Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Pertussis immunisation and serious acute neurological illness in children.
|
Br Med J (Clin Res Ed)
|
1981
|
8.48
|
2
|
Cigarette smoking in pregnancy: its influence on birth weight and perinatal mortality.
|
Br Med J
|
1972
|
7.69
|
3
|
Biochemical properties of hormone-sensitive adenylate cyclase.
|
Annu Rev Biochem
|
1980
|
3.79
|
4
|
Patient-specific decisions about hormone replacement therapy in postmenopausal women.
|
JAMA
|
1997
|
3.18
|
5
|
Relationship between the beta-adrenergic receptor and adenylate cyclase.
|
J Biol Chem
|
1977
|
2.99
|
6
|
Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.
|
J Biol Chem
|
1990
|
2.96
|
7
|
Purification of the regulatory component of adenylate cyclase.
|
Proc Natl Acad Sci U S A
|
1980
|
2.81
|
8
|
Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme.
|
J Biol Chem
|
1978
|
2.64
|
9
|
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).
|
J Biol Chem
|
1988
|
2.45
|
10
|
Epilepsy in childhood: findings from the National Child Development Study.
|
Br Med J
|
1980
|
2.37
|
11
|
Asymptomatic bacteriuria in girl entrants to Dundee primary schools.
|
Br Med J
|
1969
|
2.32
|
12
|
Resolution of some components of adenylate cyclase necessary for catalytic activity.
|
J Biol Chem
|
1977
|
2.20
|
13
|
Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator.
|
Cell
|
1992
|
2.17
|
14
|
Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1.
|
J Biol Chem
|
1992
|
2.06
|
15
|
Reconstitution of catecholamine-stimulated guanosinetriphosphatase activity.
|
Biochemistry
|
1983
|
1.87
|
16
|
Regulation of phospholipase C-beta1 by Gq and m1 muscarinic cholinergic receptor. Steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation.
|
J Biol Chem
|
1996
|
1.80
|
17
|
Whooping cough and whooping cough vaccine: the risks and benefits debate.
|
Epidemiol Rev
|
1982
|
1.79
|
18
|
Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells.
|
J Biol Chem
|
1991
|
1.63
|
19
|
Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity.
|
J Neurosci
|
1998
|
1.62
|
20
|
The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins.
|
J Biol Chem
|
1987
|
1.61
|
21
|
Rapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins.
|
Proc Natl Acad Sci U S A
|
1999
|
1.61
|
22
|
Catecholamine-stimulated GTPase cycle. Multiple sites of regulation by beta-adrenergic receptor and Mg2+ studied in reconstituted receptor-Gs vesicles.
|
J Biol Chem
|
1986
|
1.54
|
23
|
The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling.
|
J Biol Chem
|
1998
|
1.51
|
24
|
Relationship between fetal acidemia at cordocentesis and subsequent neurodevelopment.
|
Ultrasound Obstet Gynecol
|
1992
|
1.50
|
25
|
Convulsive disorders in British children.
|
Proc R Soc Med
|
1973
|
1.50
|
26
|
Reye's syndrome in children under three years old.
|
Arch Dis Child
|
1982
|
1.50
|
27
|
PDZ domain proteins: scaffolds for signaling complexes.
|
Curr Biol
|
1997
|
1.42
|
28
|
Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes.
|
Proc Natl Acad Sci U S A
|
1977
|
1.41
|
29
|
beta-Adrenergic receptor: ligand binding properties and the interaction with adenylyl cyclase.
|
Adv Cyclic Nucleotide Res
|
1977
|
1.38
|
30
|
Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10.
|
J Biol Chem
|
1999
|
1.38
|
31
|
Chimeric muscarinic cholinergic: beta-adrenergic receptors that activate Gs in response to muscarinic agonists.
|
J Biol Chem
|
1990
|
1.32
|
32
|
GTPase activity of the stimulatory GTP-binding regulatory protein of adenylate cyclase, Gs. Accumulation and turnover of enzyme-nucleotide intermediates.
