Published in Ann Neurol on June 01, 2003
Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol (2009) 3.27
Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice. J Cereb Blood Flow Metab (2005) 2.65
Evidence for stroke-induced neurogenesis in the human brain. Proc Natl Acad Sci U S A (2006) 2.55
Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice. Proc Natl Acad Sci U S A (2004) 2.20
Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J Neurotrauma (2007) 1.76
Angiogenesis, neurogenesis and brain recovery of function following injury. Curr Opin Investig Drugs (2010) 1.67
Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma (2009) 1.67
The Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART): an adaptive design phase I dose-escalation study of high-dose lovastatin in acute ischemic stroke. Int J Stroke (2008) 1.65
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Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. J Neurosci (2005) 1.54
Statin use and outcome after intracerebral hemorrhage: case-control study and meta-analysis. Neurology (2011) 1.50
Effects of AMP-activated protein kinase in cerebral ischemia. J Cereb Blood Flow Metab (2009) 1.40
Ischemic stroke and neurogenesis in the subventricular zone. Neuropharmacology (2008) 1.39
Neurorestorative treatment of stroke: cell and pharmacological approaches. NeuroRx (2006) 1.37
Post-ischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarction and improves neurological outcome in a rat model of focal cerebral ischemia. Br J Pharmacol (2007) 1.35
White matter damage and the effect of matrix metalloproteinases in type 2 diabetic mice after stroke. Stroke (2010) 1.33
Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci (2008) 1.33
Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model. Exp Mol Med (2008) 1.32
Effects of erythropoietin on reducing brain damage and improving functional outcome after traumatic brain injury in mice. J Neurosurg (2008) 1.21
Angiogenesis and improved cerebral blood flow in the ischemic boundary area detected by MRI after administration of sildenafil to rats with embolic stroke. Brain Res (2006) 1.19
Simvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhage. Stroke (2009) 1.18
Simvastatin attenuates microglial cells and astrocyte activation and decreases interleukin-1beta level after traumatic brain injury. Neurosurgery (2009) 1.16
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Multifunctional drugs for head injury. Neurotherapeutics (2009) 1.16
Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs (2009) 1.13
High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART). Cerebrovasc Dis (2009) 1.10
Thymosin beta4 improves functional neurological outcome in a rat model of embolic stroke. Neuroscience (2010) 1.09
Mannitol enhances delivery of marrow stromal cells to the brain after experimental intracerebral hemorrhage. Brain Res (2008) 1.08
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of central nervous system diseases. Arch Neurol (2010) 1.08
Niacin treatment of stroke increases synaptic plasticity and axon growth in rats. Stroke (2010) 1.07
Renal vascular structure and rarefaction. Compr Physiol (2013) 1.06
Increasing Ang1/Tie2 expression by simvastatin treatment induces vascular stabilization and neuroblast migration after stroke. J Cell Mol Med (2008) 1.05
Vascular endothelial growth factor mediates atorvastatin-induced mammalian achaete-scute homologue-1 gene expression and neuronal differentiation after stroke in retired breeder rats. Neuroscience (2006) 1.04
Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury. J Neurosurg (2008) 1.04
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Niaspan reduces high-mobility group box 1/receptor for advanced glycation endproducts after stroke in type-1 diabetic rats. Neuroscience (2011) 1.03
Multifunctional actions of approved and candidate stroke drugs. Neurotherapeutics (2009) 1.03
eNOS mediates TO90317 treatment-induced angiogenesis and functional outcome after stroke in mice. Stroke (2009) 1.03
The role of astrocytes in mediating exogenous cell-based restorative therapy for stroke. Glia (2013) 1.00
Underappreciated statin-induced myopathic weakness causes disability. Neurorehabil Neural Repair (2005) 1.00
Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke. Stroke (2008) 1.00
