Shunting inhibition modulates neuronal gain during synaptic excitation.

PubWeight™: 3.17‹?› | Rank: Top 1%

🔗 View Article (PMID 12741990)

Published in Neuron on May 08, 2003

Authors

Simon J Mitchell1, R Angus Silver

Author Affiliations

1: Department of Physiology, University College London, Gower Street, WC1E 6BT, London, United Kingdom.

Articles citing this

(truncated to the top 100)

The normalization model of attention. Neuron (2009) 5.38

How inhibition shapes cortical activity. Neuron (2011) 4.53

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors. Proc Natl Acad Sci U S A (2003) 4.33

Extrasynaptic GABAA receptors: form, pharmacology, and function. J Neurosci (2009) 2.39

Interneuron cell types are fit to function. Nature (2014) 2.34

Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity. Nat Neurosci (2005) 2.25

The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus. J Physiol (2007) 2.13

Network variability limits stimulus-evoked spike timing precision in retinal ganglion cells. Neuron (2006) 2.13

A normalization model of attentional modulation of single unit responses. PLoS One (2009) 2.06

Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. Eur J Neurosci (2010) 2.03

Input normalization by global feedforward inhibition expands cortical dynamic range. Nat Neurosci (2009) 1.91

Different transmitter transients underlie presynaptic cell type specificity of GABAA,slow and GABAA,fast. Proc Natl Acad Sci U S A (2007) 1.88

Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons. Nat Neurosci (2009) 1.83

Mechanisms of inhibition within the telencephalon: "where the wild things are". Annu Rev Neurosci (2011) 1.81

Dynamics of fast and slow inhibition from cerebellar golgi cells allow flexible control of synaptic integration. Neuron (2009) 1.79

Neuronal arithmetic. Nat Rev Neurosci (2010) 1.77

Synaptic depression enables neuronal gain control. Nature (2009) 1.76

Broad inhibition sharpens orientation selectivity by expanding input dynamic range in mouse simple cells. Neuron (2011) 1.70

Rapid desynchronization of an electrically coupled interneuron network with sparse excitatory synaptic input. Neuron (2010) 1.65

Extrasynaptic alphabeta subunit GABAA receptors on rat hippocampal pyramidal neurons. J Physiol (2006) 1.60

Receptor actions of synaptically released glutamate: the role of transporters on the scale from nanometers to microns. Biophys J (2008) 1.56

Signals and noise in an inhibitory interneuron diverge to control activity in nearby retinal ganglion cells. Nat Neurosci (2008) 1.49

Cellular mechanisms underlying stimulus-dependent gain modulation in primary visual cortex neurons in vivo. Neuron (2008) 1.48

Aspects of the homeostaic plasticity of GABAA receptor-mediated inhibition. J Physiol (2004) 1.42

Rapid temporal modulation of synchrony by competition in cortical interneuron networks. Neural Comput (2004) 1.39

Synaptic and cellular properties of the feedforward inhibitory circuit within the input layer of the cerebellar cortex. J Neurosci (2008) 1.39

Inhibitory synchrony as a mechanism for attentional gain modulation. J Physiol Paris (2005) 1.37

Network mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons. Nat Neurosci (2010) 1.32

Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover. J Neurosci (2011) 1.31

Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene. J Neurosci (2006) 1.22

A realistic large-scale model of the cerebellum granular layer predicts circuit spatio-temporal filtering properties. Front Cell Neurosci (2010) 1.21

Functional characteristics of parvalbumin- and cholecystokinin-expressing basket cells. J Physiol (2012) 1.19

Protein kinase C phosphorylation regulates membrane insertion of GABAA receptor subtypes that mediate tonic inhibition. J Biol Chem (2010) 1.19

Oscillatory multiplexing of population codes for selective communication in the mammalian brain. Nat Rev Neurosci (2014) 1.15

Neurogliaform cells in the molecular layer of the dentate gyrus as feed-forward γ-aminobutyric acidergic modulators of entorhinal-hippocampal interplay. J Comp Neurol (2011) 1.14

Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability. Psychopharmacology (Berl) (2013) 1.14

Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons. J Physiol (2007) 1.12

Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons. Hippocampus (2010) 1.12

Location-dependent effects of inhibition on local spiking in pyramidal neuron dendrites. PLoS Comput Biol (2012) 1.11

Spontaneous spiking and synaptic depression underlie noradrenergic control of feed-forward inhibition. Neuron (2011) 1.10

Ambient GABA-activated tonic inhibition sharpens auditory coincidence detection via a depolarizing shunting mechanism. J Neurosci (2011) 1.10

Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells. J Neurophysiol (2013) 1.10

Stochastic ion channel gating in dendritic neurons: morphology dependence and probabilistic synaptic activation of dendritic spikes. PLoS Comput Biol (2010) 1.08

GABA(A) receptor-mediated signaling alters the structure of spontaneous activity in the developing retina. J Neurosci (2007) 1.08

