Published in JAMA on May 21, 2003
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ (2013) 9.01
Definition, reporting, and interpretation of composite outcomes in clinical trials: systematic review. BMJ (2010) 3.46
Strength of association between umbilical cord pH and perinatal and long term outcomes: systematic review and meta-analysis. BMJ (2010) 3.32
Validity of composite end points in clinical trials. BMJ (2005) 3.26
Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials. BMJ (2007) 3.06
Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. BMJ (2011) 2.68
Cardiovascular outcomes in the AFFIRM Trial (Atrial Fibrillation Follow-Up Investigation of Rhythm Management). An assessment of individual antiarrhythmic drug therapies compared with rate control with propensity score-matched analyses. J Am Coll Cardiol (2011) 2.42
Financial ties and concordance between results and conclusions in meta-analyses: retrospective cohort study. BMJ (2007) 2.15
Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy: not all AIDS-defining conditions are created equal. Clin Infect Dis (2009) 1.86
Rethinking composite end points in clinical trials: insights from patients and trialists. Circulation (2014) 1.61
Therapeutic hypothermia following perinatal asphyxia. Arch Dis Child Fetal Neonatal Ed (2006) 1.44
Computerised interpretation of fetal heart rate during labour (INFANT): a randomised controlled trial. Lancet (2017) 1.44
Longitudinal association between medication adherence and lung health in people with cystic fibrosis. J Cyst Fibros (2011) 1.41
Competing risks analyses: objectives and approaches. Eur Heart J (2014) 1.35
Emerging role of dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes. Vasc Health Risk Manag (2008) 1.27
Delta inflation: a bias in the design of randomized controlled trials in critical care medicine. Crit Care (2010) 1.09
How well does the evidence on pioglitazone back up researchers' claims for a reduction in macrovascular events? BMJ (2005) 1.08
Characteristics of primary care practices associated with high quality of care. CMAJ (2013) 1.07
Glycemic Control for Patients With Type 2 Diabetes Mellitus: Our Evolving Faith in the Face of Evidence. Circ Cardiovasc Qual Outcomes (2016) 1.02
Methodologic issues in health informatics trials: the complexities of complex interventions. J Am Med Inform Assoc (2008) 1.01
A systematic review of cooling for neuroprotection in neonates with hypoxic ischemic encephalopathy - are we there yet? BMC Pediatr (2007) 0.97
Outcome based subgroup analysis: a neglected concern. Trials (2009) 0.97
Composite and surrogate outcomes in randomised controlled trials. BMJ (2007) 0.97
Quality of reporting internal and external validity data from randomized controlled trials evaluating stents for percutaneous coronary intervention. BMC Med Res Methodol (2009) 0.96
Analysing recurrent hospitalizations in heart failure: a review of statistical methodology, with application to CHARM-Preserved. Eur J Heart Fail (2013) 0.96
Exercise training as therapy for heart failure: current status and future directions. Circ Heart Fail (2015) 0.95
Use of composite end points to measure clinical events. JAMA (2003) 0.95
Establishment of an index with increased sensitivity for assessing murine arthritis. J Orthop Res (2011) 0.94
Alternative methods for testing treatment effects on the basis of multiple outcomes: simulation and case study. Stat Med (2011) 0.93
The effect of a pre- and post-operative orthogeriatric service on cognitive function in patients with hip fracture. The protocol of the Oslo Orthogeriatrics Trial. BMC Geriatr (2012) 0.92
Clinical trials--multiple treatments, multiple end points, and multiple lessons. JAMA (2003) 0.92
Weighting composite endpoints in clinical trials: essential evidence for the heart team. Ann Thorac Surg (2012) 0.90
The case for statins: has it really been made? J R Soc Med (2004) 0.89
The use and abuse of multiple outcomes in randomized controlled depression trials. Contemp Clin Trials (2010) 0.89
Use of alternative methodologies for evaluation of composite end points in trials of therapies for critical limb ischemia. Am Heart J (2012) 0.88
Assessing technological change in cardiothoracic surgery. Semin Thorac Cardiovasc Surg (2009) 0.86
Designing and analyzing clinical trials with composite outcomes: consideration of possible treatment differences between the individual outcomes. PLoS One (2012) 0.85
Balancing risks and benefits of therapy for patients with favorable-risk limited-stage Hodgkin lymphoma: the role of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy alone. Hematol Oncol Clin North Am (2014) 0.84