|
J Biol Chem
|
1985
|
1.27
|
33
|
Outcome of childhood status epilepticus and lengthy febrile convulsions: findings of national cohort study.
|
BMJ
|
1993
|
1.26
|
34
|
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.
|
Proc Natl Acad Sci U S A
|
1977
|
1.25
|
35
|
The carcinoid syndrome: comparison of 21 necropsy subjects with carcinoid heart disease to 15 necropsy subjects without carcinoid heart disease.
|
Am J Med
|
1985
|
1.25
|
36
|
Reconstitution of catecholamine-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase.
|
Biochemistry
|
1984
|
1.24
|
37
|
Functional reconstitution of beta-adrenergic receptors and the stimulatory GTP-binding protein of adenylate cyclase.
|
Proc Natl Acad Sci U S A
|
1982
|
1.21
|
38
|
Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits.
|
Science
|
1997
|
1.20
|
39
|
RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily.
|
J Biol Chem
|
1998
|
1.19
|
40
|
Epilepsy in the first 10 years of life: findings of the child health and education study.
|
BMJ
|
1992
|
1.17
|
41
|
Joubert-Boltshauser syndrome with polydactyly in siblings.
|
J Neurol Neurosurg Psychiatry
|
1982
|
1.16
|
42
|
ABC of 1 to 7: whooping cough.
|
Br Med J (Clin Res Ed)
|
1982
|
1.14
|
43
|
Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by beta-adrenergic receptors in reconstituted phospholipid vesicles.
|
J Biol Chem
|
1984
|
1.12
|
44
|
Functional importance of the amino terminus of Gq alpha.
|
J Biol Chem
|
1996
|
1.12
|
45
|
Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue.
|
Biochemistry
|
1999
|
1.10
|
46
|
Kinetic control of guanine nucleotide binding to soluble Galpha(q).
|
Biochem Pharmacol
|
1999
|
1.09
|
47
|
Phospholipase C-beta1 directly accelerates GTP hydrolysis by Galphaq and acceleration is inhibited by Gbeta gamma subunits.
|
J Biol Chem
|
1999
|
1.06
|
48
|
The hydrophobic tryptic core of the beta-adrenergic receptor retains Gs regulatory activity in response to agonists and thiols.
|
J Biol Chem
|
1987
|
1.06
|
49
|
Truncation of the extended carboxyl-terminal domain increases the expression and regulatory activity of the avian beta-adrenergic receptor.
|
J Biol Chem
|
1991
|
1.06
|
50
|
The catecholamine binding site of the beta-adrenergic receptor is formed by juxtaposed membrane-spanning domains.
|
J Biol Chem
|
1988
|
1.05
|
51
|
Chimeric muscarinic cholinergic:beta-adrenergic receptors that are functionally promiscuous among G proteins.
|
J Biol Chem
|
1994
|
1.04
|
52
|
Human herpesviruses-6 and -7 each cause significant neurological morbidity in Britain and Ireland.
|
Arch Dis Child
|
2005
|
1.02
|
53
|
Phosphatidylcholine-promoted interaction of the catalytic and regulatory proteins of adenylate cyclase.
|
J Biol Chem
|
1982
|
1.02
|
54
|
Infantile spasms and pertussis immunisation.
|
Lancet
|
1983
|
1.01
|
55
|
Reconstitution of receptors and G proteins in phospholipid vesicles.
|
Methods Enzymol
|
1991
|
1.01
|
56
|
Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins.
|
J Biol Chem
|
1985
|
1.00
|
57
|
Functional activation of beta-adrenergic receptors by thiols in the presence or absence of agonists.
|
J Biol Chem
|
1985
|
1.00
|
58
|
Administration of medicines in school: who is responsible?
|
BMJ
|
1998
|
0.99
|
59
|
Pertussis vaccine and severe acute neurological illnesses. Response to a recent review by members of the NCES team.
|
Vaccine
|
1989
|
0.99
|
60
|
Mapping of the mastoparan-binding site on G proteins. Cross-linking of [125I-Tyr3,Cys11]mastoparan to Go.
