Published in Arthritis Res Ther on November 04, 2002
Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J Exp Med (2008) 2.17
Citrulline-specific Th1 cells are increased in rheumatoid arthritis and their frequency is influenced by disease duration and therapy. Arthritis Rheumatol (2014) 1.12
An important step towards completing the rheumatoid arthritis cycle. Arthritis Res Ther (2008) 0.89
Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads. Biotechnol Bioeng (2015) 0.88
Systemic immunomodulation of autoimmune disease using MHC-derived recombinant TCR ligands. Curr Drug Targets Inflamm Allergy (2005) 0.87
Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate. Cell Mol Life Sci (2014) 0.85
Mapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidate. PLoS Comput Biol (2015) 0.84
Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance. Mol Ther Methods Clin Dev (2015) 0.81
Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell (1995) 5.82
Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices. Nat Biotechnol (1999) 5.13
T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature (1987) 3.96
Several common HLA-DR types share largely overlapping peptide binding repertoires. J Immunol (1998) 3.95
Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science (1998) 3.68
Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science (1995) 3.40
The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science (1999) 3.23
Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol Today (1993) 2.91
The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum (1992) 2.68
Molecular mimicry and immune-mediated diseases. FASEB J (1998) 2.53
Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology. Arthritis Rheum (1987) 2.19
X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II. Immunity (1997) 2.07
HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J Exp Med (1996) 1.99
The specificity of TCR/pMHC interaction. Curr Opin Immunol (2002) 1.99
Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning. J Exp Med (1994) 1.81
Editing of the HLA-DR-peptide repertoire by HLA-DM. EMBO J (1996) 1.74
Post-translational protein modifications in antigen recognition and autoimmunity. Trends Immunol (2001) 1.67
Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP. Nat Immunol (2002) 1.61
Structural and functional consequences of altering a peptide MHC anchor residue. J Immunol (2001) 1.51
The development of rheumatoid arthritis after recombinant hepatitis B vaccination. J Rheumatol (1998) 1.50
Influence of a dominant cryptic epitope on autoimmune T cell tolerance. Nat Immunol (2002) 1.41
Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice. Proc Natl Acad Sci U S A (1998) 1.38
Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response. Proc Natl Acad Sci U S A (1994) 1.36
Induction of autoimmune arthritis in HLA-DR4 (DRB1*0401) transgenic mice by immunization with human and bovine type II collagen. J Immunol (1998) 1.27
The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease. J Mol Med (Berl) (1998) 1.26
Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen. Eur J Immunol (1996) 1.25
How the MHC selects Th1/Th2 immunity. Immunol Today (1998) 1.16
Prediction of peptide affinity to HLA DRB1*0401. J Immunol (1995) 1.11
Rheumatic disorders developed after hepatitis B vaccination. Rheumatology (Oxford) (1999) 1.07
Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes. Eur J Immunol (2002) 1.05
Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire. J Clin Invest (1997) 1.03
Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen. J Immunol (1998) 0.95
Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proc Natl Acad Sci U S A (1998) 0.94
T cell response of I-Aq mice to self type II collagen: meshing of the binding motif of the I-Aq molecule with repetitive sequences results in autoreactivity to multiple epitopes. Int Immunol (1997) 0.91
In vitro and in vivo induction of a Th cell response toward peptides of the melanoma-associated glycoprotein 100 protein selected by the TEPITOPE program. J Immunol (2000) 0.91
Induction of anergy in human T helper 0 cells by stimulation with altered T cell antigen receptor ligands. J Immunol (1996) 0.89
Arthritis induced by proteoglycan aggrecan G1 domain in BALB/c mice. Evidence for t cell involvement and the immunosuppressive influence of keratan sulfate on recognition of t and b cell epitopes. J Clin Invest (1998) 0.88
Major histocompatibility complex controls susceptibility and dominant inheritance, but not the severity of the disease in mouse models of rheumatoid arthritis. Immunogenetics (2002) 0.87
Arthritis after hepatitis B vaccination. Report of three cases. Scand J Rheumatol (1995) 0.79
Cellular immunity to cartilage aggrecan core protein in patients with rheumatoid arthritis and non-arthritic controls. Ann Rheum Dis (1996) 0.79
The influence of HLA-DR4 (0401) on the immune response to type II collagen and the development of collagen induced arthritis in mice. J Autoimmun (2002) 0.78
Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J Immunol (2003) 4.64
Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J Exp Med (2008) 2.17
Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic mice. Arthritis Rheum (2011) 1.97
Novel small interfering RNA-containing solution protecting donor organs in heart transplantation. Circulation (2009) 1.60
Serum autoantibodies that bind citrullinated fibrinogen are frequently found in patients with rheumatoid arthritis. J Rheumatol (2006) 1.54
Carbon monoxide releasing molecules inhibit cell death resulting from renal transplantation related stress. J Urol (2012) 1.46
Association of severe inflammatory polyarthritis in primary Sjögren's syndrome: clinical, serologic, and HLA analysis. J Rheumatol (2009) 1.46
Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J Immunol (2003) 1.41
Intravenous immunoglobulin as a treatment for BK virus associated nephropathy: one-year follow-up of renal allograft recipients. Transplantation (2006) 1.38
Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. Nat Med (2009) 1.29
Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis Rheum (2010) 1.25
Optimization of elastin-like polypeptide fusions for expression and purification of recombinant proteins in plants. Biotechnol Bioeng (2009) 1.15
Gene silencing of complement C5a receptor using siRNA for preventing ischemia/reperfusion injury. Am J Pathol (2008) 1.14
Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA. J Immunol (2003) 1.11
Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference. J Immunol (2007) 1.10
Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4. Proc Natl Acad Sci U S A (2004) 1.08
Proapoptotic activity of indoleamine 2,3-dioxygenase expressed in renal tubular epithelial cells. Am J Physiol Renal Physiol (2007) 1.07
Antihomocitrullinated fibrinogen antibodies are specific to rheumatoid arthritis and frequently bind citrullinated proteins/peptides. J Rheumatol (2014) 1.07
NK cells induce apoptosis in tubular epithelial cells and contribute to renal ischemia-reperfusion injury. J Immunol (2008) 1.07
Tobacco, a highly efficient green bioreactor for production of therapeutic proteins. Biotechnol Adv (2009) 1.06
Recombinant protein production in a variety of Nicotiana hosts: a comparative analysis. Plant Biotechnol J (2010) 1.04
A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation. Blood (2009) 1.04
Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury. Am J Physiol Renal Physiol (2008) 0.97
Anti-citrullinated protein antibodies in unaffected first-degree relatives of rheumatoid arthritis patients. Arthritis Rheum (2013) 0.97
Plant recombinant erythropoietin attenuates inflammatory kidney cell injury. Plant Biotechnol J (2008) 0.95
Epstein-Barr virus seronegativity is a risk factor for late-onset posttransplant lymphoroliferative disorder in adult renal allograft recipients. Transplantation (2003) 0.95
Generation of therapeutic dendritic cells and regulatory T cells for preventing allogeneic cardiac graft rejection. Clin Immunol (2008) 0.95
Therapeutic effectiveness of orally administered transgenic low-alkaloid tobacco expressing human interleukin-10 in a mouse model of colitis. Plant Biotechnol J (2007) 0.94
Osteopontin expressed in tubular epithelial cells regulates NK cell-mediated kidney ischemia reperfusion injury. J Immunol (2010) 0.93
Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation. Kidney Int (2011) 0.92
Nitric oxide induces apoptosis in renal tubular epithelial cells through activation of caspase-8. Am J Physiol Renal Physiol (2005) 0.91
Recombinant human transferrin: beyond iron binding and transport. Biotechnol Adv (2010) 0.90
A novel expression platform for the production of diabetes-associated autoantigen human glutamic acid decarboxylase (hGAD65). BMC Biotechnol (2008) 0.90
Small interfering RNA targeting RelB protects against renal ischemia-reperfusion injury. Transplantation (2009) 0.89
Immunomodulation and regeneration of islet Beta cells by cytokines in autoimmune type 1 diabetes. J Interferon Cytokine Res (2011) 0.89
Renal tubular epithelial cell self-injury through Fas/Fas ligand interaction promotes renal allograft injury. Am J Transplant (2004) 0.89
A fusion protein derived from plants holds promising potential as a new oral therapy for type 2 diabetes. Plant Biotechnol J (2013) 0.88
Reduction of chronic allograft nephropathy by inhibition of extracellular signal-regulated kinase 1 and 2 signaling. Am J Physiol Renal Physiol (2008) 0.87
Glycyrrhizic acid ameliorates HMGB1-mediated cell death and inflammation after renal ischemia reperfusion injury. Am J Nephrol (2014) 0.87
Long-term results of pediatric renal transplantation into a dysfunctional lower urinary tract. Transplantation (2003) 0.86
Prolongation of cardiac allograft survival by inhibition of ERK1/2 signaling in a mouse model. Transplantation (2007) 0.86
Use of RNA interference to minimize ischemia reperfusion injury. Transplant Rev (Orlando) (2011) 0.84
Reduction of Foxp3-expressing regulatory T cell infiltrates during the progression of renal allograft rejection in a mouse model. Transpl Immunol (2008) 0.84
Negative regulation of the peptidylarginine deiminase type IV promoter by NF-κB in human myeloid cells. Gene (2013) 0.84
