Published in Biotechnol Bioeng on August 05, 2003
Application of the Saccharomyces cerevisiae FLP/FRT recombination system in filamentous fungi for marker recycling and construction of knockout strains devoid of heterologous genes. Appl Environ Microbiol (2010) 0.94
The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology. Mol Cell Proteomics (2010) 0.91
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A gene encoding lysine 6-aminotransferase, which forms the beta-lactam precursor alpha-aminoadipic acid, is located in the cluster of cephamycin biosynthetic genes in Nocardia lactamdurans. J Bacteriol (1991) 1.29
The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences. Proc Natl Acad Sci U S A (1995) 1.29
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A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis. Chem Biol (2000) 1.24
Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N. Antimicrob Agents Chemother (1985) 1.20
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Magnetic switching of ferroelectric domains at room temperature in multiferroic PZTFT. Nat Commun (2013) 1.18
Lysine regulation of penicillin biosynthesis in low-producing and industrial strains of Penicillium chrysogenum. J Gen Microbiol (1979) 1.16
Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum. Antimicrob Agents Chemother (1987) 1.16
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Phosphate control sequences involved in transcriptional regulation of antibiotic biosynthesis. Trends Biotechnol (1990) 1.14
Carbon catabolite regulation of the conversion of penicillin N into cephalosporin C. J Antibiot (Tokyo) (1983) 1.13
Resolution of four large chromosomes in penicillin-producing filamentous fungi: the penicillin gene cluster is located on chromosome II (9.6 Mb) in Penicillium notatum and chromosome I (10.4 Mb) in Penicillium chrysogenum. Mol Gen Genet (1993) 1.11
Arginine boxes and the argR gene in Streptomyces clavuligerus: evidence for a clear regulation of the arginine pathway. Mol Microbiol (1997) 1.11
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Vascular endothelial growth factor confers a growth advantage in vitro and in vivo to stromal cells cultured from neonatal hemangiomas. Am J Pathol (1997) 1.09
Characterization of the rrnB operon of the plant pathogen Rhodococcus fascians and targeted integrations of exogenous genes at rrn loci. Appl Environ Microbiol (1998) 1.08
Characterization and expression in Streptomyces lividans of cefD and cefE genes from Nocardia lactamdurans: the organization of the cephamycin gene cluster differs from that in Streptomyces clavuligerus. Mol Gen Genet (1993) 1.08
The bla gene of the cephamycin cluster of Streptomyces clavuligerus encodes a class A beta-lactamase of low enzymatic activity. J Bacteriol (1997) 1.07
Randomized clinical trial of self-gripping mesh versus sutured mesh for Lichtenstein hernia repair (Br J Surg 2013; 100: 474-481). Br J Surg (2013) 1.07
Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis. Chem Biol (2001) 1.07
Isolation and molecular characterization of a new vegetative MADS-box gene from Solanum tuberosum L. Planta (1998) 1.06
The pcd gene encoding piperideine-6-carboxylate dehydrogenase involved in biosynthesis of alpha-aminoadipic acid is located in the cephamycin cluster of Streptomyces clavuligerus. J Bacteriol (1998) 1.06
Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence. Appl Microbiol Biotechnol (1996) 1.05
Purification and characterization of a 2-oxoglutarate-linked ATP-independent deacetoxycephalosporin C synthase of Streptomyces lactamdurans. J Gen Microbiol (1987) 1.05
Glucose regulation of cephamycin biosynthesis in Streptomyces lactamdurans is exerted on the formation of alpha-aminoadipyl-cysteinyl-valine and deacetoxycephalosporin C synthase. J Gen Microbiol (1986) 1.05
Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit. J Bacteriol (1999) 1.04
Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes. Biochem J (1997) 1.04
Carbon catabolite repression of penicillin biosynthesis by Penicillium chrysogenum. J Antibiot (Tokyo) (1984) 1.03
Biochemical characterization and molecular genetics of nine mutants of Penicillium chrysogenum impaired in penicillin biosynthesis. J Biol Chem (1993) 1.03
Cloning, characterization of the acyl-CoA:6-amino penicillanic acid acyltransferase gene of Aspergillus nidulans and linkage to the isopenicillin N synthase gene. Mol Gen Genet (1990) 1.02
Phosphate control of pabS gene transcription during candicidin biosynthesis. Gene (1990) 1.01
Cloning, expression in Streptomyces lividans and biochemical characterization of a thermostable endo-beta-1,4-xylanase of Thermomonospora alba ULJB1 with cellulose-binding ability. Appl Microbiol Biotechnol (1997) 1.00
Large amplification of a 35-kb DNA fragment carrying two penicillin biosynthetic genes in high penicillin producing strains of Penicillium chrysogenum. Curr Genet (1989) 1.00
Two genes involved in penicillin biosynthesis are linked in a 5.1 kb SalI fragment in the genome of Penicillium chrysogenum. Mol Gen Genet (1989) 1.00
The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes. J Biol Chem (1999) 1.00