Renovascular disease, microcirculation, and the progression of renal injury: role of angiogenesis. Am J Physiol Regul Integr Comp Physiol (2011) 0.99
Simvastatin attenuates stroke-induced splenic atrophy and lung susceptibility to spontaneous bacterial infection in mice. Stroke (2013) 0.99
Chemokine, vascular and therapeutic effects of combination Simvastatin and BMSC treatment of stroke. Neurobiol Dis (2009) 0.98
Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact. Neurosurgery (2010) 0.98
Nitric oxide: considerations for the treatment of ischemic stroke. J Cereb Blood Flow Metab (2012) 0.97
Treatment of stroke with a synthetic liver X receptor agonist, TO901317, promotes synaptic plasticity and axonal regeneration in mice. J Cereb Blood Flow Metab (2009) 0.97
Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats. Exp Neurol (2011) 0.97
Niaspan treatment induces neuroprotection after stroke. Neurobiol Dis (2010) 0.96
Nitric oxide regulates Angiopoietin1/Tie2 expression after stroke. Neurosci Lett (2006) 0.96
Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity. Cell Adh Migr (2012) 0.96
Drug Insight: statins and stroke. Nat Clin Pract Cardiovasc Med (2005) 0.94
Tissue plasminogen activator treatment of stroke in type-1 diabetes rats. Neuroscience (2012) 0.93
Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models. Acta Pharmacol Sin (2011) 0.93
Rising statin use and effect on ischemic stroke outcome. BMC Med (2004) 0.93
The THRombolysis and STatins (THRaST) study. Neurology (2013) 0.92
Synergistic effect of an endothelin type A receptor antagonist, S-0139, with rtPA on the neuroprotection after embolic stroke. Stroke (2008) 0.91
Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome. J Neurol Sci (2010) 0.91
Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways. Acta Pharmacol Sin (2012) 0.91
HUCBCs increase angiopoietin 1 and induce neurorestorative effects after stroke in T1DM rats. CNS Neurosci Ther (2014) 0.91
Statin pretreatment may increase the risk of symptomatic intracranial haemorrhage in thrombolysis for ischemic stroke: results from a case-control study and a meta-analysis. J Neurol (2011) 0.90
Niaspan increases axonal remodeling after stroke in type 1 diabetes rats. Neurobiol Dis (2012) 0.90
Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice. Neuroscience (2009) 0.90
Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1. Brain Res (2013) 0.89
Long-term benefits after treatment of traumatic brain injury with simvastatin in rats. Neurosurgery (2009) 0.89
Atorvastatin promotes presenilin-1 expression and Notch1 activity and increases neural progenitor cell proliferation after stroke. Stroke (2007) 0.89
Statins in traumatic brain injury. Neurotherapeutics (2010) 0.89
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. Neuroscience (2011) 0.88
Adherence to antihypertensive agents after ischemic stroke and risk of cardiovascular outcomes. Neurology (2012) 0.88
Combination treatment of stroke with sub-therapeutic doses of Simvastatin and human umbilical cord blood cells enhances vascular remodeling and improves functional outcome. Neuroscience (2012) 0.88
Niaspan treatment increases tumor necrosis factor-alpha-converting enzyme and promotes arteriogenesis after stroke. J Cereb Blood Flow Metab (2009) 0.87
Statins Protect the Blood Brain Barrier Acutely after Experimental Intracerebral Hemorrhage. J Behav Brain Sci (2012) 0.87
Preexisting statin use is associated with greater reperfusion in hyperacute ischemic stroke. Stroke (2011) 0.86
Neurorestorative Therapy of Stroke in Type 2 Diabetes Mellitus Rats Treated With Human Umbilical Cord Blood Cells. Stroke (2015) 0.85
Impact of hyperlipidemia and statins on ischemic stroke outcomes after intra-arterial fibrinolysis and percutaneous mechanical embolectomy. Cerebrovasc Dis (2009) 0.85
Pilot trial of simvastatin in the treatment of sporadic inclusion-body myositis. Neurol Sci (2011) 0.85
Role of histamine and its receptors in cerebral ischemia. ACS Chem Neurosci (2012) 0.85
Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease. Mol Neurobiol (2012) 0.85
Vascular recovery promoted by atorvastatin and simvastatin after experimental intracerebral hemorrhage: magnetic resonance imaging and histological study. J Neurosurg (2010) 0.85
Thymosin beta4: a candidate for treatment of stroke? Ann N Y Acad Sci (2010) 0.84
