Comprehensive screening reveals strong and broadly directed human immunodeficiency virus type 1-specific CD8 responses in perinatally infected children.

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Published in J Virol on July 01, 2003

Authors

M E Feeney1, K A Roosevelt, Y Tang, K J Pfafferott, K McIntosh, S K Burchett, C Mao, B D Walker, P J R Goulder

Author Affiliations

1: Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical Schoo, Boston, Massachusetts, USA.

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Summary of a workshop on new and useful methods in viral diagnosis. J Infect Dis (1978) 1.87

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