|
J Biol Chem
|
1991
|
0.98
|
61
|
GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes.
|
Proc Natl Acad Sci U S A
|
1993
|
0.96
|
62
|
Laboratory diagnosis of disseminated intravascular coagulation.
|
Am J Clin Pathol
|
1968
|
0.94
|
63
|
A GTPase-activating protein for the G protein Galphaz. Identification, purification, and mechanism of action.
|
J Biol Chem
|
1997
|
0.93
|
64
|
Catecholamine-stimulated guanosine 5'-O-(3-thiotriphosphate) binding to the stimulatory GTP-binding protein of adenylate cyclase: kinetic analysis in reconstituted phospholipid vesicles.
|
Biochemistry
|
1984
|
0.92
|
65
|
Carboxyl-terminal domains in the avian beta 1-adrenergic receptor that regulate agonist-promoted endocytosis.
|
J Biol Chem
|
1995
|
0.91
|
66
|
Carboxyl-terminal fragments of phospholipase C-beta1 with intrinsic Gq GTPase-activating protein (GAP) activity.
|
J Biol Chem
|
1996
|
0.91
|
67
|
A truncation mutation in the avian beta-adrenergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors.
|
J Biol Chem
|
1990
|
0.90
|
68
|
Simultaneous fibrinogen and platelet survival with (75Se)selenomethionine in man. Studies in diseases with normal coagulation and in hepatocellular disease with abnormal coagulation.
|
Br J Haematol
|
1970
|
0.90
|
69
|
RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20.
|
Genomics
|
2001
|
0.89
|
70
|
Reciprocal signaling between heterotrimeric G proteins and the p21-stimulated protein kinase.
|
J Biol Chem
|
1999
|
0.89
|
71
|
Rapid binding of guanosine 5'-O-(3-thiotriphosphate) to an apparent complex of beta-adrenergic receptor and the GTP-binding regulatory protein Gs.
|
Biochemistry
|
1988
|
0.88
|
72
|
Selectivity of the beta-adrenergic receptor among Gs, Gi's, and Go: assay using recombinant alpha subunits in reconstituted phospholipid vesicles.
|
Biochemistry
|
1991
|
0.88
|
73
|
Binding of regulator of G protein signaling (RGS) proteins to phospholipid bilayers. Contribution of location and/or orientation to Gtpase-activating protein activity.
|
J Biol Chem
|
2001
|
0.87
|
74
|
ATP-dependent regulation of flagellar adenylylcyclase in gametes of Chlamydomonas reinhardtii.
|
J Biol Chem
|
1991
|
0.86
|
75
|
Prelymphoid leukemia phase of Rauscher virus infection.
|
J Natl Cancer Inst
|
1967
|
0.86
|
76
|
Gs regulation of endosome fusion suggests a role for signal transduction pathways in endocytosis.
|
J Biol Chem
|
1994
|
0.86
|
77
|
Effect of Al3+ plus F- on the catecholamine-stimulated GTPase activity of purified and reconstituted Gs.
|
Biochemistry
|
1986
|
0.86
|
78
|
Platelet and fibrinogen kinetics with ( 75 Se)selenomethionine in thrombocytopenic states. II.
|
Br J Haematol
|
1972
|
0.85
|
79
|
Cellular signalling. Viral hijack of receptors.
|
Nature
|
1990
|
0.85
|
80
|
Platelet and fibrinogen kinetics with ( 75 Se)-selenomethionine in patients with myeloproliferative disorders.
|
Br J Haematol
|
1972
|
0.85
|
81
|
Impaired left ventricular systolic and diastolic function without left ventricular dilatation associated with papillary muscle calcification in hypertrophic cardiomyopathy.
|
Am J Cardiol
|
1986
|
0.85
|
82
|
Purification of subunit composition of cytochrome c1 from bakers' yeast Saccharomyces cerevisiae.
|
Methods Enzymol
|
1978
|
0.84
|
83
|
A developmental test based on the STYCAR sequences used in the National Childhood Encephalopathy Study.