Multiple risk factor intervention trial revisited: a new perspective based on nonfatal and fatal composite endpoints, coronary and cardiovascular, during the trial. J Am Heart Assoc (2012) 0.83
Chinese Herbal Medicine Combined with Conventional Therapy for Blood Pressure Variability in Hypertension Patients: A Systematic Review of Randomized Controlled Trials. Evid Based Complement Alternat Med (2015) 0.83
Are all outcomes in chronic heart failure rated equally? An argument for a patient-centred approach to outcome assessment. Heart Fail Rev (2014) 0.83
Importance of achieving the composite endpoints in diabetes. Indian J Endocrinol Metab (2013) 0.81
Misspecification of Cox regression models with composite endpoints. Stat Med (2012) 0.81
A randomised controlled trial comparing standard or intensive management of reduced fetal movements after 36 weeks gestation--a feasibility study. BMC Pregnancy Childbirth (2013) 0.80
Concordance of effects of medical interventions on hospital admission and readmission rates with effects on mortality. CMAJ (2013) 0.80
Predicting major outcomes in type 1 diabetes: a model development and validation study. Diabetologia (2014) 0.79
Endpoint selection and relative (versus absolute) risk reporting in published medication trials. J Gen Intern Med (2011) 0.79
Biomarker validation: common data analysis concerns. Oncologist (2014) 0.79
Physiotherapy trials for the 21st century: time to raise the bar? J R Soc Med (2011) 0.79
AKI: not just a short-term problem? Clin J Am Soc Nephrol (2014) 0.79
The effect of tranexamic acid on the risk of death and hysterectomy in women with post-partum haemorrhage: statistical analysis plan for the WOMAN trial. Trials (2016) 0.79
Competing event risk stratification may improve the design and efficiency of clinical trials: secondary analysis of SWOG 8794. Contemp Clin Trials (2012) 0.78
Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial. Eur Heart J (2016) 0.78
Effectiveness and safety of glimepiride and iDPP4, associated with metformin in second line pharmacotherapy of type 2 diabetes mellitus: systematic review and meta-analysis. Int J Clin Pract (2015) 0.77
Transdermal nitroglycerin for the treatment of preterm labor: a systematic review and metaanalysis. Am J Obstet Gynecol (2013) 0.77
JUPITER: a few words of caution. Circ Cardiovasc Qual Outcomes (2009) 0.77
Coming out in color: racial/ethnic differences in the relationship between level of sexual identity disclosure and depression among lesbians. Cultur Divers Ethnic Minor Psychol (2014) 0.77
Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms. J Gerontol A Biol Sci Med Sci (2016) 0.77
Relationship of glycaemic control and hypoglycaemic episodes to 4-year cardiovascular outcomes in people with type 2 diabetes starting insulin. Diabetes Obes Metab (2015) 0.77
Comparative study of outcome measures and analysis methods for traumatic brain injury trials. J Neurotrauma (2015) 0.76
Outcome Reporting in Cardiac Surgery Trials: Systematic Review and Critical Appraisal. J Am Heart Assoc (2015) 0.76
Development of a composite endpoint for randomized controlled trials in pancreaticoduodenectomy. World J Surg (2014) 0.76
A comparative cohort study of totally laparoscopic and open aortobifemoral bypass for the treatment of advanced atherosclerosis. Vasc Health Risk Manag (2015) 0.76
Large sample inference for a win ratio analysis of a composite outcome based on prioritized components. Biostatistics (2015) 0.75
The incremental value of troponin biomarkers in risk stratification of acute coronary syndromes: is the relationship multiplicative? Open Cardiovasc Med J (2009) 0.75
Delphi-consensus weights for ischemic and bleeding events to be included in a composite outcome for RCTs in thrombosis prevention. PLoS One (2011) 0.75
Clinical Relevance of Rehospitalizations for Unstable Angina and Unplanned Revascularization Following Acute Myocardial Infarction. J Am Heart Assoc (2016) 0.75
Beyond Composite Endpoints Analysis: Semicompeting Risks as an Underutilized Framework for Cancer Research. J Natl Cancer Inst (2016) 0.75
Does fluconazole prophylaxis reduce death or invasive candida infection in extremely preterm infants? Acta Paediatr (2017) 0.75
Adherence to Cardiac Practice Guidelines in the Management of Non-ST-Elevation Acute Coronary Syndromes: A Systematic Literature Review. Curr Cardiol Rev (2017) 0.75
Fluid restriction and prophylactic indomethacin in extremely low birth weight infants. J Clin Neonatol (2012) 0.75
An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome. Stat Methods Med Res (2016) 0.75
