Published in Antivir Chem Chemother on January 01, 2003
Little evidence of bone marrow-derived hepatocytes in the replacement of injured liver. Proc Natl Acad Sci U S A (2003) 1.29
Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay. Virology (2011) 1.04
Seroprevalence of hepatitis B and C genotypes among young apparently healthy females of karachi-pakistan. Libyan J Med (2008) 1.02
Hepatitis C virus network based classification of hepatocellular cirrhosis and carcinoma. PLoS One (2012) 0.96
Involvement of a bovine viral diarrhea virus NS5B locus in virion assembly. J Virol (2004) 0.95
Establishment of a subgenomic replicon for bovine viral diarrhea virus in Huh-7 cells and modulation of interferon-regulated factor 3-mediated antiviral response. J Virol (2005) 0.90
Protective effects of quercetin on liver injury induced by ethanol. Pharmacogn Mag (2010) 0.89
Zebrafish as a potential model organism for drug test against hepatitis C virus. PLoS One (2011) 0.86
MicroRNA-27a modulates HCV infection in differentiated hepatocyte-like cells from adipose tissue-derived mesenchymal stem cells. PLoS One (2014) 0.81
Tight binding enantiomers of pre-clinical drug candidates. Bioorg Med Chem (2015) 0.79
QSAR study of HCV NS5B polymerase inhibitors using the genetic algorithm-multiple linear regression (GA-MLR). EXCLI J (2016) 0.75
Long-acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virus. Science (2014) 2.11
Mechanism of action of ribavirin in the combination treatment of chronic HCV infection. Hepatology (2002) 1.81
Comparative analysis of anti-hepatitis C virus activity and gene expression mediated by alpha, beta, and gamma interferons. J Virol (2002) 1.51
Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis. Proc Natl Acad Sci U S A (2013) 1.42
A plant-specific calreticulin is a key retention factor for a defective brassinosteroid receptor in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2009) 1.40
The role of OsBRI1 and its homologous genes, OsBRL1 and OsBRL3, in rice. Plant Physiol (2006) 1.32
Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett (2007) 1.30
Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase. Antimicrob Agents Chemother (2011) 1.23
Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis. Proc Natl Acad Sci U S A (2010) 1.22
In vitro RNA replication directed by replicase complexes isolated from the subgenomic replicon cells of hepatitis C virus. J Virol (2003) 1.20
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem (2001) 1.19
Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer. J Virol (2005) 1.17
HCV RNA-dependent RNA polymerase as a target for antiviral development. Curr Opin Pharmacol (2002) 1.13
Selection of 3'-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymerase. J Virol (2002) 1.13
Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2. Mol Cancer Ther (2007) 1.13
Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase. Bioorg Med Chem Lett (2006) 1.12
Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides. PLoS Pathog (2012) 1.11
Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole. Biochemistry (2002) 1.11
Novel nonnucleoside inhibitors that select nucleoside inhibitor resistance mutations in human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother (2006) 1.08
The amino-terminal domain of bovine viral diarrhea virus Npro protein is necessary for alpha/beta interferon antagonism. J Virol (2006) 1.03
Novel mutations in a tissue culture-adapted hepatitis C virus strain improve infectious-virus stability and markedly enhance infection kinetics. J Virol (2011) 1.02
Mutations in NS5B polymerase of hepatitis C virus: impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture. Virology (2002) 1.00
Viramidine, a prodrug of ribavirin, shows better liver-targeting properties and safety profiles than ribavirin in animals. Antivir Chem Chemother (2003) 1.00
Replicon cell culture system as a valuable tool in antiviral drug discovery against hepatitis C virus. Antivir Chem Chemother (2005) 0.99
Activation and deactivation of a broad-spectrum antiviral drug by a single enzyme: adenosine deaminase catalyzes two consecutive deamination reactions. Antimicrob Agents Chemother (2003) 0.98
ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication. PLoS One (2012) 0.98
Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure. Bioorg Med Chem Lett (2006) 0.97
Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase. Antimicrob Agents Chemother (2012) 0.97
Comparison of HCV NS3 protease and NS5B polymerase inhibitor activity in 1a, 1b and 2a replicons and 2a infectious virus. Antiviral Res (2009) 0.95
Involvement of a bovine viral diarrhea virus NS5B locus in virion assembly. J Virol (2004) 0.95
Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrob Agents Chemother (2014) 0.94
Pharmacokinetics and metabolism of [(14)C]ribavirin in rats and cynomolgus monkeys. Antimicrob Agents Chemother (2003) 0.94
Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients. J Med Chem (2013) 0.93
Recent advances in discovery and development of promising therapeutics against hepatitis C virus NS5B RNA-dependent RNA polymerase. Mini Rev Med Chem (2005) 0.93
Ribavirin, viramidine and adenosine-deaminase-catalysed drug activation: implication for nucleoside prodrug design. J Antimicrob Chemother (2003) 0.93
The Arabidopsis homolog of the mammalian OS-9 protein plays a key role in the endoplasmic reticulum-associated degradation of misfolded receptor-like kinases. Mol Plant (2012) 0.93
PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network. Nat Cell Biol (2013) 0.92
Beyond nutrients: food-derived microRNAs provide cross-kingdom regulation. Bioessays (2012) 0.92