Characterization and expression of the arginine biosynthesis gene cluster of Streptomyces clavuligerus. J Mol Microbiol Biotechnol (2000) 0.99
Mustard allergy confirmed by double-blind placebo-controlled food challenges: clinical features and cross-reactivity with mugwort pollen and plant-derived foods. Allergy (2005) 0.99
Identification of loci and functional characterization of trichothecene biosynthesis genes in filamentous fungi of the genus Trichoderma. Appl Environ Microbiol (2011) 0.99
Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum. Appl Microbiol Biotechnol (1997) 0.98
Sporulation of several species of Streptomyces in submerged cultures after nutritional downshift. J Gen Microbiol (1989) 0.98
The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase. J Bacteriol (1992) 0.97
Molecular mechanisms of chromosomal rearrangement in fungi. Crit Rev Microbiol (1999) 0.97
Characterization of the lys2 gene of Acremonium chrysogenum encoding a functional alpha-aminoadipate activating and reducing enzyme. Mol Gen Genet (2001) 0.97
Characterization of the lys2 gene of Penicillium chrysogenum encoding alpha-aminoadipic acid reductase. Mol Gen Genet (1998) 0.96
Sequential expression of macromolecule biosynthesis and candicidin formation in Streptomyces griseus. J Gen Microbiol (1977) 0.96
Gene targeting in Penicillium chrysogenum: disruption of the lys2 gene leads to penicillin overproduction. J Bacteriol (1999) 0.96
Structure and organization of the rrnD operon of 'Brevibacterium lactofermentum': analysis of the 16S rRNA gene. Microbiology (1999) 0.96
A behavioural preparation for the study of human Pavlovian conditioning. Q J Exp Psychol B (1996) 0.95
Gene organization and plasticity of the beta-lactam genes in different filamentous fungi. Antonie Van Leeuwenhoek (1999) 0.94
ATP and adenylate energy charge during phosphate-mediated control of antibiotic synthesis. Biochem Biophys Res Commun (1978) 0.94
Cross-reactivity between IgE-binding proteins from Anisakis, German cockroach, and chironomids. Allergy (1997) 0.94
Characterization of the potato MADS-box gene STMADS16 and expression analysis in tobacco transgenic plants. Plant Mol Biol (2000) 0.93
Characterization and partial purification of L-asparaginase from Corynebacterium glutamicum. J Gen Microbiol (1990) 0.93
Glucose represses formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine and isopenicillin N synthase but not penicillin acyltransferase in Penicillium chrysogenum. J Bacteriol (1986) 0.92
Molecular control mechanisms of lysine and threonine biosynthesis in amino acid-producing corynebacteria: redirecting carbon flow. FEMS Microbiol Lett (1996) 0.92
Mg,Al layered double hydroxides with intercalated indomethacin: synthesis, characterization, and pharmacological study. J Pharm Sci (2004) 0.92
A cluster of three genes (dapA, orf2, and dapB) of Brevibacterium lactofermentum encodes dihydrodipicolinate synthase, dihydrodipicolinate reductase, and a third polypeptide of unknown function. J Bacteriol (1993) 0.92
Cloning and characterization of a phosphate-regulated promoter involved in phosphate control of candicidin biosynthesis. Gene (1989) 0.92
Cloning, characterization and expression of an alpha-amylase gene from Streptomyces griseus IMRU3570. Mol Gen Genet (1991) 0.91
Penicillin and cephalosporin biosynthesis: mechanism of carbon catabolite regulation of penicillin production. Antonie Van Leeuwenhoek (1999) 0.91
Construction and characterization of promoter-probe vectors for Corynebacteria using the kanamycin-resistance reporter gene. Gene (1991) 0.91
A defined level of protein disulfide isomerase expression is required for optimal secretion of thaumatin by Aspegillus awamori. Mol Genet Genomics (2001) 0.91
A gene encoding arginyl-tRNA synthetase is located in the upstream region of the lysA gene in Brevibacterium lactofermentum: regulation of argS-lysA cluster expression by arginine. J Bacteriol (1993) 0.91
Endocrine manifestations of Langerhans cell histiocytosis diagnosed in adults. Pituitary (2010) 0.90
The pab gene of Streptomyces griseus, encoding p-aminobenzoic acid synthase, is located between genes possibly involved in candicidin biosynthesis. Gene (1993) 0.90
Pulsed-field gel electrophoresis analysis of the genome of amino acid producing corynebacteria: chromosome sizes and diversity of restriction patterns. Microbiology (1994) 0.90
Possible involvement of the lysine epsilon-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthase (pcbC) in Streptomyces clavuligerus. Microbiology (1994) 0.90
Molecular characterization of three loss-of-function mutations in the isopenicillin N-acyltransferase gene (penDE) of Penicillium chrysogenum. J Bacteriol (1994) 0.89
The isopenicillin-N acyltransferase of Penicillium chrysogenum has isopenicillin-N amidohydrolase, 6-aminopenicillanic acid acyltransferase and penicillin amidase activities, all of which are encoded by the single penDE gene. Eur J Biochem (1993) 0.89
A two-protein component 7 alpha-cephem-methoxylase encoded by two genes of the cephamycin C cluster converts cephalosporin C to 7-methoxycephalosporin C. J Bacteriol (1995) 0.89
Effect of amplification or targeted disruption of the beta-lactamase gene of Nocardia lactamdurans on cephamycin biosynthesis. Appl Microbiol Biotechnol (1996) 0.89