Published in Curr Opin Struct Biol on April 01, 2003
Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol (2004) 3.75
Sequence determinants of amyloid fibril formation. Proc Natl Acad Sci U S A (2003) 2.71
Monomer adds to preformed structured oligomers of Abeta-peptides by a two-stage dock-lock mechanism. Proc Natl Acad Sci U S A (2006) 2.01
Systematically perturbed folding patterns of amyotrophic lateral sclerosis (ALS)-associated SOD1 mutants. Proc Natl Acad Sci U S A (2005) 1.94
Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils. PLoS Comput Biol (2007) 1.71
A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils. PLoS Biol (2007) 1.56
Insights from coarse-grained Gō models for protein folding and dynamics. Int J Mol Sci (2009) 1.52
Effects of denaturants and osmolytes on proteins are accurately predicted by the molecular transfer model. Proc Natl Acad Sci U S A (2008) 1.52
A polymer physics perspective on driving forces and mechanisms for protein aggregation. Arch Biochem Biophys (2007) 1.41
Aqueous urea solution destabilizes Abeta(16-22) oligomers. Proc Natl Acad Sci U S A (2004) 1.34
Structural stability and dynamics of an amyloid-forming peptide GNNQQNY from the yeast prion sup-35. Biophys J (2006) 1.33
The elongation of yeast prion fibers involves separable steps of association and conversion. Proc Natl Acad Sci U S A (2004) 1.33
Folding of Cu/Zn superoxide dismutase suggests structural hotspots for gain of neurotoxic function in ALS: parallels to precursors in amyloid disease. Proc Natl Acad Sci U S A (2006) 1.31
Probing the instabilities in the dynamics of helical fragments from mouse PrPC. Proc Natl Acad Sci U S A (2004) 1.31
Structure and dynamics of parallel beta-sheets, hydrophobic core, and loops in Alzheimer's A beta fibrils. Biophys J (2007) 1.26
Backtracking on the folding landscape of the beta-trefoil protein interleukin-1beta? Proc Natl Acad Sci U S A (2008) 1.22
The structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study. J Mol Biol (2009) 1.19
Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins. Methods Enzymol (2006) 1.18
Gatekeeper residues in the major curlin subunit modulate bacterial amyloid fiber biogenesis. Proc Natl Acad Sci U S A (2009) 1.15
Dynamics of locking of peptides onto growing amyloid fibrils. Proc Natl Acad Sci U S A (2009) 1.15
Effect of dehydration on the aggregation kinetics of two amyloid peptides. J Phys Chem B (2009) 1.14
Principles governing oligomer formation in amyloidogenic peptides. Curr Opin Struct Biol (2010) 1.14
Polymorphism of Alzheimer's Abeta17-42 (p3) oligomers: the importance of the turn location and its conformation. Biophys J (2009) 1.13
Subdomain competition, cooperativity, and topological frustration in the folding of CheY. J Mol Biol (2008) 1.10
Annular structures as intermediates in fibril formation of Alzheimer Abeta17-42. J Phys Chem B (2008) 1.10
Self-assembly of the ionic peptide EAK16: the effect of charge distributions on self-assembly. Biophys J (2004) 1.10
Probing the mechanisms of fibril formation using lattice models. J Chem Phys (2008) 1.08
Influence of preformed Asp23-Lys28 salt bridge on the conformational fluctuations of monomers and dimers of Abeta peptides with implications for rates of fibril formation. J Phys Chem B (2009) 1.08
Role of water in protein aggregation and amyloid polymorphism. Acc Chem Res (2011) 1.06
The Japanese mutant Aβ (ΔE22-Aβ(1-39)) forms fibrils instantaneously, with low-thioflavin T fluorescence: seeding of wild-type Aβ(1-40) into atypical fibrils by ΔE22-Aβ(1-39). Biochemistry (2011) 1.05
Intrinsic disorder modulates protein self-assembly and aggregation. Proc Natl Acad Sci U S A (2012) 1.05
Hydrophobic cooperativity as a mechanism for amyloid nucleation. J Mol Biol (2007) 1.04
Characterization of the nucleation barriers for protein aggregation and amyloid formation. HFSP J (2007) 1.04
Evidence for a partially structured state of the amylin monomer. Biophys J (2009) 1.04
Theoretical model of prion propagation: a misfolded protein induces misfolding. Proc Natl Acad Sci U S A (2005) 1.02