Gain control in CA1 pyramidal cells using changes in somatic conductance. J Neurosci (2010) 1.07

Feed-forward inhibition as a buffer of the neuronal input-output relation. Proc Natl Acad Sci U S A (2009) 1.06

The critical role of Golgi cells in regulating spatio-temporal integration and plasticity at the cerebellum input stage. Front Neurosci (2008) 1.02

High-Pass Filtering and Dynamic Gain Regulation Enhance Vertical Bursts Transmission along the Mossy Fiber Pathway of Cerebellum. Front Cell Neurosci (2010) 1.01

Regulating anxiety with extrasynaptic inhibition. Nat Neurosci (2015) 1.01

Enhancement of asynchronous release from fast-spiking interneuron in human and rat epileptic neocortex. PLoS Biol (2012) 1.01

Tuned normalization explains the size of attention modulations. Neuron (2012) 0.99

Membrane voltage fluctuations reduce spike frequency adaptation and preserve output gain in CA1 pyramidal neurons in a high-conductance state. J Neurosci (2011) 0.99

Efficient "communication through coherence" requires oscillations structured to minimize interference between signals. PLoS Comput Biol (2012) 0.99

Impact of inhibitory constraint of interneurons on neuronal excitability. J Neurophysiol (2013) 0.98

Tranexamic acid concentrations associated with human seizures inhibit glycine receptors. J Clin Invest (2012) 0.97

Spinal direct current stimulation modulates the activity of gracile nucleus and primary somatosensory cortex in anaesthetized rats. J Physiol (2011) 0.97

Regulation of interneuron excitability by gap junction coupling with principal cells. Nat Neurosci (2013) 0.97

Neurogliaform and Ivy Cells: A Major Family of nNOS Expressing GABAergic Neurons. Front Neural Circuits (2012) 0.95

Seizure-induced alterations in fast-spiking basket cell GABA currents modulate frequency and coherence of gamma oscillation in network simulations. Chaos (2013) 0.95

Mechanisms contributing to central excitability changes during hearing loss. Proc Natl Acad Sci U S A (2012) 0.95

Differences in spike train variability in rat vasopressin and oxytocin neurons and their relationship to synaptic activity. J Physiol (2007) 0.94

Multiple extra-synaptic spillover mechanisms regulate prolonged activity in cerebellar Golgi cell-granule cell loops. J Physiol (2011) 0.94

Balanced synaptic input shapes the correlation between neural spike trains. PLoS Comput Biol (2011) 0.94

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits. Neuron (2016) 0.93

Spike timing regulation on the millisecond scale by distributed synaptic plasticity at the cerebellum input stage: a simulation study. Front Comput Neurosci (2013) 0.93

Discovery and rediscoveries of Golgi cells. J Physiol (2010) 0.93

Balanced excitatory and inhibitory synaptic currents promote efficient coding and metabolic efficiency. PLoS Comput Biol (2013) 0.93

Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal cultures. J Physiol (2006) 0.93

NMDA receptors with incomplete Mg²⁺ block enable low-frequency transmission through the cerebellar cortex. J Neurosci (2012) 0.91

Dendritic inhibition mediated by O-LM and bistratified interneurons in the hippocampus. Front Synaptic Neurosci (2014) 0.91

The spatiotemporal organization of cerebellar network activity resolved by two-photon imaging of multiple single neurons. Front Cell Neurosci (2014) 0.90

Dissociation of response variability from firing rate effects in frontal eye field neurons during visual stimulation, working memory, and attention. J Neurosci (2012) 0.90

The impact of tonic GABAA receptor-mediated inhibition on neuronal excitability varies across brain region and cell type. Front Neural Circuits (2014) 0.90

The cerebellar Golgi cell and spatiotemporal organization of granular layer activity. Front Neural Circuits (2013) 0.90

How shunting inhibition affects the discharge of lumbar motoneurones: a dynamic clamp study in anaesthetized cats. J Physiol (2004) 0.89

Combined LTP and LTD of modulatory inputs controls neuronal processing of primary sensory inputs. J Neurosci (2011) 0.89

In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells. J Physiol (2007) 0.89

GABA as a rising gliotransmitter. Front Neural Circuits (2014) 0.89

Excitability of cortical neurons depends upon a powerful tonic conductance in inhibitory networks. Thalamus Relat Syst (2005) 0.88

Postdepolarization potentiation of GABAA receptors: a novel mechanism regulating tonic conductance in hippocampal neurons. J Neurosci (2010) 0.88

Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder. Front Cell Neurosci (2014) 0.87

Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors. Mol Brain (2013) 0.87

Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala. J Neurophysiol (2014) 0.87

Increase in sodium conductance decreases firing rate and gain in model neurons. J Neurosci (2012) 0.87

Hearing in noisy environments: noise invariance and contrast gain control. J Physiol (2014) 0.86

Protein kinase C regulates tonic GABA(A) receptor-mediated inhibition in the hippocampus and thalamus. Eur J Neurosci (2013) 0.86