|
Child Care Health Dev
|
1986
|
0.84
|
84
|
Regulation of the catalytic component of adenylate cyclase. Potentiative interaction of stimulatory ligands and 2',5'-dideoxyadenosine.
|
Mol Pharmacol
|
1983
|
0.83
|
85
|
Physical separation of the catalytic and regulatory proteins of hepatic adenylate cyclase.
|
J Biol Chem
|
1981
|
0.83
|
86
|
Aspergillus fumigatus thrombi causing total occlusion of both coronary arterial ostia, all four major epicardial coronary arteries and coronary sinus and associated with purulent pericarditis.
|
Am J Cardiol
|
1985
|
0.82
|
87
|
Beta-adrenergic receptors display intramolecular disulfide bridges in situ: analysis by immunoblotting and functional reconstitution.
|
Mol Pharmacol
|
1988
|
0.82
|
88
|
Fetal oxygenation at cordocentesis, maternal smoking and childhood neuro-development.
|
Eur J Obstet Gynecol Reprod Biol
|
1995
|
0.82
|
89
|
Failure of oral propranolol to maintain relief from paroxysmal syncopal attacks in Fallot's tetralogy after its successful intravenous use.
|
Lancet
|
1966
|
0.81
|
90
|
Reconstitution of beta-adrenergic receptors into phospholipid vesicles: restoration of [125I]iodohydroxybenzylpindolol binding to digitonin-solubilized receptors.
|
J Cyclic Nucleotide Res
|
1980
|
0.80
|
91
|
The carboxyl-terminal anchorage domain of the turkey beta 1-adrenergic receptor is encoded by an alternatively spliced exon.
|
J Biol Chem
|
1995
|
0.80
|
92
|
A Gs-selective analog of the receptor-mimetic peptide mastoparan binds to Gs alpha in a kinked helical conformation.
|
Biochemistry
|
1997
|
0.80
|
93
|
The diencephalic syndrome of early infancy.
|
Br J Radiol
|
1969
|
0.79
|
94
|
Hormone-sensitive adenylate cyclase: resolution and reconstitution of some components necessary for regulation of the enzyme.
|
Adv Cyclic Nucleotide Res
|
1978
|
0.79
|
95
|
Individualizing therapy to prevent long-term consequences of estrogen deficiency in postmenopausal women.
|
Arch Intern Med
|
1999
|
0.78
|
96
|
Expression of human muscarinic cholinergic receptors in tobacco.
|
Plant Mol Biol
|
1997
|
0.77
|
97
|
Severe atherosclerotic coronary arterial narrowing and chronic congestive heart failure without myocardial infarction: analysis of 18 patients studied at necropsy.
|
Am J Cardiol
|
1986
|
0.77
|
98
|
A precaution when using the St. Jude Medical prosthesis in the aortic valve position.
|
Am J Cardiol
|
1984
|
0.77
|
99
|
beta-Adrenergic receptors and regulatory GTP-binding proteins: reconstitution of coupling in phospholipid vesicles.
|
Adv Cyclic Nucleotide Protein Phosphorylation Res
|
1985
|
0.77
|
100
|
Severe atherosclerotic coronary artery disease, healed myocardial infarction and chronic congestive heart failure: analysis of 81 patients studied at necropsy.
|
Am J Cardiol
|
1986
|
0.77
|
101
|
Immunisation against diphtheria, tetanus, pertussis and polio.
|
Practitioner
|
1985
|
0.77
|
102
|
Side effects of sodium valproate.
|
Br Med J
|
1977
|
0.77
|
103
|
The effect of a leukemia virus on thrombopoiesis.
|
Cancer Res
|
1968
|
0.76
|
104
|
Whooping cough: a shot in the dark.
|
Br Med J (Clin Res Ed)
|
1983
|
0.75
|
105
|
Letter: Smoking hazards to the fetus.
|
Br Med J
|
1973
|
0.75
|
106
|
Whooping cough immunization in France and Britain: discussion paper.
|
J R Soc Med
|
1983
|
0.75
|
107
|
National Childhood Encephalopathy Study: an interim report.