Interaction between amyloid-beta (1-42) peptide and phospholipid bilayers: a molecular dynamics study. Biophys J (2009) 1.02
Structures and free-energy landscapes of the wild type and mutants of the Abeta(21-30) peptide are determined by an interplay between intrapeptide electrostatic and hydrophobic interactions. J Mol Biol (2008) 1.01
Formation of partially ordered oligomers of amyloidogenic hexapeptide (NFGAIL) in aqueous solution observed in molecular dynamics simulations. Biophys J (2004) 1.00
Protein thermal aggregation involves distinct regions: sequential events in the heat-induced unfolding and aggregation of hemoglobin. Biophys J (2004) 1.00
Fibrillation precursor of superoxide dismutase 1 revealed by gradual tuning of the protein-folding equilibrium. Proc Natl Acad Sci U S A (2012) 0.98
Unfolding, aggregation, and amyloid formation by the tetramerization domain from mutant p53 associated with lung cancer. Biochemistry (2006) 0.98
Interactive sequences in the molecular chaperone, human alphaB crystallin modulate the fibrillation of amyloidogenic proteins. Int J Biochem Cell Biol (2007) 0.98
Heat-induced denaturation and aggregation of ovalbumin at neutral pH described by irreversible first-order kinetics. Protein Sci (2003) 0.97
Free energy landscapes for amyloidogenic tetrapeptides dimerization. Biophys J (2005) 0.97
SOD1 mutations targeting surface hydrogen bonds promote amyotrophic lateral sclerosis without reducing apo-state stability. J Biol Chem (2010) 0.96
A statistical-mechanical theory of fibril formation in dilute protein solutions. Biophys J (2006) 0.96
X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from Aβ(17-36). J Am Chem Soc (2014) 0.96
Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration. Front Neurol (2013) 0.96
Stabilization of discordant helices in amyloid fibril-forming proteins. Protein Sci (2004) 0.95
Investigating the mechanism of peptide aggregation: insights from mixed monte carlo-molecular dynamics simulations. Biophys J (2008) 0.95
Thermodynamic perspective on the dock-lock growth mechanism of amyloid fibrils. J Phys Chem B (2009) 0.95
Ile-phe dipeptide self-assembly: clues to amyloid formation. Biophys J (2006) 0.93
Heterogeneity in primary structure, post-translational modifications, and germline gene usage of nine full-length amyloidogenic kappa1 immunoglobulin light chains. Biochemistry (2007) 0.93
The role of Phe in the formation of well-ordered oligomers of amyloidogenic hexapeptide (NFGAIL) observed in molecular dynamics simulations with explicit solvent. Biophys J (2005) 0.92
Amyloidogenic sequences in native protein structures. Protein Sci (2010) 0.91
Unraveling the early events of amyloid-β protein (Aβ) aggregation: techniques for the determination of Aβ aggregate size. Int J Mol Sci (2012) 0.91
Structural stability and heat-induced conformational change of two complement inhibitors: C4b-binding protein and factor H. Protein Sci (2004) 0.91
Dry amyloid fibril assembly in a yeast prion peptide is mediated by long-lived structures containing water wires. Proc Natl Acad Sci U S A (2010) 0.91
Propensity to form amyloid fibrils is encoded as excitations in the free energy landscape of monomeric proteins. J Mol Biol (2014) 0.90
3DSwap: curated knowledgebase of proteins involved in 3D domain swapping. Database (Oxford) (2011) 0.90
Folding without charges. Proc Natl Acad Sci U S A (2012) 0.89
What determines the structure and stability of KFFE monomers, dimers, and protofibrils? Biophys J (2009) 0.89
A multiscale approach to characterize the early aggregation steps of the amyloid-forming peptide GNNQQNY from the yeast prion sup-35. PLoS Comput Biol (2011) 0.89
A molecular dynamics study of the early stages of amyloid-beta(1-42) oligomerization: the role of lipid membranes. Proteins (2010) 0.89
Virtual Screening for Dipeptide Aggregation: Toward Predictive Tools for Peptide Self-Assembly. J Phys Chem Lett (2011) 0.88
Insights into stability and toxicity of amyloid-like oligomers by replica exchange molecular dynamics analyses. Biophys J (2008) 0.87
Phenol red interacts with the protofibril-like oligomers of an amyloidogenic hexapeptide NFGAIL through both hydrophobic and aromatic contacts. Biophys J (2006) 0.87