Interactions between behaviorally relevant rhythms and synaptic plasticity alter coding in the piriform cortex. J Neurosci (2012) 0.86

Enhanced astroglial GABA uptake attenuates tonic GABAA inhibition of the presympathetic hypothalamic paraventricular nucleus neurons in heart failure. J Neurophysiol (2015) 0.86

Structure, function, and plasticity of GABA transporters. Front Cell Neurosci (2014) 0.86

Rapid regulation of tonic GABA currents in cultured rat hippocampal neurons. J Neurophysiol (2012) 0.86

Robustness effect of gap junctions between Golgi cells on cerebellar cortex oscillations. Neural Syst Circuits (2011) 0.85

Reduction of spike afterdepolarization by increased leak conductance alters interspike interval variability. J Neurosci (2009) 0.85

Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca2+ channels via microdomain coupling. J Neurosci (2012) 0.85

Mechanism of gain modulation at single neuron and network levels. J Comput Neurosci (2008) 0.85

Pre- and postsynaptic modulation of monosynaptic reflex by GABAA receptors on turtle spinal cord. J Physiol (2010) 0.85

Unitary IPSPs enhance hilar mossy cell gain in the rat hippocampus. J Physiol (2006) 0.84

The cortical energy needed for conscious perception. Neuroimage (2008) 0.84

A unifying principle underlying the extracellular field potential spectral responses in the human cortex. J Neurophysiol (2015) 0.84

The contribution of synaptic location to inhibitory gain control in pyramidal cells. Physiol Rep (2013) 0.84

Tonic GABAA conductance decreases membrane time constant and increases EPSP-spike precision in hippocampal pyramidal neurons. Front Neural Circuits (2013) 0.83

Articles by these authors

Tonically active GABA A receptors: modulating gain and maintaining the tone. Trends Neurosci (2004) 4.28

Synaptic connections between layer 4 spiny neurone-layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column. J Physiol (2002) 2.70

Spillover of glutamate onto synaptic AMPA receptors enhances fast transmission at a cerebellar synapse. Neuron (2002) 2.66

neuroConstruct: a tool for modeling networks of neurons in 3D space. Neuron (2007) 2.58

NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail. PLoS Comput Biol (2010) 2.45

Cerebellar LTD and pattern recognition by Purkinje cells. Neuron (2007) 2.18

Modulation of glutamate mobility reveals the mechanism underlying slow-rising AMPAR EPSCs and the diffusion coefficient in the synaptic cleft. Neuron (2004) 1.91

MorphML: level 1 of the NeuroML standards for neuronal morphology data and model specification. Neuroinformatics (2007) 1.89

The contribution of single synapses to sensory representation in vivo. Science (2008) 1.88

Fast vesicle reloading and a large pool sustain high bandwidth transmission at a central synapse. Nature (2006) 1.79

Synaptic depression enables neuronal gain control. Nature (2009) 1.76

Bassoon speeds vesicle reloading at a central excitatory synapse. Neuron (2010) 1.67

Rapid desynchronization of an electrically coupled interneuron network with sparse excitatory synaptic input. Neuron (2010) 1.65

A compact Acousto-Optic Lens for 2D and 3D femtosecond based 2-photon microscopy. Opt Express (2010) 1.49

Synaptic and cellular properties of the feedforward inhibitory circuit within the input layer of the cerebellar cortex. J Neurosci (2008) 1.39

Rapid vesicular release, quantal variability, and spillover contribute to the precision and reliability of transmission at a glomerular synapse. J Neurosci (2005) 1.26

Desensitization properties of AMPA receptors at the cerebellar mossy fiber granule cell synapse. J Neurosci (2007) 1.20

The density of AMPA receptors activated by a transmitter quantum at the climbing fibre-Purkinje cell synapse in immature rats. J Physiol (2003) 1.16

Gap junctions compensate for sublinear dendritic integration in an inhibitory network. Science (2012) 1.13

Impact of wavefront distortion and scattering on 2-photon microscopy in mammalian brain tissue. Opt Express (2011) 1.03

Sustaining rapid vesicular release at active zones: potential roles for vesicle tethering. Trends Neurosci (2012) 0.98

Determinants of synaptic integration and heterogeneity in rebound firing explored with data-driven models of deep cerebellar nucleus cells. J Comput Neurosci (2010) 0.94

NMDA receptors with incomplete Mg²⁺ block enable low-frequency transmission through the cerebellar cortex. J Neurosci (2012) 0.91

Estimation of quantal parameters with multiple-probability fluctuation analysis. Methods Mol Biol (2007) 0.86

Errors in the estimation of the variance: implications for multiple-probability fluctuation analysis. J Neurosci Methods (2005) 0.86

Flashy science: controlling neural function with light. J Neurosci (2005) 0.84

Estimation of the time course of neurotransmitter release at central synapses from the first latency of postsynaptic currents. J Neurosci Methods (2011) 0.79