|
Br Med J
|
1978
|
0.75
|
108
|
Proceedings: Convulsive problems in the National Child Development Study.
|
Arch Dis Child
|
1974
|
0.75
|
109
|
Fibrinogen survival with [75Se]Selenomethionine during L-asparaginase therapy.
|
Br J Haematol
|
1971
|
0.75
|
110
|
Reconstitution of the regulatory functions of beta-adrenergic receptors.
|
Adv Exp Med Biol
|
1984
|
0.75
|
111
|
Effect of cortisol on Rauscher virus infection.
|
Cancer Res
|
1968
|
0.75
|
112
|
Some Observations on the Occurrence of Acidosis after Anaesthesia.
|
Can Med Assoc J
|
1920
|
0.75
|
113
|
[Pathological occlusion].
|
ADM
|
1970
|
0.75
|
114
|
[Articulators].
|
ADM
|
1973
|
0.75
|
115
|
Children with epilepsy: implications for the school health service.
|
Public Health
|
1983
|
0.75
|
116
|
Immunologic mapping of the amino- and carboxy-termini of the turkey erythrocyte beta-adrenergic receptor: selective proteolysis of both domains.
|
FEBS Lett
|
1991
|
0.75
|
117
|
Radioimmunoassay of digitonin.
|
Biochim Biophys Acta
|
1982
|
0.75
|
118
|
National inquiry into convulsive disorders in childhood.
|
Arch Dis Child
|
1972
|
0.75
|
119
|
Alteration in the protein components of catecholamine-sensitive adenylate cyclase during maturation of rat reticulocytes.
|
J Biol Chem
|
1981
|
0.75
|
120
|
Neonatal tetanus (St Kilda, 19th century)
|
Lancet
|
1989
|
0.75
|
121
|
Issue for the '80s: cutting the costs of workers' rehabilitation.
|
Health Serv Manager
|
1981
|
0.75
|
122
|
Epilepsy in Bristol secondary school children.
|
Epilepsia
|
1972
|
0.75
|
123
|
Infectious mononucleosis complicated by hemolytic anemia. Report of a case.
|
Ohio State Med J
|
1967
|
0.75
|
124
|
Multiple saccular aortic aneurysms in nonspecific aortitis.
|
Am J Cardiol
|
1986
|
0.75
|
125
|
Epilepsy through four thousand years.
|
Hist Med
|
1985
|
0.75
|
126
|
Rehabilitation and workmen's compensation.
|
Occup Health Nurs
|
1975
|
0.75
|
127
|
[Pathological occlusion].
|
ADM
|
1969
|
0.75
|
128
|
The coordination of rehabilitation services.
|
ARN J
|
1977
|
0.75
|
129
|
A protamine-splitting assay of serum plasminogen.
|
Am J Clin Pathol
|
1971
|
0.75
|
130
|
Identification and partial characterization of some components of hormone-stimulated adenylate cyclase.
|
Prog Clin Biol Res
|
1979
|
0.75
|
131
|
[Occlusal adjustment for mechanical abrasion].
|
ADM
|
1971
|
0.75
|
132
|
Platelet and fibrinogen kinetics in the chronic myeloproliferative disorders.
|
Cancer
|
1972
|
0.75
|
133
|
Colloquium on signaling and molecular structure in pharmacology (La Jolla, California, March 11-12, 1997).
|
Mol Pharmacol
|
1997
|
0.75
|
134
|
16,000 home visits.
|
Nurs Times
|
1969
|
0.75
|
135
|
"Massive" calcification of a right ventricular outflow parietal pericardial patch in tetralogy of Fallot.
|
Am J Cardiol
|
1984
|
0.75
|
136
|
Learning about school leavers. The special role of the health visitor in the National Child Development Study (1958 Cohort).
|
Health Visit
|
1973
|
0.75
|
137
|
[Vertical dimension; interocclusal rest position].
|
ADM
|
1971
|
0.75
|
138
|
Purification and characterization of phospholipase C-beta 1 mutants expressed in E. coli.
|
Biochem Biophys Res Commun
|
1996
|
0.75
|