Alteration in CD45RBhi/CD45RBlo T-cell ratio following CD45RB monoclonal-antibody therapy occurs by selective deletion of CD45RBhi effector cells. Transplantation (2003) 0.84
Expression of cholera toxin B subunit and the B chain of human insulin as a fusion protein in transgenic tobacco plants. Plant Cell Rep (2005) 0.84
Re-exposure to mismatched HLA class I is a significant risk factor for graft loss: multivariable analysis of 259 kidney retransplants. Transplantation (2007) 0.83
Giving credit where credit is due: John Hunter and the discovery of erythrocyte sedimentation rate. Lancet (2005) 0.83
Production of biologically active human interleukin-4 in transgenic tobacco and potato. Plant Biotechnol J (2005) 0.83
Significance of endothelial cell survival programs for renal transplantation. Am J Kidney Dis (2003) 0.83
Characterization of the role of major histocompatibility complex in type 1 diabetes recurrence after islet transplantation. Transplantation (2004) 0.83
Plant-derived recombinant human serum transferrin demonstrates multiple functions. Plant Biotechnol J (2010) 0.82
Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist. Immunol Cell Biol (2011) 0.82
A novel platform for biologically active recombinant human interleukin-13 production. Plant Biotechnol J (2008) 0.82
Natural Killer Cells Mediate Long-term Kidney Allograft Injury. Transplantation (2015) 0.82
Deviation of xenogeneic immune response and bystander suppression in rats fed porcine blood mononuclear cells. Transpl Immunol (2007) 0.82
Analysis of genetic relationships in germplasms of Mugua in China revealed by internal transcribed spacer and its taxonomic significance. Z Naturforsch C (2010) 0.81
Early but not late allograft nephrectomy reduces allosensitization after transplant failure. Can Urol Assoc J (2011) 0.80
Preoperative Cylex assay predicts rejection risk in patients with kidney transplant. Clin Transplant (2014) 0.80
Outcome of third renal allograft retransplants versus primary transplants from paired donors. Transplantation (2009) 0.80
Induction of transient arthritis by the adoptive transfer of a collagen II specific Th1 clone to HLA-DR4 (B1*0401) transgenic mice. J Autoimmun (2002) 0.80
Double negative Treg cells promote nonmyeloablative bone marrow chimerism by inducing T-cell clonal deletion and suppressing NK cell function. Eur J Immunol (2012) 0.80
Adoptive transfer of DNT cells induces long-term cardiac allograft survival and augments recipient CD4(+)Foxp3(+) Treg cell accumulation. Transpl Immunol (2010) 0.80
CTLA-4Ig blocks the development and progression of citrullinated fibrinogen-induced arthritis in DR4-transgenic mice. Arthritis Rheum (2010) 0.79
IL-2-mediated apoptosis of kidney tubular epithelial cells is regulated by the caspase-8 inhibitor c-FLIP. Kidney Int (2005) 0.79
Use of a pelvic kidney for living transplantation: case report and review of the literature. Am J Transplant (2003) 0.79
The joy of citrulline: new insights into the diagnosis, pathogenesis, and treatment of rheumatoid arthritis. J Rheumatol (2004) 0.79
Rat genotype influences quantitative and qualitative aspects of xenogeneic immune response to pig blood mononuclear cells. Xenotransplantation (2006) 0.78
Mathematical model for pressure losses in the hemodialysis graft vascular circuit. J Biomech Eng (2005) 0.78
The influence of HLA-DR4 (0401) on the immune response to type II collagen and the development of collagen induced arthritis in mice. J Autoimmun (2002) 0.78
Anti-IL-2 receptor antibody decreases cytokine-induced apoptosis of human renal tubular epithelial cells (TEC). Nephrol Dial Transplant (2010) 0.78
Serum cytokine profile of unaffected first-degree relatives of patients with rheumatoid arthritis. J Rheumatol (2014) 0.77
High-yield expression of recombinant soybean agglutinin in plants using transient and stable systems. Transgenic Res (2010) 0.77
Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells. Transplantation (2003) 0.77
Serine protease inhibitor-6 inhibits granzyme B-mediated injury of renal tubular cells and promotes renal allograft survival. Transplantation (2014) 0.77
LF 15-0195, a novel immunosuppressive agent prevents rejection and induces operational tolerance in a mouse cardiac allograft model. Transplantation (2003) 0.77
Transgenic rice for allergy immunotherapy. Proc Natl Acad Sci U S A (2005) 0.77
Natural killer cells play a critical role in cardiac allograft vasculopathy in an interleukin-6--dependent manner. Transplantation (2014) 0.77
Temporal and spatial distribution of erythropoietin in transgenic tobacco plants. Transgenic Res (2009) 0.76
Kidney and liver transplants from donors after cardiac death: initial experience at the London Health Sciences Centre. Can J Surg (2010) 0.76
The development of a high-yield recombinant protein bioreactor through RNAi induced knockdown of ATP/ADP transporter in Solanum tuberosum. J Biotechnol (2011) 0.76
Preventing tissue injury using siRNA. Methods Mol Biol (2010) 0.76
Enhanced cardiac allograft survival by Vav1-Rac signaling blockade in a mouse model. Transpl Immunol (2007) 0.76