the Danforth's short tail locus, is required for normal development of the intervertebral disc. Genetics (2005) 1.06
The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial. Respir Res (2011) 1.06
Probucol attenuates left ventricular dysfunction and remodeling in tachycardia-induced heart failure: roles of oxidative stress and inflammation. Circulation (2002) 1.06
Expression of class A scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of atherosclerosis in diabetes. J Biol Chem (2004) 1.05
Osteoclast stimulatory transmembrane protein and dendritic cell–specific transmembrane protein cooperatively modulate cell–cell fusion to form osteoclasts and foreign body giant cells. J Bone Miner Res (2012) 1.04