Outcomes, outcomes, every where, nor any stop to think? J Gen Intern Med (2011) 0.75
Does early treatment with inhaled budesonide prevent death or bronchopulmonary dysplasia in extremely preterm infants? Acta Paediatr (2017) 0.75
Combining adverse pregnancy and perinatal outcomes for women exposed to antiepileptic drugs during pregnancy, using a latent trait model. BMC Pregnancy Childbirth (2017) 0.75
Development of a composite outcome score for a complex intervention - measuring the impact of Community Health Workers. Trials (2015) 0.75
The Anticoagulation of Calf Thrombosis (ACT) project: study protocol for a randomized controlled trial. Trials (2012) 0.75
Negative Pressure Wound Therapy on Surgical Site Infections in Women Undergoing Elective Caesarean Sections: A Pilot RCT. Healthcare (Basel) (2014) 0.75
Win Ratio -An Intuitive and Easy-To-Interpret Composite Outcome in Medical Studies. Shanghai Arch Psychiatry (2017) 0.75
Accelerometry: Improving Objective Assessments of Therapeutic Impact in Pediatric Pulmonary Arterial Hypertension. Am J Respir Crit Care Med (2017) 0.75
Clinical Trials in Veterinary Medicine: A New Era Brings New Challenges. J Vet Intern Med (2017) 0.75
Safety and immunogenicity of an inactivated split-virion influenza A/Vietnam/1194/2004 (H5N1) vaccine: phase I randomised trial. Lancet (2006) 5.72
A randomised controlled trial of the effect of educational outreach by community pharmacists on prescribing in UK general practice. Br J Gen Pract (2002) 4.37
Safety and immunogenicity of an inactivated adjuvanted whole-virion influenza A (H5N1) vaccine: a phase I randomised controlled trial. Lancet (2006) 4.22
The EuroHeart Failure survey programme-- a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis. Eur Heart J (2003) 4.09
Clinical medication review by a pharmacist of elderly people living in care homes--randomised controlled trial. Age Ageing (2006) 3.21
Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. Nat Genet (2011) 2.42
Patient-reported outcome alerts: ethical and logistical considerations in clinical trials. JAMA (2013) 2.15
Boosting immunity to influenza H5N1 with MF59-adjuvanted H5N3 A/Duck/Singapore/97 vaccine in a primed human population. Vaccine (2003) 2.04
Cluster randomised controlled trial of the effectiveness of primary care mental health workers. Br J Gen Pract (2007) 1.91
A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor. Cancer J (2004) 1.85
Impact of wound edge protection devices on surgical site infection after laparotomy: multicentre randomised controlled trial (ROSSINI Trial). BMJ (2013) 1.83
A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine. Vaccine (2009) 1.80
Vertebral fracture assessment (VFA) with a densitometer predicts future fractures in elderly women unselected for osteoporosis. J Bone Miner Res (2008) 1.69
The effect of Transtheoretical Model based interventions on smoking cessation. Soc Sci Med (2008) 1.65
A fair innings for NICE? Pharmacoeconomics (2002) 1.65
Patient-reported outcomes in randomized clinical trials: development of ISOQOL reporting standards. Qual Life Res (2012) 1.62
A controlled trial of an expert system and self-help manual intervention based on the stages of change versus standard self-help materials in smoking cessation. Addiction (2003) 1.57
The Heart Failure Revascularisation Trial (HEART). Eur J Heart Fail (2010) 1.57
Do shock absorbing insoles in recruits undertaking high levels of physical activity reduce lower limb injury? A randomized controlled trial. J R Soc Med (2006) 1.48
Evaluation of two nitrous oxide scavenging systems using infrared thermography to visualize and control emissions. J Am Dent Assoc (2009) 1.42
Commentary on the EBOR trial report. Br J Gen Pract (2002) 1.40
ORS during the 2000-2001 influenza vaccination season. Can Commun Dis Rep (2002) 1.38
An adjuvanted pandemic influenza H1N1 vaccine provides early and long term protection in health care workers. Vaccine (2010) 1.32
Improving influenza vaccine virus selection: report of a WHO informal consultation held at WHO headquarters, Geneva, Switzerland, 14-16 June 2010. Influenza Other Respir Viruses (2011) 1.32
Novel phenotypes identified by plasma biochemical screening in the mouse. Mamm Genome (2002) 1.22
The consortium for the standardization of influenza seroepidemiology (CONSISE): a global partnership to standardize influenza seroepidemiology and develop influenza investigation protocols to inform public health policy. Influenza Other Respir Viruses (2012) 1.20
Influenza virus surveillance, vaccine strain selection, and manufacture. Methods Mol Biol (2012) 1.18