Exosomes in stroke pathogenesis and therapy. J Clin Invest (2016) 0.84
Estradiol augments peri-infarct cerebral vascular density in experimental stroke. Exp Neurol (2007) 0.84
Statins in Acute Ischemic Stroke: A Systematic Review. J Stroke (2015) 0.83
HMG-CoA Reductase Inhibition Promotes Neurological Recovery, Peri-Lesional Tissue Remodeling, and Contralesional Pyramidal Tract Plasticity after Focal Cerebral Ischemia. Front Cell Neurosci (2014) 0.83
Induction of angiogenesis and modulation of vascular endothelial growth factor receptor-2 by simvastatin after traumatic brain injury. Neurosurgery (2011) 0.83
Citalopram enhances neurovascular regeneration and sensorimotor functional recovery after ischemic stroke in mice. Neuroscience (2013) 0.83
MRI detects brain reorganization after human umbilical tissue-derived cells (hUTC) treatment of stroke in rat. PLoS One (2012) 0.83
Effect of previous statin therapy on severity and outcome in ischemic stroke patients: a population-based study. J Neurol (2012) 0.83
Effect of atorvastatin on orthodontic tooth movement in male wistar rats. J Dent (Tehran) (2013) 0.83
Statins for the prevention of stroke: a meta-analysis of randomized controlled trials. PLoS One (2014) 0.82
Improvement of exhausted cerebral vasoreactivity in carotid occlusion: benefit of statins? J Neurol (2010) 0.82
MiR-126 Contributes to Human Umbilical Cord Blood Cell-Induced Neurorestorative Effects After Stroke in Type-2 Diabetic Mice. Stem Cells (2016) 0.82
Not just a rush of blood to the head. Nat Med (2012) 0.81
Neurological deficits in mice with profound biotinidase deficiency are associated with demylination and axonal degeneration. Neurobiol Dis (2012) 0.81
Effects of statin and deferoxamine administration on neurological outcomes in a rat model of intracerebral hemorrhage. Neurol Sci (2011) 0.81
Role of statin in atrial fibrillation-related stroke: an angiographic study for collateral flow. Cerebrovasc Dis (2014) 0.81
Statins Enhance Expression of Growth Factors and Activate the PI3K/Akt-mediated Signaling Pathway after Experimental Intracerebral Hemorrhage. World J Neurosci (2012) 0.81
Promoting endothelial function by S-nitrosoglutathione through the HIF-1α/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats. Drug Des Devel Ther (2015) 0.80
Simvastatin promotes adult hippocampal neurogenesis by enhancing Wnt/β-catenin signaling. Stem Cell Reports (2013) 0.80
MRI of blood-brain barrier permeability in cerebral ischemia. Transl Stroke Res (2012) 0.80
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med (2011) 69.36
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet (2004) 12.92
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature (2007) 10.94
Antiretroviral-drug resistance among patients recently infected with HIV. N Engl J Med (2002) 9.70
Integrative molecular concept modeling of prostate cancer progression. Nat Genet (2006) 8.49
Genomewide association study of leprosy. N Engl J Med (2009) 8.17
Mapping human genetic diversity in Asia. Science (2009) 7.40
In vivo genome editing using a high-efficiency TALEN system. Nature (2012) 7.11
Updated National Birth Prevalence estimates for selected birth defects in the United States, 2004-2006. Birth Defects Res A Clin Mol Teratol (2010) 7.00
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An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol (2003) 6.82
Management of lung nodules detected by volume CT scanning. N Engl J Med (2009) 6.79
KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science (2003) 6.60
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42
Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice. Nat Genet (2008) 5.64
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet (2009) 5.62
The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus). Nature (2008) 5.54
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Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis (2002) 4.23
US Renal Data System 2014 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis (2015) 3.94
Analysis of genetic linkage of HIV from couples enrolled in the HIV Prevention Trials Network 052 trial. J Infect Dis (2011) 3.78
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The SOL Genomics Network: a comparative resource for Solanaceae biology and beyond. Plant Physiol (2005) 3.65
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