Published in J Nutr on June 01, 2003
Stress granule assembly is mediated by prion-like aggregation of TIA-1. Mol Biol Cell (2004) 6.04
Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell (2012) 2.71
Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript. Free Radic Biol Med (2006) 1.73
The emerging role of mTORC1 signaling in placental nutrient-sensing. Placenta (2012) 1.12
Discovery of the genes in response to white spot syndrome virus (WSSV) infection in Fenneropenaeus chinensis through cDNA microarray. Mar Biotechnol (NY) (2006) 1.04
Insulin is required for amino acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetus. Am J Physiol Endocrinol Metab (2008) 1.00
Regulation of mTOR by amino acids and resistance exercise in skeletal muscle. Eur J Appl Physiol (2005) 0.98
Proline responding1 Plays a Critical Role in Regulating General Protein Synthesis and the Cell Cycle in Maize. Plant Cell (2014) 0.97
Nerveless and gutsy: intestinal nutrient sensing from invertebrates to humans. Semin Cell Dev Biol (2012) 0.97
Inhibition of translation initiation by volatile anesthetics involves nutrient-sensitive GCN-independent and -dependent processes in yeast. Mol Biol Cell (2005) 0.89
Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation. Am J Physiol Endocrinol Metab (2009) 0.89
The effect of branched chain amino acids on skeletal muscle mitochondrial function in young and elderly adults. J Clin Endocrinol Metab (2009) 0.86
A role for Drosophila dFoxO and dFoxO 5'UTR internal ribosomal entry sites during fasting. PLoS One (2010) 0.86
Pyruvate modifies metabolic flux and nutrient sensing during extracorporeal membrane oxygenation in an immature swine model. Am J Physiol Heart Circ Physiol (2015) 0.78
[Cellular regulation of anabolism and catabolism in skeletal muscle during immobilisation, aging and critical illness]. Wien Klin Wochenschr (2007) 0.77
Sirolimus therapy following early cyclosporine withdrawal in transplant patients: mechanisms of action and clinical results. Int J Nanomedicine (2006) 0.75
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem (2002) 3.81
Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes (2006) 3.31
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol (2002) 3.22
Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr (2005) 1.83
Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. J Biol Chem (2006) 1.78
Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner. J Biol Chem (2004) 1.77
Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle. J Physiol (2003) 1.75
ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. Biochem Biophys Res Commun (2008) 1.63
Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. J Physiol (2006) 1.48
Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. Am J Physiol Endocrinol Metab (2002) 1.48
Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation. Am J Physiol Endocrinol Metab (2005) 1.46
Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR. Am J Physiol Endocrinol Metab (2006) 1.42
Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1. J Nutr (2009) 1.35
Regulation of translation initiation by insulin and amino acids in skeletal muscle of neonatal pigs. Am J Physiol Endocrinol Metab (2003) 1.34
Regulation of cardiac and skeletal muscle protein synthesis by individual branched-chain amino acids in neonatal pigs. Am J Physiol Endocrinol Metab (2005) 1.33
Using 2H2O to study the influence of feeding on protein synthesis: effect of isotope equilibration in vivo vs. in cell culture. Am J Physiol Endocrinol Metab (2005) 1.32
Retrograde nuclear accumulation of cytoplasmic tRNA in rat hepatoma cells in response to amino acid deprivation. Proc Natl Acad Sci U S A (2007) 1.30
Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes (2002) 1.28
Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids. J Biol Chem (2011) 1.24
eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. Physiol Genomics (2009) 1.22
A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux. J Biol Chem (2013) 1.22
Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation. J Nutr (2004) 1.20
The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb. Am J Physiol Endocrinol Metab (2012) 1.20
Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome. Mol Endocrinol (2004) 1.18
The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver. Int J Biochem Cell Biol (2004) 1.17
Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. Am J Physiol Endocrinol Metab (2004) 1.13
Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients. Hum Genet (2005) 1.12
Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway. Am J Physiol Cell Physiol (2010) 1.12
Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B. Nat Cell Biol (2012) 1.11
Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients. Eur J Hum Genet (2004) 1.11
Regulation of muscle protein synthesis and the effects of catabolic states. Int J Biochem Cell Biol (2013) 1.10
Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α. J Biol Chem (2014) 1.07
Amino acids as regulators of gene expression. Nutr Metab (Lond) (2004) 1.07
Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. Am J Physiol Endocrinol Metab (2003) 1.07
Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. J Biol Chem (2012) 1.07
Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling. Proc Nutr Soc (2004) 1.06
Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1). Cell Signal (2013) 1.05
Endotoxin and cisplatin synergistically stimulate TNF-alpha production by renal epithelial cells. Am J Physiol Renal Physiol (2006) 1.05
Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B. Am J Physiol Endocrinol Metab (2003) 1.04
Amino acids do not alter the insulin-induced activation of the insulin signaling pathway in neonatal pigs. J Nutr (2004) 1.03
Rapamycin blunts nutrient stimulation of eIF4G, but not PKCepsilon phosphorylation, in skeletal muscle. Am J Physiol Endocrinol Metab (2007) 1.02
Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. J Biol Chem (2003) 1.00
Dietary protein and lactose increase translation initiation factor activation and tissue protein synthesis in neonatal pigs. Am J Physiol Endocrinol Metab (2005) 1.00
Regulation of neonatal liver protein synthesis by insulin and amino acids in pigs. Am J Physiol Endocrinol Metab (2004) 0.99
ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling. Am J Physiol Cell Physiol (2011) 0.99