Physiotherapy rehabilitation post first lumbar discectomy: a systematic review and meta-analysis of randomized controlled trials. Spine (Phila Pa 1976) (2011) 1.14
The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants. Cancer J (2002) 1.12
On the activation of soluble guanylyl cyclase by nitric oxide. Proc Natl Acad Sci U S A (2001) 1.12
Cardiovascular function and treatment in β-thalassemia major: a consensus statement from the American Heart Association. Circulation (2013) 1.11
PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition. Cell Cycle (2004) 1.10
Prevalence of heart failure and atrial fibrillation in minority ethnic subjects: the Ethnic-Echocardiographic Heart of England Screening Study (E-ECHOES). PLoS One (2011) 1.05
The unmet need for interpreting provision in UK primary care. PLoS One (2011) 1.03
What potential research participants want to know about research: a systematic review. BMJ Open (2012) 1.03
The CONSORT Patient-Reported Outcome (PRO) extension: implications for clinical trials and practice. Health Qual Life Outcomes (2013) 1.02
A cell-based H7N1 split influenza virion vaccine confers protection in mouse and ferret challenge models. Influenza Other Respir Viruses (2009) 1.01
Inconsistencies in quality of life data collection in clinical trials: a potential source of bias? Interviews with research nurses and trialists. PLoS One (2013) 1.01
Does stage-based smoking cessation advice in pregnancy result in long-term quitters? 18-month postpartum follow-up of a randomized controlled trial. Addiction (2005) 1.00
Patient reported outcomes (PROs) in clinical trials: is 'in-trial' guidance lacking? a systematic review. PLoS One (2013) 1.00
Sildenafil therapy in thalassemia patients with Doppler-defined risk of pulmonary hypertension. Haematologica (2013) 0.99
Systematic review of the clinical effectiveness of wound-edge protection devices in reducing surgical site infection in patients undergoing open abdominal surgery. Ann Surg (2012) 0.98
The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias. BMC Med Res Methodol (2008) 0.96
Prevalence of ECG abnormalities in an international survey of patients with suspected or confirmed heart failure at death or discharge. Eur J Heart Fail (2007) 0.96
Iron chelation therapy in thalassemia major: a systematic review with meta-analyses of 1520 patients included on randomized clinical trials. Blood Cells Mol Dis (2011) 0.95
Modelling effects of stair width on rates of stair climbing in a train station. Prev Med (2008) 0.95
A review of acrylamide: an industry perspective on research, analysis, formation, and control. Crit Rev Food Sci Nutr (2004) 0.95
Cross-neutralisation of antibodies elicited by an inactivated split-virion influenza A/Vietnam/1194/2004 (H5N1) vaccine in healthy adults against H5N1 clade 2 strains. Influenza Other Respir Viruses (2009) 0.94
A single-dose influenza A (H5N1) vaccine safe and immunogenic in adult and elderly patients: an approach to pandemic vaccine development. J Virol (2009) 0.94
Tissue iron evaluation in chronically transfused children shows significant levels of iron loading at a very young age. Am J Hematol (2013) 0.94
Matrix-M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model. Influenza Other Respir Viruses (2011) 0.94
Enhancing the reproducibility of serological methods used to evaluate immunogenicity of pandemic H1N1 influenza vaccines-an effective EU regulatory approach. Vaccine (2012) 0.93
Concurrent silicosis and pulmonary mycosis at death. Emerg Infect Dis (2010) 0.92
Treating thalassemia major-related iron overload: the role of deferiprone. J Blood Med (2012) 0.92
A statistical comparison of silver and SYPRO Ruby staining for proteomic analysis. Electrophoresis (2004) 0.92
Homograft conduit failure in infants is not due to somatic outgrowth. J Thorac Cardiovasc Surg (2002) 0.92
Electrocardiographic consequences of cardiac iron overload in thalassemia major. Am J Hematol (2011) 0.91
Comparison of plate-screw systems used in mandibular fracture reduction: finite element analysis. J Biomech Eng (2006) 0.91
Medicine administration errors in patients with dysphagia in secondary care: a multi-centre observational study. J Adv Nurs (2011) 0.91
Huntington's disease: current epidemiology and pharmacological management in UK primary care. Neuroepidemiology (2011) 0.90
Treatment of heart failure in adults with thalassemia major: response in patients randomised to deferoxamine with or without deferiprone. J Cardiovasc Magn Reson (2013) 0.89
Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy. Transfusion (2012) 0.89
The diagnosis of heart failure in European primary care: The IMPROVEMENT Programme survey of perception and practice. Eur J Heart Fail (2005) 0.88