Interferon-alpha2b secretion by adenovirus-mediated gene delivery in rat, rabbit, and chimpanzee results in similar pharmacokinetic profiles. Toxicol Appl Pharmacol (2002) 0.91
Remofovir mesylate: a prodrug of PMEA with improved liver-targeting and safety in rats and monkeys. Antivir Chem Chemother (2004) 0.91
Selection of clinically relevant protease inhibitor-resistant viruses using the genotype 2a hepatitis C virus infection system. Antimicrob Agents Chemother (2011) 0.91
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother (2006) 0.90
Establishment of a subgenomic replicon for bovine viral diarrhea virus in Huh-7 cells and modulation of interferon-regulated factor 3-mediated antiviral response. J Virol (2005) 0.90
Design, synthesis, and antiviral activity of adenosine 5'-phosphonate analogues as chain terminators against hepatitis C virus. J Med Chem (2005) 0.89
Viability of poliovirus/rhinovirus VPg chimeric viruses and identification of an amino acid residue in the VPg gene critical for viral RNA replication. J Virol (2003) 0.89
Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase. Bioorg Med Chem Lett (2005) 0.89
Cyclic monophosphate prodrugs of base-modified 2'-C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication. Bioorg Med Chem Lett (2007) 0.87
Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors. Bioorg Med Chem Lett (2007) 0.87
Clinical utility of current NNRTIs and perspectives of new agents in this class under development. Antivir Chem Chemother (2004) 0.87
Effects of heat shock protein gp96 on human dendritic cell maturation and CTL expansion. Biochem Biophys Res Commun (2006) 0.86
Phosphorylation of ribavirin and viramidine by adenosine kinase and cytosolic 5'-nucleotidase II: Implications for ribavirin metabolism in erythrocytes. Antimicrob Agents Chemother (2005) 0.86
Specific, sensitive and accurate liquid chromatographic-tandem mass spectrometric method for the measurement of ribavirin in rat and monkey plasma. J Chromatogr B Analyt Technol Biomed Life Sci (2002) 0.85
SOCS1 abrogates IFN's antiviral effect on hepatitis C virus replication. Antiviral Res (2012) 0.85
Promising candidates for the treatment of chronic hepatitis C. Expert Opin Investig Drugs (2003) 0.84
Narrow bandpass tunable terahertz filter based on photonic crystal cavity. Appl Opt (2012) 0.83
Hepatitis C replication inhibitors that target the viral NS4B protein. J Med Chem (2013) 0.83
Agents in clinical development for the treatment of chronic hepatitis B. Expert Opin Investig Drugs (2003) 0.82
Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors. Bioorg Med Chem Lett (2006) 0.82
Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment. J Virol (2014) 0.82
Substituted imidazopyridines as potent inhibitors of HCV replication. J Hepatol (2009) 0.82
Terahertz gas sensing based on a simple one-dimensional photonic crystal cavity with high-quality factors. Appl Opt (2014) 0.81
Synthesis of 2'-beta-C-methyl toyocamycin and sangivamycin analogues as potential HCV inhibitors. Bioorg Med Chem Lett (2005) 0.81
Inhibition of Hec1 as a novel approach for treatment of primary liver cancer. Cancer Chemother Pharmacol (2014) 0.81
HepDirect prodrugs for targeting nucleotide-based antiviral drugs to the liver. Curr Opin Investig Drugs (2006) 0.80
Identification of novel, selective and potent Chk2 inhibitors. Bioorg Med Chem Lett (2006) 0.80
Cellular growth kinetics distinguish a cyclophilin inhibitor from an HSP90 inhibitor as a selective inhibitor of hepatitis C virus. PLoS One (2012) 0.80
Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1. J Exp Clin Cancer Res (2014) 0.80
Optimized high-throughput screen for hepatitis C virus translation inhibitors. J Biomol Screen (2011) 0.80
Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: convergence of structure-based drug design and X-ray crystallographic study. Bioorg Med Chem Lett (2007) 0.79
The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function. PLoS One (2012) 0.79
In vitro characterization of GSK2485852, a novel hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother (2013) 0.79
An adaptive mutation in NS2 is essential for efficient production of infectious 1b/2a chimeric hepatitis C virus in cell culture. Virology (2011) 0.79
Synthesis of 9-(2-beta-C-methyl-beta-d-ribofuranosyl)-6-substituted purine derivatives as inhibitors of HCV RNA replication. Bioorg Med Chem Lett (2005) 0.79
Solid-phase parallel synthesis of 4-beta-D-ribofuranosylpyrazolo[4,3-d]pyrimidine nucleosides. Nucleosides Nucleotides Nucleic Acids (2005) 0.79
Targeting NS5B RNA-dependent RNA polymerase for anti-HCV chemotherapy. Curr Drug Targets Infect Disord (2003) 0.79
6-Hydrazinopurine 2'-methyl ribonucleosides and their 5'-monophosphate prodrugs as potent hepatitis C virus inhibitors. Bioorg Med Chem Lett (2007) 0.79
Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative. Acta Crystallogr D Biol Crystallogr (2005) 0.79
Slow light in a dielectric waveguide with negative-refractive-index photonic crystal cladding. Opt Express (2008) 0.79
Aqueous synthesis and fluorescence-imaging application of CdTe/ZnSe core/shell quantum dots with high stability and low cytotoxicity. J Nanosci Nanotechnol (2010) 0.78
Isothiazoles as active-site inhibitors of HCV NS5B polymerase. Bioorg Med Chem Lett (2006) 0.78
Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase. J Med Chem (2013) 0.78
The role of ribavirin-induced mutagenesis in HCV therapy: a concept or a fact? Hepatology (2003) 0.78
Synthesis of new 2'-beta-C-methyl related triciribine analogues as anti-HCV agents. Bioorg Med Chem Lett (2004) 0.78