Published in Curr Opin Pharmacol on April 01, 2003
Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol Cell Biol (2006) 1.90
TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation. Proc Natl Acad Sci U S A (2009) 1.33
TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol (2008) 1.22
The public road to high-quality curated biological pathways. Drug Discov Today (2008) 1.22
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J Lipid Res (2009) 1.08
Activation of liver X receptor decreases atherosclerosis in Ldlr⁻/⁻ mice in the absence of ATP-binding cassette transporters A1 and G1 in myeloid cells. Arterioscler Thromb Vasc Biol (2013) 1.01
Dual use of amphiphilic macromolecules as cholesterol efflux triggers and inhibitors of macrophage athero-inflammation. Biomaterials (2011) 0.96
Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells. J Biol Chem (2011) 0.92
Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J Transl Med (2008) 0.85
Nanoparticles containing a liver X receptor agonist inhibit inflammation and atherosclerosis. Adv Healthc Mater (2014) 0.84
Liver X receptor α gene polymorphisms and variable cardiovascular outcomes in patients treated with antihypertensive therapy: results from the INVEST-GENES study. Pharmacogenet Genomics (2011) 0.82
Linking lipids, Alzheimer's and LXRs? Nucl Recept Signal (2004) 0.81
Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis? Mol Neurodegener (2010) 0.81
Immunological aspects of atherosclerosis. Semin Immunopathol (2013) 0.77
Interferon Control of the Sterol Metabolic Network: Bidirectional Molecular Circuitry-Mediating Host Protection. Front Immunol (2016) 0.75
Regulation of human airway smooth muscle cell migration and relevance to asthma. Respir Res (2017) 0.75
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med (2003) 6.21
LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science (2009) 5.23
Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest (2006) 4.92
ApoE promotes the proteolytic degradation of Abeta. Neuron (2008) 4.75
Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A (2002) 4.23
LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell (2004) 4.20
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell (2005) 4.04
LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell (2008) 4.02
Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature (2008) 3.94
Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J Biol Chem (2002) 3.58
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity (2009) 2.99
Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Mol Cell (2003) 2.99
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR. Nat Rev Mol Cell Biol (2012) 2.78
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem (2001) 2.70
Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A (2002) 2.56
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A (2003) 2.50
Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu Rev Med (2006) 2.44
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab (2005) 2.42
The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab (2007) 2.32
Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest (2007) 2.24
Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol (2006) 2.22
Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation. Annu Rev Cell Dev Biol (2004) 2.21
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat Med (2006) 2.15
Endocrine functions of adipose tissue. Annu Rev Pathol (2007) 2.13
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proc Natl Acad Sci U S A (2007) 2.06
The number of x chromosomes causes sex differences in adiposity in mice. PLoS Genet (2012) 2.02
Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem (2005) 2.01
Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem (2003) 1.92
Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol Endocrinol (2005) 1.83
Liver x receptor signaling pathways and atherosclerosis. Arterioscler Thromb Vasc Biol (2010) 1.79
An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer Discov (2011) 1.77
Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology (2010) 1.67
LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. J Clin Invest (2010) 1.67
Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors. Curr Opin Genet Dev (2008) 1.66
Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle. Mol Endocrinol (2007) 1.63
Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity. Mol Endocrinol (2008) 1.59
Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition. J Lipid Res (2004) 1.58
Before they were fat: adipocyte progenitors. Cell Metab (2008) 1.58
Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt. Cell Metab (2009) 1.56
Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J Biol Chem (2002) 1.48
Fat's loss is bone's gain. J Clin Invest (2004) 1.47
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes (2009) 1.46
TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab (2011) 1.46
The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. J Biol Chem (2010) 1.44
LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab (2013) 1.39
Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production. J Biol Chem (2002) 1.29
PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism. J Lipid Res (2002) 1.29
Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow. J Lipid Res (2008) 1.28
Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance. Cell Metab (2013) 1.28
Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation. Mol Endocrinol (2008) 1.26
The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions. Mol Cell Biol (2003) 1.25
The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages. J Biol Chem (2006) 1.24
Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest (2011) 1.23
Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Mol Endocrinol (2008) 1.23
The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Mol Endocrinol (2008) 1.23
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab (2013) 1.22
The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis. Mol Endocrinol (2006) 1.22
TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol (2008) 1.22
Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2. Infect Immun (2006) 1.21
The nuclear receptor LXRα controls the functional specialization of splenic macrophages. Nat Immunol (2013) 1.20
The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes Dev (2011) 1.17
The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans. J Clin Invest (2011) 1.12
A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor. Circ Res (2006) 1.12
Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target. J Lipid Res (2004) 1.11
Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Mol Cell Biol (2011) 1.09
GPIHBP1, an endothelial cell transporter for lipoprotein lipase. J Lipid Res (2011) 1.08
Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arterioscler Thromb Vasc Biol (2012) 1.08
Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Prog Lipid Res (2013) 1.06
IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Mol Cell Biol (2013) 1.04
N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta. J Med Chem (2007) 1.01
Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. J Lipid Res (2010) 1.00
Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice. J Lipid Res (2013) 1.00
Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arterioscler Thromb Vasc Biol (2011) 0.99
The small molecule phenamil induces osteoblast differentiation and mineralization. Mol Cell Biol (2009) 0.98
Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors. J Biol Chem (2003) 0.96
A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections. J Exp Med (2006) 0.96
Adopting new orphans into the family of metabolic regulators. Mol Endocrinol (2008) 0.95
Negative regulation of Hedgehog signaling by liver X receptors. Mol Endocrinol (2009) 0.93
Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arterioscler Thromb Vasc Biol (2010) 0.93
LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice. J Lipid Res (2012) 0.92
FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors. Proc Natl Acad Sci U S A (2011) 0.92
Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor. J Lipid Res (2013) 0.92
Phosphorylation of the liver X receptors. FEBS Lett (2006) 0.92
PPARs in atherosclerosis: the clot thickens. J Clin Invest (2004) 0.91
Orphan nuclear receptors find a home in the arterial wall. Curr Atheroscler Rep (2002) 0.91
A Nurr1 pathway for neuroprotection. Cell (2009) 0.91
T0901317, an LXR agonist, augments PKA-induced vascular cell calcification. FEBS Lett (2009) 0.90
Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Proc Natl Acad Sci U S A (2014) 0.89
The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression. J Lipid Res (2010) 0.89
LXR deficiency confers increased protection against visceral Leishmania infection in mice. PLoS Negl Trop Dis (2010) 0.88
Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance. Cell Metab (2015) 0.88
Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. J Lipid Res (2012) 0.88
STAMPing out Inflammation. Cell (2007) 0.84
SUMOylation and PPARgamma: wrestling with inflammatory signaling. Cell Metab (2005) 0.83
Setting fat on fire. Nat Med (2003) 0.81
Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha. J Lipid Res (2005) 0.81
HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation. J Lipid Res (2008) 0.81
Vestigial-like 3 is an inhibitor of adipocyte differentiation. J Lipid Res (2012) 0.79
Genome-wide association studies identify new targets in cardiovascular disease. Sci Transl Med (2010) 0.78
Metabolism: Drug discovery goes for a swim. Nat Chem Biol (2013) 0.78