Adiposity predicts carotid intima-media thickness in healthy children and adolescents. J Pediatr (2009) 0.88
Animal models and antibody assays for evaluating candidate SARS vaccines: summary of a technical meeting 25-26 August 2005, London, UK. Vaccine (2006) 0.87
Relation of sex, age and concomitant diseases to drug prescription for heart failure in primary care in Europe. Eur J Heart Fail (2004) 0.87
Fatal venous thromboembolism associated with hospital admission: a cohort study to assess the impact of a national risk assessment target. Heart (2013) 0.87
Modulation of oral squamous cell carcinoma incidence in rats via diet and a novel calcium channel antagonist. Toxicol Pathol (2005) 0.87
Case finding for chronic obstructive pulmonary disease in primary care: a pilot randomised controlled trial. Br J Gen Pract (2013) 0.86
Ferritin trends do not predict changes in total body iron in patients with transfusional iron overload. Am J Hematol (2014) 0.86
Improving influenza vaccine virus selection: report of a WHO informal consultation held at WHO headquarters, Geneva, Switzerland, 14-16 June 2010. Influenza Other Respir Viruses (2013) 0.85
Centre selection for clinical trials and the generalisability of results: a mixed methods study. PLoS One (2013) 0.85
Hepatic Iron Quantification on 3 Tesla (3 T) Magnetic Resonance (MR): Technical Challenges and Solutions. Radiol Res Pract (2013) 0.84
A novel powder sample holder for the determination of glass transition temperatures by DMA. Int J Pharm (2009) 0.84
Protection of mice from H5N1 influenza challenge by prophylactic DNA vaccination using particle mediated epidermal delivery. Vaccine (2007) 0.83
A randomized controlled trial of smoking cessation for pregnant women to test the effect of a transtheoretical model-based intervention on movement in stage and interaction with baseline stage. Br J Health Psychol (2006) 0.83
Pyramidal cells of rodent presubiculum express a tetrodotoxin-insensitive Na+ current. J Physiol (2009) 0.82
Comparison of sensitivity between real-time detection of a TaqMan assay for Batrachochytrium dendrobatidis and conventional detection. Dis Aquat Organ (2011) 0.82
Protein expression analysis of drug-mediated hepatotoxicity in the Sprague-Dawley rat. Proteomics (2002) 0.82
CoLIde: a bioinformatics tool for CO-expression-based small RNA Loci Identification using high-throughput sequencing data. RNA Biol (2013) 0.81
Physiotherapy rehabilitation for whiplash associated disorder II: a systematic review and meta-analysis of randomised controlled trials. BMJ Open (2011) 0.81
In search of the optimal iron chelation therapy for patients with thalassemia major. Haematologica (2011) 0.81
Syndrome of inappropriate antidiuretic hormone secretion induced by a single dose of oral cyclophosphamide. Ann Pharmacother (2012) 0.81
A multi-component stair climbing promotional campaign targeting calorific expenditure for worksites; a quasi-experimental study testing effects on behaviour, attitude and intention. BMC Public Health (2012) 0.80
Multi-professional clinical medication reviews in care homes for the elderly: study protocol for a randomised controlled trial with cost effectiveness analysis. Trials (2011) 0.80
Using e-mail recruitment and an online questionnaire to establish effect size: A worked example. BMC Med Res Methodol (2011) 0.80
A pilot study of the immune response to whole inactivated avian influenza H7N1 virus vaccine in mice. Influenza Other Respir Viruses (2009) 0.80
Impact of active monitoring on lithium management in Norfolk. Ther Adv Psychopharmacol (2013) 0.80
The clinical utility of Multiplate analyser measurement in platelet function testing following stroke and transient ischaemic attack. Eur J Haematol (2014) 0.79
Characterization of common genetic variants in cathepsin K and testing for association with bone mineral density in a large cohort of perimenopausal women from Scotland. J Bone Miner Res (2004) 0.79
Cardiac resynchronization therapy in heart failure. Ann Intern Med (2005) 0.78
Protein expression changes in the Sprague Dawley rat liver proteome following administration of peroxisome proliferator activated receptor alpha and gamma ligands. Proteomics (2003) 0.78
Mucoid impaction: a localized form of allergic bronchopulmonary aspergillosis. Allergy Asthma Proc (2004) 0.78
Characterizing chronic pericarditis using steady-state free-precession cine MR imaging. AJR Am J Roentgenol (2002) 0.78
Designing "Real-World" trials to meet the needs of health policy makers at marketing authorization. J Clin Epidemiol (2011) 0.78