Structure and thermodynamics of colloidal protein cluster formation: comparison of square-well and simple dipolar models. J Chem Phys (2009) 0.86
Do chaperonins boost protein yields by accelerating folding or preventing aggregation? Biophys J (2008) 0.86
Protein aggregation in silico. Trends Biotechnol (2007) 0.85
SOD1-associated ALS: a promising system for elucidating the origin of protein-misfolding disease. HFSP J (2008) 0.85
Point mutations in Aβ result in the formation of distinct polymorphic aggregates in the presence of lipid bilayers. PLoS One (2011) 0.84
Web-based computational chemistry education with CHARMMing II: Coarse-grained protein folding. PLoS Comput Biol (2014) 0.83
Protein aggregation determinants from a simplified model: cooperative folders resist aggregation. Protein Sci (2005) 0.83
Light-triggered disassembly of amyloid fibrils. Langmuir (2012) 0.82
Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis. Protein Sci (2013) 0.81
Molecular Design of beta-Hairpin Peptides for Material Construction. MRS Bull (2008) 0.80
A Pairwise Preferential Interaction Model for Understanding Peptide Aggregation. Int J Thermophys (2010) 0.80
Multistep aggregation pathway of human interleukin-1 receptor antagonist: kinetic, structural, and morphological characterization. Biophys J (2009) 0.79
Helices 2 and 3 are the initiation sites in the PrP(C) → PrP(SC) transition. Biochemistry (2012) 0.78
Determination of critical nucleation number for a single nucleation amyloid-β aggregation model. Math Biosci (2016) 0.78
Transient β-hairpin formation in α-synuclein monomer revealed by coarse-grained molecular dynamics simulation. J Chem Phys (2015) 0.78
Non-linear scission/recombination kinetics of living polymerization. Eur Phys J E Soft Matter (2007) 0.78
The Dimerization State of the Mammalian High Mobility Group Protein AT-Hook 2 (HMGA2). PLoS One (2015) 0.76
Effects of environmental factors on MSP21-25 aggregation indicate the roles of hydrophobic and electrostatic interactions in the aggregation process. Eur Biophys J (2013) 0.76
The Volumetric Diversity of Misfolded Prion Protein Oligomers Revealed by Pressure Dissociation. J Biol Chem (2015) 0.76
The formation of fibrils by intertwining of filaments: model and application to amyloid Abeta protein. Biophys J (2006) 0.76
Protein thermodynamics: Are native proteins metastable? Nat Chem (2011) 0.76
Aggregation gatekeeper and controlled assembly of Trpzip β-hairpins. Biochemistry (2014) 0.75
Statistical mechanical treatments of protein amyloid formation. Int J Mol Sci (2013) 0.75
Changes of protein stiffness during folding detect protein folding intermediates. J Biol Phys (2013) 0.75
Aggregation of Chameleon Peptides: Implications of α-Helicity in Fibril Formation. J Phys Chem B (2016) 0.75
Contact-induced structure transformation in transmembrane prion propagation. Biophys J (2007) 0.75
Finite size effects in simulations of protein aggregation. PLoS One (2008) 0.75
Systematic Moiety Variations of Ultrashort Peptides Produce Profound Effects on Self-Assembly, Nanostructure Formation, Hydrogelation, and Phase Transition. Sci Rep (2017) 0.75
Deciphering the timescales and mechanisms of protein folding using minimal off-lattice models. Curr Opin Struct Biol (1999) 2.14
Probing the mechanisms of fibril formation using lattice models. J Chem Phys (2008) 1.08
Sop-GPU: accelerating biomolecular simulations in the centisecond timescale using graphics processors. Proteins (2010) 0.98
Fishing for folding nuclei in lattice models and proteins. Fold Des (1998) 0.94
Mapping the energy landscape of biomolecules using single molecule force correlation spectroscopy: theory and applications. Biophys J (2006) 0.93
Analyzing forced unfolding of protein tandems by ordered variates, 1: Independent unfolding times. Biophys J (2007) 0.91
Protein threading by learning. Proc Natl Acad Sci U S A (2001) 0.90
Order statistics theory of unfolding of multimeric proteins. Biophys J (2010) 0.88
Analyzing forced unfolding of protein tandems by ordered variates, 2: dependent unfolding times. Biophys J (2007) 0.83