Glucagon acts in a dominant manner to repress insulin-induced mammalian target of rapamycin complex 1 signaling in perfused rat liver. Am J Physiol Endocrinol Metab (2009) 0.97
Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease. Am J Physiol Endocrinol Metab (2011) 0.97
Multi-modal proteomic analysis of retinal protein expression alterations in a rat model of diabetic retinopathy. PLoS One (2011) 0.95
Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin. J Nutr (2006) 0.94
Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture. Diabetes (2010) 0.93
The alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus. J Virol (2011) 0.93
Rapamycin-sensitive induction of eukaryotic initiation factor 4F in regenerating mouse liver. Hepatology (2004) 0.92
Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome. BMC Med Genomics (2011) 0.92
Alterations in the expression of mRNAs and proteins that code for species relevant to eIF2B activity after an acute bout of resistance exercise. J Appl Physiol (1985) (2003) 0.92
Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1. Free Radic Biol Med (2009) 0.91
Feeding rapidly stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing translation initiation. J Nutr (2009) 0.91
Meal feeding alters translational control of gene expression in rat liver. J Nutr (2005) 0.91
Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. J Biol Chem (2012) 0.90
Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. Autophagy (2012) 0.90
Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bvarepsilon mRNA translation and protein synthesis. Int J Biochem Cell Biol (2008) 0.90
Leucine pulses enhance skeletal muscle protein synthesis during continuous feeding in neonatal pigs. Am J Physiol Endocrinol Metab (2013) 0.89
Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions. Prog Nucleic Acid Res Mol Biol (2006) 0.89
Regulation of the unfolded protein response by eif2Bdelta isoforms. J Biol Chem (2010) 0.89
Transcriptomic comparison of the retina in two mouse models of diabetes. J Ocul Biol Dis Infor (2009) 0.88
Differential regulation of protein synthesis and mTOR signaling in skeletal muscle and visceral tissues of neonatal pigs after a meal. Pediatr Res (2011) 0.88
Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs. J Nutr (2011) 0.88
Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism. Diabetes (2013) 0.88
Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution. Am J Physiol Lung Cell Mol Physiol (2009) 0.87
Phosphorylation of eIF2alpha in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase. Biochem J (2008) 0.87
Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression. Am J Physiol Endocrinol Metab (2011) 0.87
Cellular energy status modulates translational control mechanisms in ischemic-reperfused rat hearts. Am J Physiol Heart Circ Physiol (2005) 0.87
Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism. Am J Physiol Endocrinol Metab (2005) 0.86
Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis. Am J Physiol Endocrinol Metab (2010) 0.86
Protein synthesis and translation initiation factor activation in neonatal pigs fed increasing levels of dietary protein. J Nutr (2005) 0.86
Translational control by RGS2. J Cell Biol (2009) 0.86
Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes. J Biol Chem (2011) 0.86
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. Physiol Genomics (2011) 0.86
Sex-dependent differences in the regulation of myocardial protein synthesis following long-term ethanol consumption. Am J Physiol Regul Integr Comp Physiol (2006) 0.86
Inhibition of mammalian translation initiation by volatile anesthetics. Am J Physiol Endocrinol Metab (2006) 0.85
Translational control of protein synthesis in muscle and liver of growth hormone-treated pigs. Endocrinology (2003) 0.85
The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases. Biochem J (2002) 0.85
Effect of CCK and intracellular calcium to regulate eIF2B and protein synthesis in rat pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol (2002) 0.85
SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling. Proc Natl Acad Sci U S A (2013) 0.85
Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion. J Appl Physiol (1985) (2006) 0.84
Reduced eukaryotic initiation factor 2Bepsilon-subunit expression suppresses the transformed phenotype of cells overexpressing the protein. Cancer Res (2008) 0.82
Insulin stimulates muscle protein synthesis in neonates during endotoxemia despite repression of translation initiation. Am J Physiol Endocrinol Metab (2006) 0.82
Translational control mechanisms modulate skeletal muscle gene expression during hypertrophy. Exerc Sport Sci Rev (2003) 0.82
Glucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle. Am J Physiol Endocrinol Metab (2004) 0.82
Regulation of muscle protein synthesis in neonatal pigs during prolonged endotoxemia. Pediatr Res (2003) 0.82
Phosphorylation of eukaryotic initiation factor eIF2Bepsilon in skeletal muscle during sepsis. Am J Physiol Endocrinol Metab (2002) 0.82
Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and is partially impaired in skeletal muscle of obese rats. J Exp Biol (2011) 0.81
Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs. Am J Clin Nutr (2008) 0.81
Insulin signaling in skeletal muscle and liver of neonatal pigs during endotoxemia. Pediatr Res (2008) 0.81
REDD1 (regulated in development and DNA damage response 1) expression in skeletal muscle as a surrogate biomarker of the efficiency of glucocorticoid receptor blockade. Biochem Biophys Res Commun (2011) 0.81
Beta -oxidation of free fatty acids is required to maintain translational control of protein synthesis in heart. Am J Physiol Endocrinol Metab (2002) 0.80
The activated glucocorticoid receptor modulates presumptive autoregulation of ribosomal protein S6 protein kinase, p70 S6K. J Biol Chem (2001) 0.80
Cell-autonomous regulation of fast troponin T pre-mRNA alternative splicing in response to mechanical stretch. Am J Physiol Cell Physiol (2012) 0.80
AMPK represses TOP mRNA translation but not global protein synthesis in liver. Biochem Biophys Res Commun (2008) 0.79
Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men. Am J Physiol Endocrinol Metab (2008) 0.79
Glucosamine-induced phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 is mediated by the protein kinase R-like endoplasmic-reticulum associated kinase. Int J Biochem Cell Biol (2005) 0.79