Published in Lancet on May 24, 2003
Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola. J Virol (2006) 4.01
Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci U S A (2005) 3.37
The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A (2003) 3.02
Real-time reverse transcription-polymerase chain reaction assay for SARS-associated coronavirus. Emerg Infect Dis (2004) 2.88
Relation between randomized controlled trials published in leading general medical journals and the global burden of disease. CMAJ (2004) 2.83
Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci U S A (2003) 2.82
Tracking the evolution of the SARS coronavirus using high-throughput, high-density resequencing arrays. Genome Res (2004) 2.47
Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase. J Virol (2004) 2.29
Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice. J Virol (2005) 2.22
Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs. J Virol (2005) 2.05
Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms. J Virol (2005) 1.93
Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typing. Proc Natl Acad Sci U S A (2004) 1.82
Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses. Proc Natl Acad Sci U S A (2005) 1.75
Bayesian reconstruction of disease outbreaks by combining epidemiologic and genomic data. PLoS Comput Biol (2014) 1.74
Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clin Microbiol Rev (2007) 1.68
Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: molecular epidemiology and genome evolution. Proc Natl Acad Sci U S A (2004) 1.66
Mosaic evolution of the severe acute respiratory syndrome coronavirus. J Virol (2004) 1.61
Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome. BMC Immunol (2005) 1.61
A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis. J Virol (2004) 1.53
Severe acute respiratory syndrome, Beijing, 2003. Emerg Infect Dis (2004) 1.37
Profiles of antibody responses against severe acute respiratory syndrome coronavirus recombinant proteins and their potential use as diagnostic markers. Clin Diagn Lab Immunol (2004) 1.34
Identification of an antigenic determinant on the S2 domain of the severe acute respiratory syndrome coronavirus spike glycoprotein capable of inducing neutralizing antibodies. J Virol (2004) 1.32
Generation and characterization of DNA vaccines targeting the nucleocapsid protein of severe acute respiratory syndrome coronavirus. J Virol (2004) 1.30
Role of China in the quest to define and control severe acute respiratory syndrome. Emerg Infect Dis (2003) 1.29
Generation of synthetic severe acute respiratory syndrome coronavirus pseudoparticles: implications for assembly and vaccine production. J Virol (2004) 1.26
Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus. J Virol (2005) 1.26
Small molecules targeting severe acute respiratory syndrome human coronavirus. Proc Natl Acad Sci U S A (2004) 1.25
Genomic and bioinformatics analysis of HAdV-4, a human adenovirus causing acute respiratory disease: implications for gene therapy and vaccine vector development. J Virol (2005) 1.24
Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003. BMC Infect Dis (2004) 1.21
SARS-CoV infection in a restaurant from palm civet. Emerg Infect Dis (2005) 1.12
SARS transmission pattern in Singapore reassessed by viral sequence variation analysis. PLoS Med (2005) 1.11
The laboratory diagnosis of severe acute respiratory syndrome: emerging laboratory tests for an emerging pathogen. Clin Biochem Rev (2004) 1.08
Contact heterogeneity and phylodynamics: how contact networks shape parasite evolutionary trees. Interdiscip Perspect Infect Dis (2010) 1.07
Healthcare worker seroconversion in SARS outbreak. Emerg Infect Dis (2004) 1.07
Severe acute respiratory syndrome coronavirus sequence characteristics and evolutionary rate estimate from maximum likelihood analysis. J Virol (2004) 1.07
A genome sequence of novel SARS-CoV isolates: the genotype, GD-Ins29, leads to a hypothesis of viral transmission in South China. Genomics Proteomics Bioinformatics (2003) 1.06
Detection of severe acute respiratory syndrome coronavirus in blood of infected patients. J Clin Microbiol (2004) 1.04
SARS molecular epidemiology: a Chinese fairy tale of controlling an emerging zoonotic disease in the genomics era. Philos Trans R Soc Lond B Biol Sci (2007) 1.03
Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett (2007) 1.02
B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein. J Virol (2005) 1.01
Influenza as a model system for studying the cross-species transfer and evolution of the SARS coronavirus. Philos Trans R Soc Lond B Biol Sci (2004) 1.01
Persistent replication of severe acute respiratory syndrome coronavirus in human tubular kidney cells selects for adaptive mutations in the membrane protein. J Virol (2008) 1.00
Moderate mutation rate in the SARS coronavirus genome and its implications. BMC Evol Biol (2004) 1.00
Development of a Western blot assay for detection of antibodies against coronavirus causing severe acute respiratory syndrome. Clin Diagn Lab Immunol (2004) 0.96
Characterization of a unique group-specific protein (U122) of the severe acute respiratory syndrome coronavirus. J Virol (2004) 0.96
Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs. Emerg Infect Dis (2004) 0.96
Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV). BMC Genomics (2005) 0.95
Severe acute respiratory syndrome: report of treatment and outcome after a major outbreak. Thorax (2004) 0.95
Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation. J Virol (2006) 0.94
A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection. BMC Infect Dis (2004) 0.93
Date of origin of the SARS coronavirus strains. BMC Infect Dis (2004) 0.92
Coronaviridae and SARS-associated coronavirus strain HSR1. Emerg Infect Dis (2004) 0.92
Without its N-finger, the main protease of severe acute respiratory syndrome coronavirus can form a novel dimer through its C-terminal domain. J Virol (2008) 0.90
Genetic variation of SARS coronavirus in Beijing Hospital. Emerg Infect Dis (2004) 0.88
A strategy for searching antigenic regions in the SARS-CoV spike protein. Genomics Proteomics Bioinformatics (2003) 0.88
Questions about comparative genomics of SARS coronavirus isolates. Lancet (2003) 0.87
Bioinformatics analysis of SARS coronavirus genome polymorphism. BMC Bioinformatics (2004) 0.86
Genetic screen for monitoring severe acute respiratory syndrome coronavirus 3C-like protease. J Virol (2004) 0.86
The era of genomic epidemiology. Neuroepidemiology (2009) 0.84
Inhibition of severe acute respiratory syndrome virus replication by small interfering RNAs in mammalian cells. J Virol (2004) 0.82
Severe acute respiratory syndrome (SARS): chest radiographic features in children. Pediatr Radiol (2003) 0.81
Clinical, Laboratory, and Radiologic Manifestation of SARS. Curr Infect Dis Rep (2004) 0.81
Molecular mechanisms of severe acute respiratory syndrome (SARS). Respir Res (2005) 0.81
Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Genomics Proteomics Bioinformatics (2003) 0.81
Severe acute respiratory syndrome: clinical and laboratory manifestations. Clin Biochem Rev (2004) 0.81
Structure of the SARS coronavirus main proteinase as an active C2 crystallographic dimer. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.81
SARS coronavirus detection. Emerg Infect Dis (2004) 0.81
Lack of SARS transmission and U.S. SARS case-patient. Emerg Infect Dis (2004) 0.80
Molecular epidemiology of SARS-associated coronavirus, Beijing. Emerg Infect Dis (2005) 0.79
Scalable transcriptional analysis routine--multiplexed quantitative real-time polymerase chain reaction platform for gene expression analysis and molecular diagnostics. J Mol Diagn (2005) 0.79
Evolution and population genomics of the Lyme borreliosis pathogen, Borrelia burgdorferi. Trends Genet (2015) 0.79
Severe acute respiratory syndrome (SARS): epidemiology and clinical features. Postgrad Med J (2004) 0.78
SARS-CoV genome polymorphism: a bioinformatics study. Genomics Proteomics Bioinformatics (2005) 0.77
Topographic changes in SARS coronavirus-infected cells at late stages of infection. Emerg Infect Dis (2004) 0.77
Palindromes in SARS and Other Coronaviruses. INFORMS J Comput (2004) 0.77
Comparative analysis of the SARS coronavirus genome: a good start to a long journey. Lancet (2003) 0.77
Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus. Virology (2015) 0.76
A new infectious disease challenge: Urbani severe acute respiratory syndrome (SARS) associated coronavirus. Immunology (2003) 0.76
Evolution and variation of the SARS-CoV genome. Genomics Proteomics Bioinformatics (2003) 0.76
Genome organization of the SARS-CoV. Genomics Proteomics Bioinformatics (2003) 0.75
A facile inhibitor screening of SARS coronavirus N protein using nanoparticle-based RNA oligonucleotide. Int J Nanomedicine (2012) 0.75
Performance of single-step gel-based reverse transcription-PCR (RT-PCR) assays equivalent to that of real-time RT-PCR assays for detection of the severe acute respiratory syndrome-associated coronavirus. J Clin Microbiol (2005) 0.75
The E protein is a multifunctional membrane protein of SARS-CoV. Genomics Proteomics Bioinformatics (2003) 0.75
A simple and rapid approach for screening of SARS-coronavirus genotypes: an evaluation study. BMC Infect Dis (2005) 0.75
The structural characterization and antigenicity of the S protein of SARS-CoV. Genomics Proteomics Bioinformatics (2003) 0.75
Reasoning of spike glycoproteins being more vulnerable to mutations among 158 coronavirus proteins from different species. J Mol Model (2004) 0.75
SARS: responding to an unknown virus. Eur J Clin Microbiol Infect Dis (2004) 0.75
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science (2002) 20.59
International network of cancer genome projects. Nature (2010) 20.35
The B73 maize genome: complexity, diversity, and dynamics. Science (2009) 18.73
ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38
Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci U S A (2005) 13.54
Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A (2003) 13.00
An oestrogen-receptor-alpha-bound human chromatin interactome. Nature (2009) 12.16
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res (2004) 9.18
Comment on " 'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature". Science (2003) 8.79
Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res (2005) 8.73
Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer. Cancer Res (2006) 8.08
Gene identification signature (GIS) analysis for transcriptome characterization and genome annotation. Nat Methods (2005) 7.87
Mapping human genetic diversity in Asia. Science (2009) 7.40
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell (2007) 7.05
Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science (2011) 6.93
A first-generation haplotype map of maize. Science (2009) 6.82
