Published in J Cancer Res Clin Oncol on May 21, 2003
The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. J Cell Biol (2006) 2.10
DLC-1:a Rho GTPase-activating protein and tumour suppressor. J Cell Mol Med (2007) 2.09
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells. Cancer Res (2005) 1.94
Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver. Int J Biochem Cell Biol (2007) 1.64
The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis. Cancer Cell (2009) 1.14
Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma. PLoS One (2008) 1.08
High-resolution array CGH clarifies events occurring on 8p in carcinogenesis. BMC Cancer (2008) 0.98
Deleted in liver cancer protein family in human malignancies (Review). Oncol Lett (2011) 0.89
Differential expression of breast cancer-associated genes between stage- and age-matched tumor specimens from African- and Caucasian-American Women diagnosed with breast cancer. BMC Res Notes (2012) 0.88
PIWI-interacting RNA 021285 is involved in breast tumorigenesis possibly by remodeling the cancer epigenome. Carcinogenesis (2015) 0.84
MicroRNA-200c and microRNA-31 regulate proliferation, colony formation, migration and invasion in serous ovarian cancer. J Ovarian Res (2015) 0.83
The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity. BMC Cancer (2015) 0.77
Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri. Oncotarget (2017) 0.75
Rho GTPases: signaling, migration, and invasion. Exp Cell Res (2000) 2.82
Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. Cancer Res (1998) 2.59
Clinical significance of alterations of chromosome 8 in high-grade, advanced, nonmetastatic prostate carcinoma. J Natl Cancer Inst (1999) 1.70
Strong indication for a breast cancer susceptibility gene on chromosome 8p12-p22: linkage analysis in German breast cancer families. Oncogene (1997) 1.61
Loss of heterozygosity and linkage analysis in breast carcinoma: indication for a putative third susceptibility gene on the short arm of chromosome 8. Oncogene (1995) 1.58
Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc Natl Acad Sci U S A (2002) 1.51
DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1. Cancer Res (2000) 1.48
Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes. Oncogene (1999) 1.39
Allelic losses at chromosome 8p21-23 are early and frequent events in the pathogenesis of lung cancer. Cancer Res (1999) 1.32
Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. FEBS Lett (2002) 1.27
FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis. Proc Natl Acad Sci U S A (2001) 1.15
Allelic loss of chromosomal arm 8p in breast cancer progression. Am J Pathol (1998) 1.13
Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma. Oncogene (1999) 1.04
Localization of multiple melanoma tumor-suppressor genes on chromosome 11 by use of homozygosity mapping-of-deletions analysis. Am J Hum Genet (2000) 0.97
Localization of chromosome 8p regions involved in early tumorigenesis of oral and laryngeal squamous carcinoma. Oncogene (1998) 0.95
Chromosome region 8p11-p21: refined mapping and molecular alterations in breast cancer. Genes Chromosomes Cancer (1998) 0.92
High frequency of allelic imbalance at regions of chromosome arm 8p in ovarian carcinoma. Cancer Genet Cytogenet (2001) 0.92
Localization of a tumor suppressor gene associated with the progression of human breast carcinoma within a 1-cM interval of 8p22-p23.1. Cancer (1999) 0.89
Sequence variants of DLC1 in colorectal and ovarian tumours. Hum Mutat (2000) 0.87
Loss of heterozygosity at chromosome segments 8p22 and 8p11.2-21.1 in transitional-cell carcinoma of the urinary bladder. Int J Cancer (2000) 0.87
Detailed physical and deletion mapping of 8p with isolation of YAC clones from tumour suppressor loci involved in colorectal cancer. Oncogene (1996) 0.86
Refined deletion mapping in sporadic breast cancer at chromosomal region 8p12-p21 and association with clinicopathological parameters. Eur J Cancer (2000) 0.85
8pter-p23 deletion is associated with racial differences in prostate cancer outcome. Clin Cancer Res (2000) 0.85
Identification of a region of homozygous deletion on 8p22-23.1 in medulloblastoma. Oncogene (2002) 0.83
Mutation analysis and mRNA expression of trail-receptors in human breast cancer. Int J Cancer (2002) 0.80
Deletion mapping and linkage analysis provide strong indication for the involvement of the human chromosome region 8p12-p22 in breast carcinogenesis. Br J Cancer (1997) 0.77
Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype. Clin Cancer Res (2005) 5.70
Pathology of ovarian cancers in BRCA1 and BRCA2 carriers. Clin Cancer Res (2004) 2.17
Identification of brain- and bone-specific breast cancer metastasis genes. Cancer Lett (2008) 1.54
Limited relevance of the CHEK2 gene in hereditary breast cancer. Int J Cancer (2004) 1.49
SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer. Oncogene (2003) 1.46
Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker. Int J Cancer (2009) 1.37
Tumor suppressor activity of profilin requires a functional actin binding site. Mol Biol Cell (2004) 1.23
ST18 is a breast cancer tumor suppressor gene at human chromosome 8q11.2. Oncogene (2004) 1.19
Mutation and expression of PDGFRA and KIT in malignant peripheral nerve sheath tumors, and its implications for imatinib sensitivity. Carcinogenesis (2005) 1.11
Gastric cancer surgery in elderly patients. World J Surg (2006) 1.07
Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines. Genes Chromosomes Cancer (2003) 1.03
Subclassification of nerve sheath tumors by gene expression profiling. Brain Pathol (2004) 1.03
Characterization of {gamma}-aminobutyric acid type A receptor-associated protein, a novel tumor suppressor, showing reduced expression in breast cancer. Cancer Res (2005) 0.92
Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated breast tumor suppression. Genes Chromosomes Cancer (2006) 0.92
Body mass index does not affect systematic D2 lymph node dissection and postoperative morbidity in gastric cancer patients. Ann Surg Oncol (2003) 0.90
Mutation analysis of BRCA1 and BRCA2 genes in Iranian high risk breast cancer families. J Cancer Res Clin Oncol (2005) 0.90
Comparison of gene expression data from human and mouse breast cancers: identification of a conserved breast tumor gene set. Int J Cancer (2007) 0.90
Suppression of polyploidy by the BRCA2 protein. Cancer Lett (2007) 0.86
Prognostic value of cytokeratin-positive bone marrow cells of gastric cancer patients. Ann Surg Oncol (2007) 0.83
Screening for large rearrangements of the BRCA1 gene in German breast or ovarian cancer families using semi-quantitative multiplex PCR method. Hum Mutat (2003) 0.82
Profile of differentially expressed genes after transfer of chromosome 17 into the breast cancer cell line CAL51. Genes Chromosomes Cancer (2005) 0.81
Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway. Biol Chem (2007) 0.80
Mutation analysis and mRNA expression of trail-receptors in human breast cancer. Int J Cancer (2002) 0.80
Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines. Biol Chem (2003) 0.78
SV40 large T antigen-transformed human primary normal and cancerous mammary epithelial cells are phenotypically similar but can be distinguished in 3D culture with selection medium. Int J Cancer (2008) 0.77
A network of clinically and functionally relevant genes is involved in the reversion of the tumorigenic phenotype of MDA-MB-231 breast cancer cells after transfer of human chromosome 8. Oncogene (2005) 0.77
Hamster polyomavirus-derived virus-like particles are able to transfer in vitro encapsidated plasmid DNA to mammalian cells. Virus Genes (2006) 0.77
Chimeric bacteriophage fr virus-like particles harboring the immunodominant C-terminal region of hamster polyomavirus VP1 induce a strong VP1-specific antibody response in rabbits and mice. Viral Immunol (2002) 0.76