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev (2007) 6.71
Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res (2009) 6.43
Whole-genome cartography of estrogen receptor alpha binding sites. PLoS Genet (2007) 5.85
Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A (2006) 5.27
Fusion transcripts and transcribed retrotransposed loci discovered through comprehensive transcriptome analysis using Paired-End diTags (PETs). Genome Res (2007) 4.99
RNA viral community in human feces: prevalence of plant pathogenic viruses. PLoS Biol (2006) 4.93
Multiplex sequencing of paired-end ditags (MS-PET): a strategy for the ultra-high-throughput analysis of transcriptomes and genomes. Nucleic Acids Res (2006) 4.51
Next-generation DNA sequencing of paired-end tags (PET) for transcriptome and genome analyses. Genome Res (2009) 4.47
ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32
Comparative population genomics of maize domestication and improvement. Nat Genet (2012) 3.78
Evolution of the mammalian transcription factor binding repertoire via transposable elements. Genome Res (2008) 3.76
Biopipe: a flexible framework for protocol-based bioinformatics analysis. Genome Res (2003) 3.45
Gene expression profiles of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers. J Natl Cancer Inst (2002) 3.40
Tumor hypoxia imaging with [F-18] fluoromisonidazole positron emission tomography in head and neck cancer. Clin Cancer Res (2006) 3.17
Transcriptome profiling of human and murine ESCs identifies divergent paths required to maintain the stem cell state. Stem Cells (2005) 3.16
Genetic structure and domestication history of the grape. Proc Natl Acad Sci U S A (2011) 2.89
Genome-wide computational identification and manual annotation of human long noncoding RNA genes. RNA (2010) 2.85
Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Cancer Res (2011) 2.81
Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells. Genome Biol (2004) 2.77
Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor. J Infect Dis (2011) 2.69
Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients. Breast Cancer Res (2006) 2.69
Fugu genome analysis provides evidence for a whole-genome duplication early during the evolution of ray-finned fishes. Mol Biol Evol (2004) 2.65
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet (2010) 2.62
Rnnotator: an automated de novo transcriptome assembly pipeline from stranded RNA-Seq reads. BMC Genomics (2010) 2.62
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Nat Biotechnol (2004) 2.60
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell (2011) 2.58
A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol (2012) 2.54
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nat Biotechnol (2005) 2.51
Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors. EMBO J (2011) 2.51
Tracking the evolution of the SARS coronavirus using high-throughput, high-density resequencing arrays. Genome Res (2004) 2.47
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell (2008) 2.46
Effects of propofol and ketamine as combined anesthesia for electroconvulsive therapy in patients with depressive disorder. J ECT (2012) 2.43
Regulation of estrogen receptor-mediated long range transcription via evolutionarily conserved distal response elements. J Biol Chem (2008) 2.34
Transcriptome analysis of zebrafish embryogenesis using microarrays. PLoS Genet (2005) 2.32
Identification of cell cycle-regulated genes in fission yeast. Mol Biol Cell (2004) 2.29
Direct-method SAD phasing of proteins enhanced by the use of intrinsic bimodal phase distributions in the subsequent phase-improvement process. Acta Crystallogr D Biol Crystallogr (2009) 2.28
A genome-wide characterization of microRNA genes in maize. PLoS Genet (2009) 2.23
Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness. Cancer Res (2002) 2.21
Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem (2012) 2.16
Initiating oncogenic event determines gene-expression patterns of human breast cancer models. Proc Natl Acad Sci U S A (2002) 2.15
REST regulates distinct transcriptional networks in embryonic and neural stem cells. PLoS Biol (2008) 2.12
Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin. Immunity (2010) 2.08
Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc Natl Acad Sci U S A (2005) 2.07
Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation. Mol Cell (2007) 2.05
Gene expression profiles derived from fine needle aspiration correlate with response to systemic chemotherapy in breast cancer. Breast Cancer Res (2002) 2.04
Integrative model of genomic factors for determining binding site selection by estrogen receptor-α. Mol Syst Biol (2010) 2.04
Rapid genomic characterization of the genus vitis. PLoS One (2010) 2.04
Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res (2006) 2.02
Single-atom catalysis of CO oxidation using Pt1/FeOx. Nat Chem (2011) 1.98
Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res (2010) 1.96
Low-diversity bacterial community in the gut of the fruitfly Drosophila melanogaster. Environ Microbiol (2011) 1.94
Re-emergence of Chikungunya virus in South-east Asia: virological evidence from Sri Lanka and Singapore. J Gen Virol (2009) 1.85
The airborne metagenome in an indoor urban environment. PLoS One (2008) 1.81
Comparative study of four time series methods in forecasting typhoid fever incidence in China. PLoS One (2013) 1.78